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Information on EC 3.4.22.B25 - calpain 5 and Organism(s) Homo sapiens and UniProt Accession O15484
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3.4.22.B25 calpain 5Specify your search results
Word Map
- 3.4.22.B25
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vitreoretinopathy
- neovascularization
- retinal
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adniv
- uveitis
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photoreceptors
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intraocular
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calcium-activated
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calmodulin-like
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electroretinography
- medicine
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
capn5, calpain-5, calpain 5, htra-3, ncl-3, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
calpain htra-3
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-
-
-
htra-3
-
-
-
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nCL-3
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-
-
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CAS REGISTRY NUMBER
COMMENTARY
78990-62-2
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
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CAPN5 seems to influence traits related to increased risk for cardiovascular diseases. CAPN5 may be a candidate gene for metabolic syndrome
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
CAPN5 seems to influence traits related to increased risk for cardiovascular diseases. CAPN5 may be a candidate gene for metabolic syndrome
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
the enzyme carries the nuclear localization signal RRRK (aa 2124)
additional information
unlike findings in classical calpains, which are characterized as being mainly cytosolic, CAPN5 is predominantly a noncytosolic calpain, present in the nucleus in the nucleic acidbinding protein fraction. The enzyme CAPN5 is associated with one or more nuclear bodies. Non-nuclear, particularly perinuclear. CAPN5 is found in punctate domains associated with promyelocytic leukemia protein within the nucleus
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
evolution
calpain 5 is a non-classical member of the calpain family. It lacks the EF hand motif characteristic of classical calpains but retains catalytic and Ca2 binding domains, and it contains a unique C-terminal domain
physiological function
hepatitis C uses the membrane protein CD81 to invade human liver cells. Calpain-5 and the ubiquitin ligase Casitas B-lineage lymphoma proto-oncogene CBLB form a complex with CD81 and support hepatitis C virus entry. Calpain-5 and CBLB are required for a post-binding and pre-replication step in the hepatitis C virus life cycle. Knockout of calpain-5 and CBLB reduces susceptibility to all tested hepatitis C virus genotypes
additional information
the enzyme is associated with nuclear promyelocytic leukemia protein bodies
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). CAN5_HUMAN
640
0
73169
Swiss-Prot
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene Capn5, DNA and amino acid sequence determination and analysis, quantitative real-time PCR expression analysis
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
medicine
CAPN5 plays a role in polycystic ovary syndrome susceptibility in humans. The haplotypes H (GGCA) and I (GGTG) are overrepresented in patients when compared with controls. The presence of familial antecedents of obesity and essential hypertension in polycystic ovary syndrome women is associated with a non-random distribution of CAPN5 haplotypes. Association between CAPN5 gene and polycystic ovary syndrome patients with amenorrhoea and aggregation of diabetes mellitus
medicine
hepatitis C uses the membrane protein CD81 to invade human liver cells. Calpain-5 and the ubiquitin ligase Casitas B-lineage lymphoma proto-oncogene CBLB form a complex with CD81 and support hepatitis C virus entry. Calpain-5 and CBLB are required for a post-binding and pre-replication step in the hepatitis C virus life cycle. Knockout of calpain-5 and CBLB reduces susceptibility to all tested hepatitis C virus genotypes
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Strausberg R.L.; Feingold E.A.; Grouse L.H.; Derge J.G.; et al.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
Proc. Natl. Acad. Sci. USA
99
16899-16903
2002
Homo sapiens (O15484), Mus musculus (O08688)
Matena, K.; Boehm, T.; Dear, N.
Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily
Genomics
48
117-120
1998
Homo sapiens (O15484), Homo sapiens, Mus musculus (O08688), Mus musculus
Mugita, N.; Kimura, Y.; Ogawa, M.; Saya, H.; Nakao, M.
Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene
Biochem. Biophys. Res. Commun.
239
845-850
1997
Homo sapiens (O15484), Homo sapiens
Waghray, A.; Wang, D.S.; McKinsey, D.; Hayes, R.L.; Wang, K.K.
Molecular cloning and characterization of rat and human calpain-5
Biochem. Biophys. Res. Commun.
324
46-51
2004
Homo sapiens (O15484), Homo sapiens, Rattus norvegicus (Q8R4C0)
Gonzalez, A.; Saez, M.E.; Aragon, M.J.; Galan, J.J.; Vettori, P.; Molina, L.; Rubio, C.; Real, L.M.; Ruiz, A.; Ramirez-Lorca, R.
Specific haplotypes of the CALPAIN-5 gene are associated with polycystic ovary syndrome
Hum. Reprod.
21
943-951
2006
Homo sapiens (O15484), Homo sapiens
Saez Maria , S.M.; Martinez-Larrad Maria , M.M.; Ramirez-Lorca Repos, R.R.; Gonzalez-Sanchez Jose , G.J.; Zabena Carin, Z.C.; Martinez-Calatrava Maria , M.M.; Gonzalez Alejandr, G.A.; Moron Francisco , M.F.; Ruiz Agusti, R.A.; Serrano-Rios Manue, S.M.
Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels
BMC Med. Genet.
8
1-1
2007
Homo sapiens
Singh, R.; Brewer, M.K.; Mashburn, C.B.; Lou, D.; Bondada, V.; Graham, B.; Geddes, J.W.
Calpain 5 is highly expressed in the central nervous system (CNS), carries dual nuclear localization signals, and is associated with nuclear promyelocytic leukemia protein bodies
J. Biol. Chem.
289
19383-19394
2014
Homo sapiens (O15484), Mus musculus (O08688), Mus musculus C57/BL6J (O08688), Rattus norvegicus (Q8R4C0), Rattus norvegicus Sprague-Dawley (Q8R4C0)
Bruening, J.; Lasswitz, L.; Banse, P.; Kahl, S.; Marinach, C.; Vondran, F.; Kaderali, L.; Silvie, O.; Pietschmann, T.; Meissner, F.; Gerold, G.
Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB
PLoS Pathog.
14
e1007111
2018
Homo sapiens (O15484), Homo sapiens
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