Reference on EC 3.4.22.65 - peptidase 1 (mite)
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pernas, M.; Sanchez-Ramos, I.; Sanchez-Monge, R.; Lombardero, M.; Arteaga, C.; Castanera, P.; Salcedo, G.
Der p 1 and Der f 1, the highly related and major allergens from house dust mites, are differentially affected by a plant cystatin
Clin. Exp. Allergy
30
972-978
2000
Dermatophagoides farinae, Dermatophagoides pteronyssinus
Takai, T.; Mineki, R.; Nakazawa, T.; Takaoka, M.; Yasueda, H.; Murayama, K.; Okumura, K.; Ogawa, H.
Maturation of the activities of recombinant mite allergens Der p 1 and Der f 1, and its implication in the blockade of proteolytic activity
FEBS Lett.
531
265-272
2002
Dermatophagoides farinae, Dermatophagoides pteronyssinus
Yasuhara, T.; Takai, T.; Yuuki, T.; Okudaira, H.; Okumura, Y.
Biologically active recombinant forms of a major house dust mite group 1 allergen Der f 1 with full activities of both cysteine protease and IgE binding
Clin. Exp. Allergy
31
116-124
2001
Dermatophagoides farinae
Shoji, H.; Shibuya, I.; Hirai, M.; Horiuchi, H.; Takagi, M.
Production of recombinant Der f1 with the native IgE-binding activity using a baculovirus expression system
Biosci. Biotechnol. Biochem.
61
1668-1673
1997
Dermatophagoides farinae
Shoji, H.; Hanawa, M.; Shibuya, I.; Hirai, M.; Yasuhara, T.; Okumura, Y.; Yamakawa, H.
Production of recombinant mite allergen Der f1 in insect cells and characterization of products
Biosci. Biotechnol. Biochem.
60
621-625
1996
Dermatophagoides farinae
Shoji, H.; Horiuchi, H.; Takagi, M.
Production of recombinant Der f1 (a major mite allergen) by Aspergillus oryzae
Biosci. Biotechnol. Biochem.
63
703-709
1999
Dermatophagoides farinae
Takahashi, K.; Takai, T.; Yasuhara, T.; Yuuki, T.; Ohtake, Y.; Yokota, T.; Okumura, Y.
Production of enzymatically and immunologically active Der f1 in Escherichia coli
Int. Arch. Allergy Immunol.
122
108-114
2000
Dermatophagoides farinae
Takahashi, K.; Takai, T.; Yasuhara, T.; Yokota, T.; Okumura, Y.
Effects of site-directed mutagenesis in the cysteine residues and the N-glycosylation motif in recombinant Der f1 on secretion and protease activity
Int. Arch. Allergy Immunol.
124
454-460
2001
Dermatophagoides farinae
Thomas, W.R.; Stewart, G.A.; Simpson, R.J.; Chua, K.Y.; Plozza, T.M.; Dilworth, R.J.; Nisbet, A.; Turner, K.J.
Cloning and expression of DNA coding for the major house dust mite allergen Der p 1 in Escherichia coli
Int. Arch. Allergy Appl. Immunol.
85
127-129
1988
Dermatophagoides pteronyssinus (P08176)
Gough, L.; Schulz, O.; Sewell, H.F.; Shakib, F.
The cysteine protease activity of the major dust mite allergen Der p 1 selectively enhances the immunoglobulin E antibody response
J. Exp. Med.
190
1897-1902
1999
Dermatophagoides pteronyssinus
Schulz, O.; Sutton, B.J.; Beavil, R.L.; Shi, J.; Sewell, H.F.; Gould, H.J.; Laing, P.; Shakib, F.
Cleavage of the low-affinity receptor for human IgE (CD23) by a mite cysteine protease: nature of the cleaved fragment in relation to the structure and function of CD23
Eur. J. Immunol.
27
584-588
1997
Dermatophagoides pteronyssinus
Schulz, O.; Laing, P.; Sewell, H.F.; Shakib, F.
Der p I, a major allergen of the house dust mite, proteolytically cleaves the low-affinity receptor for human IgE (CD23)
Eur. J. Immunol.
25
3191-3194
1995
Dermatophagoides pteronyssinus
Shakib, F.; Gough, L.
The proteolytic activity of Der p 1 selectively enhances IgE synthesis: a link between allergenicity and cysteine protease activity
Clin. Exp. Allergy
30
751-752
2000
Dermatophagoides pteronyssinus
John, R.J.; Rusznak, C.; Ramjee, M.; Lamont, A.G.; Abrahamson, M.; Hewitt, E.L.
Functional effects of the inhibition of the cysteine protease activity of the major house dust mite allergen Der p 1 by a novel peptide-based inhibitor
Clin. Exp. Allergy
30
784-793
2000
Dermatophagoides pteronyssinus
Takai, T.; Kato, T.; Sakata, Y.; Yasueda, H.; Izuhara, K.; Okumura, K.; Ogawa, H.
Recombinant Der p 1 and Der f 1 exhibit cysteine protease activity but no serine protease activity
Biochem. Biophys. Res. Commun.
328
944-952
2005
Dermatophagoides pteronyssinus
Kauffman Henk , K.H.; Tamm Michae, T.M.; Timmerman J. Andre , T.J.; Borger Pete, B.P.
House dust mite major allergens Der p 1 and Der p 5 activate human airway-derived epithelial cells by protease-dependent and protease-independent mechanisms
Clin. Mol. Allergy
4
5-5
2006
Dermatophagoides pteronyssinus
Takai, T.; Kato, T.; Ota, M.; Yasueda, H.; Kuhara, T.; Okumura, K.; Ogawa, H.
Recombinant Der p 1 and Der f 1 with in vitro enzymatic activity to cleave human CD23, CD25 and alpha1-antitrypsin, and in vivo IgE-eliciting activity in mice
Int. Arch. Allergy Immunol.
137
194-200
2005
Dermatophagoides farinae, Dermatophagoides pteronyssinus
Takai, T.; Mizuuchi, E.; Kikuchi, Y.; Nagamune, T.; Okumura, K.; Ogawa, H.
Glycosylation of recombinant proforms of major house dust mite allergens Der p 1 and Der f 1 decelerates the speed of maturation
Int. Arch. Allergy Immunol.
139
181-187
2006
Dermatophagoides pteronyssinus
Wong, C.K.; Li, M.L.; Wang, C.B.; Ip, W.K.; Tian, Y.P.; Lam, C.W.
House dust mite allergen Der p 1 elevates the release of inflammatory cytokines and expression of adhesion molecules in co-culture of human eosinophils and bronchial epithelial cells
Int. Immunol.
18
1327-1335
2006
Dermatophagoides pteronyssinus
Takai, T.; Kato, T.; Yasueda, H.; Okumura, K.; Ogawa, H.
Analysis of the structure and allergenicity of recombinant pro- and mature Der p 1 and Der f 1: Major conformational IgE epitopes blocked by prodomains
J. Allergy Clin. Immunol.
115
555-563
2005
Dermatophagoides farinae, Dermatophagoides pteronyssinus
Pichavant, M.; Charbonnier, A.; Taront, S.; Brichet, A.; Wallaert, B.; Pestel, J.; Tonnel, A.; Gosset, P.
Asthmatic bronchial epithelium activated by the proteolytic allergen Der p 1 increases selective dendritic cell recruitment
J. Allergy Clin. Immunol.
115
771-778
2005
Dermatophagoides pteronyssinus
de Halleux, S.; Stura, E.; VanderElst, L.; Carlier, V.; Jacquemin, M.; Saint-Remy, J.
Three-dimensional structure and IgE-binding properties of mature fully active Der p 1, a clinically relevant major allergen
J. Allergy Clin. Immunol.
117
571-576
2006
Dermatophagoides pteronyssinus, Dermatophagoides pteronyssinus (P08176)
Adam, E.; Hansen, K.K.; Astudillo, O.F.; Coulon, L.; Bex, F.; Duhant, X.; Jaumotte, E.; Hollenberg, M.D.; Jacquet, A.
The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism
J. Biol. Chem.
281
6910-6923
2006
Dermatophagoides pteronyssinus
Tempels-Pavlica, Z.; Oosting, A.J.; Terreehorst, I.; van Wijk, R.G.; Bruijnzeel-Koomen, C.A.; de Monchy, J.G.; Aalberse, R.C.
Differential effect of mattress covers on the level of Der p 1 and Der f 1 in dust
Clin. Exp. Allergy
34
1444-1447
2004
Dermatophagoides farinae
Kato, T.; Takai, T.; Mitsuishi, K.; Okumura, K.; Ogawa, H.
Cystatin A inhibits IL-8 production by keratinocytes stimulated with Der p 1 and Der f 1: biochemical skin barrier against mite cysteine proteases
J. Allergy Clin. Immunol.
116
169-176
2005
Dermatophagoides farinae
Perfetti, L.; Ferrari, M.; Galdi, E.; Pozzi, V.; Cottica, D.; Grignani, E.; Minoia, C.; Moscato, G.
House dust mites (Der p 1, Der f 1), cat (Fel d 1) and cockroach (Bla g 2) allergens in indoor work-places (offices and archives)
Sci. Total Environ.
328
15-21
2004
Dermatophagoides farinae
Zhang, J.; Hamilton, J.M.; Garrod, D.R.; Robinson, C.
Interactions between mature Der p 1 and its free prodomain indicate membership of a new family of C1 peptidases
Allergy
62
1302-1309
2007
Dermatophagoides pteronyssinus
Meno Kar, M.K.; Thorsted Peter , T.P.; Ipsen Henri, I.H.; Kristensen Ol, K.O.; Larsen Jorgen , L.J.; Spangfort Michael , S.M.; Gajhede Michae, G.M.; Lund Kaar, L.K.
The metal binding site of the major house dust mite allergen Der p 1
J. Allergy Clin. Immunol.
118
971-971
2006
Dermatophagoides pteronyssinus (P08176)
Deb, R.; Shakib, F.; Reid, K.; Clark, H.
Major house dust mite allergens Dermatophagoides pteronyssinus 1 and Dermatophagoides farinae 1 degrade and inactivate lung surfactant proteins A and D
J. Biol. Chem.
282
36808-36819
2007
Dermatophagoides pteronyssinus
Kikuchi, Y.; Takai, T.; Kuhara, T.; Ota, M.; Kato, T.; Hatanaka, H.; Ichikawa, S.; Tokura, T.; Akiba, H.; Mitsuishi, K.; Ikeda, S.; Okumura, K.; Ogawa, H.
Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p1 to sensitization toward IgE and IgG responses
J. Immunol.
177
1609-1617
2006
Dermatophagoides pteronyssinus
Nakamura, T.; Hirasawa, Y.; Takai, T.; Mitsuishi, K.; Okuda, M.; Kato, T.; Okumura, K.; Ikeda, S.; Ogawa, H.
Reduction of skin barrier function by proteolytic activity of a recombinant house dust mite major allergen Der f 1
J. Invest. Dermatol.
126
2719-2723
2006
Dermatophagoides farinae
Szalai, K.; Fuhrmann, J.; Pavkov, T.; Scheidl, M.; Wallmann, J.; Braemswig, K.H.; Vrtala, S.; Scheiner, O.; Keller, W.; Saint-Remy, J.M.; Neumann, D.; Pali-Schoell, I.; Jensen-Jarolim, E.
Mimotopes identify conformational B-cell epitopes on the two major house dust mite allergens Der p 1 and Der p 2
Mol. Immunol.
45
1308-1317
2008
Dermatophagoides pteronyssinus
Lienard, D.; Tran Dinh, O.; van Oort, E.; Van Overtvelt, L.; Bonneau, C.; Wambre, E.; Bardor, M.; Cosette, P.; Didier-Laurent, A.; de Borne, F.D.; Delon, R.; van Ree, R.; Moingeon, P.; Faye, L.; Gomord, V.
Suspension-cultured BY-2 tobacco cells produce and mature immunologically active house dust mite allergens
Plant Biotechnol. J.
5
93-108
2007
Dermatophagoides pteronyssinus
Zhang, J.; Saint-Remy, J.M.; Garrod, D.R.; Robinson, C.
Comparative enzymology of native and recombinant house dust mite allergen Der p 1
Allergy
64
469-477
2009
Dermatophagoides pteronyssinus
Cui, Y.; Zhou, P.; Peng, J.; Peng, M.; Zhou, Y.; Lin, Y.; Liu, L.
Cloning, sequence analysis, and expression of cDNA coding for the major house dust mite allergen, Der f 1, in Escherichia coli
Braz. J. Med. Biol. Res.
41
380-388
2008
Dermatophagoides farinae (Q58A71), Dermatophagoides farinae
Walgraffe, D.; Matteotti, C.; El Bakkoury, M.; Garcia, L.; Marchand, C.; Bullens, D.; Vandenbranden, M.; Jacquet, A.
A hypoallergenic variant of Der p 1 as a candidate for mite allergy vaccines
J. Allergy Clin. Immunol.
123
1150-1156
2009
Dermatophagoides pteronyssinus
Maneechotesuwan, K.; Wamanuttajinda, V.; Kasetsinsombat, K.; Huabprasert, S.; Yaikwawong, M.; Barnes, P.J.; Wongkajornsilp, A.
Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite-sensitive patients with asthma
J. Allergy Clin. Immunol.
123
239-248
2009
Dermatophagoides pteronyssinus
Chruszcz, M.; Chapman, M.D.; Vailes, L.D.; Stura, E.A.; Saint-Remy, J.M.; Minor, W.; Pomes, A.
Crystal structures of mite allergens Der f 1 and Der p 1 reveal differences in surface-exposed residues that may influence antibody binding
J. Mol. Biol.
386
520-530
2009
Dermatophagoides farinae, Dermatophagoides pteronyssinus
Spertini, F.; Berney, M.; Foradini, F.; Roulet, C.A.
Major mite allergen Der f 1 concentration is reduced in buildings with improved energy performance
Allergy
65
623-629
2010
Dermatophagoides farinae, Dermatophagoides pteronyssinus
Asturias, J.A.; Ibarrola, I.; Arilla, M.C.; Vidal, C.; Ferrer, A.; Gamboa, P.M.; Vinuela, J.E.; Sanz, M.L.; Andreu, C.; Martinez, A.
Engineering of major house dust mite allergens Der p 1 and Der p 2 for allergen-specific immunotherapy
Clin. Exp. Allergy
39
1088-1098
2009
Dermatophagoides pteronyssinus
Horlock, C.; Shakib, F.; Jones, N.S.; Sewell, H.F.; Ghaemmaghami, A.M.
Differential protein expression by dendritic cells from atopic and non-atopic individuals after stimulation by the major house dust mite allergen Der p 1
Int. Arch. Allergy Immunol.
150
237-251
2009
Dermatophagoides pteronyssinus
Takai, T.; Kato, T.; Hatanaka, H.; Inui, K.; Nakazawa, T.; Ichikawa, S.; Mitsuishi, K.; Ogawa, H.; Okumura, K.
Modulation of allergenicity of major house dust mite allergens Der f 1 and Der p 1 by interaction with an endogenous ligand
J. Immunol.
183
7958-7965
2009
Dermatophagoides farinae, Dermatophagoides pteronyssinus
Bussieres, L.; Bordas-Le Floch, V.; Bulder, I.; Chabre, H.; Nony, E.; Lautrette, A.; Berrouet, C.; Nguefeu, Y.; Horiot, S.; Baron-Bodo, V.; Van Overtvelt, L.; De Conti, A.M.; Schlegel, A.; Maguet, N.; Mouz, N.; Lemoine, P.; Batard, T.; Moingeon, P.
Recombinant fusion proteins assembling Der p 1 and Der p 2 allergens from Dermatophagoides pteronyssinus
Int. Arch. Allergy Immunol.
153
141-151
2010
Dermatophagoides pteronyssinus (P49273), Dermatophagoides pteronyssinus
Mueller, G.A.; Edwards, L.L.; Aloor, J.J.; Fessler, M.B.; Glesner, J.; Pomes, A.; Chapman, M.D.; London, R.E.; Pedersen, L.C.
The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins
J. Allergy Clin. Immunol.
125
909-917.e4
2010
Dermatophagoides pteronyssinus (P49273)
Herman, J.; Thelen, N.; Smargiasso, N.; Mailleux, A.C.; Luxen, A.; Cloes, M.; De Pauw, E.; Chevigne, A.; Galleni, M.; Dumez, M.E.
Der p 1 is the primary activator of Der p 3, Der p 6 and Der p 9 the proteolytic allergens produced by the house dust mite Dermatophagoides pteronyssinus
Biochim. Biophys. Acta
1840
1117-1124
2014
Dermatophagoides pteronyssinus (P08176), Dermatophagoides pteronyssinus
Li, C.; Jiang, Y.; Guo, W.; Liu, Z.
Production of a chimeric allergen derived from the major allergen group 1 of house dust mite species in Nicotiana benthamiana
Hum. Immunol.
74
531-537
2013
Dermatophagoides pteronyssinus (P08176), Dermatophagoides farinae (Q58A71)
Henriquez, O.A.; Den Beste, K.; Hoddeson, E.K.; Parkos, C.A.; Nusrat, A.; Wise, S.K.
House dust mite allergen Der p 1 effects on sinonasal epithelial tight junctions
Int. Forum Allergy Rhinol.
3
630-635
2013
Dermatophagoides pteronyssinus (P08176)
Newton, G.K.; Perrior, T.R.; Jenkins, K.; Major, M.R.; Key, R.E.; Stewart, M.R.; Firth-Clark, S.; Lloyd, S.M.; Zhang, J.; Francis-Newton, N.J.; Richardson, J.P.; Chen, J.; Lai, P.; Garrod, D.R.; Robinson, C.
The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma
J. Med. Chem.
57
9447-9462
2014
Dermatophagoides pteronyssinus (P08176)
Al-Ghouleh, A.; Johal, R.; Sharquie, I.; Emara, M.; Harrington, H.; Shakib, F.; Ghaemmaghami, A.
The glycosylation pattern of common allergens: The recognition and uptake of Der p 1 by epithelial and dendritic cells is carbohydrate dependent
PLoS ONE
7
e33929
2012
Dermatophagoides pteronyssinus (P08176)
Ling, C.; Zhang, J.; Chen, H.; Zou, Z.; Lai, H.; Zhang, J.; Lin, D.; Tao, A.
Expression and refolding of mite allergen pro-Der f1 from inclusion bodies in Escherichia coli
Protein Expr. Purif.
109
93-98
2015
Dermatophagoides farinae (P16311)
Miyajima, K.; Suzuki, Y.; Miki, D.; Arai, M.; Arakawa, T.; Shimomura, H.; Shiba, K.; Mitsubayashi, K.
Direct analysis of airborne mite allergen (Der f1) in the residential atmosphere by chemifluorescent immunoassay using bioaerosol sampler
Talanta
123
241-246
2014
Dermatophagoides farinae (P16311), Dermatophagoides farinae
Marconi, G.; Albertini, E.; Mari, A.; Palazzo, P.; Porceddu, A.; Raggi, L.; Bolis, L.; Lancioni, H.; Palomba, A.; Lucentini, L.; Lanfaloni, L.; Marcucci, F.; Falcinelli, M.; Panara, F.
In planta expression of a mature Der p 1 allergen isolated from an Italian strain of Dermatophagoides pteronyssinus
Transgenic Res.
21
523-535
2012
Dermatophagoides pteronyssinus (B5AYU7), Dermatophagoides pteronyssinus
html completed
