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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
fluorescein-labeled casein + H2O
?
-
-
-
?
4-(4-dimethylaminophenylazo)benzoyl-gamma-aminobutyryl-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-[5-(2-aminoethyl)-amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-gamma-aminobutyryl-Ile-His-Pro-Phe-His-Leu-Val-Ile-His + Thr-[5-(2-aminoethyl)-amino]naphthalene-1-sulfonic acid
-
-
-
?
4-(4-dimethylaminophenylazo)benzoyl-gamma-aminobutyryl-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-[5-(2-aminoethyl)-amino]naphthalene-1-sulfonic acid + H2O
?
-
-
-
?
Arg-Glu-[5-(aminoethyl)aminonaphthalene sulfonate]-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys-[4'-dimethylaminoazobenzene-4-carboxylate]-Arg + H2O
?
-
-
-
?
azocasein + H2O
?
-
-
-
-
?
Azocoll + H2O
?
-
-
-
-
?
Bovine serum albumin + H2O
?
Bovine serum albumin + H2O
Hydrolyzed bovine serum albumin
-
-
-
?
complement component C3b + H2O
?
-
-
-
-
?
complement component C4b + H2O
?
-
-
-
-
?
complement component C5 + H2O
?
-
-
-
-
?
complement components C3b + H2O
?
-
substrate for isoforms Sap1, Sap2, Sap3, but not for Sap9
-
-
?
complement components C4b + H2O
?
-
substrate for isoforms Sap1, Sap2, Sap3, but not for Sap9
-
-
?
complement components C5 + H2O
?
-
substrate for isoforms Sap1, Sap2, Sap3, but not for Sap9
-
-
?
E-cadherin + H2O
?
-
Candida albicans strains JKC19 and SC5314 degrade E-cadherin at pH 4.0, the 10fold concentrated growth media of the strains HLC-52, HLC-54, 32723 and B1134 cause degradation at pH 4.0, strains HLC-52 and HLC-54 also at pH 6.0
-
-
?
factor H + H2O
?
-
the enzyme cleaves and inactivates factor H, diminishing its complement regulatory activity
-
-
?
FRETS-25Ala + H2O
?
isozyme Sap1 shows highest activity towards FRETS-25Ala
-
-
?
FRETS-25Xaa + H2O
?
all Sap isozymes prefer Arg and Lys at the Xaa position
-
-
?
Hemoglobin + H2O
?
-
-
-
-
?
hide powder azure + H2O
?
-
-
-
-
?
Human stratum corneum + H2O
?
-
-
-
-
?
Keratin + H2O
?
-
-
-
-
?
Lys-Pro-Ala-Arg-Phe-Nph-Arg-Leu + H2O
?
-
-
-
?
Lys-Pro-Ala-Arg-Phe-Nph-Arg-Leu + H2O
Lys-Pro-Ala-Arg-Phe + Nph-Arg-Leu
-
-
-
?
macrophage factor H-receptor CR3 + H2O
?
-
the enzyme cleaves and inactivates macrophage factor H-receptor CR3
-
-
?
macrophage factor H-receptor CR4 + H2O
?
-
the enzyme cleaves and inactivates macrophage factor H-receptor CR4
-
-
?
Myeloma proteins of the type A1 and A2 + H2O
?
-
-
-
-
?
oxidized insulin B chain + H2O
?
cleavage sites of Sap2p: FV-/-NQHLCGSHL-/-V-/-EA-/-LYLVCGERGFF-/-YTPKA
-
-
?
Oxidized insulin B-chain + H2O
?
-
low side-chain specificity, preferential attack on hydrophobic amino acid residues
-
-
?
protein + H2O
hydrolyzed protein
-
-
-
?
Proteinase inhibitors of human serum + H2O
?
-
-
-
-
?
additional information
?
-
Albumin + H2O
?
-
-
-
-
?
Albumin + H2O
?
-
low side-chain specificity, preferential attack on hydrophobic amino acid residues
-
-
?
Albumin + H2O
?
cleavage by Sap2p shows a low side-chain specificity
-
-
?
Bovine serum albumin + H2O
?
-
-
-
?
Bovine serum albumin + H2O
?
-
-
-
-
?
casein + H2O
?
-
isoforms Sap1, Sap2, Sap3, and Sap9 cleave casein
-
-
?
casein + H2O
?
isozyme Sap6 shows highest activity towards casein
-
-
?
additional information
?
-
isoenzyme SAP6 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP6 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP6 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP6 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP6 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP6 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
-
isoenzyme SAP6 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
trypsinogen kinase activity
-
-
?
additional information
?
-
-
not: horse ferritin
-
-
?
additional information
?
-
-
synthetic anilides
-
-
?
additional information
?
-
-
clots milk at pH 5.5
-
-
?
additional information
?
-
-
the enzyme plays an important role in superficial infection by affecting the human stratum corneum of the skin and nail
-
-
?
additional information
?
-
-
the enzyme enables Candida albicans to use exogenous proteins as the sole source of nitrogen
-
-
?
additional information
?
-
candidapepsin is implicated in the degradation of host proteins involved in defense and barrier function
-
-
?
additional information
?
-
candidapepsin is implicated in the degradation of host proteins involved in defense and barrier function
-
-
?
additional information
?
-
candidapepsin is implicated in the degradation of host proteins involved in defense and barrier function. Sap2p degrades the Fc portion of IgG, IgA, complement factor C3 and endogenous protease inhibitors in human serum
-
-
?
additional information
?
-
candidapepsin is implicated in the degradation of host proteins involved in defense and barrier function. Sap2p degrades the Fc portion of IgG, IgA, complement factor C3 and endogenous protease inhibitors in human serum
-
-
?
additional information
?
-
-
distinct secreted aspartic proteinase plays a crucial role in the induction of chemokine response during Candida albicans vaginal infections
-
-
?
additional information
?
-
isoenzyme SAP1 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP1 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP1 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP1 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP1 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP1 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
-
isoenzyme SAP1 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP2 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP2 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP2 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP2 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP2 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP2 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
-
isoenzyme SAP2 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP3 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP3 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP3 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP3 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP3 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP3 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
-
isoenzyme SAP3 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP4 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP4 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP4 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP4 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP4 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP4 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
-
isoenzyme SAP4 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP5 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP5 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP5 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP5 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP5 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP5 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
-
isoenzyme SAP5 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
extremely broad specificity range
-
-
?
additional information
?
-
extremely broad specificity range
-
-
?
additional information
?
-
-
Candida albicans strain SC5314 Sap1-6 mutants do not degrade E-cadherin
-
-
?
additional information
?
-
-
isoform Sap9 preferentially cleaves a peptide backbone at adjacent basic residues e.g. Lys-Arg or Arg-Arg when these are followed by an acidic amino acid residue
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Bovine serum albumin + H2O
?
-
-
-
-
?
complement component C3b + H2O
?
-
-
-
-
?
complement component C4b + H2O
?
-
-
-
-
?
complement component C5 + H2O
?
-
-
-
-
?
factor H + H2O
?
-
the enzyme cleaves and inactivates factor H, diminishing its complement regulatory activity
-
-
?
macrophage factor H-receptor CR3 + H2O
?
-
the enzyme cleaves and inactivates macrophage factor H-receptor CR3
-
-
?
macrophage factor H-receptor CR4 + H2O
?
-
the enzyme cleaves and inactivates macrophage factor H-receptor CR4
-
-
?
protein + H2O
hydrolyzed protein
-
-
-
?
additional information
?
-
additional information
?
-
isoenzyme SAP6 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP6 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP6 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP6 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP6 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP6 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
-
isoenzyme SAP6 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
-
the enzyme plays an important role in superficial infection by affecting the human stratum corneum of the skin and nail
-
-
?
additional information
?
-
-
the enzyme enables Candida albicans to use exogenous proteins as the sole source of nitrogen
-
-
?
additional information
?
-
candidapepsin is implicated in the degradation of host proteins involved in defense and barrier function
-
-
?
additional information
?
-
candidapepsin is implicated in the degradation of host proteins involved in defense and barrier function
-
-
?
additional information
?
-
candidapepsin is implicated in the degradation of host proteins involved in defense and barrier function. Sap2p degrades the Fc portion of IgG, IgA, complement factor C3 and endogenous protease inhibitors in human serum
-
-
?
additional information
?
-
candidapepsin is implicated in the degradation of host proteins involved in defense and barrier function. Sap2p degrades the Fc portion of IgG, IgA, complement factor C3 and endogenous protease inhibitors in human serum
-
-
?
additional information
?
-
-
distinct secreted aspartic proteinase plays a crucial role in the induction of chemokine response during Candida albicans vaginal infections
-
-
?
additional information
?
-
isoenzyme SAP1 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP1 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP1 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP1 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP1 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP1 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
-
isoenzyme SAP1 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP2 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP2 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP2 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP2 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP2 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP2 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
-
isoenzyme SAP2 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP3 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP3 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP3 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP3 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP3 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP3 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
-
isoenzyme SAP3 is related to the vaginopathic potential of Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP4 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP4 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP4 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP4 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP4 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP4 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
-
isoenzyme SAP4 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP5 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP5 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP5 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP5 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP5 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
isoenzyme SAP5 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
-
isoenzyme SAP5 is correlated with systemic infections by Candida albicans
-
-
?
additional information
?
-
-
isoform Sap9 preferentially cleaves a peptide backbone at adjacent basic residues e.g. Lys-Arg or Arg-Arg when these are followed by an acidic amino acid residue
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
pepstatin A
strong inhibitor
(1R,5R,7R)-3-benzyl-7-(piperidin-1-ylcarbonyl)-6,8-dioxa-3-azabicyclo[3.2.1]octan-2-one
-
74% inhibition at 0.02 mM
(1R,5R,7R)-3-benzyl-N-(2-hydroxyethyl)-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carboxamide
-
71% inhibition at 0.02 mM
(1R,5R,7R)-3-benzyl-N-(3-hydroxypropyl)-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carboxamide
-
23% inhibition at 0.02 mM
(1R,5R,7R)-3-benzyl-N-[(1R)-2-hydroxy-1-phenylethyl]-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carboxamide
-
31% inhibition at 0.02 mM
(1R,5R,7R)-3-benzyl-N-[(2R)-1-hydroxy-3-phenylpropan-2-yl]-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carboxamide
-
29% inhibition at 0.02 mM
(1R,5R,7R)-3-benzyl-N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carboxamide
-
30% inhibition at 0.02 mM
(1R,5R,7R)-3-benzyl-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carboxamide
-
71% inhibition at 0.02 mM
(1R,5R,7R)-3-benzyl-N-[(2S)-1-hydroxypropan-2-yl]-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carboxamide
-
35% inhibition at 0.02 mM
(1R,5R,7R)-N-(2-aminoethyl)-3-benzyl-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carboxamide
-
63% inhibition at 0.02 mM
(1R,5S,7R)-3-benzyl-7-(1,4-diazepan-1-ylcarbonyl)-6,8-dioxa-3-azabicyclo[3.2.1]octan-2-one
-
63% inhibition at 0.02 mM
(1R,5S,7R)-3-benzyl-7-(morpholin-4-ylcarbonyl)-6,8-dioxa-3-azabicyclo[3.2.1]octan-2-one
-
62% inhibition at 0.02 mM
(1R,5S,7R)-3-benzyl-7-(thiomorpholin-4-ylcarbonyl)-6,8-dioxa-3-azabicyclo[3.2.1]octan-2-one
-
58% inhibition at 0.02 mM
(1R,5S,7R)-3-benzyl-7-[[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]carbonyl]-6,8-dioxa-3-azabicyclo[3.2.1]octan-2-one
-
34% inhibition at 0.02 mM
(1R,5S,7R)-3-benzyl-7-[[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]carbonyl]-6,8-dioxa-3-azabicyclo[3.2.1]octan-2-one
-
48% inhibition at 0.02 mM
(1R,5S,7R)-3-benzyl-7-[[4-(2-hydroxyethyl)piperazin-1-yl]carbonyl]-6,8-dioxa-3-azabicyclo[3.2.1]octan-2-one
-
58% inhibition at 0.02 mM
(1R,5S,7S)-3-benzyl-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carboxylic acid [1-hydroxymethyl-3(R)-methylbutyl]amide
-
60% inhibition at 0.02 mM
(1R,5S,7S)-3-benzyl-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carboxylic acid [1-hydroxymethyl-3(S)-methylbutyl]amide
-
33% inhibition at 0.02 mM
(1S,5R,7R)-3-benzyl-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carboxylic acid benzyl-(1-hydroxymethyl-3-methylbutyl)amide
-
35% inhibition at 0.02 mM
(1S,5R,7R)-3-benzyl-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carboxylic acid [1-hydroxymethyl-3(R)-methylbutyl]amide
-
29% inhibition at 0.02 mM
(1S,5S,7S)-3-benzyl-7-(piperidine-1-carbonyl)-6,8-dioxa-3-azabicyclo[3.2.1]octan-2-one
-
50% inhibition at 0.02 mM
(2R,3S)-phenylnorstatine
the 2R hydroxyl compound is 100- to 1000fold more potent than the 2S hydroxyl derivative
(2S,3S)-phenylnorstatine
the 2R hydroxyl compound is 100- to 1000fold more potent than the 2S hydroxyl derivative
1,2-epoxy-3-(4-nitrophenoxy)propane
-
not
acetyl-Phe-Ile-Phe-psi[OH-OH]-Phe-Glu-Phe-acetyl
-
transition-state peptidomimetic TS-41
acetyl-Trp-Phe-psi[OH-OH]-Phe-Trp-acetyl
-
transition-state peptidomimetic TS-49
acetyl-Trp-Ser-Phe-psi[OH-OH]-Phe-kynurenic acid
-
transition-state peptidomimetic TS-57
acetyl-Trp-Val-Phe-psi[OH-OH]-Phe-Glu-Phe-acetyl
-
transition-state peptidomimetic TS-43
acetyl-Trp-Val-Phe-psi[OH-OH]-Phe-Val-acetyl
-
transition-state peptidomimetic TS-75
acetyl-Trp-Val-Phe-psi[OH-OH]-Phe-Val-Trp-acetyl
-
transition-state peptidomimetic TS-42
amprenavir
-
most effective inhibitor of Sap2, about 92% inhibition at 0.1 mM
Arg-Ile-Phe-psi[CH2-NH]-Phe-Gln-Arg
-
transition-state peptidomimetic TS-2
Diazoacetylnorleucine methyl ester
-
not
ethyl 4-[[(1R,5S,7R)-3-benzyl-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]oct-7-yl]carbonyl]piperazine-1-carboxylate
-
74% inhibition at 0.02 mM
kynurenic acid-Dtg-Phe-psi(S,R,S)[OH]-Phe-dimethylphenoxyacetic acid
-
transition-state peptidomimetic TS-92
kynurenic acid-Dtg-Phe-psi[OH-OH]-Phe-phenoxyacetic acid
-
transition-state peptidomimetic TS-63
kynurenic acid-Thr-Phe-psi(S,R,S)[OH]-Phe-dimethylphenoxyacetic acid
-
transition-state peptidomimetic TS-93
kynurenic acid-Thr-Phe-psi[OH-OH]-Phe-kynurenic acid
-
transition-state peptidomimetic TS-59
kynurenic acid-Val-Phe-psi(S,R,S)[OH]-Phe-dimethylphenoxyacetic acid
-
transition-state peptidomimetic TS-94
kynurenic acid-Val-Phe-psi(S,R,S)[OH]-Phe-Val-kynurenic acid
-
transition-state peptidomimetic TS-91
kynurenic acid-Val-Phe-psi[OH-OH]-Phe-Val-kynurenic acid
Lys-Ile-Phe-psi[CH2-NH]-Phe-Gln-Arg
-
transition-state peptidomimetic TS-23
mycogenic silver nanoparticles
-
after 24 h of incubation, significant reduction (87%) in metabolic activity is observed with 100 ppm mycogenic silver nanoparticles
-
SDS
-
tolerated at 0.01% w/v, decrease of activity at 0.1% w/v, 1% completely destroys activity within a few min
t-butoxylcarbonyl-Phe-psi[OH-OH]-Phe-Dtg-phenoxyacetic acid
-
transition-state peptidomimetic TS-54
t-butoxylcarbonyl-Phe-psi[OH-OH]-Phe-Glu-Phe-acetyl
-
transition-state peptidomimetic TS-53
Trp-Ile-Phe-psi[CH2-NH]-Phe-Gln-Trp
-
transition-state peptidomimetic TS-10
Xan-Dtg-Val-psi(S,R,S)[OH]-Val-Dtg-Xan
-
transition-state peptidomimetic TS-90
kynurenic acid-Val-Phe-psi[OH-OH]-Phe-Val-kynurenic acid
-
best inhibitor
kynurenic acid-Val-Phe-psi[OH-OH]-Phe-Val-kynurenic acid
-
transition-state peptidomimetic TS-70
pepstatin
-
-
pepstatin A
-
-
pepstatin A
strong inhibitor
pepstatin A
IC50 for sap2p: 27 nM
pepstatin A
isozymes 1-10 except 7
ritonavir
-
-
saquinavir
-
-
additional information
-
phenylmethylsulfonyl fluoride
-
additional information
-
tosyl-L-Phe chloromethyl ketone
-
additional information
-
not: soybean trypsin inhibitor
-
additional information
-
heavy metal ions
-
additional information
-
methyl 2-diazoacetamidohexanoate
-
additional information
-
SH-blocking reagents
-
additional information
-
p-bromophenacyl bromide
-
additional information
cis-configured epoxides and aziridines containing hydrophobic moieties and amino acid esters as new potential inhibitors
-
additional information
-
cis-configured epoxides and aziridines containing hydrophobic moieties and amino acid esters as new potential inhibitors
-
additional information
-
isozyme Sap7 is not inhibited by pepstatin A, leupeptin, phenylmethylsulfonyl fluoride and EDTA
-
additional information
isozyme Sap7 is not inhibited by pepstatin A, leupeptin, phenylmethylsulfonyl fluoride and EDTA
-
additional information
isozyme Sap7 is not inhibited by pepstatin A, leupeptin, phenylmethylsulfonyl fluoride and EDTA
-
additional information
isozyme Sap7 is not inhibited by pepstatin A, leupeptin, phenylmethylsulfonyl fluoride and EDTA
-
additional information
isozyme Sap7 is not inhibited by pepstatin A, leupeptin, phenylmethylsulfonyl fluoride and EDTA
-
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Tetracycline-inducible expression of individual secreted aspartic proteases in Candida albicans allows isoenzyme-specific inhibitor screening
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52
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Candida albicans, Candida albicans (P0CY27), Candida albicans (P0CY29), Candida albicans (P0DJ06), Candida albicans (P43094), Candida albicans (Q59SU1), Candida albicans (Q59VH7), Candida albicans (Q5A8N2), Candida albicans (Q5AEM6)
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3
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The role of secreted aspartyl proteinases in Candida albicans keratitis
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Azole antifungals induce up-regulation of SAP4, SAP5 and SAP6 secreted proteinase genes in filamentous Candida albicans cells in vitro and in vivo
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72
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Inhibition of hyphae formation and SIR2 expression in Candida albicans treated with fresh Allium sativum (garlic) extract
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Human oral keratinocyte E-cadherin degradation by Candida albicans and Candida glabrata
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169
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brenda
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Limited role of secreted aspartyl proteinases Sap1 to Sap6 in Candida albicans virulence and host immune response in murine hematogenously disseminated candidiasis
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78
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brenda
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Inhibition of secreted aspartyl proteinase activity in biofilms of Candida species by mycogenic silver nanoparticles
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46
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Candida albicans, Pichia kudriavzevii, [Candida] glabrata, Candida parapsilosis, Candida tropicalis
brenda
Ibrisimovic, M.; Ibrisimovic-Mehmedinovic, N.; Dedic, J.; Kesic, A.; Maric, S.; Sestan, A.
Effects of various metal and drug agents on excretion of enzyme aspartyl proteinase in Candida albicans and its role in human physiological processes
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62
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Candida albicans
-
brenda
Svoboda, E.; Schneider, A.E.; Sandor, N.; Lermann, U.; Staib, P.; Kremlitzka, M.; Bajtay, Z.; Barz, D.; Erdei, A.; Jozsi, M.
Secreted aspartic protease 2 of Candida albicans inactivates factor H and the macrophage factor H-receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18)
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168
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Candida albicans
brenda
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Novel aggregation properties of Candida albicans secreted aspartyl proteinase SAP6 mediate virulence in oral candidiasis
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83
2614-2626
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Candida albicans (Q5AC08), Candida albicans, Candida albicans CAI4 (Q5AC08)
brenda
Willems, H.M.E.; Bruner, W.S.; Barker, K.S.; Liu, J.; Palmer, G.E.; Peters, B.M.
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85
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2017
Candida albicans
brenda
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Molecular docking of various bioactive compounds from essential oil of Trachyaspermum ammi against the fungal enzyme candidapepsin-1
J. Appl. Pharm. Sci.
9
21-32
2019
Candida albicans (P0CY27), Candida albicans SG5314 (P0CY27)
-
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Dutton, L.C.; Jenkinson, H.F.; Lamont, R.J.; Nobbs, A.H.
Role of Candida albicans secreted aspartyl protease Sap9 in interkingdom biofilm formation
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74
ftw005
2016
Candida albicans
brenda
Gogol, M.; Bochenska, O.; Zawrotniak, M.; Karkowska-Kuleta, J.; Zajac, D.; Rapala-Kozik, M.
Roles of Candida albicans aspartic proteases in host-pathogen interactions
Pathophysiological Aspects of Proteases (ed. Chakraborti S. and Dhalla N.)
1
353-380
2017
Candida albicans
-
brenda
Gabrielli, E.; Sabbatini, S.; Roselletti, E.; Kasper, L.; Perito, S.; Hube, B.; Cassone, A.; Vecchiarelli, A.; Pericolini, E.
In vivo induction of neutrophil chemotaxis by secretory aspartyl proteinases of Candida albicans
Virulence
7
819-825
2016
Candida albicans (P0DJ06), Candida albicans (Q5AC08)
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