Reference on EC 3.4.23.22 - Endothiapepsin
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Subramanian, E.; Swan, I.D.A.; Liu, M.; Davies, D.R.; Jenkins, J.A.; Tickle, I.J.; Blundell, T.L.
Homology among acid proteases: comparison of crystal structures at 3A resolution of acid proteases from Rhizopus chinensis and Endothia parasitica
Proc. Natl. Acad. Sci. USA
74
556-559
1977
Cryphonectria parasitica
Whitaker, J.R.
Protease of Endothia parasitica
Methods Enzymol.
19
436-445
1970
Cryphonectria parasitica
-
Williams, D.C.; Whitaker, J.R.; Caldwell, P.V.
Hydrolysis of peptide bonds of the oxidized B-chain of insulin by Endothia parasitica protease
Arch. Biochem. Biophys.
149
52-61
1972
Cryphonectria parasitica
Barkholt, V.
Amino acid sequence of endothiapepsin. Complete primary structure of the aspartic protease from Endothia parasitica
Eur. J. Biochem.
167
327-338
1987
Cryphonectria parasitica
Cooper, J.; Foundling, S.; Hemmings, A.; Blundell, T.; Jones, D.M.; Hallett, A.; Szelke, M.
The structure of a synthetic pepsin inhibitor complexed with endothiapepsin
Eur. J. Biochem.
169
215-221
1987
Cryphonectria parasitica
Brown, E.D.; Wynne, M.G.; Clarke, A.J.; Yada, R.Y.
Purification of two fungal aspartic proteinases using fast protein liquid chromatography
Agric. Biol. Chem.
54
1563-1565
1990
Cryphonectria parasitica
-
Cooper, J.; Quail, W.; Frazao, C.; Foundling, S.I.; Blundell, T.L.; Humblet, C.; Lunney, E.A.; Lowther, W.T.; Dunn, B.M.
X-ray crystallographic analysis of inhibition of endothiapepsin by cyclohexyl renin inhibitors
Biochemistry
31
8142-8150
1992
Cryphonectria parasitica
Bailey, D.; Cooper, J.B.; Veerapandian, B.; Blundell, T.L.; Atrash, B.; Jones, D.M.; Szelke, M.
X-ray-crystallographic studies of complexes of pepstatin A and a statine-containing human renin inhibitor with endothiapepsin
Biochem. J.
289
363-371
1993
Cryphonectria parasitica
Veerapandian, B.; Cooper, J.B.; Sali, A.; Blundell, T.L.
X-ray analyses of aspartic proteinases. III. Three-dimensional structure of endothiapepsin complexed with a transition-state isostere inhibitor of renin at 1.6 A resolution
J. Mol. Biol.
216
1017-1029
1990
Cryphonectria parasitica
Sali, A.; Veerapandian, B.; Cooper, J.B.; Foundling, S.I.; Hoover, D.J.; Blundell, T.L.
High-resolution X-ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor: the analysis of the inhibitor binding and description of the rigid body shift in the enzyme
EMBO J.
8
2179-2188
1989
Cryphonectria parasitica
Bailey, D.; Cooper, J.B.
A structural comparison of 21 inhibitor complexes of the aspartic proteinase from Endothia parasitica
Protein Sci.
3
2129-2143
1994
Cryphonectria parasitica
Valler, M.J.; Kay, J.; Aoyagi, T.; Dunn, B.M.
The interaction of aspartic proteinases with naturally-occurring inhibitors from actinomycetes and Ascaris lumbricoides
J. Enzyme Inhib.
1
77-82
1985
Cryphonectria parasitica
Cooper, J.B.; Myles, D.A.
A preliminary neutron Laue diffraction study of the aspartic proteinase endothiapepsin
Acta Crystallogr. Sect. D
56
246-248
2000
Endothia sp.
-
Coates, L.; Erskine, P.T.; Mall, S.; Williams, P.A.; Gill, R.S.; Wood, S.P.; Cooper, J.B.
The structure of endothiapepsin complexed with the gem-diol inhibitor PD-135,040 at 1.37 A
Acta Crystallogr. Sect. D
59
978-981
2003
Cryphonectria parasitica
Coates, L.; Erskine, P.T.; Wood, S.P.; Myles, D.A.; Cooper, J.B.
A neutron Laue diffraction study of endothiapepsin: implications for the aspartic proteinase mechanism
Biochemistry
40
13149-13157
2001
Endothia sp.
Coates, L.; Erskine, P.T.; Crump, M.P.; Wood, S.P.; Cooper, J.B.
Five atomic resolution structures of endothiapepsin inhibitor complexes: implications for the aspartic proteinase mechanism
J. Mol. Biol.
318
1405-1415
2002
Cryphonectria parasitica
Stultz, C.M.; Karplus, M.
Dynamic ligand design and combinatorial optimization: designing inhibitors to endothiapepsin
Proteins
40
258-289
2000
Endothia sp.
Cooper, J.B.
Endothiapepsin
Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. )
1
104-107
2004
Cryphonectria parasitica
-
Vidossich, P.; Carloni, P.
Binding of phosphinate and phosphonate inhibitors to aspartic proteases: a first-principles study
J. Phys. Chem. B
110
1437-1442
2006
Cryphonectria parasitica
Alexov, E.
Calculating proton uptake/release and binding free energy taking into account ionization and conformation changes induced by protein-inhibitor association: application to plasmepsin, cathepsin D and endothiapepsin-pepstatin complexes
Proteins
56
572-584
2004
Cryphonectria parasitica
Coates, L.; Erskine, P.T.; Mall, S.; Gill, R.; Wood, S.P.; Myles, D.A.; Cooper, J.B.
X-ray, neutron and NMR studies of the catalytic mechanism of aspartic proteinases
Eur. Biophys. J.
35
559-566
2006
Cryphonectria parasitica
Koester, H.; Craan, T.; Brass, S.; Herhaus, C.; Zentgraf, M.; Neumann, L.; Heine, A.; Klebe, G.
A small nonrule of 3 compatible fragment library provides high hit rate of endothiapepsin crystal structures with various fragment chemotypes
J. Med. Chem.
54
7784-7796
2011
Cryphonectria parasitica (P11838)
Mondal, M.; Radeva, N.; Fanlo-Virgos, H.; Otto, S.; Klebe, G.; Hirsch, A.K.
Fragment linking and optimization of inhibitors of the aspartic protease endothiapepsin fragment-based drug design facilitated by dynamic combinatorial chemistry
Angew. Chem. Int. Ed. Engl.
55
9422-9426
2016
Cryphonectria parasitica (P11838)
Mondal, M.; Unver, M.Y.; Pal, A.; Bakker, M.; Berrier, S.P.; Hirsch, A.K.
Fragment-based drug design facilitated by protein-templated click chemistry fragment linking and optimization of inhibitors of the aspartic protease endothiapepsin
Chemistry
22
14826-14830
2016
Cryphonectria parasitica (P11838)
Jumde, V.R.; Mondal, M.; Gierse, R.M.; Unver, M.Y.; Magari, F.; van Lier, R.C.W.; Heine, A.; Klebe, G.; Hirsch, A.K.H.
Design and synthesis of bioisosteres of acylhydrazones as stable inhibitors of the aspartic protease endothiapepsin
ChemMedChem
13
2266-2270
2018
Cryphonectria parasitica (P11838)
Hartman, A.M.; Mondal, M.; Radeva, N.; Klebe, G.; Hirsch, A.K.
Structure-based optimization of inhibitors of the aspartic protease endothiapepsin
Int. J. Mol. Sci.
16
19184-19194
2015
Cryphonectria parasitica (P11838)
Radeva, N.; Krimmer, S.G.; Stieler, M.; Fu, K.; Wang, X.; Ehrmann, F.R.; Metz, A.; Huschmann, F.U.; Weiss, M.S.; Mueller, U.; Schiebel, J.; Heine, A.; Klebe, G.
Experimental active-site mapping by fragments hot spots remote from the catalytic center of endothiapepsin
J. Med. Chem.
59
7561-7575
2016
Cryphonectria parasitica (P11838)
Radeva, N.; Schiebel, J.; Wang, X.; Krimmer, S.G.; Fu, K.; Stieler, M.; Ehrmann, F.R.; Metz, A.; Rickmeyer, T.; Betz, M.; Winquist, J.; Park, A.Y.; Huschmann, F.U.; Weiss, M.S.; Mueller, U.; Heine, A.; Klebe, G.
Active site mapping of an aspartic protease by multiple fragment crystal structures versatile warheads to address a catalytic dyad
J. Med. Chem.
59
9743-9759
2016
Cryphonectria parasitica (P11838)
Mondal, M.; Groothuis, D.; Hirsch, A.
Fragment growing exploiting dynamic combinatorial chemistry of inhibitors of the aspartic protease endothiapepsin
MedChemComm
6
1267-1271
2015
Cryphonectria parasitica (P11838)
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