Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 3.4.22.B29 - calpain 9 and Organism(s) Mus musculus and UniProt Accession Q9D805

for references in articles please use BRENDA:EC3.4.22.B29
preliminary BRENDA-supplied EC number
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B29 calpain 9
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Mus musculus
UNIPROT: Q9D805
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
broad endopeptidase specificity
Synonyms
ncl-4, calpain 9, calpain-9, digestive tract-specific calpain, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
digestive tract-specific calpain
-
-
-
-
nCL-4
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
78990-62-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
peptide + H2O
hydrolyzed peptide
show the reaction diagram
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
regulates the enzyme, contains 2 EF-hand calcium-binding domains
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
TGFbeta-induced mesenchymal transition of a murine breast epithelial cell line is dependent on induction of expression of calpain 9. Mice lacking functional CAPN9 are viable and fertile but show overt protection from bleomycin-induced lung fibrosis, carbon tetrachloride-induced liver fibrosis, and angiotensin II-induced cardiac fibrosis and dysfunction
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CAN9_MOUSE
690
0
78977
Swiss-Prot
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (O14815), Mus musculus (Q9D805), Mus musculus C57/BL6J (Q9D805), Rattus norvegicus (O35920)
Manually annotated by BRENDA team
Kawai, J.; Shinagawa, A.; Shibata, K.; Yoshino, M.; Itoh, M.; et al.
Functional annotation of a full-length mouse cDNA collection
Nature
409
685-690
2001
Mus musculus (Q9D805), Mus musculus C57/BL6J (Q9D805)
Manually annotated by BRENDA team
Lee, H.J.; Sorimachi, H.; Jeong, S.Y.; Ishiura, S.; Suzuki, K.
Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract
Biol. Chem.
379
175-183
1998
Homo sapiens (O14815), Homo sapiens, Mus musculus (Q9D805), Mus musculus, Rattus norvegicus (O35920)
Manually annotated by BRENDA team
Kim, D.H.; Beckett, J.D.; Nagpal, V.; Seman-Senderos, M.A.; Gould, R.A.; Creamer, T.J.; MacFarlane, E.G.; Chen, Y.; Bedja, D.; Butcher, J.T.; Mitzner, W.; Rouf, R.; Hata, S.; Warren, D.S.; Dietz, H.C.
Calpain 9 as a therapeutic target in TGFbeta-induced mesenchymal transition and fibrosis
Sci. Transl. Med.
11
eaau2814
2019
Mus musculus
Manually annotated by BRENDA team