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poly(ADP-ribose) polymerase + H2O
85000 Da fragment + ?
caspase-3 is the predominant poly(ADP-ribose) polymerase cleaving enzyme
-
-
?
poly(ADP-ribose) polymerase + H2O
?
-
-
-
?
transcription factor Pax7 + H2O
?
acetyl-Asp-Glu-Val-Asp-4-nitroanilide + H2O
acetyl-Asp-Glu-Val-Asp + 4-nitroaniline
-
-
-
-
?
acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin + H2O
acetyl-Asp-Glu-Val-Asp + 7-amino-4-trifluoromethylcoumarin
-
-
-
-
?
acetyl-Asp-Glu-Val-Asp-p-nitroanilide + H2O
acetyl-Asp-Glu-Val-Asp + p-nitroaniline
-
-
-
-
?
alpha-spectrin + H2O
?
-
-
production of a 120 kDa fragment
-
?
Asp-Glu-Val-Asp-4-nitroanilide + H2O
Asp-Glu-Val-Asp + 4-nitroaniline
-
caspase-3 specific substrate
-
-
?
beta-catenin + H2O
?
-
processing of beta-catenin, production of a 70000 Da fragment
-
-
?
LLVY-4-methylcoumarin 7-amide + H2O
LLVY + 7-amino-4-methylcoumarin
-
-
-
-
?
procaspase-6 + H2O
caspase-6 + ?
pre-interleukin-1beta + H2O
additional information
-
transcription factor Pax7 + H2O
?
-
-
-
?
transcription factor Pax7 + H2O
?
compensatory growth and regeneration of skeletal muscle is dependent on the resident stem cell population, satellite cells (SCs). Self-renewal and maintenance of the SC niche is coordinated by the paired-box transcription factor Pax7. Continued expression of this protein inhibits the myoblast differentiation program. Caspase 3 cleavage inactivation of Pax7 is a crucial step for terminating the self-renewal process
-
-
?
19 S proteasome + H2O
?
-
-
-
-
?
19 S proteasome + H2O
?
-
caspase-3 specifically cleaves the 19 S component of 26 S proteasome Rpt2, Rpt6, and Rpn2 in skeletal muscle stimulating proteasome activity
-
-
?
procaspase-6 + H2O
caspase-6 + ?
-
activation
-
-
?
procaspase-6 + H2O
caspase-6 + ?
-
activation requires caspase-3
-
-
?
Rpt5 + H2O
?
-
-
-
-
?
Rpt5 + H2O
?
-
in myoblasts, Rpt5 is sensitive to caspase-3-induced cleavage but in myotubes, it is not sensitive. Caspase-3 cleavage of Rpt5 is responsible for the difference in the patterns of proteasome subunit cleavage in myoblasts compared with myotubes
-
-
?
pre-interleukin-1beta + H2O
additional information
-
-
a 28000 Da fragement and a 17000 Da fragement, less efficient hydrolysis than with caspase-1
?
pre-interleukin-1beta + H2O
additional information
-
-
-
a 28000 Da fragement and a 17000 Da fragement, less efficient hydrolysis than with caspase-1
?
additional information
?
-
-
apoptosis is triggered through intrinsic mitochondrial pathway by caspase 3-activation involving mitochondrial membrane potential damage and reactive oxygen species production
-
-
?
additional information
?
-
-
caspase-3 activity is absent in case of coronary occlusion with and without subsequent revascularization in C57BL6 mice after transient ligation followed by 24 h of reperfusion, or 24 h persistent ligation, overview
-
-
?
additional information
?
-
-
caspase-3 activity is involved in cell death, e.g. induced by simulated ischemia and reperfusion with pH playing an important role, overview
-
-
?
additional information
?
-
-
caspase-3 is activated during apoptosis, overexpression of bovine growth hormone has antiapoptotic effects in several cell lines, including human colonic adenocarcinoma cells, and in colonic mucosa reducing the activation of caspase-3, molecular mechanisms and regulation, overview
-
-
?
additional information
?
-
-
caspase-3 is an effector caspase lying downstream from both intrinsic apoptotic pathway mediators and extrinsic apoptotic pathway mediators
-
-
?
additional information
?
-
-
caspase-3 is an effector caspase. The intrinsic death pathway involves mitochondrial release of cytochrome c, which interacts with Apaf-1 and dATP to promote procaspase-9 autoactivation, which in turn activates downstream effectors such as caspase-3, -6, and -7. Increased caspase-3 activation is involved in apoptosis, inhibition of caspase-8 impairs Leptospira interrogans-induced caspase-3 and -6 activation, as well as PARP and lamin A/C cleavage and apoptosis, overview. Leptospira interrogans-induced apoptosis in macrophages is mediated by caspase-3 and -6 activation through a FADDcaspase-8-dependent pathway, independently of mitochondrial cytochrome ccaspase-9-dependent signaling. Caspase-3 is required for the activation of caspase-6 and seems to be involved in caspase-9 activation through a feedback amplification loop. Regulation, overview
-
-
?
additional information
?
-
-
caspase-3 is involved in apoptosis
-
-
?
additional information
?
-
-
caspase-3 is one of the key executioners of apoptosis and responsible for the partial or total proteolytic cleavage of many proteins. Senescence-accelerated prone mice 8 and senescence-accelerated resistant mice 1 show a drop in age-related proteolytic activity of caspase-3, but the caspase-independent cell death, owing to high p53 and apoptosis-inducing factor levels, might be an alternative pathway of cell death in the aged brain
-
-
?
additional information
?
-
-
caspases are a family of cysteine aspartic acid-specific proteases playing an important role in apoptotic processes in mammalian cells. Among them, caspase-3 is an essential protease that degrades other protein substrates inside the cells at an early stage of apoptosis
-
-
?
additional information
?
-
-
inotodiol, a lanostane triterpenoid, from Inonotus obliquus, inhibits P388 cell proliferation through caspase-3-dependent apoptosis
-
-
?
additional information
?
-
-
nonobese diabetic mouse acinar cells at 16 weeks show increased caspase 3 activity, as well as increased expression of TNF-alpha receptor1, increased Bax, tumour protein 53-induced nuclear protein1alpha, and chromatin condensation, apoptosis patterns, overview
-
-
?
additional information
?
-
-
caspase-3 causes chromatin condensation through DNA fragmentation
-
-
?
additional information
?
-
-
the caspase-3 cleavage site is present within the ATPase domain of Rpt subunits
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
poly(ADP-ribose) polymerase + H2O
85000 Da fragment + ?
caspase-3 is the predominant poly(ADP-ribose) polymerase cleaving enzyme
-
-
?
transcription factor Pax7 + H2O
?
compensatory growth and regeneration of skeletal muscle is dependent on the resident stem cell population, satellite cells (SCs). Self-renewal and maintenance of the SC niche is coordinated by the paired-box transcription factor Pax7. Continued expression of this protein inhibits the myoblast differentiation program. Caspase 3 cleavage inactivation of Pax7 is a crucial step for terminating the self-renewal process
-
-
?
19 S proteasome + H2O
?
-
caspase-3 specifically cleaves the 19 S component of 26 S proteasome Rpt2, Rpt6, and Rpn2 in skeletal muscle stimulating proteasome activity
-
-
?
beta-catenin + H2O
?
-
processing of beta-catenin, production of a 70000 Da fragment
-
-
?
procaspase-6 + H2O
caspase-6 + ?
-
activation requires caspase-3
-
-
?
Rpt5 + H2O
?
-
in myoblasts, Rpt5 is sensitive to caspase-3-induced cleavage but in myotubes, it is not sensitive. Caspase-3 cleavage of Rpt5 is responsible for the difference in the patterns of proteasome subunit cleavage in myoblasts compared with myotubes
-
-
?
additional information
?
-
additional information
?
-
-
apoptosis is triggered through intrinsic mitochondrial pathway by caspase 3-activation involving mitochondrial membrane potential damage and reactive oxygen species production
-
-
?
additional information
?
-
-
caspase-3 activity is absent in case of coronary occlusion with and without subsequent revascularization in C57BL6 mice after transient ligation followed by 24 h of reperfusion, or 24 h persistent ligation, overview
-
-
?
additional information
?
-
-
caspase-3 activity is involved in cell death, e.g. induced by simulated ischemia and reperfusion with pH playing an important role, overview
-
-
?
additional information
?
-
-
caspase-3 is activated during apoptosis, overexpression of bovine growth hormone has antiapoptotic effects in several cell lines, including human colonic adenocarcinoma cells, and in colonic mucosa reducing the activation of caspase-3, molecular mechanisms and regulation, overview
-
-
?
additional information
?
-
-
caspase-3 is an effector caspase lying downstream from both intrinsic apoptotic pathway mediators and extrinsic apoptotic pathway mediators
-
-
?
additional information
?
-
-
caspase-3 is an effector caspase. The intrinsic death pathway involves mitochondrial release of cytochrome c, which interacts with Apaf-1 and dATP to promote procaspase-9 autoactivation, which in turn activates downstream effectors such as caspase-3, -6, and -7. Increased caspase-3 activation is involved in apoptosis, inhibition of caspase-8 impairs Leptospira interrogans-induced caspase-3 and -6 activation, as well as PARP and lamin A/C cleavage and apoptosis, overview. Leptospira interrogans-induced apoptosis in macrophages is mediated by caspase-3 and -6 activation through a FADDcaspase-8-dependent pathway, independently of mitochondrial cytochrome ccaspase-9-dependent signaling. Caspase-3 is required for the activation of caspase-6 and seems to be involved in caspase-9 activation through a feedback amplification loop. Regulation, overview
-
-
?
additional information
?
-
-
caspase-3 is involved in apoptosis
-
-
?
additional information
?
-
-
caspase-3 is one of the key executioners of apoptosis and responsible for the partial or total proteolytic cleavage of many proteins. Senescence-accelerated prone mice 8 and senescence-accelerated resistant mice 1 show a drop in age-related proteolytic activity of caspase-3, but the caspase-independent cell death, owing to high p53 and apoptosis-inducing factor levels, might be an alternative pathway of cell death in the aged brain
-
-
?
additional information
?
-
-
caspases are a family of cysteine aspartic acid-specific proteases playing an important role in apoptotic processes in mammalian cells. Among them, caspase-3 is an essential protease that degrades other protein substrates inside the cells at an early stage of apoptosis
-
-
?
additional information
?
-
-
inotodiol, a lanostane triterpenoid, from Inonotus obliquus, inhibits P388 cell proliferation through caspase-3-dependent apoptosis
-
-
?
additional information
?
-
-
nonobese diabetic mouse acinar cells at 16 weeks show increased caspase 3 activity, as well as increased expression of TNF-alpha receptor1, increased Bax, tumour protein 53-induced nuclear protein1alpha, and chromatin condensation, apoptosis patterns, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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van de Craen, M.; Berx, G.; van den Brande, I.; Fiers, W.; Declercq, W.; Vandenabeele, P.
Proteolytic cleavage of beta-catenin by caspases: an in vitro analysis
FEBS Lett.
458
167-170
1999
Mus musculus
brenda
van de Craen, M.; Vandenabeele, P.; Declercq, W.; van den Brande, I.; van Loo, G.; Molemans, F.; Schotte, P.; van Criekinge, W.; Beyaert, R.; Fiers, W.
Characterization of seven murine caspase family members
FEBS Lett.
403
61-69
1997
Mus musculus (P70677), Mus musculus, Mus musculus C3H/An (P70677)
brenda
Mukasa, T.; Urase, K.; Momoi, M.Y.; Kimura, I.; Momoi, T.
Specific expression of CPP32 in sensory neurons of mouse embryos and activation of CPP32 in the apoptosis induced by a withdrawal of NGF
Biochem. Biophys. Res. Commun.
231
770-774
1997
Mus musculus (P70677), Mus musculus
brenda
Djerbi, M.; Darreh-Shori, T.; Zhivotovsky, B.; Grandien, A.
Characterization of the human FLICE-inhibitory protein locus and comparison of the anti-apoptotic activity of four different FLIP isoforms
Scand. J. Immunol.
54
180-189
2001
Mus musculus
brenda
Han, B.H.; Xu, D.; Choi, J.; Han, Y.; Xanthoudakis, S.; Roy, S.; Tam, J.; Vaillancourt, J.; Colucci, J.; Siman, R.; Giroux, A.; Robertson, G.S.; Zamboni, R.; Nicholson, D.W.; Holtzman, D.M.
Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury
J. Biol. Chem.
277
30128-30136
2002
Homo sapiens, Mus musculus
brenda
Deveraux, Q.L.; Roy, N.; Stennicke, H.R.; Van Arsdale, T.; Zhou, Q.; Srinivasula, S.M.; Alnemri, E.S.; Salvesen, G.S.; Reed, J.C.
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
EMBO J.
17
2215-2223
1998
Homo sapiens, Mus musculus
brenda
Zhang, Y.; Bhavnani, B.R.
Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens
BMC Neurosci.
7
49
2006
Mus musculus, Rattus norvegicus
brenda
Burkhardt, B.R.; Greene, S.R.; White, P.; Wong, R.K.; Brestelli, J.E.; Yang, J.; Robert, C.E.; Brusko, T.M.; Wasserfall, C.H.; Wu, J.; Atkinson, M.A.; Gao, Z.; Kaestner, K.H.; Wolf, B.A.
PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21)
Gene
369
134-141
2006
Mus musculus, Mus musculus C57/BL6
brenda
Kiang, J.G.; Bowman, P.D.; Lu, X.; Li, Y.; Wu, B.W.; Loh, H.H.; Tsen, K.T.; Tsokos, G.C.
Geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity: role of inducible nitric oxide synthase
J. Appl. Physiol.
103
1045-1055
2007
Mus musculus
brenda
Samuel, M.A.; Morrey, J.D.; Diamond, M.S.
Caspase 3-dependent cell death of neurons contributes to the pathogenesis of West Nile virus encephalitis
J. Virol.
81
2614-2623
2007
Mus musculus
brenda
Andersen, A.D.; Poulsen, K.A.; Lambert, I.H.; Pedersen, S.F.
HL-1 mouse cardiomyocyte injury and death after simulated ischemia and reperfusion: roles of pH, Ca2+-independent phospholipase A2, and Na+/H+ exchange
Am. J. Physiol. Cell Physiol.
296
C1277-C1242
2009
Mus musculus, Mus musculus HL-1
brenda
Nomura, M.; Takahashi, T.; Uesugi, A.; Tanaka, R.; Kobayashi, S.
Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis
Anticancer Res.
28
2691-2696
2008
Mus musculus
brenda
Johnke, R.M.; Smith, E.S.; Cariveau, M.J.; Evans, M.J.; Kilburn, J.M.; Bakken, N.T.; Nangami, G.N.
Radioprotection of murine gastrointestinal epithelium by interleukin-1alpha involves down-regulation of the apoptotic response
Anticancer Res.
28
3601-3607
2009
Mus musculus, Mus musculus C57BL/6
brenda
Yi, J.Y.; Hirabayashi, Y.; Choi, Y.K.; Kodama, Y.; Kanno, J.; Han, J.H.; Inoue, T.; Yoon, B.I.
Benzene activates caspase-4 and -12 at the transcription level, without an association with apoptosis, in mouse bone marrow cells lacking the p53 gene
Arch. Toxicol.
83
795-803
2009
Mus musculus
brenda
Calafat, M.; Larocca, L.; Roca, V.; Hauk, V.; Pregi, N.; Nesse, A.; Perez Leiros, C.
Vasoactive intestinal peptide inhibits tumor necrosis factor-alpha-induced apoptotic events in acinar cells from non-obese diabetic mice submandibular glands
Arthritis Res. Ther.
11
R53
2009
Mus musculus
brenda
Jen, C.Y.; Lin, C.Y.; Leu, S.F.; Huang, B.M.
Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis through caspase-9 pathway
Evid. Based. Complement Alternat. Med.
2009
1-10
2009
Mus musculus
brenda
French, C.J.; Spees, J.L.; Zaman, A.K.; Taatjes, D.J.; Sobel, B.E.
The magnitude and temporal dependence of apoptosis early after myocardial ischemia with or without reperfusion
FASEB J.
23
1177-1185
2009
Mus musculus, Mus musculus C57BL6
brenda
Bogazzi, F.; Ultimieri, F.; Raggi, F.; Russo, D.; Lombardi, M.; Cosci, C.; Brogioni, S.; Gasperi, M.; Bartalena, L.; Martino, E.
Reduced colonic apoptosis in mice overexpressing bovine growth hormone occurs through changes in several kinase pathways
Growth Horm. IGF Res.
19
432-441
2009
Mus musculus
brenda
Jin, D.; Ojcius, D.M.; Sun, D.; Dong, H.; Luo, Y.; Mao, Y.; Yan, J.
Leptospira interrogans induces apoptosis in macrophages via caspase-8- and caspase-3-dependent pathways
Infect. Immun.
77
799-809
2009
Homo sapiens, Mus musculus
brenda
Harikumar, K.B.; Kuttan, G.; Kuttan, R.
Phyllanthus amarus inhibits cell growth and induces apoptosis in Dalton's lymphoma ascites cells through activation of caspase 3 and down regulation of bcl-2
Integr. Cancer Ther.
8
190-194
2009
Mus musculus, Mus musculus BALB/c
brenda
Barry, G.M.; Breakwell, L.; Fragkoudis, R.; Attarzadeh-Yazdi, G.; Rodriguez-Andres, J.; Kohl, A.; Fazakerley, J.K.
PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type-I interferon response
J. Gen. Virol.
90
1382-1391
2009
Mus musculus
brenda
Caballero, B.; Vega-Naredo, I.; Sierra, V.; Huidobro-Fernandez, C.; Soria-Valles, C.; De Gonzalo-Calvo, D.; Tolivia, D.; Pallas, M.; Camins, A.; Rodriguez-Colunga, M.J.; Coto-Montes, A.
Melatonin alters cell death processes in response to age-related oxidative stress in the brain of senescence-accelerated mice
J. Pineal Res.
46
106-114
2009
Mus musculus
brenda
Bae, K.H.; Moon, C.W.; Lee, Y.; Park, T.G.
Intracellular delivery of heparin complexed with chitosan-g-poly(ethylene glycol) for inducing apoptosis
Pharm. Res.
26
93-100
2009
Mus musculus
brenda
Bhutia, S.K.; Mallick, S.K.; Maiti, S.; Maiti, T.K.
Inhibitory effect of Abrus abrin-derived peptide fraction against Daltons lymphoma ascites model
Phytomedicine
16
377-385
2009
Mus musculus
brenda
Kim, K.W.; Moretti, L.; Lu, B.
M867, a novel selective inhibitor of caspase-3 enhances cell death and extends tumor growth delay in irradiated lung cancer models
PLoS ONE
3
e2275
2008
Homo sapiens, Mus musculus
brenda
Wang, X.H.; Zhang, L.; Mitch, W.E.; LeDoux, J.M.; Hu, J.; Du, J.
Caspase-3 cleaves specific 19 S proteasome subunits in skeletal muscle stimulating proteasome activity
J. Biol. Chem.
285
21249-21257
2010
Mus musculus
brenda
Katao, Y.; Shishido, M.; Inami, K.; Matsumoto, N.; Sawai, H.
An inhibitory role for caspase-3 at the late stage of RANKL-induced osteoclast differentiation in RAW264 cells and mouse bone marrow macrophages
Cell Biol. Int.
38
723-728
2014
Mus musculus
brenda
Dick, S.A.; Chang, N.C.; Dumont, N.A.; Bell, R.A.; Putinski, C.; Kawabe, Y.; Litchfield, D.W.; Rudnicki, M.A.; Megeney, L.A.
Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells
Proc. Natl. Acad. Sci. USA
112
E5246-E5252
2015
Mus musculus (P70677)
brenda