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Information on EC 3.4.23.B8 - human T-cell leukemia virus type 1 protease

for references in articles please use BRENDA:EC3.4.23.B8
preliminary BRENDA-supplied EC number
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UNIPROT: Q82134
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The expected taxonomic range for this enzyme is: Human T-cell leukemia virus type I
Reaction Schemes
Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-/-PIVQ- cleavage site.
Synonyms
htlv-1 protease, htlv-i protease, htlv-1 pr, htlv-i pr, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
HTLV-I protease
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-
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retropepsin (human T-cell leukemia virus)
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simian T-cell leukemia virus endopeptidase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
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-
CAS REGISTRY NUMBER
COMMENTARY hide
144114-21-6
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Ace-Pro-Val-Ile-Leu-Pro-Ile-NMe + H2O
Ace-Pro-Val-Ile-Leu + Pro-Ile-NMe
show the reaction diagram
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-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
Q82134_9DELA
125
0
13460
TrEMBL
other Location (Reliability: 2)
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
molecular dynamics simulation. In the apo-enzyme, the two catalytic residues are chemically equivalent and are expected to be both unprotonated. Upon substrate binding, the catalytic residues of HTLV-1 protease evolve to a singly protonated state, in which the carboxylic oxygen atom OD1 of Asp32 is protonated and forms a hydrogen bond with the OD1 atom of Asp32' , which is unprotonated
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ma, S.; Vogt, K.; Petrillo, N.; Ruhoff, A.
Characterizing the protonation states of the catalytic residues in apo and substrate-bound human T-cell leukemia virus type 1 protease
Comput. Biol. Chem.
56
61-70
2015
Human T-cell leukemia virus type I (Q82134), Human T-cell leukemia virus type I
Manually annotated by BRENDA team