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Information on EC 3.4.23.41 - yapsin 1

for references in articles please use BRENDA:EC3.4.23.41

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IUBMB Comments

In peptidase family A1 of pepsin, and weakly inhibited by pepstatin. Can partially substitute for kexin in a deficient strain of yeast. The homologous product of the Mkc7 gene (Saccharomyces cerevisiae) has similar catalytic activity and has been termed yapsin 2

The enzyme appears in viruses and cellular organisms
Reaction Schemes
hydrolyses various precursor proteins with Arg or Lys in P1, and commonly Arg or Lys also in P2. The P3 amino acid is usually non-polar, but otherwise additional basic amino acids are favourable in both non-prime and prime positions

Synonyms
yapsin 1, yeast aspartic protease 3, yeast aspartic protease, yap3 gene product, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
hydrolyses various precursor proteins with Arg or Lys in P1, and commonly Arg or Lys also in P2. The P3 amino acid is usually non-polar, but otherwise additional basic amino acids are favourable in both non-prime and prime positions
show the reaction diagram
Highest Expressing Human Cell Lines
Cell Line Links Gene Links