Reference on EC 3.4.23.38 - plasmepsin I and Organism(s) Plasmodium falciparum and UniProt Accession P39898

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Goldberg, D.E.; Slater, A.F.G.; Beavis, R.; Chait, B.; Cerami, A.; Henderson, G.B.
Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease
J. Exp. Med.
173
961-969
1991
Plasmodium falciparum
Manually annotated by BRENDA team
Francis, S.E.; Gluzman, I.Y.; Oksman, A.; Knickerbocker, A.; Mueller, R.; Bryant, M.L.; Sherman, D.R.; Russell, D.G.; Goldberg, D.E.
Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase
EMBO J.
13
306-317
1994
Plasmodium falciparum
Manually annotated by BRENDA team
Gluzman, I.Y.; Francis, S.E.; Oksman, A.; Smith, C.E.; Duffin, K.L.; Goldberg, D.E.
Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway
J. Clin. Invest.
93
1602-1608
1994
Plasmodium falciparum
Manually annotated by BRENDA team
Ersmark, K.; Feierberg, I.; Bjelic, S.; Hamelink, E.; Hackett, F.; Blackman, M.J.; Hulten, J.; Samuelsson, B.; Aqvist, J.; Hallberg, A.
Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity
J. Med. Chem.
47
110-122
2004
Plasmodium falciparum
Manually annotated by BRENDA team
Berry, C.
Plasmepsins as antimalarial targets
Curr. Opin. Drug Discov. Devel.
3
624-629
2000
Plasmodium falciparum
Manually annotated by BRENDA team
Dahlgren, A.; Kvarnstrom, I.; Vrang, L.; Hamelink, E.; Hallberg, A.; Rosenquist, A.; Samuelsson, B.
New inhibitors of the malaria aspartyl proteases plasmepsin I and II
Bioorg. Med. Chem.
11
3423-3437
2003
Plasmodium falciparum
Manually annotated by BRENDA team
Francis, S.E.; Banerjee, R.; Goldberg, D.E.
Biosynthesis and maturation of the malaria aspartic hemoglobinases plasmepsins I and II
J. Biol. Chem.
272
14961-14968
1997
Plasmodium falciparum
Manually annotated by BRENDA team
Moon, R.P.; Bur, D.; Loetscher, H.; D'Arcy, A.; Tyas, L.; Oefner, C.; Grueninger-Leitch, F.; Mona, D.; Rupp, K.; Dorn, A.; Matile, H.; Certa, U.; Berry, C.; Kay, J.; Ridley, R.G.
Studies on plasmepsins I and II from the malarial parasite Plasmodium falciparum and their exploitation as drug targets
Adv. Exp. Med. Biol.
436
397-406
1998
Plasmodium falciparum
Manually annotated by BRENDA team
Noteberg, D.; Hamelink, E.; Hulten, J.; Wahlgren, M.; Vrang, L.; Samuelsson, B.; Hallberg, A.
Design and synthesis of plasmepsin I and plasmepsin II inhibitors with activity in Plasmodium falciparum-infected cultured human erythrocytes
J. Med. Chem.
46
734-746
2003
Plasmodium falciparum
Manually annotated by BRENDA team
Siripurkpong, P.; Yuvaniyama, J.; Wilairat, P.; Goldberg, D.E.
Active Site Contribution to Specificity of the Aspartic Proteases Plasmepsins I and II
J. Biol. Chem.
277
41009-41013
2002
Plasmodium falciparum
Manually annotated by BRENDA team
Tyas, L.; Gluzman, I.; Moon, R.P.; Rupp, K.; Westling, J.; Ridley, R.G.; Kay, J.; Goldberg, D.E.; Berry, C.
Naturally-occurring and recombinant forms of the aspartic proteinases plasmepsins I and II from the human malaria parasite Plasmodium falciparum
FEBS Lett.
454
210-214
1999
Plasmodium falciparum
Manually annotated by BRENDA team
Tyas, L.; Moon, R.P.; Loetscher, H.; Dunn, B.M.; Kay, J.; Ridley, R.G.; Berry, C.
Plasmepsins I and II from the malarial parasite Plasmodium falciparum
Adv. Exp. Med. Biol.
436
407-411
1998
Plasmodium falciparum
Manually annotated by BRENDA team
Moon, R.P.; Tyas, L.; Certa, U.; Rupp, K.; Bur, D.; Jacquet, C.; Matile, H.; Loetscher, H.; Grueninger-Leitch, F.; et al.
Expression and characterization of plasmepsin I from Plasmodium falciparum
Eur. J. Biochem.
244
552-560
1997
Plasmodium falciparum
Manually annotated by BRENDA team
Ersmark, K.; Nervall, M.; Gutierrez-de-Teran, H.; Hamelink, E.; Janka, L.K.; Clemente, J.C.; Dunn, B.M.; Gogoll, A.; Samuelsson, B.; Qvist, J.; Hallberg, A.
Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IV
Bioorg. Med. Chem.
14
2197-2208
2006
Plasmodium falciparum
Manually annotated by BRENDA team
Johansson, P.O.; Chen, Y.; Belfrage, A.K.; Blackman, M.J.; Kvarnstroem, I.; Jansson, K.; Vrang, L.; Hamelink, E.; Hallberg, A.; Rosenquist, A.; Samuelsson, B.
Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs
J. Med. Chem.
47
3353-3366
2004
Plasmodium falciparum
Manually annotated by BRENDA team
Johansson, P.O.; Lindberg, J.; Blackman, M.J.; Kvarnstroem, I.; Vrang, L.; Hamelink, E.; Hallberg, A.; Rosenquist, A.; Samuelsson, B.
Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II
J. Med. Chem.
48
4400-4409
2005
Plasmodium falciparum
Manually annotated by BRENDA team
Ersmark, K.; Samuelsson, B.; Hallberg, A.
Plasmepsins as potential targets for new antimalarial therapy
Med. Res. Rev.
26
626-666
2006
Plasmodium falciparum
Manually annotated by BRENDA team
Hof, F.; Schutz, A.; Fah, C.; Meyer, S.; Bur, D.; Liu, J.; Goldberg, D.E.; Diederich, F.
Starving the malaria parasite: inhibitors active against the aspartic proteases plasmepsins I, II, and IV
Angew. Chem.
45
2138-2141
2006
Plasmodium falciparum
Manually annotated by BRENDA team
Boss, C.; Corminboeuf, O.; Grisostomi, C.; Meyer, S.; Jones, A.F.; Prade, L.; Binkert, C.; Fischli, W.; Weller, T.; Bur, D.
Achiral, cheap, and potent inhibitors of plasmepsins I, II, and IV
ChemMedChem
1
1341-1345
2006
Plasmodium falciparum
Manually annotated by BRENDA team
Bonilla, J.A.; Moura, P.A.; Bonilla, T.D.; Yowell, C.A.; Fidock, D.A.; Dame, J.B.
Effects on growth, hemoglobin metabolism and paralogous gene expression resulting from disruption of genes encoding the digestive vacuole plasmepsins of Plasmodium falciparum
Int. J. Parasitol.
37
317-327
2007
Plasmodium falciparum (P39898), Plasmodium falciparum
Manually annotated by BRENDA team
DellAgli, M.; Parapini, S.; Galli, G.; Vaiana, N.; Taramelli, D.; Sparatore, A.; Liu, P.; Dunn, B.M.; Bosisio, E.; Romeo, S.
High antiplasmodial activity of novel plasmepsins I and II inhibitors
J. Med. Chem.
49
7440-7449
2006
Plasmodium falciparum
Manually annotated by BRENDA team
Bonilla, J.A.; Bonilla, T.D.; Yowell, C.A.; Fujioka, H.; Dame, J.B.
Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function
Mol. Microbiol.
65
64-75
2007
Plasmodium falciparum
Manually annotated by BRENDA team
Xiao, H.; Tanaka, T.; Ogawa, M.; Yada, R.Y.
Expression and enzymatic characterization of the soluble recombinant plasmepsin I from Plasmodium falciparum
Protein Eng. Des. Sel.
20
625-633
2007
Plasmodium falciparum
Manually annotated by BRENDA team
Liu, P.; Marzahn, M.; Robbins, A.; Gutierrez-de-Teran, H.; Rodriguez, D.; McClung, S.; Stevens, S.; Yowell, C.; Dame, J.; McKenna, R.; Dunn, B.
Recombinant plasmepsin 1 from the human malaria parasite Plasmodium falciparum: Enzymatic characterization, active site inhibitor design, and structural analysis
Biochemistry
48
4086-99
2009
Plasmodium falciparum (P39898), Plasmodium falciparum
Manually annotated by BRENDA team
Moura, P.A.; Dame, J.B.; Fidock, D.A.
Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors
Antimicrob. Agents Chemother.
53
4968-4978
2009
Plasmodium falciparum
Manually annotated by BRENDA team
Friedman, R.; Caflisch, A.
Discovery of plasmepsin inhibitors by fragment-based docking and consensus scoring
ChemMedChem
4
1317-1326
2009
Plasmodium falciparum
Manually annotated by BRENDA team
Bhaumik, P.; Horimoto, Y.; Xiao, H.; Miura, T.; Hidaka, K.; Kiso, Y.; Wlodawer, A.; Yada, R.Y.; Gustchina, A.
Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum
J. Struct. Biol.
175
73-84
2011
Plasmodium falciparum (P39898), Plasmodium falciparum
Manually annotated by BRENDA team