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Information on EC 3.4.22.B75 - SENP7 peptidase and Organism(s) Mus musculus and UniProt Accession Q8BUH8

for references in articles please use BRENDA:EC3.4.22.B75
preliminary BRENDA-supplied EC number
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B75 SENP7 peptidase
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This record set is specific for:
Mus musculus
UNIPROT: Q8BUH8
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms. SENP67 prefers the LRGG-/- sequence versus the QTGG-/- sequence.
Synonyms
sumo protease senp7, sumo/sentrin/smt3-specific peptidase, sentrin-specific protease 7, sumo-specific protease senp7, sumo-specific protease 7, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SENP7 SUMO-protease
-
-
SUMO protease SENP7
-
-
SUMO-specific protease SENP7
-
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
SUMO1-HP1 + H2O
HP1 + SUMO1
show the reaction diagram
-
deSUMOylation
-
-
?
SUMOylated HP1alpha + H2O
HP1alpha + SUMO
show the reaction diagram
-
SUMO deconjugation by enzyme SENP7
-
-
?
additional information
?
-
-
a module of two PxVxL HP1 interaction motifs on enzyme SENP7 mediates association with HP1, molecular basis for the interaction between SENP7 and HP1, the capacity for SENP7 to interact with HP1 in cells and its capacity to de-SUMOylate SUMO1-HP1 are independent
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
SUMO1-HP1 + H2O
HP1 + SUMO1
show the reaction diagram
-
deSUMOylation
-
-
?
SUMOylated HP1alpha + H2O
HP1alpha + SUMO
show the reaction diagram
-
SUMO deconjugation by enzyme SENP7
-
-
?
additional information
?
-
-
a module of two PxVxL HP1 interaction motifs on enzyme SENP7 mediates association with HP1, molecular basis for the interaction between SENP7 and HP1, the capacity for SENP7 to interact with HP1 in cells and its capacity to de-SUMOylate SUMO1-HP1 are independent
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
malfunction
metabolism
-
HP1 enrichment at pericentric heterochromatin is essential for proper chromosome segregation, the process requires H3K9me3 and the SUMO protease SENP7
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SENP7_MOUSE
1037
0
116346
Swiss-Prot
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C979S
-
site-directed mutagenesis
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant expression of GFP-tagged wild-type and mutant enzyme SENP7
-
recombinant exxpression of GFP-tagged SENP7 constructs in NIH-3T3 cell nuclei
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Romeo, K.; Louault, Y.; Cantaloube, S.; Loiodice, I.; Almouzni, G.; Quivy, J.
The SENP7 SUMO-protease presents a module of two HP1 interaction motifs that locks HP1 protein at pericentric heterochromatin
Cell Rep.
10
771-782
2015
Mus musculus
Manually annotated by BRENDA team
Maison, C.; Romeo, K.; Bailly, D.; Dubarry, M.; Quivy, J.P.; Almouzni, G.
The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin
Nat. Struct. Mol. Biol.
19
458-460
2012
Mus musculus
Manually annotated by BRENDA team
Juarez-Vicente, F.; Luna-Pelaez, N.; Garcia-Dominguez, M.
The Sumo protease Senp7 is required for proper neuronal differentiation
Biochim. Biophys. Acta
1863
1490-1498
2016
Mus musculus (Q8BUH8)
Manually annotated by BRENDA team
Huang, C.J.; Wu, D.; Jiao, X.F.; Khan, F.A.; Xiong, C.L.; Liu, X.M.; Yang, J.; Yin, T.L.; Huo, L.J.
Maternal SENP7 programs meiosis architecture and embryo survival in mouse
Biochim. Biophys. Acta
1864
1195-1206
2017
Mus musculus (Q8BUH8)
Manually annotated by BRENDA team