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Information on EC 3.4.23.46 - memapsin 2 and Organism(s) Danio rerio and UniProt Accession Q6NZT7

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.46 memapsin 2
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This record set is specific for:
Danio rerio
UNIPROT: Q6NZT7 not found.
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Word Map
The taxonomic range for the selected organisms is: Danio rerio
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein
Synonyms
bace1, gamma-secretase, presenilin 1, presenilin-1, bace-1, alpha-secretase, presenilin-2, memapsin 2, beta-site amyloid precursor protein cleaving enzyme, bace 1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amyloid precursor protein secretase
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-
-
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APP secretase
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-
-
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aspartic protease BACE
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-
-
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aspartic protease BACE1
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-
-
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aspartic proteinase BACE1
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-
-
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beta protein amyloidogenase
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-
-
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beta-amyloid protein precursor secretase
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-
-
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beta-secretase
-
-
-
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beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1 (BACE1)
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-
-
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beta-site APP-cleaving enzyme 1
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-
-
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D-aspartyl-beta-amyloid secretase
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-
-
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gamma-secretase
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memapsin 1
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-
-
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membrane-bound aspartic protease
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-
-
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protease Asp2
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-
-
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proteinase BACE1
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-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
158736-49-3
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
amyloid precursor protein + H2O
amyloid beta protein 40 + amyloid beta protein 42
show the reaction diagram
-
-
-
-
?
Notch + H2O
Notch intracellular domain + ?
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
amyloid precursor protein + H2O
amyloid beta protein 40 + amyloid beta protein 42
show the reaction diagram
-
-
-
-
?
Notch + H2O
Notch intracellular domain + ?
show the reaction diagram
-
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
AD115
-
a fragment of Gleevec
AD28
-
a fragment of Gleevec
AD94
-
a fragment of Gleevec
AD95
-
a fragment of Gleevec, strong inhibition
Gleevec
-
-
N- [N-(3,5-difluorophenacetyl-L-alanyl)]-S-phenylglycine tert-butyl ester
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complete inhibition at 0.1 mM
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
homozygous bace1 mutants are hypomyelinated in the peripheral nervous system while the central nervous system is not affected. The number of mechanosensory neuromasts is elevated. Double homozygous Bace1/Bace2 fish do not enhance the single mutant phenotypes indicating non-redundant distinct physiological functions. Single homozygous bace1 mutants as well as double homozygous bace1 and bace2 mutants are viable and fertile
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
Q6NZT7_DANRE
505
1
55661
TrEMBL
Mitochondrion (Reliability: 5)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Arslanova, D.; Yang, T.; Xu, X.; Wong, S.T.; Augelli-Szafran, C.E.; Xia, W.
Phenotypic analysis of images of zebrafish treated with Alzheimers gamma-secretase inhibitors
BMC Biotechnol.
10
24
2010
Danio rerio
Manually annotated by BRENDA team
van Bebber, F.; Hruscha, A.; Willem, M.; Schmid, B.; Haass, C.
Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes
J. Neurochem.
127
471-481
2013
Danio rerio (Q6NZT7), Danio rerio
Manually annotated by BRENDA team