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Information on EC 3.4.24.11 - neprilysin and Organism(s) Homo sapiens and UniProt Accession P08473

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.11 neprilysin
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Select one or more organisms in this record:
This record set is specific for:
Homo sapiens
UNIPROT: P08473 not found.
Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
The taxonomic range for the selected organisms is: Homo sapiens
Reaction Schemes
preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'
Synonyms
acute lymphoblastic leukemia antigen, antigen, CALLA (common acute lymphoblastic leukemia-associated), CALLA, CALLA (common acute lymphoblastic leukemia-associated) antigens, CALLA antigen, CALLA glycoproteins, CD10, CD10/neutral endopeptidase, CD10/neutral endopeptidase 24.11, common acute lymphoblastic leukemia antigen, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acute lymphoblastic leukemia antigen
247
-
antigen, CALLA (common acute lymphoblastic leukemia-associated)
-
-
-
-
CALLA
CALLA (common acute lymphoblastic leukemia-associated) antigens
-
-
-
-
CALLA antigen
-
-
-
-
CALLA glycoproteins
-
-
-
-
CD10/neutral endopeptidase
247
-
CD10/neutral endopeptidase 24.11
247
-
common acute lymphoblastic leukemia antigen
common acute lymphoblastic leukemia-associated antigens
-
-
-
-
Common acute lymphocytic leukemia antigen
-
-
-
-
endopeptidase CD10
247
-
Endopeptidase-2
-
-
-
-
endopeptidase-24.11
enkephalinase
EP24.11
247
-
glycoprotein, CALLA
-
-
-
-
kidney-brush-border neutral endopeptidase
-
-
-
-
kidney-brush-border neutral peptidase
-
-
-
-
kidney-brush-border neutral proteinase
-
-
-
-
membrane metalloendopeptidase
-
-
-
-
NEP, enkephalinase, neutrophil cluster-differentiation antigen 10, common acute lymphoblastic leukemia antigen
247
-
NEP/CD10
247
-
neutral endopeptidase
neutral endopeptidase 24.11
neutral endopeptidase 24.11/CD10
247
-
neutral metallendopeptidase
-
-
-
-
peptidase, endo-
-
-
-
-
peptidase, membrane metalloendo-
-
-
-
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skin fibroblast elastase
296522
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
82707-54-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(7-methoxycoumarin-4-yl)acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(2,4-dinitrophenyl) + H2O
(7-methoxycoumarin-4-yl)acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala + Phe-Lys-(2,4-dinitrophenyl)
show the reaction diagram
-
bradykinin-based quenched fluorescent substrate assay
-
-
?
alpha-endorphin + H2O
?
show the reaction diagram
-
-
-
-
?
amyloid beta peptide + H2O
?
show the reaction diagram
amyloid beta peptide1-40 + H2O
?
show the reaction diagram
amyloid beta peptide1-40 + H2O
amyloid beta peptide Asp1-Lys16 + amyloid beta peptide Asp1-Leu17 + amyloid beta peptide Asp1-Phe19
show the reaction diagram
-
the wild-type enzyme cleaves Ab1-40 predominantly at Lys16-Leu17, Leu17-Val18 and Phe19-Phe20. The mutant G399V/G714K cleaves preferentially at Phe20-Ala21
main cleavage fragments after 60 min with the wild-type enzyme. After 360 min these fragments are degraded further, accompanied by the appearance of Val12-Leu17 and Tyr10-Leu17 fragments
-
?
amyloid beta peptide1-42 + H2O
?
show the reaction diagram
Angiotensin + H2O
?
show the reaction diagram
-
-
-
-
?
Arg-vasopressin + H2O
?
show the reaction diagram
-
-
-
-
?
bradykinin + H2O
?
show the reaction diagram
-
-
-
-
?
Elastin + H2O
?
show the reaction diagram
-
-
-
-
?
endothelin-1 + H2O
?
show the reaction diagram
-
-
-
-
?
gamma-endorphin + H2O
?
show the reaction diagram
-
-
-
-
?
gastri-releasing peptide + H2O
?
show the reaction diagram
-
-
-
-
?
GLP-1 + H2O
?
show the reaction diagram
-
-
-
-
?
Glucagon + H2O
?
show the reaction diagram
-
-
-
-
?
glutaryl-Ala-Ala-Phe-4-methoxy-2-naphthylamide + H2O
glutaryl-Ala-Ala + Phe-4-methoxy-2-naphthylamide
show the reaction diagram
-
-
-
-
?
insulin B chain + H2O
?
show the reaction diagram
leucine5-enkephalin + H2O
?
show the reaction diagram
-
Tyr-Gly-Gly-Phe-Leu is cleaved at the Gly-Phe bond by the wild-type enzyme
-
-
?
N-(4-carboxy-1-oxobutyl)-L-alanyl-L-alanyl-N-(4-methoxy-2-naphthalenyl)-L-phenylalaninamide + H2O
N-(4-carboxy-1-oxobutyl)-L-alanyl-L-alanyl-L-phenylalanine + 4-methoxy-2-naphthylamine
show the reaction diagram
-
-
-
-
?
Neurokinin A + H2O
?
show the reaction diagram
-
-
-
-
?
neurokinin B + H2O
?
show the reaction diagram
-
-
-
-
?
neurotensin + H2O
?
show the reaction diagram
-
-
-
-
?
nociceptin + H2O
?
show the reaction diagram
-
-
-
-
?
pulmonary vasodilative vasoactive intestinal peptide + H2O
?
show the reaction diagram
-
rapid inactivation
-
-
?
somatostatin 14 + H2O
?
show the reaction diagram
-
-
-
-
?
somatostatin 28 + H2O
?
show the reaction diagram
-
-
-
-
?
Substance P + H2O
?
show the reaction diagram
-
-
-
-
?
Z-Ala-Ala-Leu-4-nitroanilide + H2O
Z-Ala-Ala-Leu + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
2-aminobenzoyl-ARFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-AR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-DRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-DR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-FRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-FR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-HRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-HR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-IRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-IR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-KRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-KR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-LRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-LR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-NRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-NR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RAFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RA + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RDFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RD + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-REFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RE + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-rGF-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-D-Arg-Gly + Phe-N-(2,4-dinitrophenyl)ethylenediamine
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RGFK(Dnp)-OH + H2O
2-aminobenzoyl-RG + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RGFK-2,4-dinitrophenyl amide + H2O
2-aminobenzoyl-RG + FK-2,4-dinitrophenyl amide
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RGFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RG + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-rGL-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-D-Arg-Gly + Leu-N-(2,4dinitrophenyl)ethylenediamine
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-rGV-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-D-Arg-Gly + Val-N-(2,4-dinitrophenyl)ethylenediamine
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RHFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RH + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RKFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RK + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RNFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RN + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RPFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RP + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RQFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RQ + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RRFK-2,4-dinitrophenyl amide + H2O
2-aminobenzoyl-RR + FK-2,4-dinitrophenyl amide
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-rRL-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-D-Arg-L-Arg + Leu-N-(2,4-dinitrophenyl)ethylenediamine
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RSFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RS + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-rSL-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-D-Arg-L-Ser + Leu-N-(2,4-dinitrophenyl)ethylenediamine
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RTFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RT + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-SRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-SR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-TRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-TR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-VRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-VR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-WRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-WR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-YRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-YR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
alpha-neoendorphin + H2O
?
show the reaction diagram
-
-
-
-
?
amyloid beta(1-40) mutant A21G + H2O
?
show the reaction diagram
-
Flemish variant of amyloid beta. Decreased degradation by neprilysin compared to either wild-type peptide or the other mutant peptides
-
-
?
amyloid beta(1-40) mutant D23N + H2O
?
show the reaction diagram
-
Iowa variant of amyloid beta
-
-
?
amyloid beta(1-40) mutant E22G + H2O
?
show the reaction diagram
-
Arctic variant of amyloid beta
-
-
?
amyloid beta(1-40) mutant E22K + H2O
?
show the reaction diagram
-
Italian variant of amyloid beta
-
-
?
amyloid beta(1-40) mutant E22Q + H2O
?
show the reaction diagram
-
Dutch variant of amyloid beta
-
-
?
amyloid beta(1-40) peptide + H2O
?
show the reaction diagram
-
-
-
-
?
Angiotensin I + H2O
?
show the reaction diagram
-
-
-
-
?
Angiotensin II + H2O
?
show the reaction diagram
-
-
-
-
?
angiotensin(1-9) + H2O
?
show the reaction diagram
-
-
-
-
?
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O
?
show the reaction diagram
-
-
-
-
?
Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-PheNH2 + H2O
?
show the reaction diagram
-
-
-
-
?
Atrial natriuretic factor + H2O
?
show the reaction diagram
beta-amyloid peptide + H2O
?
show the reaction diagram
-
-
-
-
?
beta-lipotropin(61-69) + H2O + H2O
?
show the reaction diagram
-
-
-
-
?
beta-neoendorphin + H2O
?
show the reaction diagram
-
-
-
-
?
bradykinin + H2O
?
show the reaction diagram
-
-
-
-
?
cholecystokinin-8 + H2O
?
show the reaction diagram
-
-
-
-
-
D-Ala2-Leu5-enkephalin + H2O
Tyr-D-Ala-Gly + Phe-Leu
show the reaction diagram
-
i.e. Tyr-D-Ala-Gly-Phe-Leu
-
-
?
dynorphin + H2O
?
show the reaction diagram
-
-
-
-
?
enkephalin + H2O
?
show the reaction diagram
-
hydrolysis at Gly3-Phe4
-
-
?
exendin-4 + H2O
?
show the reaction diagram
-
poor substrate
-
-
?
FMRF amide + H2O
?
show the reaction diagram
-
-
-
-
?
gamma-endorphin + H2O
?
show the reaction diagram
-
-
-
-
?
gastric inhibitor peptide + H2O
?
show the reaction diagram
-
poor substrate
-
-
?
gastrin + H2O
?
show the reaction diagram
-
-
-
-
?
gastrin G-17 + H2O
?
show the reaction diagram
gastrin releasing peptide-10 + H2O
?
show the reaction diagram
-
-
-
-
-
GLP-1(7-36)amide + H2O
?
show the reaction diagram
-
insulinotropic peptide hormone
-
-
?
Glucagon + H2O
?
show the reaction diagram
-
-
-
-
?
His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 + H2O
His-Lys-Thr-Asp-Ser + Phe-Val-Gly + Leu-Met-NH2
show the reaction diagram
-
-
-
-
?
insulin B chain + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin 1beta + H2O
?
show the reaction diagram
-
-
-
-
?
Leu5-enkephalin + H2O
?
show the reaction diagram
-
-
-
-
?
Luteinizing hormone-releasing hormone + H2O
?
show the reaction diagram
-
-
-
-
?
Met-enkephalin-Arg6-Gly7-Leu + H2O
?
show the reaction diagram
-
-
-
-
?
Met-Leu-Phe + H2O
?
show the reaction diagram
-
chemotactic peptide
-
-
?
Met5-enkephalin-Arg6-Phe7 + H2O
?
show the reaction diagram
-
-
-
-
?
N-dansyl-D-Ala-Gly-p-nitrophenyl-Ala-Gly + H2O
?
show the reaction diagram
-
-
-
-
?
N-formyl-L-Met-Leu-Phe + H2O
?
show the reaction diagram
-
the enzyme may play an important role in modulating chemotactic response by cleavage of the chemotactic substance N-formyl-Met-Leu-Phe
-
-
-
N-Formyl-Met-Leu-Phe + H2O
N-Formyl-Met + Leu-Phe
show the reaction diagram
-
-
-
?
neurokinin B + H2O
?
show the reaction diagram
-
-
-
-
?
neuropeptide Y + H2O
truncated neuropeptide Y + C-terminal fragments of neuropeptide Y
show the reaction diagram
-
-
neuropeptide Y 21-36 and 31-36 are the most abundant fragments generated in vivo
-
?
neurotensin + H2O
?
show the reaction diagram
oxytocin + H2O
?
show the reaction diagram
-
-
-
-
?
physalaemin + H2O
?
show the reaction diagram
-
-
-
-
?
Secretin + H2O
?
show the reaction diagram
-
-
-
-
?
Substance P + H2O
?
show the reaction diagram
succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide + H2O
succinyl-Ala-Ala + Phe-4-methylcoumarin 7-amide
show the reaction diagram
succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
succinyl-Ala-Ala-Phe-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
Tyr-Gly-Gly-Phe-Met + H2O
Tyr-Gly-Gly + Phe-Met
show the reaction diagram
-
i.e. methionine enkephalin
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
amyloid beta peptide + H2O
?
show the reaction diagram
amyloid beta peptide1-40 + H2O
?
show the reaction diagram
amyloid beta peptide1-42 + H2O
?
show the reaction diagram
bradykinin + H2O
?
show the reaction diagram
-
-
-
-
?
Elastin + H2O
?
show the reaction diagram
-
-
-
-
?
insulin B chain + H2O
?
show the reaction diagram
-
multiple cleavage sites
-
-
?
leucine5-enkephalin + H2O
?
show the reaction diagram
-
Tyr-Gly-Gly-Phe-Leu is cleaved at the Gly-Phe bond by the wild-type enzyme
-
-
?
pulmonary vasodilative vasoactive intestinal peptide + H2O
?
show the reaction diagram
-
rapid inactivation
-
-
?
N-formyl-L-Met-Leu-Phe + H2O
?
show the reaction diagram
-
the enzyme may play an important role in modulating chemotactic response by cleavage of the chemotactic substance N-formyl-Met-Leu-Phe
-
-
-
neuropeptide Y + H2O
truncated neuropeptide Y + C-terminal fragments of neuropeptide Y
show the reaction diagram
-
-
neuropeptide Y 21-36 and 31-36 are the most abundant fragments generated in vivo
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Hg2+
-
0.001-0.05 mM, modifies the recombinant enzyme conformation, and highly reduces the enzyme activity. Hg2+ incubation increases NEP protein levels, but does not change NEP mRNA levels nor the levels of the amyloid intracellular domain peptide, a protein fragment with transcriptional activity. The Hg2+-induced inhibition of the enzyme activity may be mediated by a conformational change resulting in reduced amyloid beta1-42 degradation
Insulin B chain
-
inhibits the activity with substrate N-(4-carboxy-1-oxobutyl)-L-alanyl-L-alanyl-N-(4-methoxy-2-naphthalenyl)-L-phenylalaninamide
N-phenethylphosphonyl-L-leucyl-L-tryptophan
-
NPLT, synthesis of the phosphoramidon derivative with enhanced permeability into the skin that shows inability to inhibit type I and type IV collagenase, but inhibits fibroblast elastase
phosphoramidon
U46619
-
a thromboxane mimetic
Z-Leu-Leu-Leu-H
-
-
(2(R,S)-2-sulfanyl-2-benzyl)acetyl-Ala-Pro
-
-
(2(R,S)-2-sulfanyl-2-benzyl)acetyl-Leu-Tyr
-
-
(2(R,S)-2-sulfanyl-2-benzyl)acetyl-Phe-Ala
-
-
(2(R,S)-2-sulfanyl-2-benzyl)acetyl-Phe-Tyr
-
-
(2(R,S)-2-sulfanyl-2-isopropyl)acetyl-Ile-Tyr
-
-
(2R)-2-[(1-[[(1S)-1-carboxy-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethyl]carbamoyl]cyclopentyl)methyl]-5-oxopentanoic acid
-
-
(2R)-2-[(1-[[(1S)-1-carboxy-2-(4-ethyl-1,3-oxazol-2-yl)ethyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
-
-
(2R)-2-[(1-[[(1S)-1-carboxy-2-(4-phenyl-1,3-oxazol-2-yl)ethyl]carbamoyl]cyclopentyl)methyl]-5-oxopentanoic acid
-
-
(2R)-2-[(1-[[(1S)-1-carboxy-2-(4-phenyl-1,3-oxazol-2-yl)ethyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
-
-
(2R)-2-[(1-[[(1S)-1-carboxy-2-(5-phenyl-1,3,4-oxadiazol-2-yl)ethyl]carbamoyl]cyclopentyl)methyl]-5-oxopentanoic acid
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(2R)-2-[(1-[[(1S)-1-carboxy-2-(5-phenyl-1,3-oxazol-2-yl)ethyl]carbamoyl]cyclopentyl)methyl]-5-oxopentanoic acid
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(2R)-2-[(1-[[(1S)-1-carboxy-2-(5-phenyl-1,3-oxazol-2-yl)ethyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
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(2R)-2-[[1-([(1S)-1-carboxy-2-[4-(2-methylpropyl)-1,3-oxazol-2-yl]ethyl]carbamoyl)cyclopentyl]methyl]pentanoic acid
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(2R)-2-[[1-([(1S)-1-carboxy-2-[5-(4-chlorophenyl)-1,3-oxazol-2-yl]ethyl]carbamoyl)cyclopentyl]methyl]-5-oxopentanoic acid
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(2S)-2-[[(2S)-1-[[(1S)-2-(biphenyl-4-yl)-1-carboxyethyl]amino]-5-methyl-1-oxohexan-2-yl]amino]-4-phenylbutanoic acid (non-preferred name)
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4-hydroxy-nonenal
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intracellular neprilysin develops 4-hydroxy-nonenal adducts after 24 h of 4-hydroxy-nonenal treatment. 4-Hydroxy-nonenal-modified neprilysin shows decreased catalytic activity, which is associated with elevations in amyloid beta1-40 in SH-SY5Y and H4 APP695wt cells. Incubation of cells with amyloid beta1-42 also induces 4-hydroxy-nonenal adduction of neprilysin
Acetorphan
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amyloid beta1-42
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incubation of cells with amyloid beta1-42 induces 4-hydroxy-nonenal adduction of neprilysin. In an apparent compensatory response, amyloid beta-treated cells show increased neprilysin mRNA and protein expression. Despite elevations in neprilysin protein, the activity is significantly lower compared with the neprilysin protein level
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angiotensin I
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atrial natriuretic factor
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bradykinin
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cis-4-[([1-[(2S)-2-carboxy-3-(2-methoxyethoxy)propyl]cyclopentyl]carbonyl)amino]cyclohexanecarboxylic acid
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EDTA
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LCZ696
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LCZ696 is a dual-acting angiotensin II-receptor and neprilysin inhibitor (ARNI) in a single molecule: angiotensin-receptor blockade via its valsartan molecular moiety, and neprilysin inhibition via its AHU377 molecular moiety. In a randomized, double-blind, placebo-controlled, active comparator study it is shown that compared with valsartan, dual-acting LCZ696 provides complementary and fully additive reduction of blood pressure
Leu5-enkephalin
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MCB3937
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bifunctional inhibitor of NEP and DPP-IV
MCB4241
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bifunctional inhibitor of NEP and DPP-IV
Met5-enkephalin
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N-([1-[(2S)-2-carboxy-3-[[N2-(methylsulfonyl)-L-lysyl]amino]propyl]cyclopentyl]carbonyl)-L-tyrosine
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N-[5-fluoresceinyl]-N'-[6-(3-mercapto-2-benzyl-1-oxopropyl)amino-1-hexyl]thiocarbamide
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the inhibitor is a very potent probe for detecting membrane-bound enzyme for biological studies or diagnostic applications. Particularly useful for detecting the membrane-bound enzyme by flow cytometry
neurotensin
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opiorphin
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phosphoramidon
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Substance P
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Tat peptide 5118
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thiol
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kidney enzyme; lung enzyme
thiorphan-NH2
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valsartan
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LCZ696 comprises molecular moieties of valsartan, and of the NEP inhibitor prodrug AHU377 ((2R,4S)-5-biphenyl-4-yl-5-(3-carboxy-propionylamino)-2-methyl-pentanoic acid ethyl ester) (1:1 molar ratio). Oral administration of healthy volunteers is associated with increases in plasma cGMP, renin concentration and activity, and angiotensin II, providing evidence for NEP inhibition and angiotensin receptor blockade
additional information
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
estrogen
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estrogen stimulates degradation of beta-amyloid peptide by up-regulating neprilysin
additional information
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both staurosporine-stimulated caspase-3 activation, p53 and neprilysin expression and activity are not affected by over-expression or depletion of presenilin complex component TMP21
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