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EC Tree
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
broad endopeptidase specificity
Synonyms
capn11, calpain-11, calpain 11,
more
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calcium-activated neutral proteinase 11
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peptide + H2O
hydrolyzed peptide
peptide + H2O
hydrolyzed peptide
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peptide + H2O
hydrolyzed peptide
the enzyme catalyzes limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction
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peptide + H2O
hydrolyzed peptide
the enzyme catalyzes limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction
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Ca2+
contains 2 EF-hand calcium-binding domains
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Neuralgia
The gene regulatory network in different brain regions of neuropathic pain mouse models.
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SwissProt
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weak activity
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highest expression in
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weak activity
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CAN11_HUMAN
739
0
84423
Swiss-Prot
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Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (Q9UMQ6)
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Strausberg R.L.; Feingold E.A.; Grouse L.H.; Derge J.G.; et al.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
Proc. Natl. Acad. Sci. USA
99
16899-16903
2002
Homo sapiens (Q9UMQ6)
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Dear, T.N.; Moller, A.; Boehm, T.
CAPN11: a calpain with high mRNA levels in testis and located on chromosome 6
Genomics
59
243-247
1999
Homo sapiens (Q9UMQ6), Homo sapiens
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