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Disease on EC 3.4.23.49 - omptin

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Anthrax
Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.
Validated MALDI-TOF-MS method for anthrax lethal factor provides early diagnosis and evaluation of therapeutics.
Bernard-Soulier Syndrome
Responses to aggregating agents after cleavage of GPIb of human platelets by the O-sialoglycoprotein endoprotease from Pasteurella haemolytica- potential surrogates for Bernard-Soulier platelets?
Bone Resorption
Peptide aldehyde inhibitors of cathepsin K inhibit bone resorption both in vitro and in vivo.
Borna Disease
Processing of the Borna disease virus glycoprotein gp94 by the subtilisin-like endoprotease furin.
Botulism
Direct biosensor detection of botulinum neurotoxin endopeptidase activity in sera from patients with type A botulism.
Breast Neoplasms
Deubiquitination and stabilization of estrogen receptor ? by ubiquitin-specific protease 7 promotes breast tumorigenesis.
Heterologous expression and characterization of the aspartic endoprotease Pep4um from Ustilago maydis, a homolog of the human Chatepsin D, an important breast cancer therapeutic target.
Ubiquitin-specific protease 7 downregulation suppresses breast cancer in vitro.
Carcinogenesis
Deubiquitination and stabilization of estrogen receptor ? by ubiquitin-specific protease 7 promotes breast tumorigenesis.
Ubiquitin-specific protease 7 (USP7) is essential for endometrial stromal cell decidualization in mice.
Ubiquitin-specific protease 7 is a druggable target that is essential for pancreatic cancer growth and chemoresistance.
Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis.
USP7 manipulation by viral proteins.
Carcinoma, Hepatocellular
Clinical Significance of Ubiquitin Specific Protease 7 (USP7) in Predicting Prognosis of Hepatocellular Carcinoma and its Functional Mechanisms.
Reconstitution of human hepatoma endosome-endosome fusion in vitro: potential roles for an endoprotease and a phosphoprotein phosphatase.
Regulated production of mature insulin by non-beta-cells.
Ubiquitin-specific protease 7 accelerates p14(ARF) degradation by deubiquitinating thyroid hormone receptor-interacting protein 12 and promotes hepatocellular carcinoma progression.
Ubiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance.
Carcinoma, Non-Small-Cell Lung
USP7 promotes cell proliferation through the stabilization of Ki-67 protein in non-small cell lung cancer cells.
Carcinoma, Ovarian Epithelial
Ubiquitin-specific protease 7 expression is a prognostic factor in epithelial ovarian cancer and correlates with lymph node metastasis.
Cataract
Oxidation of cysteine residues from alpha-A crystallin during cataractogenesis of the human lens.
Celiac Disease
Development of wheat genotypes expressing a glutamine-specific endoprotease from barley and a prolyl endopeptidase from Flavobacterium meningosepticum or Pyrococcus furiosus as a potential remedy to celiac disease.
Coinfection
Proteolytic processing of human cytomegalovirus glycoprotein B (gpUL55) is mediated by the human endoprotease furin.
Colonic Neoplasms
Expression of USP7 and MARCH7 Is Correlated with Poor Prognosis in Epithelial Ovarian Cancer.
Colorectal Neoplasms
Functional protease profiling with reporter peptides in serum specimens of colorectal cancer patients: demonstration of its routine diagnostic applicability.
Cystitis
Distribution and genetic association of putative uropathogenic virulence factors iroN, iha, kpsMT, ompT and usp in Escherichia coli isolated from urinary tract infections in Japan.
Cysts
Characterization of a multicopy family of genes encoding a surface-expressed serine endoprotease in rat Pneumocystis carinii.
Dental Plaque
Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases.
Diphtheria
Common Reference-Based Tandem Mass Tag Multiplexing for the Relative Quantification of Peptides: Design and Application to Degradome Analysis of Diphtheria Toxoid.
Duodenal Ulcer
Measurement of tryptase in endoscopic gastroduodenal biopsies: distribution and relationship with ulcer disease.
Duodenitis
Measurement of tryptase in endoscopic gastroduodenal biopsies: distribution and relationship with ulcer disease.
Endometriosis
CAPN 7 promotes the migration and invasion of human endometrial stromal cell by regulating matrix metalloproteinase 2 activity.
Enterobacteriaceae Infections
New Promising Targets for Synthetic Omptin-Based Peptide Vaccine against Gram-Negative Pathogens.
Gastroenteritis
The outer membrane protease PgtE of Salmonella enterica interferes with the alternative complement pathway by cleaving factors B and H.
Hematologic Neoplasms
Ubiquitin-specific protease 7 as a potential therapeutic target in dogs with hematopoietic malignancies.
Hemorrhagic Fever, Crimean
Crimean-Congo hemorrhagic fever virus glycoprotein processing by the endoprotease SKI-1/S1P is critical for virus infectivity.
Herpes Simplex
Overexpression of the ubiquitin-specific protease 7 resulting from transfection or mutations in the ICP0 binding site accelerates rather than depresses herpes simplex virus 1 gene expression.
Structural Characterization of Interaction between Human Ubiquitin-specific Protease 7 and Immediate-Early Protein ICP0 of Herpes Simplex Virus-1.
Herpes Zoster
Proteolytic processing of human zona pellucida proteins.
Hidradenitis Suppurativa
A novel NCSTN missense mutation in the signal peptide domain causes hidradenitis suppurativa, which has features characteristic of an autoinflammatory keratinization disease.
Hypertension
Effects of a neutral endoprotease enzyme inhibitor, thiorphan, on hemodynamics and renal excretory function in four models of experimental hypertension.
Infections
A Novel Fungal Protease Expressed in Endophytic Infection of Poa Species.
Are tryptase and cathepsin D related to Helicobacter pylori infection and mucosal gastrin in peptic ulcer?
Expression of factor X and its significance for the determination of paramyxovirus tropism in the chick embryo.
Influence of Helicobacter pylori on tryptase and cathepsin D in peptic ulcer.
Inhibition of outer membrane proteases of the omptin family by aprotinin.
Proteolytic processing of human cytomegalovirus glycoprotein B (gpUL55) is mediated by the human endoprotease furin.
The Pla surface protease/adhesin of Yersinia pestis mediates bacterial invasion into human endothelial cells.
Two Isoforms of Yersinia pestis Plasminogen Activator Pla: Intraspecies Distribution, Intrinsic Disorder Propensity, and Contribution to Virulence.
Influenza in Birds
Location and character of the cellular enzyme that cleaves the hemagglutinin of a virulent avian influenza virus.
Sequence specificity of furin, a proprotein-processing endoprotease, for the hemagglutinin of a virulent avian influenza virus.
Influenza, Human
Activation of an influenza virus A/turkey/Oregon/71 HA insertion variant by the subtilisin-like endoprotease furin.
Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease.
Pulmonary surfactant is a potential endogenous inhibitor of proteolytic activation of Sendai virus and influenza A virus.
Insulinoma
Expression and processing of mouse proopiomelanocortin in bovine adrenal chromaffin cells. A model system to study tissue-specific prohormone processing.
Proprotein-Processing Endoprotease Furin and its Substrate Parathyroid Hormone-Related Protein Are Coexpressed in Insulinoma Cells.
Leukemia
Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7).
USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia.
Leukemia, Myeloid
Knockout of the RAS endoprotease RCE1 accelerates myeloid leukemia by downregulating GADD45b.
Leukemia, Myeloid, Acute
Inhibition of ubiquitin-specific protease 7 sensitizes acute myeloid leukemia to chemotherapy.
Lipodystrophy
A novel homozygous Ala529Val LMNA mutation in Turkish patients with mandibuloacral dysplasia.
Genetic basis of lipodystrophies and management of metabolic complications.
Liver Neoplasms
Hypoxia induces miR-210, leading to anti-apoptosis in ovarian follicular cells of marine medaka Oryzias melastigma.
Lung Neoplasms
Ubiquitin-specific protease 7 expression is a prognostic factor in epithelial ovarian cancer and correlates with lymph node metastasis.
USP7 promotes cell proliferation through the stabilization of Ki-67 protein in non-small cell lung cancer cells.
Lymphatic Metastasis
Ubiquitin-specific protease 7 expression is a prognostic factor in epithelial ovarian cancer and correlates with lymph node metastasis.
Measles
Engineered serine protease inhibitor prevents furin-catalyzed activation of the fusion glycoprotein and production of infectious measles virus.
Mucormycosis
Characterization of an extracellular subtilisin protease of Rhizopus microsporus and evidence for its expression during invasive rhinoorbital mycosis.
Multiple Sclerosis
Cathepsin G, and not the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human B lymphocytes.
Myocardial Infarction
Co-elevation of brain natriuretic peptide and proprotein-processing endoprotease furin after myocardial infarction in rats.
Neoplasm Metastasis
Ubiquitin-specific protease 7 expression is a prognostic factor in epithelial ovarian cancer and correlates with lymph node metastasis.
Ubiquitin?specific protease 7 promotes osteosarcoma cell metastasis by inducing epithelial?mesenchymal transition.
USP7 deubiquitinates and stabilizes EZH2 in prostate cancer cells.
Neoplasms
(1)H, (13)C and (15)N backbone resonance assignment for the 40.5 kDa catalytic domain of Ubiquitin Specific Protease 7 (USP7).
A novel NCSTN missense mutation in the signal peptide domain causes hidradenitis suppurativa, which has features characteristic of an autoinflammatory keratinization disease.
Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing.
An Integrated in silico Approach and in?vitro Study for the Discovery of Small-Molecule USP7 Inhibitors as Potential Cancer Therapies.
Binding affinity and dissociation pathway predictions for a series of USP7 inhibitors with pyrimidinone scaffold by multiple computational methods.
Chemical Approaches to Intervening in Ubiquitin Specific Protease 7 (USP7) Function for Oncology and Immune Oncology Therapies.
Clinical Significance of Ubiquitin Specific Protease 7 (USP7) in Predicting Prognosis of Hepatocellular Carcinoma and its Functional Mechanisms.
Clinical significance of USP7 and EZH2 in predicting prognosis of laryngeal squamous cell carcinoma and their possible functional mechanism.
ERBB3-induced furin promotes the progression and metastasis of ovarian cancer via the IGF1R/STAT3 signaling axis.
Expression of USP7 and MARCH7 Is Correlated with Poor Prognosis in Epithelial Ovarian Cancer.
Furin-mediated processing of Pro-C-type natriuretic peptide.
Hypoxia induces miR-210, leading to anti-apoptosis in ovarian follicular cells of marine medaka Oryzias melastigma.
In Vivo Bioluminescence Imaging of Furin Activity in Breast Cancer Cells Using Bioluminogenic Substrates.
Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer.
Inhibition of K-ras-transformed rodent and human cancer cell growth via induction of apoptosis by irreversible inhibitors of Ras endoprotease.
Legumain protease-activated tuftsin-functionalized nanoparticles for dual-targeting TAMs and cancer chemotherapy.
Modulation of proliferation and chemosensitivity by procathepsin D and its peptides in ovarian cancer.
Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM-17.
Nuclear expression of MDM2 in hibernoma: a potential diagnostic pitfall.
Polyarginines are potent furin inhibitors.
Proteolytic processing activates a viral superantigen.
Proteome Analysis of USP7 Substrates Revealed Its Role in Melanoma Through PI3K/Akt/FOXO and AMPK Pathways.
Recent advances in the development of ubiquitin-specific-processing protease 7 (USP7) inhibitors.
Recent advances on the intervention sites targeting USP7-MDM2-p53 in cancer therapy.
Selective and reversible inhibitors of ubiquitin-specific protease 7: a patent evaluation (WO2013030218).
STAT3 repressed USP7 expression is crucial for colon cancer development.
Targeting ubiquitin specific protease 7 in cancer: A deubiquitinase with great prospects.
Targeting Ubiquitin-Specific Protease 7 (USP7) in Cancer: A New Insight to Overcome Drug Resistance.
The emerging nature of Ubiquitin-specific protease 7 (USP7): a new target in cancer therapy.
Ubiquitin-specific protease 7 expression is a prognostic factor in epithelial ovarian cancer and correlates with lymph node metastasis.
Ubiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance.
Ubiquitin-specific protease 7 regulates nucleotide excision repair through deubiquitinating XPC protein and preventing XPC protein from undergoing ultraviolet light-induced and VCP/p97 protein-regulated proteolysis.
Ubiquitin?specific protease 7 promotes osteosarcoma cell metastasis by inducing epithelial?mesenchymal transition.
Upregulation of deubiquitinase USP7 by transcription factor FOXO6 promotes EC progression via targeting the JMJD3/CLU axis.
USP7 deubiquitinates and stabilizes EZH2 in prostate cancer cells.
USP7 inhibition inhibits proliferation and induces megakaryocytic differentiation in MDS cells by upregulating gelsolin.
USP7 manipulation by viral proteins.
[Identifying Inhibitors of USP7-HDM2 Protein-Protein Interaction (PPI) by the in Silico Fragment-mapping Method].
Neuroblastoma
HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma.
Neurotoxicity of microglial cathepsin D revealed by secretome analysis.
Regulation by retinoic acid of insulin-degrading enzyme and of a related endoprotease in human neuroblastoma cell lines.
Newcastle Disease
Identification of endoprotease activity in the trans Golgi membranes of rat liver cells that specifically processes in vitro the fusion glycoprotein precursor of virulent Newcastle disease virus.
Osteosarcoma
Gene expression changes in BALB/3T3 transformants induced by poly(L-lactic acid) or polyurethane films.
Synthesis of human parathyroid-hormone-related protein(1-141) in Saccharomyces cerevisiae. A correct amino-terminal processing vital for the hormone's biological activity is obtained by an ubiquitin fusion protein approach.
Ubiquitin?specific protease 7 promotes osteosarcoma cell metastasis by inducing epithelial?mesenchymal transition.
Ovarian Neoplasms
Modulation of proliferation and chemosensitivity by procathepsin D and its peptides in ovarian cancer.
Pancreatic Neoplasms
Ubiquitin-specific protease 7 is a druggable target that is essential for pancreatic cancer growth and chemoresistance.
Pancreatitis
In vivo imaging with fluorescent smart probes to assess treatment strategies for acute pancreatitis.
Peptic Ulcer
Are tryptase and cathepsin D related to Helicobacter pylori infection and mucosal gastrin in peptic ulcer?
Influence of Helicobacter pylori on tryptase and cathepsin D in peptic ulcer.
Picornaviridae Infections
Protein cleavage in virus-infected cells.
Plague
Adhesive properties of the purified plasminogen activator Pla of Yersinia pestis.
An active site water network in the plasminogen activator pla from Yersinia pestis.
Fibrinolytic and procoagulant activities of Yersinia pestis and Salmonella enterica.
Molecular adaptation of a plant-bacterium outer membrane protease towards plague virulence factor Pla.
Polyphosphate and omptins: novel bacterial procoagulant agents.
Proteolytic inactivation of tissue factor pathway inhibitor by bacterial omptins.
Proteolytic processing of the Yersinia pestis YapG autotransporter by the omptin protease Pla and the contribution of YapG to murine plague pathogenesis.
Structural basis for activation of an integral membrane protease by lipopolysaccharide.
The Pla surface protease/adhesin of Yersinia pestis mediates bacterial invasion into human endothelial cells.
Progeria
Different prelamin A forms accumulate in human fibroblasts: a study in experimental models and progeria.
RNAi of FACE1 protease results in growth inhibition of human cells expressing lamin A: implications for Hutchinson-Gilford progeria syndrome.
Prostatic Neoplasms
Design of synthetic hexapeptide substrates for prostate-specific antigen using single-position minilibraries.
Improving the Selectivity of PACE4 Inhibitors through Modifications of the P1 Residue.
The Deubiquitinating Enzyme USP7 Regulates Androgen Receptor Activity by Modulating Its Binding to Chromatin.
Prostatitis
Distribution and genetic association of putative uropathogenic virulence factors iroN, iha, kpsMT, ompT and usp in Escherichia coli isolated from urinary tract infections in Japan.
Pyelonephritis
Distribution and genetic association of putative uropathogenic virulence factors iroN, iha, kpsMT, ompT and usp in Escherichia coli isolated from urinary tract infections in Japan.
Rickets
[From gene to disease; hypophosphataemic rickets and the PHEX gene]
Stomach Neoplasms
Prohormone convertase furin has a role in gastric cancer cell proliferation with parathyroid hormone-related peptide in a reciprocal manner.
Stomach Ulcer
Measurement of tryptase in endoscopic gastroduodenal biopsies: distribution and relationship with ulcer disease.
Tetanus
A single mutation in the recombinant light chain of tetanus toxin abolishes its proteolytic activity and removes the toxicity seen after reconstitution with native heavy chain.
Cytotoxic effects of a chimeric protein consisting of tetanus toxin light chain and anthrax toxin lethal factor in non-neuronal cells.
Typhoid Fever
The outer membrane protease PgtE of Salmonella enterica interferes with the alternative complement pathway by cleaving factors B and H.
Vaccinia
Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo.
The Dfur2 gene of Drosophila melanogaster: genetic organization, expression during embryogenesis, and pro-protein processing activity of its translational product Dfurin2.
Virus Diseases
USP7 manipulation by viral proteins.
Vitiligo
Association and expression of antigen processing gene PSMB8 coding for Low Molecular Mass Protease 7 (LMP7) with Vitiligo in North India: case-control study.