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Disease on EC 3.4.22.57 - caspase-4

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients.
Alzheimer Disease
Caspase-4 is partially cleaved by calpain via the impairment of Ca2+ homeostasis under the ER stress.
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death.
Presenilin-1 mutation activates the signaling pathway of caspase-4 in endoplasmic reticulum stress-induced apoptosis.
Amyotrophic Lateral Sclerosis
Familiar amyotrophic lateral sclerosis (FALS)-linked SOD1 mutation accelerates neuronal cell death by activating cleavage of caspase-4 under ER stress in an in vitro model of FALS.
Arthritis, Rheumatoid
[Effect of ubiquitin-proteasome pathway on TRAIL inducing apoptosis]
Asthma
Caspase-11 promotes allergic airway inflammation.
Elevated expression of the NLRP3 inflammasome in neutrophilic asthma.
Bacterial Infections
Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis.
The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1 Target and Controls IL-1? Secretion by Inflammasomes.
Blindness
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.
Brain Injuries
Caspases and their role in inflammation and ischemic neuronal death. Focus on caspase-12.
Recombinant erythropoietin is neuroprotective in a novel mouse oxidative injury model.
Brain Ischemia
Caspases and their role in inflammation and ischemic neuronal death. Focus on caspase-12.
Breast Neoplasms
Inhibition of mitogen-activated protein kinase signaling pathway sensitizes breast cancer cells to endoplasmic reticulum stress-induced apoptosis.
Mutational analysis of caspase 1, 4, and 5 genes in common human cancers.
Retraction Note: TET2 inhibits tumorigenesis of breast cancer cells by regulating caspase-4.
TET2 inhibits tumorigenesis of breast cancer cells by regulating caspase-4.
The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors.
Burkholderia Infections
Guanylate-Binding Protein-Dependent Noncanonical Inflammasome Activation Prevents Burkholderia thailandensis-Induced Multinucleated Giant Cell Formation.
Carcinogenesis
Inflammasomes of the intestinal epithelium.
Retraction Note: TET2 inhibits tumorigenesis of breast cancer cells by regulating caspase-4.
TET2 inhibits tumorigenesis of breast cancer cells by regulating caspase-4.
Carcinoma
A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing.
Caspase 4 Overexpression as a Prognostic Marker in Clear Cell Renal Cell Carcinoma: A Study Based on the Cancer Genome Atlas Data Mining.
Mutational analysis of caspase 1, 4, and 5 genes in common human cancers.
[Expression and correlation of apoptosis-related gene c-IAP2 and caspase-4 in head and cervical undifferentiation squamous cell carcinoma]
[Expression and correlation of apoptosis-related gene c-IAP2 and caspase-4 in sinonasal squamous carcinoma]
Carcinoma, Non-Small-Cell Lung
Altered lung tissue lipidomic profile in caspase-4 positive non-small cell lung cancer (NSCLC) patients.
Circulating and tumor-associated caspase-4: a novel diagnostic and prognostic biomarker for non-small cell lung cancer.
Correction: Circulating and tumor-associated caspase-4: a novel diagnostic and prognostic biomarker for non-small cell lung cancer.
Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients.
Carcinoma, Renal Cell
Caspase 4 Overexpression as a Prognostic Marker in Clear Cell Renal Cell Carcinoma: A Study Based on the Cancer Genome Atlas Data Mining.
Carcinoma, Squamous Cell
Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients.
[Expression and correlation of apoptosis-related gene c-IAP2 and caspase-4 in head and cervical undifferentiation squamous cell carcinoma]
[Expression and correlation of apoptosis-related gene c-IAP2 and caspase-4 in sinonasal squamous carcinoma]
Chorioamnionitis
A Role for the Inflammasome in Spontaneous Labor at Term with Acute Histologic Chorioamnionitis.
A Role for the Inflammasome in Spontaneous Preterm Labor With Acute Histologic Chorioamnionitis.
Choriocarcinoma
Assessment of caspase-4 released free AFC by RP-HPLC and fluorescence detection.
Cell-specific RNA interference by peptide-inhibited-peptidase-activated siRNAs.
Colitis
Glutathione peroxidase 8 negatively regulates caspase-4/11 to protect against colitis.
Colitis, Ulcerative
Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potential.
Glutathione peroxidase 8 negatively regulates caspase-4/11 to protect against colitis.
Colonic Neoplasms
Caspase-4 is essential for saikosaponin a-induced apoptosis acting upstream of caspase-2 and ?-H2AX in colon cancer cells.
Colorectal Neoplasms
Mutational analysis of caspase 1, 4, and 5 genes in common human cancers.
Salmonella enterica Infection of Murine and Human Enteroid-Derived Monolayers Elicits Differential Activation of Epithelium-Intrinsic Inflammasomes.
Coronary Disease
Caspase-11-Gasdermin D-Mediated Pyroptosis Is Involved in the Pathogenesis of Atherosclerosis.
Cowpox
Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases.
Cystinosis
Caspase-4 may play a role in loss of proximal tubules and renal injury in nephropathic cystinosis.
Dengue
Involvement of caspase-4 in IL-1 beta production and pyroptosis in human macrophages during dengue virus infection.
Epilepsy
[Apoptosis and expression of Caspase 3 and Caspase 4 in neurocytes of refractory human temporal lobe epilepsy].
Epilepsy, Temporal Lobe
[Apoptosis and expression of Caspase 3 and Caspase 4 in neurocytes of refractory human temporal lobe epilepsy].
Geographic Atrophy
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.
Glioma
Sulindac sulfide inhibits sarcoendoplasmic reticulum Ca2+ ATPase, induces endoplasmic reticulum stress response, and exerts toxicity in glioma cells: relevant similarities to and important differences from celecoxib.
Gram-Negative Bacterial Infections
A genome-wide screen identifies IRF2 as a key regulator of caspase-4 in human cells.
Dangerous Liaisons: Caspase-11 and Reactive Oxygen Species Crosstalk in Pathogen Elimination.
Hepatitis B, Chronic
[Study of endoplasmic reticulum stress role in hepatic failure induced by severe hepatitis B].
Hip Dislocation
Apoptotic pathways of macrophages within osteolytic interface membrane in periprosthestic osteolysis after total hip replacement.
Infections
Anti-Inflammatory Activity of PYNOD and Its Mechanism in Humans and Mice.
Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells.
Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization.
Caspases and their role in inflammation and ischemic neuronal death. Focus on caspase-12.
Dangerous Liaisons: Caspase-11 and Reactive Oxygen Species Crosstalk in Pathogen Elimination.
Development of an ex vivo Tissue Platform to Study the Human Lung Response to Coxiella burnetii.
Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions.
Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11.
Involvement of caspase-4 in IL-1 beta production and pyroptosis in human macrophages during dengue virus infection.
Modulation of the immune-related gene responses to protect mice against Japanese encephalitis virus using the antimicrobial peptide, tilapia hepcidin 1-5.
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.
Salmonella enterica Infection of Murine and Human Enteroid-Derived Monolayers Elicits Differential Activation of Epithelium-Intrinsic Inflammasomes.
SERPINB1-mediated checkpoint of inflammatory caspase activation.
The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection.
TLR2 and Nod2 Mediate Resistance or Susceptibility to Fatal Intracellular Ehrlichia Infection in Murine Models of Ehrlichiosis.
Leukemia
Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis.
Liver Diseases
Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of Bad.
Lung Injury
IGF2BP2 knockdown inhibits LPS-induced pyroptosis in BEAS-2B cells by targeting caspase 4, a crucial molecule of the non-canonical pyroptosis pathway.
Lung Neoplasms
Altered lung tissue lipidomic profile in caspase-4 positive non-small cell lung cancer (NSCLC) patients.
Calcium and survivin are involved in the induction of apoptosis by dihydroartemisinin in human lung cancer SPC-A-1 cells.
Celecoxib induces cell death on non-small cell lung cancer cells through endoplasmic reticulum stress.
Circulating and tumor-associated caspase-4: a novel diagnostic and prognostic biomarker for non-small cell lung cancer.
Correction: Circulating and tumor-associated caspase-4: a novel diagnostic and prognostic biomarker for non-small cell lung cancer.
Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients.
[Effect of Viqi Chutan Recipe on Caspase-4 and DNA-PK of Cell Apoptosis Approach in Transplanted Lung Cancer A549 Cells in Nude Mice].
Melanoma
A Role for the Inflammasome in Spontaneous Labor at Term with Acute Histologic Chorioamnionitis.
Caspase-4 is required for activation of inflammasomes.
Chinese Propolis Exerts Anti-Proliferation Effects in Human Melanoma Cells by Targeting NLRP1 Inflammatory Pathway, Inducing Apoptosis, Cell Cycle Arrest, and Autophagy.
Glucose-regulated protein 78 antagonizes cisplatin and adriamycin in human melanoma cells.
Inhibition of endoplasmic reticulum stress-induced apoptosis of melanoma cells by the ARC protein.
Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis.
Proteomic analysis and the antimetastatic effect of N-(4-methyl)phenyl-O-(4-methoxy) phenyl-thionocarbamate-induced apoptosis in human melanoma SK-MEL-28 cells.
TRAIL-induced apoptosis of human melanoma cells involves activation of caspase-4.
Vitamin E ?-tocotrienol triggers endoplasmic reticulum stress-mediated apoptosis in human melanoma cells.
Mucocutaneous Lymph Node Syndrome
Correlation between NF-?B signal pathway-mediated caspase-4 activation and Kawasaki disease.
Neoplasms
1-[2-(2-Methoxyphenylamino)ethylamino]-3-(naphthalene-1-yloxy)propan-2-ol as a potential anticancer drug.
A genome-wide RNA interference screen identifies caspase 4 as a factor required for tumor necrosis factor alpha signaling.
Altered lung tissue lipidomic profile in caspase-4 positive non-small cell lung cancer (NSCLC) patients.
Andrographolide-induced apoptosis in human renal tubular epithelial cells: Roles of endoplasmic reticulum stress and inflammatory response.
Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib.
Canonical Secretomes, Innate Immune Caspase-1-, 4/11-Gasdermin D Non-Canonical Secretomes and Exosomes May Contribute to Maintain Treg-Ness for Treg Immunosuppression, Tissue Repair and Modulate Anti-Tumor Immunity via ROS Pathways.
Caspase 4 Overexpression as a Prognostic Marker in Clear Cell Renal Cell Carcinoma: A Study Based on the Cancer Genome Atlas Data Mining.
Circulating and tumor-associated caspase-4: a novel diagnostic and prognostic biomarker for non-small cell lung cancer.
Direct cytotoxicity produced by adenoviral-mediated interferon ? gene transfer in interferon-resistant cancer cells involves ER stress and caspase 4 activation.
Enhancing cytotoxic and apoptotic effect in OVCAR-3 and MDAH-2774 cells with all-trans retinoic acid and zoledronic acid: a paradigm of synergistic molecular targeting treatment for ovarian cancer.
Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients.
Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity.
Mutational analysis of caspase 1, 4, and 5 genes in common human cancers.
Role of Smac in cephalostatin-induced cell death.
TLR2 and Nod2 Mediate Resistance or Susceptibility to Fatal Intracellular Ehrlichia Infection in Murine Models of Ehrlichiosis.
Tumor necrosis factor-alpha can provoke cleavage and activation of sterol regulatory element-binding protein in ethanol-exposed cells via a caspase-dependent pathway that is cholesterol insensitive.
Vitamin E succinate suppresses prostate tumor growth by inducing apoptosis.
[Effect of Viqi Chutan Recipe on Caspase-4 and DNA-PK of Cell Apoptosis Approach in Transplanted Lung Cancer A549 Cells in Nude Mice].
[Expression and correlation of apoptosis-related gene c-IAP2 and caspase-4 in sinonasal squamous carcinoma]
Neuroblastoma
Homocysteine induces PUMA-mediated mitochondrial apoptosis in SH-SY5Y cells.
NF-?B Regulates Caspase-4 Expression and Sensitizes Neuroblastoma Cells to Fas-Induced Apoptosis.
Neuroectodermal Tumors, Primitive
Endoplasmic Reticulum Stress in Pancreatic Neuroendocrine Tumors is Linked to Clinicopathological Parameters and Possible Epigenetic Regulations.
Obstetric Labor, Premature
A Role for the Inflammasome in Spontaneous Preterm Labor With Acute Histologic Chorioamnionitis.
Ovarian Neoplasms
?-NETA induces pyroptosis of epithelial ovarian cancer cells through the GSDMD/caspase-4 pathway.
Pancreatic Neoplasms
Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum.
Peptic Ulcer
Caspase-4: A Therapeutic Target for Peptic Ulcer Disease.
Periodontitis
Periodontal Inflammation-Triggered by Periodontal Ligament Stem Cell Pyroptosis Exacerbates Periodontitis.
Pneumonia
Bacterial Pore-Forming Toxins Promote the Activation of Caspases in Parallel to Necroptosis to Enhance Alarmin Release and Inflammation During Pneumonia.
Pulmonary Disease, Chronic Obstructive
Chronic Obstructive Pulmonary Disease-Derived Circulating Cells Release IL-18 and IL-33 under Ultrafine Particulate Matter Exposure in a Caspase-1/8-Independent Manner.
Circulating and tumor-associated caspase-4: a novel diagnostic and prognostic biomarker for non-small cell lung cancer.
Salmonella Infections
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.
Sepsis
A critical role for human caspase-4 in endotoxin sensitivity.
Cathepsin B regulates non-canonical NLRP3 inflammasome pathway by modulating activation of caspase-11 in Kupffer cells.
Complement pathway amplifies caspase-11-dependent cell death and endotoxin-induced sepsis severity.
Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11.
Sphingosine-1-phosphate Receptor 2 Signaling Promotes Caspase-11-dependent Macrophage Pyroptosis and Worsens Escherichia coli Sepsis Outcome.
Shock, Septic
A critical role for human caspase-4 in endotoxin sensitivity.
Glutathione peroxidase 8 negatively regulates caspase-4/11 to protect against colitis.
The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages.
Starvation
Inhibition of CLIC4 enhances autophagy and triggers mitochondrial and ER stress-induced apoptosis in human glioma U251 cells under starvation.
Stomach Ulcer
Caspase-4 activation in association with decreased adenosine deaminase activity may be a factor for gastric ulcer.
Teratocarcinoma
ER Stress-Mediated Apoptotic Pathway Induced by Amyloid-beta.
Virus Diseases
Involvement of caspase-4 in IL-1 beta production and pyroptosis in human macrophages during dengue virus infection.