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Information on EC 3.4.23.36 - Signal peptidase II

for references in articles please use BRENDA:EC3.4.23.36

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IUBMB Comments

An 18-kDa enzyme present in bacterial inner membranes. Inhibited by pepstatin and the antibiotic globomycin. Type example of peptidase family A8. Formerly EC 3.4.99.35

The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
  • 3.4.23.36
  • globomycin
  • intramembrane
  • 3hpalmitate
  • sppl2b
  • lipobox
  • lipid-modified
  • diacylglyceryl
  • spp-like
  • isoleucyl-trna
  • braun
  • intramembrane-cleaving
  • triacylated
  • medicine

Synonyms
signal peptidase ii, sppl2a, lipoprotein signal peptidase, prolipoprotein signal peptidase, spase ii, sppl2c, signal peptide peptidase-like 2a, type ii signal peptidase, lipoprotein-specific signal peptidase, lipoprotein signal peptidase ii, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Release of signal peptides from bacterial membrane prolipoproteins including murein prolipoprotein. Hydrolyses -Xaa-Yaa-Zaa-/-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral sidechains
show the reaction diagram
Xaa is hydrophobic (preferably Leu) and Xbb (Ala or Ser) and Xcc (Gly or Ala) have small, neutral side chains, release of signal peptides from bacterial membrane prolipoproteins including murein prolipoprotein
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PATHWAY SOURCE
PATHWAYS
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