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Information on EC 3.4.22.B67 - Ulp2 peptidase and Organism(s) Arabidopsis thaliana and UniProt Accession Q0WKV8

for references in articles please use BRENDA:EC3.4.22.B67
preliminary BRENDA-supplied EC number
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B67 Ulp2 peptidase
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This record set is specific for:
Arabidopsis thaliana
UNIPROT: Q0WKV8
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Word Map
  • 3.4.22.B67
  • sumoylation
  • checkpoint
  • deconjugation
  • sumo-1
  • sumo-protein
  • helicase
  • sumo-specific
  • hydroxyurea
  • restart
  • nuclear-localization
  • poly-sumo
  • dna-damaging
  • nucleolar
  • ubiquitin-related
  • spindle
  • euploidy
  • polysumoylation
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Ulp2 hydrolyses the SUMO-SUMO linkage in poly-SUMO chains. It catalyzes desumoylation of SUMO-modified-Ndc10 kinetochore protein, SUMO-modified-Bir1 kinetochore protein or SUMO-modified-Cep3 kinetochore protein.
Synonyms
ulp2p, smt3-specific protease, ulp2 sumo protease, ulp2 sumo isopeptidase, sumo isopeptidase ulp2, sumo de-conjugating/chain-editing enzyme ulp2p, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
probable ubiquitin-like-specific protease 2A
-
probable ubiquitin-like-specific protease 2B
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
isoform Spf2
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
loss-of-function mutant's phenotypes included late flowering, altered leaf morphology and severely impaired seed production. Seeds are also bigger. Mutants constitutively accumulate SUMO conjugates, and expression in yeast complements the loss of Ulp2 but not ScUlp1. Isoform Spf1 seems to be much more expressed than isoform Spf2. Compared to Spf2, Spf1 mutant alleles display more prominent phenotypes in leaf morphology, flowering time, pigment accumulation, and increased SUMO conjugates
physiological function
loss-of-function mutant's phenotypes included late flowering, altered leaf morphology and severely impaired seed production. Seeds are also bigger. Mutants constitutively accumulate SUMO conjugates, and expression in yeast complements the loss of Ulp2 but not ScUlp1. Isoform Spf1 seems to be much more expressed than isoform Spf2. Compared to Spf2, Spf1 mutant alleles display more prominent phenotypes in leaf morphology, flowering time, pigment accumulation, and increased SUMO conjugates
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ULP2A_ARATH
774
0
87796
Swiss-Prot
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Castro, P.H.; Santos, M.A.; Freitas, S.; Cana-Quijada, P.; Lourenco, T.; Rodrigues, M.A.A.; Fonseca, F.; Ruiz-Albert, J.; Azevedo, J.E.; Tavares, R.M.; Castillo, A.G.; Bejarano, E.R.; Azevedo, H.
Arabidopsis thaliana SPF1 and SPF2 are nuclear-located ULP2-like SUMO proteases that act downstream of SIZ1 in plant development
J. Exp. Bot.
69
4633-4649
2018
Arabidopsis thaliana (Q0WKV8), Arabidopsis thaliana (Q8L7S0)
Manually annotated by BRENDA team