Reference on EC 3.4.23.34 - cathepsin E
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lapresle, C.; Puizdar, V.; Porchon-Bertolotto, C.; Joukoff, E.; Turk, V.
Structural differences between rabbit cathepsin E and cathepsin D
Biol. Chem. Hoppe-Seyler
367
523-526
1986
Oryctolagus cuniculus
Yamamoto, K.; Ueno, E.; Uemura, H.; Kato, Y.
Biochemical and immunochemical similarity between erythrocyte membrane aspartic proteinase and cathepsin E
Biochem. Biophys. Res. Commun.
148
267-272
1987
Homo sapiens, Rattus norvegicus
Yonezawa, S.; Fujii, K.; Maejima, Y.; Tamoto, K.; Mori, Y.; Muto, N.
Further studies on rat cathepsin E: subcellular localization and existence of the active subunit form
Arch. Biochem. Biophys.
267
176-183
1988
Rattus norvegicus
Jupp, R.A.; Richards, A.D.; Kay, J.; Dunn, B.M.; Wyckoff, J.B.; Samloff, M.; Yamamoto, K.
Identification of the aspartic proteinases from human erythrocyte membranes and gastric mucosa (slow-moving proteinase) as catalytically equivalent to cathepsin E
Biochem. J.
254
895-898
1988
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
Wiederanders, B.; Schaper, S.; Kirschke, H.
Isolation and some properties of a cathepsin E type proteinase from rat spleen
Biomed. Biochim. Acta
48
23-32
1989
Rattus norvegicus
Azuma, T.; Pals, G.; Mohandas, T.K.; Couvreur, J.M.; Taggert, R.T.
Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases
J. Biol. Chem.
264
16748-16753
1989
Homo sapiens
Ueno, E.; Sakai, H.; Kato, Y.; Yamamoto, K.
Activation mechanism of erythrocyte cathepsin E. evidence for the occurrence of the membrane-associated active enzyme
J. Biochem.
105
878-882
1989
Homo sapiens
Thomas, D.J.; Richards, A.D.; Jupp, R.A.; Ueno, E.; Yamamoto, K.; Samloff, I.M.; Dunn, B.M.; Kay, J.
Stabilisation of cathepsin E by ATP
FEBS Lett.
243
145-148
1989
Homo sapiens
Yonezawa, S.; Takahashi, T.; Ichinose, M.; Miki, K.; Tanaka, J.; Gasa, S.
Structural studies of rat cathepsin E: amino-terminal structure and carbohydrate units of mature enzyme
Biochem. Biophys. Res. Commun.
166
1032-1038
1990
Rattus norvegicus
Athauda, S.B.P.; Matsuzaki, O.; Kageyama, T.; Takahashi, K.
Structural evidence for two isozymic forms and the carbohydrate attachment site of human gastric cathepsin E
Biochem. Biophys. Res. Commun.
168
878-885
1990
Homo sapiens
Athauda, S.B.P.; Takahashi, T.; Inoue, H.; Ichinose, M.; Takahashi, K.
Proteolytic activity and cleavage specificity of cathepsin E at the physiological pH as examined towards the B chain of oxidized insulin
FEBS Lett.
292
53-56
1991
Homo sapiens
Athauda, S.B.P.; Takahashi, T.; Kageyama, T.; Takahashi, K.
Autocatalytic processing of procathepsin E to cathepsin E and their structural differences
Biochem. Biophys. Res. Commun.
175
152-158
1991
Homo sapiens
Kageyama, T.; Ichinose, M.; Tsukada, S.; Miki, K.; Kurokawa, K.; Koiwai, O.; Tanji, M.; Yakabe, E.; Athauda, S.B.P.; Takahashi, K.
Gastric procathepsin E and progastricsin from guinea pig. Purification, molecular cloning of cDNAs, and characterization of enzymatic properties, with special reference to procathepsin E
J. Biol. Chem.
267
16450-16459
1992
Cavia porcellus
Robinson, P.S.; Lees, W.E.; Kay, J.; Cook, N.D.
Kinetic parameters for the generation of endothelins-1,-2 and -3 by human cathepsin E
Biochem. J.
284
407-409
1992
Homo sapiens
Kageyama, T.; Ichinose, M.; Miki, K.; Moriyama, A.; Yonezawa, S.; Tanji, M.; Athauda, S.B.P.; Takahashi, K.
Isolation, characterization, and structure of procathepsin E and cathepsin E from the gastric mucosa of guinea pig
Adv. Exp. Med. Biol.
362
211-221
1995
Cavia porcellus
Kiselev, A.F.; Gul'nik, S.V.; Tarasova, N.I.
Human stomach cathepsin E action on human immunoglobulins
Adv. Exp. Med. Biol.
306
369-371
1991
Homo sapiens
Takeda-Ezaki, M.; Yamamoto, K.
Isolation and biochemical characterization of procathepsin E from human erythrocyte membranes
Arch. Biochem. Biophys.
304
352-358
1993
Homo sapiens
Athauda, S.B.P.; Arakawa, H.; Nishigai, M.; Takahashi, T.; Takahashi, K.
Inhibition of cathepsin E by alpha 2-macroglobulin and the resulting structural changes in the inhibitor
J. Biochem.
113
526-530
1993
Homo sapiens
Tsukuba, T.; Hori, H.; Azuma, T.; Takahashi, T.; Taggart, R.T.; Akamine, A.; Ezaki, M.; Nakanishi, H.; Sakai, H.; Yamamoto, K.
Isolation and characterization of recombinant human cathepsin E expressed in Chinese hamster ovary cells
J. Biol. Chem.
268
7276-7282
1993
Homo sapiens
Hill, J.; Montgomery, D.S.; Kay, J.
Human cathepsin E produced in E. coli
FEBS Lett.
326
101-104
1993
Homo sapiens
Inokuchi, T.; Kobayashi, K.; Horiuchi, S.
Purification and characterization of cathepsin E type acid proteinase from gastric mucosa of bullfrog, Rana catesbeiana
J. Biochem.
115
76-81
1994
Lithobates catesbeianus
Kageyama, T.
Procathepsin E and cathepsin E
Methods Enzymol.
248
120-136
1995
Cavia porcellus, Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
Iida, H.; Matsuba, T.; Yamada, M.; Azuma, T.; Suzuki, H.; Yamamoto, K.; Hori, H.
Purification and characterization of recombinant human cathepsin E
Adv. Exp. Med. Biol.
362
325-330
1995
Homo sapiens
Athauda, S.B.P.; Kageyama, T.; Takahashi, T.; Inoue, H.; Ichinose, M.; Ukai, M.; Takahashi, K.
Isolation and characterization of human gastric procathepsin E and cathepsin E
Adv. Exp. Med. Biol.
362
201-210
1995
Homo sapiens
Tsukuba, T.; Masayuki, Y.; Hori, H.; Azuma, T.; Yamamoto, K.
Comparison of biochemical properties of natural and recombinant cathepsin E
Adv. Exp. Med. Biol.
362
331-334
1995
Homo sapiens
Fowler, S.D.; Kay, J.; Dunn, B.M.; Tatnell, P.J.
Monomeric human cathepsin E
FEBS Lett.
366
72-74
1995
Homo sapiens
Okamoto, K.; Yu, H.; Misumi, Y.; Ikehara, Y.; Yamamoto, K.
Isolation and sequencing of two cDNA clones encoding rat spleen cathepsin E and analysis of the activation of purified procathepsin E
Arch. Biochem. Biophys.
322
103-111
1995
Rattus norvegicus
Kageyama, T.; Takahashi, K.
A cathepsin D-like acid proteinase from human gastric mucosa. Purification and characterization
J. Biochem.
87
725-735
1980
Homo sapiens
Arnold, D.; Keilholz, W.; Schild, H.; Dumrese, T.; Stevanovic, S.; Rammensee, H.G.
Substrate specificity of cathepsins D and E determined by N-terminal and C-terminal sequencing of peptide pools
Eur. J. Biochem.
249
171-179
1997
Homo sapiens
Liu, J.; Tsukuba, T.; Okamoto, K.; Ohishi, M.; Yamamoto, K.
Mutational analysis of residues in two consensus motifs in the active sites of cathepsin E
J. Biochem.
132
493-499
2002
Rattus norvegicus
Athauda, S.B.; Takahashi, K.
Distinct cleavage specificity of human cathepsin E at neutral pH with special preference for Arg-Arg bonds
Protein Pept. Lett.
9
15-22
2002
Homo sapiens
Chou, K.C.
Modeling the tertiary structure of human cathepsin-E
Biochem. Biophys. Res. Commun.
331
56-60
2005
Homo sapiens
Yasuda, Y.; Kohmura, K.; Kadowaki, T.; Tsukuba, T.; Yamamoto, K.
A new selective substrate for cathepsin E based on the cleavage site sequence of alpha2-macroglobulin
Biol. Chem.
386
299-305
2005
Homo sapiens, Rattus norvegicus
Tsukuba, T.; Ikeda, S.; Okamoto, K.; Yasuda, Y.; Sakai, E.; Kadowaki, T.; Sakai, H.; Yamamoto, K.
Characterization of rat cathepsin E and mutants with changed active-site residues and lacking propeptides and N-glycosylation, expressed in human embryonic kidney 293T cells
FEBS J.
273
219-229
2006
Rattus norvegicus
Yasuda, Y.; Tsukuba, T.; Okamoto, K.; Kadowaki, T.; Yamamoto, K.
The role of the cathepsin E propeptide in correct folding, maturation and sorting to the endosome
J. Biochem.
138
621-630
2005
Rattus norvegicus
Henningsson, F.; Yamamoto, K.; Saftig, P.; Reinheckel, T.; Peters, C.; Knight, S.D.; Pejler, G.
A role for cathepsin E in the processing of mast-cell carboxypeptidase A
J. Cell Sci.
118
2035-2042
2005
Mus musculus
Chain, B.M.; Free, P.; Medd, P.; Swetman, C.; Tabor, A.B.; Terrazzini, N.
The expression and function of cathepsin E in dendritic cells
J. Immunol.
174
1791-1800
2005
Homo sapiens, Mus musculus
Ostermann, N.; Gerhartz, B.; Worpenberg, S.; Trappe, J.; Eder, J.
Crystal structure of an activation intermediate of cathepsin E
J. Mol. Biol.
342
889-899
2004
Homo sapiens
Cappiello, M.G.; Wu, Z.; Scott, B.B.; McGeehan, G.M.; Harrison, R.K.
Purification and characterization of recombinant human cathepsin E expressed in human kidney cell line 293
Protein Expr. Purif.
37
53-60
2004
Homo sapiens
Busquets, L.; Guillen, H.; DeFord, M.E.; Suckow, M.A.; Navari, R.M.; Castellino, F.J.; Prorok, M.
Cathepsin E is a specific marker of dysplasia in APC mouse intestine
Tumour Biol.
27
36-42
2006
Mus musculus
Page, J.L.; Strom, S.C.; Omiecinski, C.J.
Regulation of the human cathepsin E gene by the constitutive androstane receptor
Arch. Biochem. Biophys.
467
132-138
2007
Homo sapiens
Zaidi, N.; Herrmann, T.; Voelter, W.; Kalbacher, H.
Recombinant cathepsin E has no proteolytic activity at neutral pH
Biochem. Biophys. Res. Commun.
360
51-55
2007
Mus musculus
Zaidi, N.; Kalbacher, H.
Cathepsin E: a mini review
Biochem. Biophys. Res. Commun.
367
517-522
2008
Homo sapiens, Mus musculus
Shin, M.; Kadowaki, T.; Iwata, J.; Kawakubo, T.; Yamaguchi, N.; Takii, R.; Tsukuba, T.; Yamamoto, K.
Association of cathepsin E with tumor growth arrest through angiogenesis inhibition and enhanced immune responses
Biol. Chem.
388
1173-1181
2007
Homo sapiens
Kawakubo, T.; Okamoto, K.; Iwata, J.; Shin, M.; Okamoto, Y.; Yasukochi, A.; Nakayama, K.I.; Kadowaki, T.; Tsukuba, T.; Yamamoto, K.
Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface
Cancer Res.
67
10869-10878
2007
Mus musculus
Zaidi, N.; Herrmann, T.; Baechle, D.; Schleicher, S.; Gogel, J.; Driessen, C.; Voelter, W.; Kalbacher, H.
A new approach for distinguishing cathepsin E and D activity in antigen-processing organelles
FEBS J.
274
3138-3149
2007
Homo sapiens
Kakehashi, H.; Nishioku, T.; Tsukuba, T.; Kadowaki, T.; Nakamura, S.; Yamamoto, K.
Differential regulation of the nature and functions of dendritic cells and macrophages by cathepsin E
J. Immunol.
179
5728-5737
2007
Mus musculus
Burster, T.; Reich, M.; Zaidi, N.; Voelter, W.; Boehm, B.O.; Kalbacher, H.
Cathepsin E regulates the presentation of tetanus toxin C-fragment in PMA activated primary human B cells
Biochem. Biophys. Res. Commun.
377
1299-1303
2008
Homo sapiens (P14091), Homo sapiens
da Rocha Fragoso, R.; Lourenco, I.T.; Batista, J.A.; Oliveira-Neto, O.B.; Silva, M.C.; Rocha, T.L.; Coutinho, M.V.; Grossi-de-Sa, M.F.
Meloidogyne incognita: molecular cloning and characterization of a cDNA encoding a cathepsin D-like aspartic proteinase
Exp. Parasitol.
121
115-123
2009
Meloidogyne incognita (Q1A2Z2), Meloidogyne incognita
Tsukuba, T.; Yanagawa, M.; Okamoto, K.; Okamoto, Y.; Yasuda, Y.; Nakayama, K.I.; Kadowaki, T.; Yamamoto, K.
Impaired chemotaxis and cell adhesion due to decrease in several cell-surface receptors in cathepsin E-deficient macrophages
J. Biochem.
145
565-573
2009
Mus musculus (P70269)
Kitamura, K.; Yoshida, C.; Kinoshita, Y.; Kadowaki, T.; Takahashi, Y.; Tayama, T.; Kawakubo, T.; Naimuddin, M.; Salimullah, M.; Nemoto, N.; Hanada, K.; Husimi, Y.; Yamamoto, K.; Nishigaki, K.
Development of systemic in vitro evolution and its application to generation of peptide-aptamer-based inhibitors of cathepsin E
J. Mol. Biol.
387
1186-1198
2009
Rattus norvegicus (P16228)
Shigematsu, N.; Fukuda, T.; Yamamoto, T.; Nishioku, T.; Yamaguchi, T.; Himeno, M.; Nakayama, K.I.; Tsukuba, T.; Kadowaki, T.; Okamoto, K.; Higuchi, S.; Yamamoto, K.
Association of cathepsin E deficiency with the increased territorial aggressive response of mice
J. Neurochem.
105
1394-1404
2008
Mus musculus
Yoshida, C.; Kuniwake, A.; Naimuddin, M.; Nishigaki, K.
Molecular design guided by a local map of sequence space: DNA aptamers that inhibit cathepsin E
Oligonucleotides
18
1-8
2008
Rattus norvegicus
Caruso, M.; Moore, J.; Goodall, G.J.; Thomas, M.; Phillis, S.; Tyskin, A.; Cheetham, G.; Lerda, N.; Takahashi, H.; Ruszkiewicz, A.
Over-expression of cathepsin E and trefoil factor 1 in sessile serrated adenomas of the colorectum identified by gene expression analysis
Virchows Arch.
454
291-302
2009
Homo sapiens (P14091)
Yasukochi, A.; Kawakubo, T.; Nakamura, S.; Yamamoto, K.
Cathepsin E enhances anticancer activity of doxorubicin on human prostate cancer cells showing resistance to TRAIL-mediated apoptosis
Biol. Chem.
391
947-958
2010
Homo sapiens
Kwan, J.C.; Eksioglu, E.A.; Liu, C.; Paul, V.J.; Luesch, H.
Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation
J. Med. Chem.
52
5732-5747
2009
Homo sapiens
Abd-Elgaliel, W.R.; Tung, C.H.
Selective detection of Cathepsin E proteolytic activity
Biochim. Biophys. Acta
1800
1002-1008
2010
Homo sapiens
Cruz-Monserrate, Z.; Abd-Elgaliel, W.; Grote, T.; Deng, D.; Ji, B.; Arumugam, T.; Wang, H.; Tung, C.; Logsdon, C.
Detection of pancreatic cancer tumours and precursor lesions by cathepsin E activity in mouse models
Gut
61
1315-1322
2012
Homo sapiens
Biyani, M.; Futakami, M.; Kitamura, K.; Kawakubo, T.; Suzuki, M.; Yamamoto, K.; Nishigaki, K.
In vitro selection of cathepsin E-activity-enhancing peptide aptamers at neutral pH
Int. J. Pept.
2011
834525
2011
Rattus norvegicus
Harada, Y.; Zhang, J.; Imari, K.; Yamasaki, R.; Ni, J.; Wu, Z.; Yamamoto, K.; Kira, J.I.; Nakanishi, H.; Hayashi, Y.
Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis
Pain
160
2050-2062
2019
Mus musculus
Hiramatsu, S.; Watanabe, K.S.; Zeggar, S.; Asano, Y.; Miyawaki, Y.; Yamamura, Y.; Katsuyama, E.; Katsuyama, T.; Watanabe, H.; Takano-Narazaki, M.; Matsumoto, Y.; Kawabata, T.; Sada, K.E.; Wada, J.
Regulation of cathepsin E gene expression by the transcription factor Kaiso in MRL/lpr mice derived CD4+ T cells
Sci. Rep.
9
3054
2019
Mus musculus
html completed
