Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 3.4.22.6 - chymopapain

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abscess
Fulminating septicemia secondary to oxygen-ozone therapy for lumbar disc herniation: case report.
Anaphylaxis
Anaphylactic reactions following intradiscal injection of chymopapain under local anesthesia.
Anaphylactic reactions following the intradiscal injection of chymopapain under local anesthesia.
Anaphylactic reactions to chymopapain during general anesthesia: a case report.
Anaphylactic reactions to intradiscal chymopapain.
Anaphylactic shock associated with chymopapain skin test. A case report and review of the literature.
Anaphylactoid reaction to chymopapain.
Anaphylaxis and chymopapain.
Anaphylaxis associated with chymopapain injections.
Anaphylaxis from chymopapain.
Anaphylaxis secondary to chymopapain.
Anaphylaxis to chymopapain after antihistamine pretreatment.
Automated percutaneous lumbar discectomy.
Chemonucleolysis with calpain I in rabbits.
Chemonucleolysis. Current status and future outlook.
Chymopapain allergy: case reports and identification of patients at risk for chymopapain anaphylaxis.
Correlation between hypersensitivity to parenteral chymopapain and the presence of IgE anti-chymopapain antibody.
Decreased incidence and mortality of anaphylaxis to chymopapain.
Five-year results from chemonucleolysis with chymopapain or collagenase: a prospective randomized study.
Iatrogenic pseudoanaphylaxis.
Predicting anaphylaxis to chymopapain.
Pretreatment serum levels of IgE to chymopapain in reactive patients.
Prevention of chymopapain anaphylaxis by screening chemonucleolysis candidates with cutaneous chymopapain testing.
Prevention of chymopapain anaphylaxis by screening chemonucleolysis candidates with cutaneous chymopapain testing. A preliminary report.
Prospective evaluation of chymopapain sensitivity in patients undergoing chemonucleolysis.
Proteins: chymopapain and insulin.
Safety of chemonucleolysis. Adverse effects reported in the United States, 1982-1991.
Skin testing and chymopapain anaphylaxis. A case report.
Skin testing for chymopapain allergy in chemonucleolysis.
Skin testing in chymopapain anaphylaxis.
The use of antihistamines in the prevention and treatment of anaphylaxis and anaphylactoid reactions.
Two anaphylactic deaths after chemonucleolysis.
Use of prophylactic combined H1 and H2 antagonists reduces mortality in chymopapain anaphylaxis.
[Anaphylaxis to chymopapain induced by exertion]
[Anesthesiologic aspects of chemonucleolysis in local anesthesia]
[Chemonucleolysis using chymopapain and collagenase. 3-year results of a prospective randomized study]
[Chymopapain allergy. Diagnostic value of a skin test before and after chemonucleolysis]
[Clinical experience with intradisk chymopapain administration in lumbar intervertebral disk displacement]
[Immunologic methods of study for evaluating the risk of anaphylactic reactions in intradisk chymopapain injections]
[Intradiscal injection of hypertonic saline, phenol-glycerin and osmic acid for the treatment of lumbar disc herniation: an experimental study]
[Sensitization to chymopapain in patients treated with chemonucleolysis]
Aneurysm
Hemorrhagic complications after the lumbar injection of chymopapain.
Arachnoiditis
Effect of repeated injections of chymopapain in the epidural space.
Asthma
Proteins: chymopapain and insulin.
[Skin tests and chymopapain-specific immunoglobulins E after chemonucleolysis]
Bone Resorption
The effect of bone remodeling inhibition by zoledronic acid in an animal model of cartilage matrix damage.
Brain Diseases
Acute encephalopathy and third-nerve palsy after chymopapain injection.
Carcinoma, Hepatocellular
[Cytotoxicity of chymopapain combined with pingyangmycin on mouse hepatoma cell line hepa-6]
Cerebral Hemorrhage
Multiple cerebral hemorrhages following chymopapain chemonucleolysis. Case report.
Colonic Neoplasms
Intracellularly biorecognizable derivatives of 5-fluorouracil. Implications for site-specific delivery in the human condition.
Discitis
Discitis following chemonucleolysis. An experimental study.
Fulminating septicemia secondary to oxygen-ozone therapy for lumbar disc herniation: case report.
Intervertebral disc infection after lumbar chemonucleolysis: report of a case.
Intervertebral disk-space infection after chymopapain injection.
Modic changes, possible causes and relation to low back pain.
Drug Hypersensitivity
[Sensitization to chymopapain in patients treated with chemonucleolysis]
Erythema
[Changes in plasma histamine and catecholamines levels after injection of chymopapain in chemonucleolysis]
Hyperalgesia
Chymopapain-induced reduction of proinflammatory phospholipase A2 activity and amelioration of neuropathic behavioral changes in an in vivo model of acute sciatica.
Hypersensitivity
Brain Activation in a Cynomolgus Macaque Model of Chymopapain-Induced Discogenic Low Back Pain: A Preliminary Study.
Chemonucleolysis as treatment for herniated lumbar disc.
Chymopapain allergy: case reports and identification of patients at risk for chymopapain anaphylaxis.
Chymopapain induced allergic reactions.
Correlation between hypersensitivity to parenteral chymopapain and the presence of IgE anti-chymopapain antibody.
Evaluation of papain/chymopapain cross allergenicity.
Immunoglobulin E antibodies to papaya proteinases and their relevance to chemonucleolysis.
Incidence and risk factors for latent sensitization to chymopapain: predictive skin-prick tests in 700 candidates for chemonucleolysis.
Local ocular anaphylaxis to papain enzyme contained in a contact lens cleansing solution.
Prospective comparative study of intradiscal high-dose and low-dose collagenase versus chymopapain.
Proteins: chymopapain and insulin.
Skin testing for chymopapain allergy in chemonucleolysis.
Skin tests for chymopapain allergy.
[Allergy to chymopapain: value of predictive tests before chemonucleolysis]
[Chymopapain allergy. Diagnostic value of a skin test before and after chemonucleolysis]
[Clinical experience with intradisk chymopapain administration in lumbar intervertebral disk displacement]
[Detection of patients at risk of allergy to chymopapain before and after chemonucleolysis. Choice of preventive medication]
[Incidence and prevention of allergic reactions following chemonucleolysis with chymopapain]
[Sensitization to chymopapain in patients treated with chemonucleolysis]
Hypesthesia
Urological complications following chemonucleolysis.
Hypotension
Sudden hypotension with a test dose of chymopapain.
Infections
Discitis following chemonucleolysis. An experimental study.
Intervertebral disk-space infection after chymopapain injection.
Safety of chemonucleolysis. Adverse effects reported in the United States, 1982-1991.
Intervertebral Disc Degeneration
Modic changes, possible causes and relation to low back pain.
The changes in the intervertebral disc after chemonucleolysis demonstrated by magnetic resonance imaging.
The long-term effect of chemonucleolysis on the intervertebral disc as assessed by magnetic resonance imaging.
The use of chymopapain in degenerative disc disease: a preliminary report.
Intervertebral Disc Displacement
A randomized, double-blind study to compare low-dose with standard-dose chymopapain in the treatment of herniated lumbar intervertebral discs.
Adolescent disc protrusions. A long term follow-up of chymopapain therapy.
Adolescent disc protrusions. A long-term follow-up of surgery compared to chymopapain.
Cervical chemonucleolysis.
Cervical nucleolysis: indications, technique, results. 190 patients.
Chemonucleolysis as treatment for herniated lumbar disc.
Chemonucleolysis for sciatica. A critical review.
Chemonucleolysis. The relationship of the physical findings, discography, and myelography to the clinical result.
Chemonucleolysis: advantages and disadvantages.
Chymopapain and prolapsed disc.
Chymopapain chemonucleolysis. A preliminary report.
Chymopapain chemonucleolysis: a review of 105 cases.
Chymopapain chemonucleolysis: correlation of diagnostic radiographic factors and clinical outcome.
Chymopapain chemonucleolysis: CT changes after treatment.
Chymopapain for intervertebral disc herniation.
Chymopapain for the treatment of intervertebral disc herniation. A preliminary report of a double-blind study.
Chymopapain for the treatment of intervertebral disc herniation. The final report of a double-blind study.
Chymopapain versus conventional surgery for lumbar disc herniation. 10-year results of treatment.
Combined biochemical and clinical investigation of chemonucleolysis failures.
Comparison of tissue reaction with chondroitinase ABC and chymopapain in rabbits as the basis of clinical application in chemonucleolysis.
Computed tomography and differential diagnosis of the extruded lumbar disc.
Computed tomography scanning after chymopapain injection for herniated nucleus pulposus. A prospective study.
Continuing experience with chemonucleolysis.
Does the MMPI predict chemonucleolysis outcome?
Duration of symptoms and disc configuration in chemonucleolysis.
Effects of chemonucleolysis demonstrated by MR imaging.
Experimental chemonucleolysis with chymopapain in canine intervertebral disks.
Experimental studies on the effects of recombinant human matrix metalloproteinases on herniated disc tissues--how to facilitate the natural resorption process of herniated discs.
Injection of cymopapain into intervertebral discs. Preliminary report on 72 patients with symptoms of disc disease.
Intradiscal pressure after intradiscal injection of hypertonic saline: an experimental study.
Intradiscal pressure after repeat intradiscal injection of hypertonic saline: an experimental study.
Intraoperative chymopapain in lumbar laminotomy for disc disease: a less invasive technique.
Laser-assisted diskectomy performed by an internist resulting in cauda equina syndrome.
Long-term changes in the magnetic resonance image after chemonucleolysis.
Low-dose, low-volume chemonucleolysis. A biochemical study.
Lumbar disc herniations: the predictive value of the Health Attribution Test (HAT) and the Minnesota Multiphasic Personality Inventory (MMPI).
Lumbar discal herniation in the elderly: long-term results of chymopapain chemonucleolysis.
Magnetic resonance imaging findings 10 years after treatment for lumbar disc herniation.
Modic changes, possible causes and relation to low back pain.
Percutaneous lumbar diskectomy using a new aspiration probe: porcine and cadaver model.
Plasma radio-frequency-based diskectomy for treatment of cervical herniated nucleus pulposus: feasibility, safety, and preliminary clinical results.
Post-chymopapain (chemonucleolysis)--clinical and computed tomography correlation: preliminary results.
Repeat chemonucleolysis is safe and effective.
Repeat chymopapain injections. Results and complications.
Sciatica caused by disc herniation: Why is Chymopapain Chemonucleolysis denied to our patients?
Serial changes observed by magnetic resonance imaging in the intervertebral disc after chemonucleolysis. A consideration of the mechanism of chemonucleolysis.
The dose-related effect of intradiscal chymopapain on rabbit intervertebral discs.
The effect of chymopapain on low back pain.
The effect of spondylosis on the outcome of chemonucleolysis.
The long-term results of chymopapain. Ten-year follow-up of 268 patients after chemonucleolysis.
The treatment of herniated disc in Australia. Costs and benefits of intradiscal injection of chymopapain and surgery.
Transforaminal posterolateral endoscopic discectomy with or without the combination of a low-dose chymopapain: a prospective randomized study in 280 consecutive cases.
Treatment of chronic low back pain - new approaches on the horizon.
Treatment of lumbar disc herniation by chymopapain chemonucleolysis. A report on 120 patients.
[Chemonucleolysis of lumbar disk prolapse. Choice and complications]
[Clinical experience with intradisk chymopapain administration in lumbar intervertebral disk displacement]
[Failure of chemonucleolysis and its surgical treatment. Apropos of 268 cases]
[Herniation of a lumbar disk in the elderly. Results of chemonucleolysis]
[Lumbar disk prolapse treated with chymopapain]
[Lumbar disk prolapses and radiological spinal intervention. What do the randomized controlled trials say?]
[Nucleolytic action of chondroitinase ABC on the lumbar disc of the rabbit]
[Treatment by nucleolysis using chymopapain of disk hernias of purely lumbalgic form]
[Treatment of soft cervical hernia by percutaneous intradiscal injection of aprotinin]
[Unsatisfactory results of intradiscal injection of triamcinolone hexacetonide in the treatment of sciatica caused by intervertebral disk herniation]
Leukemia, Myeloid
CD34-positive cell selection by immunomagnetic beads and chymopapain.
Myelitis, Transverse
Possible role of collagen in transverse myelitis and chymopapain-induced paraplegia.
Oculomotor Nerve Diseases
Acute encephalopathy and third-nerve palsy after chymopapain injection.
Paralysis
The response of nerve tissue to chymopapain.
Paraplegia
Automated percutaneous lumbar discectomy.
Paraplegia following chymopapain injection. A case report.
Paresthesia
Urological complications following chemonucleolysis.
Peripheral Nerve Injuries
Peripheral nerve injury by chymopapain injection.
Pruritus
[Changes in plasma histamine and catecholamines levels after injection of chymopapain in chemonucleolysis]
Radiculopathy
Experimental studies on the effect of chymopapain on nerve root compression caused by intervertebral disk material.
Recognition of lumbar disc disease with magnetic resonance imaging.
Rhinitis
Proteins: chymopapain and insulin.
[Skin tests and chymopapain-specific immunoglobulins E after chemonucleolysis]
Sciatic Neuropathy
Chymopapain-induced reduction of proinflammatory phospholipase A2 activity and amelioration of neuropathic behavioral changes in an in vivo model of acute sciatica.
Sciatica
Adolescent disc protrusions. A long-term follow-up of surgery compared to chymopapain.
Backache and sciatica. A report of 90 patients treated by intradiscal injection of chymopapain (discase).
Biomechanical analysis of canine intervertebral discs after chymopapain injection. A preliminary report.
Chemonucleolysis for relief of sciatica due to a herniated intervertebral disc.
Chemonucleolysis for sciatica. A critical review.
Chemonucleolysis. The relationship of the physical findings, discography, and myelography to the clinical result.
Chymopapain chemonucleolysis. A preliminary report.
Chymopapain for the treatment of intervertebral disc herniation. A preliminary report of a double-blind study.
Chymopapain for the treatment of intervertebral disc herniation. The final report of a double-blind study.
Chymopapain-induced reduction of proinflammatory phospholipase A2 activity and amelioration of neuropathic behavioral changes in an in vivo model of acute sciatica.
Chymopapain. A 10-year, double-blind study.
Evaluation and treatment of chemonucleolysis failures.
Immunoglobulin E antibodies to papaya proteinases and their relevance to chemonucleolysis.
Long-term results of chymopapain injections.
Low-dose, low-volume chemonucleolysis. A biochemical study.
Lumbar chymopapain nucleolysis.
Mechanism of action of intradiscal chymopapain in the treatment of sciatica: a clinical, biochemical, and radiological study.
Safer proteinase treatment of sciatica. A biochemical preview of chymopapain inhibitors.
Safety and efficacy of chymopapain (Chymodiactin) in herniated nucleus pulposus with sciatica. Results of a randomized, double-blind study.
Safety and efficacy of chymopapain (Discase) in the treatment of sciatica due to a herniated nucleus pulposus. Results of a randomized, double-blind study.
Sciatica and Chymopapain.
Sciatica caused by disc herniation: Why is Chymopapain Chemonucleolysis denied to our patients?
The biochemistry of the action of chymopapain in relief of sciatica.
Treatment of sciatica. A comparative survey of complications of surgical treatment and nucleolysis with chymopapain.
[Double-blind study of the treatment of disc lumbosciatica by chemonucleolysis]
[Herniation of a lumbar disk in the elderly. Results of chemonucleolysis]
[Lumbar disk prolapse treated with chymopapain]
[Nucleolytic action of chondroitinase ABC on the lumbar disc of the rabbit]
[Treatment of low back pain and sciatica by intradiskal injection of chymopapain. Comparative analysis of the results of diskectomy and chemonucleolysis]
[Treatment of low back pain and sciatica by intradiskal injection of chymopapain]
[Treatment of lumbar sciatica with chymopapain injections in the intervertebral disk. A 7-year clinical study]
[Unsatisfactory results of intradiscal injection of triamcinolone hexacetonide in the treatment of sciatica caused by intervertebral disk herniation]
Scoliosis
Spinal flexibility increase after chymopapain injection is dose dependent: a possible alternative to anterior release in scoliosis.
Spasm
A randomized, double-blind study to compare low-dose with standard-dose chymopapain in the treatment of herniated lumbar intervertebral discs.
Update and review of chemonucleolysis.
Spinal Cord Injuries
Intrathecal injection of a specific enzyme in rats as a model for chemically induced spinal cord injury.
Spondylosis
The effect of spondylosis on the outcome of chemonucleolysis.
Subarachnoid Hemorrhage
Hemorrhagic complications after the lumbar injection of chymopapain.
Subarachnoid hemorrhage following chymopapain chemonucleolysis. Case report.
Synovitis
Scintigraphic evaluation of dogs with acute synovitis after treatment with glucosamine hydrochloride and chondroitin sulfate.
Tachycardia
[Changes in plasma histamine and catecholamines levels after injection of chymopapain in chemonucleolysis]
Urinary Retention
Urological complications following chemonucleolysis.
Urticaria
Proteins: chymopapain and insulin.