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Information on EC 3.4.22.B66 - caspase-12 and Organism(s) Mus musculus and UniProt Accession O08736
for references in articles please use BRENDA:EC3.4.22.B66preliminary BRENDA-supplied EC number
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3.4.22.B66 caspase-12Specify your search results
Word Map
- 3.4.22.B66
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chop
- caspase-3
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glucose-regulated
- bcl-2
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tunel
- jnk
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neuroprotective
- atf6
- myocardial
- calpains
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stress-mediated
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cardiomyocytes
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reperfusion
- thapsigargin
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stress-related
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inositol-requiring
- tunicamycin
- dutp
- xbp1
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stress-associated
- salubrinal
- eif2alpha
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tudca
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4-phenylbutyric
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mitochondria-mediated
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p-eif2
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tauroursodeoxycholic
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mitochondria-dependent
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ers-induced
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p-perk
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ers-related
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er-stress
- grp
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gadd153
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casp11
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protein-78
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factor-6
- m-calpain
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phospho-eif2
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x-box-binding
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p-ire1
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gadd34
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er-specific
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tg-induced
- medicine
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residue-residue
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tunicamycin-induced
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template-based
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pkr-like
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stress-specific
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rna-like
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
caspase-12, casp12, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
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benzene, increase of caspase-12 expression after 12 days of oral benzene treatment to p53KO mice
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
procaspase-12 is predominantly located on the cytoplasmic side of the endoplasmic reticulum
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
carbon tetrachloride-induced apoptosis and liver damage is markedly reduced in caspase-12-deficient mice
physiological function
physiological function
physiological function
caspase-12 plays a pivotal role in carbon tetrachloride-induced hepatic apoptosis through the activation of the downstream effector caspase-3 directly and/or indirectly via capase-9 activation
physiological function
apoptosis is elevated when myoblasts are subjected to cyclic mechanical stretch for 12, 24, and 36 hr. Cyclic mechanical stretch triggers the endoplasmic reticulum stress and caspase-12 cleavage. Endoplasmic reticulum stress inhibitor GSK 2606414 suppresses the cyclic mechanical stretch-induced cleavage of caspase-12 and myoblast apoptosis. Silencing of caspase-12 attenuates the apoptosis of myoblasts. Cells overexpressing a truncated caspase-12 segment which starts from Asp94 and ends at Asn419, undergo apoptosis under both static and stretched conditions
physiological function
caspase-12 knockout mice also lack caspase-11 expression. Caspase-12 deficiency in both ex vivo-stimulated bone-marrow-derived macrophages and in in vivo-challenged mice fails to increase caspase-1 activation. Release of mature IL-1beta and IL-18 by both the canonical and noncanonical inflammasome pathways is consequently also not enhanced by deletion of caspase-12
physiological function
in mice with experimental autoimmune encephalomyelitis, expression of chaperone CHOP, caspase-12, and protein disulfide isomerase is upregulated in the brain. Elevated levels of caspase-12/CHOP are observed in astrocytes, oligodendrocytes, and microglia in the hippocampus section of experimental autoimmune encephalomyelitis mice
physiological function
loss of caspase-12 in mouse strains predisposes mice to develop obesity, metabolic inflammation, and insulin resistance, whereas loss of caspase-11 has no effect. The Nlrp3 inflammasome pathway mediates the metabolic syndrome of caspase-12 deficient mice
physiological function
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caspase-12 is an important upstream messenger in POX-induced apoptosis in EL-4 cells
physiological function
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caspase-12 plays a role in controlling West Nile virus viral infection via the pattern recognition receptor RIG-I. Caspase-12 positively modulates the production of type I interferon by regulating E3 ubiquitin ligase TRIM25-mediated ubiquitination of RIG-I
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
activation of caspase-12 is detected in the liver at 12 and 24 h after carbon tetrachloride treatment
O,O-diethyl-O-4-nitrophenylphosphate up-regulates caspase-12 expression in a dose-dependent manner, and pre-treatment with EGTA, heparin or procaine significantly inhibits O,O-diethyl-O-4-nitrophenylphosphate-induced increase of caspase-12 expression. During the application of 5 nM POX for 0-8 h, caspase-12 expression increases significantly and continuously, and reaches the peak after 8 h treatment. However, caspase-12 expression after treatment with 5 nM POX for 16 h is similar to the control
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yi, J.Y.; Hirabayashi, Y.; Choi, Y.K.; Kodama, Y.; Kanno, J.; Han, J.H.; Inoue, T.; Yoon, B.I.
Benzene activates caspase-4 and -12 at the transcription level, without an association with apoptosis, in mouse bone marrow cells lacking the p53 gene
Arch. Toxicol.
83
795-803
2009
Mus musculus
Wang, P.; Arjona, A.; Zhang, Y.; Sultana, H.; Dai, J.; Yang, L.; LeBlanc, P.M.; Doiron, K.; Saleh, M.; Fikrig, E.
Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I
Nat. Immunol.
11
912-919
2010
Mus musculus
Li, L.; Cao, Z.; Jia, P.; Wang, Z.
Calcium signals and caspase-12 participated in paraoxon-induced apoptosis in EL4 cells
Toxicol. In Vitro
24
728-736
2010
Mus musculus
Liu, H.; Wang, Z.; Nowicki, M.J.
Caspase-12 mediates carbon tetrachloride-induced hepatocyte apoptosis in mice
World J. Gastroenterol.
20
18189-18198
2014
Mus musculus (O08736)
Kamarehei, M.; Kabudanian Ardestani, S.; Firouzi, M.; Zahednasab, H.; Keyvani, H.; Harirchian, M.H.
Increased expression of endoplasmic reticulum stress-related caspase-12 and CHOP in the hippocampus of EAE mice
Brain Res. Bull.
147
174-182
2019
Mus musculus (O08736)
Song, J.; Zhang, Q.; Wang, S.; Yang, F.; Chen, Z.; Dong, Q.; Ji, Q.; Yuan, X.; Ren, D.
Cleavage of caspase-12 at Asp94, mediated by endoplasmic reticulum stress (ERS), contributes to stretch-induced apoptosis of myoblasts
J. Cell. Physiol.
233
9473-9487
2018
Mus musculus (O08736)
Skeldon, A.M.; Morizot, A.; Douglas, T.; Santoro, N.; Kursawe, R.; Kozlitina, J.; Caprio, S.; Mehal, W.Z.; Saleh, M.
Caspase-12, but not Caspase-11, inhibits obesity and insulin resistance
J. Immunol.
196
437-447
2016
Mus musculus (O08736), Mus musculus, Homo sapiens (Q6UXS9), Homo sapiens
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Release 2023.1 (January 2023)
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