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Information on EC 3.4.22.68 - Ulp1 peptidase and Organism(s) Arabidopsis thaliana and UniProt Accession Q8GYL3

for references in articles please use BRENDA:EC3.4.22.68
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.68 Ulp1 peptidase
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This record set is specific for:
Arabidopsis thaliana
UNIPROT: Q8GYL3 not found.
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Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-/-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein
Synonyms
senp1, senp2, sumo protease, senp6, sumo-specific protease, senp7, smt3ip1, ulp1 protease, sumo protease 1, sumo-specific protease 2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ELS1
an ESD4 homologue
C48.001
-
-
-
-
ELS1
an ESD4 homologue
Small ubiquitin-related modifier protein 1 conjugate proteinase
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-
-
-
Smt3-protein conjugate proteinase
-
-
-
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Ulp1
-
-
-
-
Ulp1 endopeptidase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
252852-50-9
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
small ubiquitin-related modifier-protein + H2O
small ubiquitin-related modifier-protein + protein
show the reaction diagram
SUMO-specific proteases, SENPs, reversibly remove small ubiquitin-related modifier-protein, SUMO, from the SUMOylated proteins
-
-
r
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
small ubiquitin-related modifier-protein + H2O
small ubiquitin-related modifier-protein + protein
show the reaction diagram
SUMO-specific proteases, SENPs, reversibly remove small ubiquitin-related modifier-protein, SUMO, from the SUMOylated proteins
-
-
r
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
ELS1
UniProt
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
growth defects caused by loss of ESD4 function are not due to increased synthesis of the stress signal salicylic acid. ELS1 depletion causes no measurable alterations in flowering and leaf development
physiological function
SUMO protease ESD4 and ESD4-like SUMO protease 1, i.e. ELS1 or AtULP1a, show close sequence similarity, but different properties and are functionally distinct, overview
malfunction
growth defects caused by loss of ESD4 function are not due to increased synthesis of the stress signal salicylic acid, enzyme depletion causes delay in flowering
physiological function
SUMO protease ESD4 and ESD4-like SUMO protease 1, i.e. ELS1 or AtULP1a, show close sequence similarity, but different properties and are functionally distinct, overview
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ULP1A_ARATH
502
0
58169
Swiss-Prot
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C461S
site-directed mutagenesis, ELS1C461S is not capable of cleaving the extension oV the carboxyl terminus of SUMO1
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene ULP1A, DNA and amino acid sequence determination, genotyping, recombinant expression in Arabidopsis thaliana plants and in leaves of Nicotioana bentamiana using transfection via Agrobacterium tumefaciens. An expressed GFP-ELS1 construct has a generally non-nuclear localization, being detectable at membranes and in the cytoplasm
gene ESD4, DNA and amino acid sequence determination, genotyping
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hermkes, R.; Fu, Y.-F.; Nuerrenberg, K.; Budhiraja, R.; Schmelzer, E.; Elrouby, N.; Dohmen, R.J.; Bachmair, A.; Coupland, G.
Distinct roles for Arabidopsis SUMO protease ESD4 and its closest homolog ELS1
Planta
233
63-73
2011
Arabidopsis thaliana (Q8GYL3), Arabidopsis thaliana (Q94F30), Arabidopsis thaliana
Manually annotated by BRENDA team