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Disease on EC 3.4.24.21 - astacin

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Alzheimer Disease
Expression, purification and initial characterization of human meprin ? from Pichia pastoris.
Amnesia
Snake toxins with high selectivity for subtypes of muscarinic acetylcholine receptors.
astacin deficiency
Down-regulation of the liver-derived plasma protein fetuin-B mediates reversible female infertility.
Cholera
The effect of opiates on the intestinal immune response to cholera toxin in mice.
Diabetic Nephropathies
Meprin beta metalloprotease gene polymorphisms associated with diabetic nephropathy in the Pima Indians.
Escherichia coli Infections
Zebrafish nephrosin helps host defence against Escherichia coli infection.
Herpes Zoster
A chromosome-level genome of black rockfish, Sebastes schlegelii, provides insights into the evolution of live birth.
A Primary Evaluation of Potential Small-Molecule Inhibitors of the Astacin Metalloproteinase Ovastacin, a Novel Drug Target in Female Infertility Treatment.
Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis.
Association of high fetuin-B concentrations in serum with fertilization rate in IVF: a cross-sectional pilot study.
BaP exposure causes oocyte meiotic arrest and fertilization failure to weaken female fertility.
Brefeldin A impairs porcine oocyte meiotic maturation via interruption of organelle dynamics.
Down-regulation of the liver-derived plasma protein fetuin-B mediates reversible female infertility.
Dynein promotes porcine oocyte meiotic progression by maintaining cytoskeletal structures and cortical granule arrangement.
Exposure to aristolochic acid I compromises the maturational competency of porcine oocytes via oxidative stress-induced DNA damage.
Glycan-Independent Gamete Recognition Triggers Egg Zinc Sparks and ZP2 Cleavage to Prevent Polyspermy.
Hatching gland development and hatching in zebrafish embryos: A role for zinc and its transporters Zip10 and Znt1a.
Intracellular activation of ovastacin mediates pre-fertilization hardening of the zona pellucida.
Limited proteolysis by acrosin affects sperm-binding and mechanical resilience of the mouse zona pellucida.
Mammalian gamete fusion depends on the inhibition of ovastacin by fetuin-B.
Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases.
Melamine Impairs Female Fertility via Suppressing Protein Level of Juno in Mouse Eggs.
Melatonin improves the fertilization ability of post-ovulatory aged mouse oocytes by stabilizing ovastacin and Juno to promote sperm binding and fusion.
Melatonin protects oocyte quality from Bisphenol A-induced deterioration in the mouse.
Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy.
Recombinant fetuin-B protein maintains high fertilization rate in cumulus cell-free mouse oocytes.
The E-modulus of the oocyte is a non-destructive measure of zona pellucida hardening.
The protective role of melatonin in porcine oocyte meiotic failure caused by the exposure to benzo(a)pyrene.
Zinc sparks induce physiochemical changes in the egg zona pellucida that prevent polyspermy.
Infections
Identification and activity of inhibitors of the essential nematode-specific metalloprotease DPY-31.
Zebrafish nephrosin helps host defence against Escherichia coli infection.
Infertility
A Primary Evaluation of Potential Small-Molecule Inhibitors of the Astacin Metalloproteinase Ovastacin, a Novel Drug Target in Female Infertility Treatment.
Infertility, Female
A Primary Evaluation of Potential Small-Molecule Inhibitors of the Astacin Metalloproteinase Ovastacin, a Novel Drug Target in Female Infertility Treatment.
Inflammatory Bowel Diseases
An integrated in silico approach to understand protein-protein interactions: human meprin-? with fetuin-A.
First insight into structure-activity relationships of selective meprin ? inhibitors.
Pharmacophore modeling coupled with molecular dynamic simulation approach to identify new leads for meprin-? metalloprotease.
Leukemia
Identification and characterization of human and mouse ovastacin: a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish.
Lymphoma
Identification and characterization of human and mouse ovastacin: a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish.
Myopia
Muscarinic antagonist control of myopia: evidence for m4 and m1 receptor-based pathways in the inhibition of experimentally-induced axial myopia in the tree shrew.
Neoplasms
Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors.
Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3.
Phorbol 12-myristate 13-acetate-induced ectodomain shedding and phosphorylation of the human meprinbeta metalloprotease.
Spit and venom from scytodes spiders: a diverse and distinct cocktail.
The metalloprotease meprinbeta processes E-cadherin and weakens intercellular adhesion.
Two alpha subunits and one beta subunit of meprin zinc-endopeptidases are differentially expressed in the zebrafish Danio rerio.
Neurodegenerative Diseases
An integrated in silico approach to understand protein-protein interactions: human meprin-? with fetuin-A.
Pharmacophore modeling coupled with molecular dynamic simulation approach to identify new leads for meprin-? metalloprotease.
Paralysis
Isolation of neurotoxic peptides from the venom of the 'armed' spider Phoneutria nigriventer.
Renal Insufficiency
First insight into structure-activity relationships of selective meprin ? inhibitors.
Tetanus
The active site structure of tetanus neurotoxin resolved by multiple scattering analysis in X-Ray absorption spectroscopy.
X-ray absorption spectroscopy study of zinc coordination in tetanus neurotoxin, astacin, alkaline protease and thermolysin.
Whooping Cough
Comparison between the vasoactive actions of endothelin and arginine vasopressin in pithed rats after pretreatment with BAY K 8644, nifedipine or pertussis toxin.
Pertussis toxin prevents neomycin-induced calcium-dependent electrophysiological effects in rat hippocampal slices.
Role of renal sympathetic nerves in regulating renovascular responses to angiotensin II in spontaneously hypertensive rats.