Reference on EC 3.4.22.54 - calpain-3
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Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (P20807), Sus scrofa (P43368), Bos taurus (P51186), Mus musculus (Q64691)
Nakajima, T.; Fukiage, C.; Azuma, M.; Ma, H.; Shearer, T.R.
Different expression patterns for ubiquitous calpains and Capn3 splice variants in monkey ocular tissues
Biochim. Biophys. Acta
1519
55-64
2001
Macaca fascicularis (Q9GLG7), Macaca fascicularis
Ilian, M.A.; Morton, J.D.; Kent, M.P.; Le Couteur, C.E.; Hickford, J.; Cowley, R.; Bickerstaffe, R.
Intermuscular variation in tenderness: association with the ubiquitous and muscle-specific calpains
J. Anim. Sci.
79
122-132
2001
Bos taurus (P51186), Bos taurus, Ovis aries (Q9TTH8)
Strausberg R.L.; Feingold E.A.; Grouse L.H.; Derge J.G.; et al.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
Proc. Natl. Acad. Sci. USA
99
16899-16903
2002
Homo sapiens (P20807)
Sorimachi H.; Tsukahara T.; Okada-Ban M.; Sugita H.; Ishiura S.; Suzuki K.
Identification of a third ubiquitous calpain species - chicken muscle expresses four distinct calpains
Biochim. Biophys. Acta
1261
381-393
1995
Gallus gallus (Q92177)
Sorimachi H.; Imajoh-Ohmi S.; Emori Y.; Kawasaki H.; Ohno S.; Minami Y.; Suzuki K.
Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and mu-types. Specific expression of the mRNA in skeletal muscle
J. Biol. Chem.
264
20106-20111
1989
Rattus norvegicus (P16259), Homo sapiens (P20807)
Briley G.P.; Riggs P.K.; Womack, J.E.; Hancock, D.L.; Bidwell, C.A.
Chromosomal localization of the porcine skeletal muscle calpain gene
Mamm. Genome
7
226-228
1996
Sus scrofa (P43368), Sus scrofa
Richard, I.; Brenguier, L.; Dincer P.; et al.
Multiple independent molecular etiology for limb-girdle muscular dystrophy type 2A patients from various geographical origins
Am. J. Hum. Genet.
60
1128-1138
1997
Homo sapiens (P20807), Homo sapiens, Sus scrofa (P43368)
Richard, I.; Roudaut, C.; Saenz, A.; Pogue, R.; et al.
Calpainopathy - a survey of mutations and polymorphisms
Am. J. Hum. Genet.
64
1524-1540
1999
Homo sapiens (P20807), Homo sapiens
Fardeau, M.; Hillaire, D.; Mignard, C.; Feingold, N.; Feingold, J.; Mignard, D.; de Ubeda, B.; Collin, H.; Tome, F.M.S.; Richard, I.; Beckmann J.S.
Juvenile limb-girdle muscular dystrophy. Clinical, histopathological and genetic data from a small community living in the Reunion island
Brain
119
295-308
1996
Homo sapiens (P20807)
-
Richard, I.; Broux, O.; Allamand, V.; et al.
Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A
Cell
81
27-40
1995
Homo sapiens (P20807), Homo sapiens
Dincer, P.; Leturcq, F.; Richard, I.; et.al.
A biochemical, genetic, and clinical survey of autosomal recessive limb girdle muscular dystrophies in Turkey
Ann. Neurol.
42
222-229
1997
Homo sapiens (P20807), Homo sapiens
Urtasun, M.; Saenz, A.; Roudaut, C.; et al.
Limb-girdle muscular dystrophy in Guipuzcoa (Basque Country, Spain)
Brain
121
1735-1747
1998
Homo sapiens (P20807)
-
Haeffner, K.; Speer, A.; Huebner, C.; Voit, T.; Oexle, K.
A small in-frame deletion within the protease domain of muscle-specific calpain, p94 causes early-onset limb-girdle muscular dystrophy 2A
Hum. Mutat.
1
S298-S300
1998
Homo sapiens (P20807)
-
Penisson-Besnier, I.; Richard, I.; Dubas, F.; Beckmann, J.S.; Fardeau, M.
Pseudometabolic expression and phenotypic variability of calpain deficiency in two siblings
Muscle Nerve
21
1078-1080
1998
Homo sapiens (P20807)
Kawai, H.; Akaike, M.; Kunishige, M.; et al.
Clinical, pathological, and genetic features of limb-girdle muscular dystrophy type 2A with new calpain 3 gene mutations in seven patients from three Japanese families
Muscle Nerve
21
1493-1501
1998
Homo sapiens (P20807), Homo sapiens
Nonneman, D.; Koohmaraie, M.
Molecular cloning and mapping of the bovine and ovine skeletal muscle-specific calpains
Anim. Genet.
30
456-458
1999
Bos taurus (P51186), Ovis aries (Q9TTH8)
de Tullio, R.; Stifanese, R.; Salamino, F.; Pontremoli, S.; Melloni, E.
Characterization of a new p94-like calpain form in human lymphocytes
Biochem. J.
375
689-696
2003
Homo sapiens
Guyon, J.R.; Kudryashova, E.; Potts, A.; Dalkilic, I.; Brosius, M.A.; Thompson, T.G.; Beckmann, J.S.; Kunkel, L.M.; Spencer, M.J.
Calpain 3 cleaves filamin C and regulates its ability to interact with gamma- and delta-sarcoglycans
Muscle Nerve
28
472-483
2003
Mus musculus, Rattus norvegicus
Jia, Z.; Petrounevitch, V.; Wong, A.; Moldoveanu, T.; Davies, P.L.; Elce, J.S.; Beckmann, J.S.
Mutations in calpain 3 associated with limb girdle muscular dystrophy: analysis by molecular modeling and by mutation in m-calpain
Biophys. J.
80
2590-2596
2001
Homo sapiens
Rey, M.A.; Davies, P.L.
The protease core of the muscle-specific calpain, p94, undergoes Ca2+-dependent intramolecular autolysis
FEBS Lett.
532
401-406
2002
Homo sapiens
Sorimachi, H.; Saido, T.C.; Suzuki, K.
New era of calpain research. Discovery of tissue-specific calpains
FEBS Lett.
343
1-5
1994
Gallus gallus, Homo sapiens, Rattus norvegicus
Welm, A.L.; Timchenko, N.A.; Ono, Y.; Sorimachi, H.; Radomska, H.S.; Tenen, D.G.; Lekstrom-Himes, J.; Darlington, G.J.
C/EBPalpha is required for proteolytic cleavage of cyclin A by calpain 3 in myeloid precursor cells
J. Biol. Chem.
277
33848-33856
2002
Homo sapiens, Mus musculus
Richard, I.; Beckmann, J.S.
Molecular cloning of mouse canp3, the gene associated with limb-girdle muscular dystrophy 2A in human
Mamm. Genome
7
377-379
1996
Mus musculus (Q64691)
Murphy, R.M.; Snow, R.J.; Lamb, G.D.
m-Calpain and calpain-3 are not autolyzed with exhaustive exercise in humans
Am. J. Physiol.
290
C116-C122
2006
Homo sapiens, Rattus norvegicus
Ravulapalli, R.; Diaz, B.G.; Campbell, R.L.; Davies, P.L.
Homodimerization of calpain 3 penta-EF-hand domain
Biochem. J.
388
585-591
2005
Homo sapiens (P20807)
Garcia Diaz, B.E.; Gauthier, S.; Davies, P.L.
Ca2+ dependency of calpain 3 (p84) activation
Biochemistry
45
3714-3722
2006
Homo sapiens
Saenz, A.; Leturcq, F.; et.al.
LGMD2A: genotype-phenotype correlations based on a large mutational survey on the calpain 3 gene
Brain
128
732-742
2005
Homo sapiens
Duguez, S.; Bartoli, M.; Richard, I.
Calpain 3: a key regulator of the sarcomere?
FEBS J.
273
3427-3436
2006
Homo sapiens
Kramerova, I.; Kudryashova, E.; Tidball, J.G.; Spencer, M.J.
Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro
Hum. Mol. Genet.
13
1373-1388
2004
Mus musculus
Kramerova, I.; Kudryashova, E.; Venkatraman, G.; Spencer, M.J.
Calpain 3 participates in sarcomere remodeling by acting upstream of the ubiquitin-proteasome pathway
Hum. Mol. Genet.
14
2125-2134
2005
Mus musculus
Huebsch, K.A.; Kudryashova, E.; et.al.
Mdm muscular dystrophy: interactions with calpain 3 and a novel functional role for titin's N2A domain
Hum. Mol. Genet.
14
2801-2811
2005
Mus musculus
Geesink, G.H.; Taylor, R.G.; Koohmaraie, M.
Calpain 3/p94 is not involved in postmortem proteolysis
J. Anim. Sci.
83
1646-1652
2005
Mus musculus
Ono, Y.; Kakinuma, K.; Torii, F.; Irie, A.; Nakagawa, K.; Labeit, S.; Abe, K.; Suzuki, K.; Sorimachi, H.
Possible regulation of the conventional calpain system by skeletal muscle-specific calpain, p94/calpain 3
J. Biol. Chem.
279
2761-2771
2004
Mus musculus
Diaz, B.G.; Moldoveanu, T.; Kuiper, M.J.; Campbell, R.L.; Davies, P.L.
Insertion sequence 1 of muscle-specific calpain p94, acts as an internal propeptide
J. Biol. Chem.
279
27656-27666
2004
Homo sapiens
Fanin, M.; Nascimbeni, A.C.; Angelini, C.
Screening of calpain-3 autolytic activity in LGMD muscle: a functional map of CAPN3 gene mutations
J. Med. Genet.
44
38-43
2007
Homo sapiens
Kramerova, I.; Kudryashova, E.; Wu, B.; Spencer, M.J.
Regulation of the M-cadherin-beta-catenin complex by calpain 3 during terminal stages of myogenic differentiation
Mol. Cell. Biol.
26
8437-8447
2006
Mus musculus
Cohen, N.; Kudryashova, E.; Kramerova, I.; Anderson, L.V.; Beckmann, J.S.; Bushby, K.; Spencer, M.J.
Identification of putative in vivo substrates of calpain 3 by comparative proteomics of overexpressing transgenic and nontransgenic mice
Proteomics
6
6075-6084
2006
Mus musculus
Norton, L.; Parr, T.; Bardsley, R.G.; Ye, H.; Tsintzas, K.
Characterization of GLUT4 and calpain expression in healthy human skeletal muscle during fasting and refeeding
Acta Physiol. (Oxf.)
189
233-240
2007
Homo sapiens
Yang, X.; Chen, J.; Xu, Q.; Zhao, R.
Muscle type-specific responses of myoD and calpain 3 expression to recombinant porcine growth hormone in the pig
Animal
1
989-996
2007
Sus scrofa
Ono, Y.; Hayashi, C.; Doi, N.; Kitamura, F.; Shindo, M.; Kudo, K.; Tsubata, T.; Yanagida, M.; Sorimachi, H.
Comprehensive survey of p94/calpain 3 substrates by comparative proteomics - possible regulation of protein synthesis by p94
Biotechnol. J.
2
565-576
2007
Homo sapiens (P20807)
Benayoun, B.; Baghdiguian, S.; Lajmanovich, A.; Bartoli, M.; Daniele, N.; Gicquel, E.; Bourg, N.; Raynaud, F.; Pasquier, M.A.; Suel, L.; Lochmuller, H.; Lefranc, G.; Richard, I.
NF-{kappa}B-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A
FASEB J.
22
1521-1529
2007
Homo sapiens
Huang, Y.; de Morree, A.; van Remoortere, A.; Bushby, K.; Frants, R.R.; den Dunnen, J.; van der Maarel, S.M.
Calpain 3 is a modulator of the dysferlin protein complex in skeletal muscle
Hum. Mol. Genet.
17
1855-1866
2008
Homo sapiens
Tang, Y.; Liu, X.; Zoltoski, R.K.; Novak, L.A.; Herrera, R.A.; Richard, I.; Kuszak, J.R.; Kumar, N.M.
Age-related cataracts in alpha3Cx46-knockout mice are dependent on a calpain 3 isoform
Invest. Ophthalmol. Vis. Sci.
48
2685-2694
2007
Mus musculus
Murphy, R.M.; Goodman, C.A.; McKenna, M.J.; Bennie, J.; Leikis, M.; Lamb, G.D.
Calpain-3 is autolyzed and hence activated in human skeletal muscle 24 h following a single bout of eccentric exercise
J. Appl. Physiol.
103
926-931
2007
Homo sapiens
Hayashi, C.; Ono, Y.; Doi, N.; Kitamura, F.; Tagami, M.; Mineki, R.; Arai, T.; Taguchi, H.; Yanagida, M.; Hirner, S.; Labeit, D.; Labeit, S.; Sorimachi, H.
Multiple molecular interactions implicate connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscle
J. Biol. Chem.
23
14801-14814
2008
Homo sapiens (P20807), Mus musculus (Q64691)
Ojima, K.; Ono, Y.; Doi, N.; Yoshioka, K.; Kawabata, Y.; Labeit, S.; Sorimachi, H.
Myogenic stage, sarcomere length, and protease activity modulate localization of muscle-specific calpain
J. Biol. Chem.
282
14493-14504
2007
Homo sapiens (P20807), Mus musculus (Q64691)
Garnham, C.; Hanna, R.; Chou, J.; Low, K.; Gourlay, K.; Campbell, R.; Beckmann, J.; Davies, P.
Limb-girdle muscular dystrophy type 2A can result from accelerated autoproteolytic inactivation of calpain 3
Biochemistry
48
3457-3467
2009
Homo sapiens
Zhang, Z.R.; Liu, Y.P.; Yao, Y.G.; Jiang, X.S.; Du, H.R.; Zhu, Q.
Identification and association of the single nucleotide polymorphisms in calpain3 (CAPN3) gene with carcass traits in chickens
BMC Genet.
10
10
2009
Gallus gallus (Q92177), Gallus gallus
Barendse, W.; Harrison, B.E.; Bunch, R.J.; Thomas, M.B.
Variation at the Calpain 3 gene is associated with meat tenderness in zebu and composite breeds of cattle
BMC Genet.
9
41
2008
Bos taurus (P51186), Bos taurus
Vissing, K.; Overgaard, K.; Nedergaard, A.; Fredsted, A.; Schjerling, P.
Effects of concentric and repeated eccentric exercise on muscle damage and calpain-calpastatin gene expression in human skeletal muscle
Eur. J. Appl. Physiol.
103
323-332
2008
Homo sapiens (P20807), Homo sapiens
Kramerova, I.; Kudryashova, E.; Wu, B.; Ottenheijm, C.; Granzier, H.; Spencer, M.J.
Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle
Hum. Mol. Genet.
17
3271-3280
2008
Mus musculus
Murphy, R.M.; Lamb, G.D.
Endogenous calpain-3 activation is primarily governed by small increases in resting cytoplasmic [Ca2+] and is not dependent on stretch
J. Biol. Chem.
284
7811-7819
2009
Rattus norvegicus
Blazquez, L.; Azpitarte, M.; Saenz, A.; Goicoechea, M.; Otaegui, D.; Ferrer, X.; Illa, I.; Gutierrez-Rivas, E.; Vilchez, J.J.; Lopez de Munain, A.
Characterization of novel CAPN3 isoforms in white blood cells: an alternative approach for limb-girdle muscular dystrophy 2A diagnosis
Neurogenetics
9
173-182
2008
Homo sapiens
Beckmann, J.S.; Spencer, M.
Calpain 3, the "gatekeeper" of proper sarcomere assembly, turnover and maintenance
Neuromuscul. Disord.
18
913-921
2008
Mus musculus
Mellgren, R.L.; Miyake, K.; Kramerova, I.; Spencer, M.J.; Bourg, N.; Bartoli, M.; Richard, I.; Greer, P.A.; McNeil, P.L.
Calcium-dependent plasma membrane repair requires m- or mu-calpain, but not calpain-3, the proteasome, or caspases
Biochim. Biophys. Acta
1793
1886-1893
2009
Mus musculus
Moretti, D.; Del Bello, B.; Cosci, E.; Biagioli, M.; Miracco, C.; Maellaro, E.
Novel variants of muscle calpain 3 identified in human melanoma cells: cisplatin-induced changes in vitro and differential expression in melanocytic lesions
Carcinogenesis
30
960-967
2009
Homo sapiens
Ravulapalli, R.; Campbell, R.L.; Gauthier, S.Y.; Dhe-Paganon, S.; Davies, P.L.
Distinguishing between calpain heterodimerization and homodimerization
FEBS J.
276
973-982
2009
Homo sapiens
Kramerova, I.; Kudryashova, E.; Wu, B.; Germain, S.; Vandenborne, K.; Romain, N.; Haller, R.G.; Verity, M.A.; Spencer, M.J.
Mitochondrial abnormalities, energy deficit and oxidative stress are features of calpain 3 deficiency in skeletal muscle
Hum. Mol. Genet.
18
3194-3205
2009
Mus musculus
Dayanithi, G.; Richard, I.; Viero, C.; Mazuc, E.; Mallie, S.; Valmier, J.; Bourg, N.; Herasse, M.; Marty, I.; Lefranc, G.; Mangeat, P.; Baghdiguian, S.
Alteration of sarcoplasmic reticulum ca release in skeletal muscle from calpain 3-deficient mice
Int. J. Cell Biol.
2009
340346
2009
Mus musculus
Mora, L.; Sentandreu, M.A.; Koistinen, K.M.; Fraser, P.D.; Toldra, F.; Bramley, P.M.
Naturally generated small peptides derived from myofibrillar proteins in Serrano dry-cured ham
J. Agric. Food Chem.
57
3228-3234
2009
Sus scrofa
Stuelsatz, P.; Pouzoulet, F.; Lamarre, Y.; Dargelos, E.; Poussard, S.; Leibovitch, S.; Cottin, P.; Veschambre, P.
Down-regulation of MyoD by calpain 3 promotes generation of reserve cells in C2C12 myoblasts
J. Biol. Chem.
285
12670-12683
2010
Mus musculus
Ono, Y.; Ojima, K.; Torii, F.; Takaya, E.; Doi, N.; Nakagawa, K.; Hata, S.; Abe, K.; Sorimachi, H.
Skeletal muscle-specific calpain is an intracellular Na+-dependent protease
J. Biol. Chem.
285
22986-22998
2010
Rattus norvegicus
Gornik, S.G.; Westrop, G.D.; Coombs, G.H.; Neil, D.M.
Molecular cloning and localization of a calpain-like protease from the abdominal muscle of Norway lobster Nephrops norvegicus
Mol. Biol. Rep.
37
2009-2019
2010
Nephrops norvegicus
Charlton, R.; Henderson, M.; Richards, J.; Hudson, J.; Straub, V.; Bushby, K.; Barresi, R.
Immunohistochemical analysis of calpain 3: advantages and limitations in diagnosing LGMD2A
Neuromuscul. Disord.
19
449-457
2009
Homo sapiens
Laure, L.; Daniele, N.; Suel, L.; Marchand, S.; Aubert, S.; Bourg, N.; Roudaut, C.; Duguez, S.; Bartoli, M.; Richard, I.
A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-?B pathway in skeletal muscle
FEBS J.
277
4322-4337
2010
Homo sapiens (P20807)
Roperto, S.; De Tullio, R.; Raso, C.; Stifanese, R.; Russo, V.; Gaspari, M.; Borzacchiello, G.; Averna, M.; Paciello, O.; Cuda, G.; Roperto, F.
Calpain3 is expressed in a proteolitically active form in papillomavirus-associated urothelial tumors of the urinary bladder in cattle
PLoS ONE
5
e10299
2010
Bos taurus (P51186), Bos taurus
de Morree, A.; Lutje Hulsik, D.; Impagliazzo, A.; van Haagen, H.H.; de Galan, P.; van Remoortere, A.; t Hoen, P.A.; van Ommen, G.B.; Frants, R.R.; van der Maarel, S.M.
Calpain 3 is a rapid-action, unidirectional proteolytic switch central to muscle remodeling
PLoS ONE
5
e11940
2010
Homo sapiens
Charton, K.; Sarparanta, J.; Vihola, A.; Milic, A.; Jonson, P.H.; Suel, L.; Luque, H.; Boumela, I.; Richard, I.; Udd, B.
CAPN3-mediated processing of C-terminal titin replaced by pathological cleavage in titinopathy
Hum. Mol. Genet.
24
3718-3731
2015
Homo sapiens (P20807), Mus musculus (Q64691)
Ermolova, N.; Kramerova, I.; Spencer, M.J.
Autolytic activation of calpain 3 proteinase is facilitated by calmodulin protein
J. Biol. Chem.
290
996-1004
2015
Mus musculus (Q64691), Mus musculus
Pistoni, M.; Shiue, L.; Cline, M.S.; Bortolanza, S.; Neguembor, M.V.; Xynos, A.; Ares, M.; Gabellini, D.
Rbfox1 downregulation and altered calpain 3 splicing by FRG1 in a mouse model of facioscapulohumeral muscular dystrophy (FSHD)
PLoS Genet.
9
e1003186
2013
Homo sapiens (P20807), Homo sapiens, Mus musculus (Q64691), Mus musculus
Kumchantuek, T.; Nakata, H.; Sakulsak, N.; Yamamoto, M.; Iseki, S.
Expression and localization of calpain 3 in the submandibular gland of mice
Arch. Oral Biol.
70
9-15
2016
Mus musculus (Q64691), Mus musculus
Ono, Y.; Ojima, K.; Shinkai-Ouchi, F.; Hata, S.; Sorimachi, H.
An eccentric calpain, CAPN3/p94/calpain-3
Biochimie
122
169-187
2016
Homo sapiens (P20807), Homo sapiens
Ono, Y.; Sorimachi, H.
Amino acid sequence alignment of vertebrate CAPN3/calpain-3/p94
Data Brief
5
366-367
2015
Homo sapiens (P20807)
Ye, Q.; Campbell, R.L.; Davies, P.L.
Structures of human calpain-3 protease core with and without bound inhibitor reveal mechanisms of calpain activation
J. Biol. Chem.
293
4056-4070
2018
Homo sapiens (P20807), Homo sapiens
Michel, L.Y.; Hoenderop, J.G.; Bindels, R.J.
Calpain-3-mediated regulation of the Na+-Ca2+ exchanger isoform 3
Pflugers Arch.
468
243-255
2016
Homo sapiens (P20807)
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