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Information on EC 3.4.24.11 - neprilysin and Organism(s) Drosophila melanogaster and UniProt Accession Q8T062

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.11 neprilysin
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This record set is specific for:
Drosophila melanogaster
UNIPROT: Q8T062 not found.
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Word Map
The taxonomic range for the selected organisms is: Drosophila melanogaster
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'
Synonyms
neprilysin, neutral endopeptidase, enkephalinase, calla, endopeptidase-24.11, neutral endopeptidase 24.11, common acute lymphoblastic leukemia antigen, nep 24.11, nep/cd10, membrane metalloendopeptidase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
neprilysin 4
Q9I7I4
two isoforms exist due to different splice-variants: larger isoform A is expressed as a membrane bound protein and isoform B lacking the N-terminal cytosolic and transmembrane region is expressed as a soluble protein
antigen, CALLA (common acute lymphoblastic leukemia-associated)
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CALLA
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CALLA (common acute lymphoblastic leukemia-associated) antigens
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CALLA antigen
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CALLA glycoproteins
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CD10
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common acute lymphoblastic leukemia-associated antigens
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Common acute lymphocytic leukemia antigen
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Endopeptidase-2
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endopeptidase-24.11
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enkephalinase
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glycoprotein, CALLA
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kidney-brush-border neutral endopeptidase
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kidney-brush-border neutral peptidase
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kidney-brush-border neutral proteinase
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membrane metalloendopeptidase
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NEP
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neprilysin 4
-
two isoforms exist due to different splice-variants: larger isoform A is expressed as a membrane bound protein and isoform B lacking the N-terminal cytosolic and transmembrane region is expressed as a soluble protein
neutral endopeptidase
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neutral endopeptidase 24.11
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neutral metallendopeptidase
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peptidase, endo-
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peptidase, membrane metalloendo-
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CAS REGISTRY NUMBER
COMMENTARY hide
82707-54-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
angiotensin I + H2O
?
show the reaction diagram
Q9I7I4
51.6% degradation
-
-
?
bradykinin + H2O
?
show the reaction diagram
Q9I7I4
27.8% degradation
-
-
?
Substance P + H2O
?
show the reaction diagram
Q9I7I4
85.8% degradation
-
-
?
tachykinin + H2O
?
show the reaction diagram
Q9I7I4
27.8% degradation
-
-
?
angiotensin I + H2O
?
show the reaction diagram
Q9I7I4
51.6% degradation
-
-
?
bradykinin + H2O
?
show the reaction diagram
Q9I7I4
27.8% degradation
-
-
?
Substance P + H2O
?
show the reaction diagram
Q9I7I4
85.8% degradation
-
-
?
tachykinin + H2O
?
show the reaction diagram
Q9I7I4
27.8% degradation
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
phosphoramidon
Q9I7I4
-
thiorphan
Q9I7I4
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phosphoramidon
Q9I7I4
-
thiorphan
Q9I7I4
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
35
Q9I7I4
assay at
35
Q9I7I4
assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
Q9I7I4
expression is demonstrated during embryogenesis in pericardial cells, muscle founder cells, glia cells and male gonads. At least one isoform of NEP4 is found in every developmental stage
Manually annotated by BRENDA team
Q9I7I4
expression is demonstrated during embryogenesis in pericardial cells, muscle founder cells, glia cells and male gonads. At least one isoform of NEP4 is found in every developmental stage
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
Q9I7I4
isoform B is expressed as a soluble protein
-
Manually annotated by BRENDA team
Q9I7I4
isoform A is expressed as a membrane bound protein
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
NEP4_DROME
1040
1
119577
Swiss-Prot
Secretory Pathway (Reliability: 5)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
113000
Q9I7I4
isoform B, SDS-PAGE using purified NEP4 antiserum
120000
Q9I7I4
isoform A, SDS-PAGE using purified NEP4 antiserum
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed as a GST-fusion protein in Escherichia coli
Q9I7I4
expressed as a GST-fusion protein in Escherichia coli
Q9I7I4
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Meyer, H.; Panz, M.; Zmojdzian, M.; Jagla, K.; Paululat, A.
Neprilysin 4, a novel endopeptidase from Drosophila melanogaster, displays distinct substrate specificities and exceptional solubility states
J. Exp. Biol.
212
3673-3683
2009
Drosophila melanogaster, Drosophila melanogaster (Q9I7I4)
Manually annotated by BRENDA team