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Disease on EC 3.4.22.B24 - calpain 4

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Kidney Injury
Protective role of endothelial calpain knockout in lipopolysaccharide-induced acute kidney injury via attenuation of the p38-iNOS pathway and NO/ROS production.
Adenocarcinoma of Lung
miR-124 suppresses proliferation and invasion of nasopharyngeal carcinoma cells through the Wnt/?-catenin signaling pathway by targeting Capn4.
Breast Neoplasms
The oncoprotein HBXIP enhances migration of breast cancer cells through increasing filopodia formation involving MEKK2/ERK1/2/Capn4 signaling.
Carcinogenesis
Calpain Small Subunit 1 Protein in the Prognosis of Cancer Survivors and Its Clinicopathological Correlation.
Increased Expression of Capn4 is Associated with the Malignancy of Human Glioma.
Carcinoma
Capn4 contributes to tumor invasion and metastasis in clear cell renal cell carcinoma cells via modulating talin-focal adhesion kinase signaling pathway.
Capn4 Enhances Osteopontin Expression through Activation of the Wnt/?-Catenin Pathway to Promote Epithelial Ovarian Carcinoma Metastasis.
Capn4 mRNA level is correlated with tumour progression and clinical outcome in clear cell renal cell carcinoma.
Capn4 promotes esophageal squamous cell carcinoma metastasis by regulating ZEB1 through the Wnt/?-catenin signaling pathway.
Capn4 regulates migration and invasion of ovarian carcinoma cells via targeting osteopontin-mediated PI3K/AKT signaling pathway.
High expression of Capn4 is associated with metastasis and poor prognosis in esophageal squamous cell carcinoma.
MiR-337-3p suppresses the proliferation and metastasis of clear cell renal cell carcinoma cells via modulating Capn4.
Carcinoma, Hepatocellular
Capn4 contributes to tumour growth and metastasis of hepatocellular carcinoma by activation of the FAK-Src signalling pathways.
Capn4 overexpression underlies tumor invasion and metastasis after liver transplantation for hepatocellular carcinoma.
Hepatitis B Virus X Protein Drives Multiple Cross-Talk Cascade Loops Involving NF-?B, 5-LOX, OPN and Capn4 to Promote Cell Migration.
Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells.
Overexpression of Capns1 Predicts Poor Prognosis and Correlates with Tumor Progression in Renal Cell Carcinoma.
Prognostic significance of Capn4 overexpression in intrahepatic cholangiocarcinoma.
Carcinoma, Non-Small-Cell Lung
Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2.
Carcinoma, Ovarian Epithelial
Capn4 Enhances Osteopontin Expression through Activation of the Wnt/?-Catenin Pathway to Promote Epithelial Ovarian Carcinoma Metastasis.
Carcinoma, Renal Cell
Capn4 contributes to tumor invasion and metastasis in clear cell renal cell carcinoma cells via modulating talin-focal adhesion kinase signaling pathway.
Capn4 mRNA level is correlated with tumour progression and clinical outcome in clear cell renal cell carcinoma.
MiR-337-3p suppresses the proliferation and metastasis of clear cell renal cell carcinoma cells via modulating Capn4.
Cholangiocarcinoma
Overexpression of Capns1 Predicts Poor Prognosis and Correlates with Tumor Progression in Renal Cell Carcinoma.
Prognostic significance of Capn4 overexpression in intrahepatic cholangiocarcinoma.
Colorectal Neoplasms
Capn4 promotes colorectal cancer cell proliferation by increasing MAPK7 through activation of the Wnt/?-Catenin pathway.
Suppression of Capn4 by microRNA-1271 impedes the proliferation and invasion of colorectal cancer cells.
Endotoxemia
Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation.
Protective role of endothelial calpain knockout in lipopolysaccharide-induced acute kidney injury via attenuation of the p38-iNOS pathway and NO/ROS production.
Esophageal Neoplasms
High expression of Capn4 is associated with metastasis and poor prognosis in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Capn4 promotes esophageal squamous cell carcinoma metastasis by regulating ZEB1 through the Wnt/?-catenin signaling pathway.
High expression of Capn4 is associated with metastasis and poor prognosis in esophageal squamous cell carcinoma.
Glioblastoma
miR-124 suppresses the migration and invasion of glioma cells in vitro via Capn4.
Glioma
Increased Expression of Capn4 is Associated with the Malignancy of Human Glioma.
miR-124 suppresses the migration and invasion of glioma cells in vitro via Capn4.
Heart Failure
Calpain protects the heart from hemodynamic stress.
Hepatitis B
Hepatitis B Virus X Protein Drives Multiple Cross-Talk Cascade Loops Involving NF-?B, 5-LOX, OPN and Capn4 to Promote Cell Migration.
Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells.
Kidney Neoplasms
Capn4 induces human renal cancer cell proliferation by activating NF-?B signaling pathway through FAK phosphorylation.
Lung Neoplasms
Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2.
Lymphatic Metastasis
Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2.
High expression of Capn4 is associated with metastasis and poor prognosis in esophageal squamous cell carcinoma.
Melanoma
Capn4 promotes epithelial-mesenchymal transition in human melanoma cells through activation of the Wnt/?-catenin pathway.
Myocardial Infarction
Deficiency of Capn4 Gene Inhibits Nuclear Factor-?B (NF-?B) Protein Signaling/Inflammation and Reduces Remodeling after Myocardial Infarction.
Nasopharyngeal Carcinoma
Capn4 Is a Marker of Poor Clinical Outcomes and Promotes Nasopharyngeal Carcinoma Metastasis via NF-?B-Induced MMP2 Expression.
Capn4 is induced by and required for Epstein-Barr virus latent membrane protein 1 promotion of nasopharyngeal carcinoma metastasis through ERK/AP-1 signaling.
miR-124 suppresses proliferation and invasion of nasopharyngeal carcinoma cells through the Wnt/?-catenin signaling pathway by targeting Capn4.
Neoplasm Metastasis
Capn4 contributes to tumor invasion and metastasis in clear cell renal cell carcinoma cells via modulating talin-focal adhesion kinase signaling pathway.
Capn4 contributes to tumor invasion and metastasis in gastric cancer via activation of the Wnt/?-catenin/MMP9 signalling pathways.
Capn4 contributes to tumour growth and metastasis of hepatocellular carcinoma by activation of the FAK-Src signalling pathways.
Capn4 Enhances Osteopontin Expression through Activation of the Wnt/?-Catenin Pathway to Promote Epithelial Ovarian Carcinoma Metastasis.
Capn4 Is a Marker of Poor Clinical Outcomes and Promotes Nasopharyngeal Carcinoma Metastasis via NF-?B-Induced MMP2 Expression.
Capn4 is induced by and required for Epstein-Barr virus latent membrane protein 1 promotion of nasopharyngeal carcinoma metastasis through ERK/AP-1 signaling.
Capn4 overexpression indicates poor prognosis of ovarian cancer patients.
Capn4 overexpression underlies tumor invasion and metastasis after liver transplantation for hepatocellular carcinoma.
Capn4 promotes esophageal squamous cell carcinoma metastasis by regulating ZEB1 through the Wnt/?-catenin signaling pathway.
Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2.
Capn4 regulates migration and invasion of ovarian carcinoma cells via targeting osteopontin-mediated PI3K/AKT signaling pathway.
Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells.
High expression of Capn4 is associated with metastasis and poor prognosis in esophageal squamous cell carcinoma.
miR-124 suppresses proliferation and invasion of nasopharyngeal carcinoma cells through the Wnt/?-catenin signaling pathway by targeting Capn4.
MiR-337-3p suppresses the proliferation and metastasis of clear cell renal cell carcinoma cells via modulating Capn4.
Overexpression of Capns1 Predicts Poor Prognosis and Correlates with Tumor Progression in Renal Cell Carcinoma.
Neoplasms
Calpain Small Subunit 1 Protein in the Prognosis of Cancer Survivors and Its Clinicopathological Correlation.
Capn4 contributes to tumor invasion and metastasis in clear cell renal cell carcinoma cells via modulating talin-focal adhesion kinase signaling pathway.
Capn4 contributes to tumor invasion and metastasis in gastric cancer via activation of the Wnt/?-catenin/MMP9 signalling pathways.
Capn4 contributes to tumour growth and metastasis of hepatocellular carcinoma by activation of the FAK-Src signalling pathways.
Capn4 Enhances Osteopontin Expression through Activation of the Wnt/?-Catenin Pathway to Promote Epithelial Ovarian Carcinoma Metastasis.
Capn4 expression is modulated by microRNA-520b and exerts an oncogenic role in prostate cancer cells by promoting Wnt/?-catenin signaling.
Capn4 induces human renal cancer cell proliferation by activating NF-?B signaling pathway through FAK phosphorylation.
Capn4 Is a Marker of Poor Clinical Outcomes and Promotes Nasopharyngeal Carcinoma Metastasis via NF-?B-Induced MMP2 Expression.
Capn4 mRNA level is correlated with tumour progression and clinical outcome in clear cell renal cell carcinoma.
Capn4 overexpression indicates poor prognosis of ovarian cancer patients.
Capn4 overexpression underlies tumor invasion and metastasis after liver transplantation for hepatocellular carcinoma.
Capn4 promotes colorectal cancer cell proliferation by increasing MAPK7 through activation of the Wnt/?-Catenin pathway.
Capn4 promotes epithelial-mesenchymal transition in human melanoma cells through activation of the Wnt/?-catenin pathway.
Capn4 promotes esophageal squamous cell carcinoma metastasis by regulating ZEB1 through the Wnt/?-catenin signaling pathway.
Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2.
Cyclin E in breast tumors is cleaved into its low molecular weight forms by calpain.
Growth of hepatocellular carcinoma in the regenerating liver.
High expression of Capn4 is associated with metastasis and poor prognosis in esophageal squamous cell carcinoma.
Increased Expression of Capn4 is Associated with the Malignancy of Human Glioma.
Suppression of Capn4 by microRNA-1271 impedes the proliferation and invasion of colorectal cancer cells.
Neoplasms, Squamous Cell
High expression of Capn4 is associated with metastasis and poor prognosis in esophageal squamous cell carcinoma.
Ovarian Neoplasms
Capn4 Enhances Osteopontin Expression through Activation of the Wnt/?-Catenin Pathway to Promote Epithelial Ovarian Carcinoma Metastasis.
Capn4 overexpression indicates poor prognosis of ovarian cancer patients.
Prostatic Neoplasms
Capn4 expression is modulated by microRNA-520b and exerts an oncogenic role in prostate cancer cells by promoting Wnt/?-catenin signaling.
Retinoblastoma
Calpain modulates cyclin-dependent kinase inhibitor 1B (p27(Kip1)) in cells of the osteoblast lineage.
Stomach Neoplasms
Capn4 contributes to tumor invasion and metastasis in gastric cancer via activation of the Wnt/?-catenin/MMP9 signalling pathways.
MiR-99a and MiR-491 Regulate Cisplatin Resistance in Human Gastric Cancer Cells by Targeting CAPNS1.
Virus Diseases
Capn4 Is a Marker of Poor Clinical Outcomes and Promotes Nasopharyngeal Carcinoma Metastasis via NF-?B-Induced MMP2 Expression.