Disease on EC 3.4.24.21 - astacin
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Alzheimer Disease
Expression, purification and initial characterization of human meprin ? from Pichia pastoris.
Amnesia
Snake toxins with high selectivity for subtypes of muscarinic acetylcholine receptors.
astacin deficiency
Down-regulation of the liver-derived plasma protein fetuin-B mediates reversible female infertility.
Diabetic Nephropathies
Meprin beta metalloprotease gene polymorphisms associated with diabetic nephropathy in the Pima Indians.
Escherichia coli Infections
Zebrafish nephrosin helps host defence against Escherichia coli infection.
Herpes Zoster
A chromosome-level genome of black rockfish, Sebastes schlegelii, provides insights into the evolution of live birth.
Herpes Zoster
A Primary Evaluation of Potential Small-Molecule Inhibitors of the Astacin Metalloproteinase Ovastacin, a Novel Drug Target in Female Infertility Treatment.
Herpes Zoster
Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis.
Herpes Zoster
Association of high fetuin-B concentrations in serum with fertilization rate in IVF: a cross-sectional pilot study.
Herpes Zoster
BaP exposure causes oocyte meiotic arrest and fertilization failure to weaken female fertility.
Herpes Zoster
Brefeldin A impairs porcine oocyte meiotic maturation via interruption of organelle dynamics.
Herpes Zoster
Down-regulation of the liver-derived plasma protein fetuin-B mediates reversible female infertility.
Herpes Zoster
Dynein promotes porcine oocyte meiotic progression by maintaining cytoskeletal structures and cortical granule arrangement.
Herpes Zoster
Exposure to aristolochic acid I compromises the maturational competency of porcine oocytes via oxidative stress-induced DNA damage.
Herpes Zoster
Glycan-Independent Gamete Recognition Triggers Egg Zinc Sparks and ZP2 Cleavage to Prevent Polyspermy.
Herpes Zoster
Hatching gland development and hatching in zebrafish embryos: A role for zinc and its transporters Zip10 and Znt1a.
Herpes Zoster
Intracellular activation of ovastacin mediates pre-fertilization hardening of the zona pellucida.
Herpes Zoster
Limited proteolysis by acrosin affects sperm-binding and mechanical resilience of the mouse zona pellucida.
Herpes Zoster
Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases.
Herpes Zoster
Melamine Impairs Female Fertility via Suppressing Protein Level of Juno in Mouse Eggs.
Herpes Zoster
Melatonin improves the fertilization ability of post-ovulatory aged mouse oocytes by stabilizing ovastacin and Juno to promote sperm binding and fusion.
Herpes Zoster
Melatonin protects oocyte quality from Bisphenol A-induced deterioration in the mouse.
Herpes Zoster
Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy.
Herpes Zoster
Recombinant fetuin-B protein maintains high fertilization rate in cumulus cell-free mouse oocytes.
Herpes Zoster
The E-modulus of the oocyte is a non-destructive measure of zona pellucida hardening.
Herpes Zoster
The protective role of melatonin in porcine oocyte meiotic failure caused by the exposure to benzo(a)pyrene.
Herpes Zoster
Zinc sparks induce physiochemical changes in the egg zona pellucida that prevent polyspermy.
Infections
Identification and activity of inhibitors of the essential nematode-specific metalloprotease DPY-31.
Infertility
A Primary Evaluation of Potential Small-Molecule Inhibitors of the Astacin Metalloproteinase Ovastacin, a Novel Drug Target in Female Infertility Treatment.
Infertility, Female
A Primary Evaluation of Potential Small-Molecule Inhibitors of the Astacin Metalloproteinase Ovastacin, a Novel Drug Target in Female Infertility Treatment.
Inflammatory Bowel Diseases
An integrated in silico approach to understand protein-protein interactions: human meprin-? with fetuin-A.
Inflammatory Bowel Diseases
First insight into structure-activity relationships of selective meprin ? inhibitors.
Inflammatory Bowel Diseases
Pharmacophore modeling coupled with molecular dynamic simulation approach to identify new leads for meprin-? metalloprotease.
Leukemia
Identification and characterization of human and mouse ovastacin: a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish.
Lymphoma
Identification and characterization of human and mouse ovastacin: a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish.
Myopia
Muscarinic antagonist control of myopia: evidence for m4 and m1 receptor-based pathways in the inhibition of experimentally-induced axial myopia in the tree shrew.
Neoplasms
Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors.
Neoplasms
Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3.
Neoplasms
Phorbol 12-myristate 13-acetate-induced ectodomain shedding and phosphorylation of the human meprinbeta metalloprotease.
Neoplasms
The metalloprotease meprinbeta processes E-cadherin and weakens intercellular adhesion.
Neoplasms
Two alpha subunits and one beta subunit of meprin zinc-endopeptidases are differentially expressed in the zebrafish Danio rerio.
Neurodegenerative Diseases
An integrated in silico approach to understand protein-protein interactions: human meprin-? with fetuin-A.
Neurodegenerative Diseases
Pharmacophore modeling coupled with molecular dynamic simulation approach to identify new leads for meprin-? metalloprotease.
Paralysis
Isolation of neurotoxic peptides from the venom of the 'armed' spider Phoneutria nigriventer.
Renal Insufficiency
First insight into structure-activity relationships of selective meprin ? inhibitors.
Tetanus
The active site structure of tetanus neurotoxin resolved by multiple scattering analysis in X-Ray absorption spectroscopy.
Tetanus
X-ray absorption spectroscopy study of zinc coordination in tetanus neurotoxin, astacin, alkaline protease and thermolysin.
Whooping Cough
Comparison between the vasoactive actions of endothelin and arginine vasopressin in pithed rats after pretreatment with BAY K 8644, nifedipine or pertussis toxin.
Whooping Cough
Pertussis toxin prevents neomycin-induced calcium-dependent electrophysiological effects in rat hippocampal slices.
Whooping Cough
Role of renal sympathetic nerves in regulating renovascular responses to angiotensin II in spontaneously hypertensive rats.
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