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Information on EC 3.4.22.70 - sortase A

for references in articles please use BRENDA:EC3.4.22.70

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IUBMB Comments

In peptidase family C60.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
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The enzyme catalyses a cell wall sorting reaction in which a surface protein with a sorting signal containing a LPXTG motif is cleaved between the Thr and Gly residue. The resulting threonine carboxyl end of the protein is covalently attached to a pentaglycine cross-bridge of peptidoglycan.

Synonyms
sortase a, sortase srta, sortase a transpeptidase, sortase transpeptidase, srta protein, srta sortase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
The enzyme catalyses a cell wall sorting reaction in which a surface protein with a sorting signal containing a LPXTG motif is cleaved between the Thr and Gly residue. The resulting threonine carboxyl end of the protein is covalently attached to a pentaglycine cross-bridge of peptidoglycan.
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