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Information on EC 3.4.23.B1 - napsin and Organism(s) Mus musculus and UniProt Accession O09043

for references in articles please use BRENDA:EC3.4.23.B1
preliminary BRENDA-supplied EC number
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.B1 napsin
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This record set is specific for:
Mus musculus
UNIPROT: O09043
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The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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proteolytic cleavage of polypeptides to large and stable peptides
belongs to the aspartic proteinases
Synonyms
napsin a, napsin, napsin-a, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TA02 protein
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
208934-04-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
polypeptide + H2O
peptides
show the reaction diagram
-
-
-
-
?
additional information
?
-
association of napsin A to tumor growth inhibition determined
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
polypeptide + H2O
peptides
show the reaction diagram
-
-
-
-
?
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
napsin A-expressing cells shown to form tumors in SCID mice with lower efficiency and slower onset compared to vector-transfected control cells
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
alveolar
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
additional information
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no activity and mRNA expression in B-lymphocytes
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
NAPSA_MOUSE
419
0
45544
Swiss-Prot
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mori, K.; Shimizu, H.; Konno, A.; Iwanaga, T.
Immunohistochemical localization of napsin and its potential role in protein catabolism in renal proximal tubules
Arch. Histol. Cytol.
65
359-368
2002
Mus musculus, Rattus norvegicus (Q9QX71)
Manually annotated by BRENDA team
Ueno, T.; Elmberger, G.; Weaver, T.E.; Toi, M.; Linder, S.
The aspartic protease napsin A suppresses tumor growth independent of its catalytic activity
Lab. Invest.
88
256-263
2008
Mus musculus (O09043), Homo sapiens (O96009), Homo sapiens
Manually annotated by BRENDA team