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Information on EC 3.4.22.53 - calpain-2 and Organism(s) Homo sapiens and UniProt Accession P17655
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3.4.22.53 calpain-2Specify your search results
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- 3.4.22.53
- calpains
- calpastatin
- mu-calpain
-
calcium-dependent
-
ca2+-dependent
- proteinase
- myofibrillar
- cytoskeletal
- cataract
-
zymography
- longissimus
-
meat
-
autolysis
- calpeptin
-
tender
- casein
- cathepsins
-
3.4.22.17
-
postmortem
-
calpain-mediated
- caspase-12
- lumborum
-
autolyzed
-
lens-specific
- talin
- alpha-spectrin
-
canps
-
cataractogenesis
-
warner-bratzler
- spectrin
-
slaughter
- semimembranosus
-
calpain-specific
- desmin
-
calpain-calpastatin
- lenses
-
calpain-dependent
-
atrogin-1
- medicine
-
calpain-induced
- fodrin
- myofibril
-
ca2+-activated
-
calmodulin-like
-
caseinolytic
- thoracis
-
ca2+-requiring
-
troponin-t
- micro-calpain
-
calpain-like
-
proteolyzed
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
m-calpain, calpain ii, calpain-2, calpain 2, calpain2, ncl-2, milli-calpain, mitochondrial m-calpain, calpain-2-like, rat calpain 2, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
calcium-activated neutral protease II
-
-
-
-
calpain 2
calpain II
calpain xCL-2 (Xenopus leavis)
-
-
-
-
CAPN2 g.p. (Homo sapiens)
-
-
-
-
m-calpain
milli-calpain
-
-
-
-
calpain 2
-
-
-
-
calpain II
-
-
-
-
m-calpain
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
702693-80-9
-
78990-62-2
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
tert-butyloxycarbonyl-L-leucyl-L-methionine-7-amido-4-chloromethylcoumarin + H2O
tert-butyloxycarbonyl-L-leucyl-L-methionine + 7-amino-4-chloromethylcoumarin
-
-
-
-
?
myocillin + H2O
?
-
calpain II is responsible for the intracellular processing of myocilin in the lumen of the endoplasmic reticulum. It is proposed that this cleavage might regulate extracellular interactions of myocilin, contributing to the control of intraocular pressure
-
-
?
additional information
?
-
enzyme is involved in cytoskeleton remodelling and signal transduction
-
-
?
additional information
?
-
-
enzyme is involved in cytoskeleton remodelling and signal transduction
-
-
?
additional information
?
-
enzyme is involved in essential cellular functions mediated by calcium. Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit
-
-
?
additional information
?
-
-
enzyme plays a pivotal role during the earlier stages of myogenesis, particularly during fusion. MyoD and myogenin can transactivate capn2, but MyoD shows a higher transactivation level for the regulatory sequences
-
-
?
additional information
?
-
-
calpain mediates calcium-induced activation of the Erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons
-
-
?
additional information
?
-
pathological conditions associated with the gene of calpain 2: muscular dystrophy, stroke, traumatic brain injury, spinal cord injury, Alzheimer's diseases, Parkinson's disease, neurodegenerative disorders, cataracts, cancer
-
-
?
additional information
?
-
-
pathological conditions associated with the gene of calpain 2: muscular dystrophy, stroke, traumatic brain injury, spinal cord injury, Alzheimer's diseases, Parkinson's disease, neurodegenerative disorders, cataracts, cancer
-
-
?
additional information
?
-
-
calpain 2activity is critical for the life cycle of echovirus 1 and important in the multiplication of the viral RNA genome
-
-
?
additional information
?
-
-
calpain mediates angiogenic effects induced by vascular endothelial growth factor by modulating actin cytoskeletal organization
-
-
?
additional information
?
-
-
calpain-2 plays an important role in lung endothelial cell migration and proliferation
-
-
?
additional information
?
-
-
catalytic activity of calpain is required to limit pseudopod formation in the direction of chemoattractant and for efficient chemotaxis. Calpain 2 is a novel component of the frontness signal that promotes polarization during chemotaxis
-
-
?
additional information
?
-
-
m-calpain activity is triggered by Ca2+-influx and promoted mainly through the phosphatidylinositol 3-kinase pathway
-
-
?
additional information
?
-
-
M-calpain is the major candidate of the proteinase to generate the aggrecan product with the COOH terminal neoepitope VPGVA709 (consisting of two NH2 terminal globular domain G1 and G2 and KS side chains) during the intracellular aggrecan processing
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
myocillin + H2O
?
-
calpain II is responsible for the intracellular processing of myocilin in the lumen of the endoplasmic reticulum. It is proposed that this cleavage might regulate extracellular interactions of myocilin, contributing to the control of intraocular pressure
-
-
?
additional information
?
-
enzyme is involved in cytoskeleton remodelling and signal transduction
-
-
?
additional information
?
-
-
enzyme is involved in cytoskeleton remodelling and signal transduction
-
-
?
additional information
?
-
enzyme is involved in essential cellular functions mediated by calcium. Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit
-
-
?
additional information
?
-
-
enzyme plays a pivotal role during the earlier stages of myogenesis, particularly during fusion. MyoD and myogenin can transactivate capn2, but MyoD shows a higher transactivation level for the regulatory sequences
-
-
?
additional information
?
-
-
calpain mediates calcium-induced activation of the Erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons
-
-
?
additional information
?
-
pathological conditions associated with the gene of calpain 2: muscular dystrophy, stroke, traumatic brain injury, spinal cord injury, Alzheimer's diseases, Parkinson's disease, neurodegenerative disorders, cataracts, cancer
-
-
?
additional information
?
-
-
pathological conditions associated with the gene of calpain 2: muscular dystrophy, stroke, traumatic brain injury, spinal cord injury, Alzheimer's diseases, Parkinson's disease, neurodegenerative disorders, cataracts, cancer
-
-
?
additional information
?
-
-
calpain 2activity is critical for the life cycle of echovirus 1 and important in the multiplication of the viral RNA genome
-
-
?
additional information
?
-
-
calpain mediates angiogenic effects induced by vascular endothelial growth factor by modulating actin cytoskeletal organization
-
-
?
additional information
?
-
-
calpain-2 plays an important role in lung endothelial cell migration and proliferation
-
-
?
additional information
?
-
-
catalytic activity of calpain is required to limit pseudopod formation in the direction of chemoattractant and for efficient chemotaxis. Calpain 2 is a novel component of the frontness signal that promotes polarization during chemotaxis
-
-
?
additional information
?
-
-
m-calpain activity is triggered by Ca2+-influx and promoted mainly through the phosphatidylinositol 3-kinase pathway
-
-
?
additional information
?
-
-
M-calpain is the major candidate of the proteinase to generate the aggrecan product with the COOH terminal neoepitope VPGVA709 (consisting of two NH2 terminal globular domain G1 and G2 and KS side chains) during the intracellular aggrecan processing
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
upregulation of calpain 2 post eccentric exercise
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
cell line DLD-1. In KRASWT/- cells serum starvation induces CAPN2 expression, nucleolar accumulation
-
calpain 2 is important for both the formation of invadopodia and invasive capacity of breast cancer cells
-
pulmonary microvascular endothelial cell. Incubation of the cells with vascular endothelial growth factor results in dose- and time-dependent increases in calpain activity and protein content of calpain-2. Vascular endothelial growth factor does not change the protein contents of calpain-1 and the small subunit or of calpastatin. Inhibition of calpain activity by siRNA directed against calpain-2 and by overexpression of calpastatin prevents vascular endothelial growth factor-induced increases in actin stress fibers in endothelial cells and angiogenesis
-
membrane abnormalities and altered signaling pathways observed in Duchenne muscular dystrophy lymphocytes may be due to the increased association of calpain II onto membrane and cytosol
-
calpain 2 activity is critical for the life cycle of echovirus 1 and important in the multiplication of the viral RNA genome
-
active calpain 2 is concentrated in the trailing edge of the migrating T cell
-
physiological shear stress elicits Ca2+ influx-sensitive activation of m-calain in umbilical vein endothelial cells
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
in KRASWT/- cells serum starvation induces CAPN2 expression, nucleolar accumulation
-
membrane abnormalities and altered signaling pathways observed in Duchenne muscular dystrophy lymphocytes may be due to the increased association of calpain II onto membrane and cytosol
-
membrane abnormalities and altered signaling pathways observed in Duchenne muscular dystrophy lymphocytes may be due to the increased association of calpain II onto membrane and cytosol
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
calpain-1 and calpain-2 play opposite functions in both synaptic plasticity/learning and memory and neuroprotection/neurodegeneration. Calpain-1 activation is necessary for certain forms of synaptic plasticity and learning and memory, while calpain-2 activation during a brief consolidation period limits the extent of plasticity/learning. Calpain-1 is neuroprotective, while calpain-2 is neurodegenerative. Calpain-2 activation, through the selective degradation of phosphatase PTEN, is linked to the regulation of mTOR-mediated local protein synthesis
malfunction
metabolism
-
calpain 2 regulates endothelial nitric oxide synthase phosphorylation during cord formation by lymphatic endothelial cells on Matrigel
physiological function
malfunction
-
calpain inhibition blocks the increased colonic epithelial cell invasion caused by NM IIA knockdown
malfunction
-
in vivo knockdown of calpain2 disrupts metastasis among apoptosis-resistant tumors
malfunction
-
inhibition of calpain activity limits cell migration and in vitro wound healing of IEC-6 cells
malfunction
-
knockdown of calpain 2 expression or chemical inhibition of calpain activity reduces glioblastoma cell invasion by 90%. Decreased expression of calpain 2 does not influence morphology or migration
malfunction
-
knockdown of calpain 2 inhibits T cell migration at both the level of single cell tracking and general cell speed
malfunction
-
the knockdown of calpain 2 significantly reduces cord formation, adhesion, and migration of human lymphatic microvascular dermal-derived endothelial cells on Matrigel compared to the control
physiological function
-
calpain 2 plays a role in the generation of the low molecular weight-androgen receptor in CWR22-R1 cells
physiological function
-
calpain-2 is crucial for promotion of migration and metastasis by caspase-8
physiological function
-
m-calpain up-regulates alpha- and beta-actin in alveolar rhabdomyosarcoma cells
physiological function
-
calpain 2 controls turnover of lymphocyte function-associated antigen-1 adhesions on migrating T lymphocytes
physiological function
-
calpain 2 is required for matrix metalloproteinase-2 activity in glioblastoma cells. Calpain 2 is required for glioblastoma cell invasion, but not migration
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). CAN2_HUMAN
700
0
79995
Swiss-Prot
other Location (Reliability: 2)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
32000
-
1 * 80000 + 1 * 32000, only the 80000 Da subunit shows catalytic ativity, SDS-PAGE
80000
-
1 * 80000 + 1 * 32000, only the 80000 Da subunit shows catalytic ativity, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
dimer
-
1 * 80000 + 1 * 32000, only the 80000 Da subunit shows catalytic ativity, SDS-PAGE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phosphoprotein
-
brain-derived neurotrophic factor stimulates m-calpain serine phosphorylation
side-chain modification
-
calpain-2 is small ubiquitin-like modifier-modified at lysine residue 390, sumoylation is important for calpain-2 activity
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
full-length human m-calpain containing an N-terminal Gly-Arg-Arg-Asp-Arg-Ser L-chain elongation overexpressed in a baculovirus expression system. Crystals grown by vapor diffusion. The 2.3 A crystal structure of full length heterodimeric m-calpain crystallized in the absence of calcium reveals an oval disc-like shape, with the papain-like catalytic domain dII and the two calmodulin, like domains dIV+dVI occupying opposite poles, and the tumor necrosis factor alpha-like beta-sandwich domain dIII and the N-terminal segments dI+dV located between
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
C105S
-
mutant enzyme of mutant large subunit m-C105S-80K, coexpressed with 30000 Da subunit in Sf-9 cells does not degrade casein nor the artificial substrate succinyl-Leu-Leu-Val-Tyr-4-methylcoumaryl-7-amide. The mutant enzyme does not show autolytic activity with Ca2+
K390R
-
overexpression of K390R mutant fails to increase the calpain activity since sumoylation at K390 is important for calpain-2 activity
additional information
used as a model for calpain 3 in combination with calpastatin-inhibited rat calpain 2
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
m-calpain loses 50-55% of its proteolytic activity within 5 min during incubation at pH 7.5 in 300 mM or high salt and at a slower rat in 100 mM salt. This loss of activity is not reversed by dialysis for 18 h against a low-ionic-strength buffer at pH 7.5. Proteolytic activity of the unautolyzed calpains is not affected by incubation for 45 min at ionic strength up to 1000 mM. Ionic strengths of 100 mM or above cause dissociation of the two subunits of autolyzed calpains. The dissociated large subunits aggregate to form dimers and trimers, which are proteolytically inactive
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
functional analysis of the upstream region of the gene for the large subunit by means of transient expression assay on HeLa cells using chloramphenicol transferase constructs identifies four negative regulatory regions tandemly reiterated just upstream of the promoter region, P1 and P2
development of an adenoviral vector harboring calpain-2 siRNA expression unit in which sense and anti-sense strands composing the siRNA duplex are connected by a loop and transcribed into a siRNA in porcine pulmonary artery endothelial cells. The adenoviral vector harboring calpain-2 siRNA expression unit is a valuable tool to study the biology of calpains
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
0.1 mM indomethacin and 0.1 mM NS-398 decrease expression of calpain 2 in total membrane fractions and in plasma membranes by 70%, while 0.001 mM SC-560 decreases expression of calpain 2 in total membrane fractions and in plasma membranes by 30%
-
a 6-day treatment with siRNA results in an about 60% reduction of calpain 2 protein levels in R1 cells
-
brain-derived neurotrophic factor and epidermal growth factor activate neuronal m-calpain via mitogen-activated protein kinase-dependent phosphorylation
-
incubation of human retinal microvascular endothelial cells with vascular endothelial growth factor results in 1.6fold increased activity of calpain 2 at 24 h
-
p38 MAPK and JNK are required to stimulate m-calpain activity when TRPM7 is overexpressed, TRPM7-mediated activation of m-calpain is not dependent on the nature of the divalent conducted by the channel
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
-
m-calpain is a marker of tumor aggressiveness and is apotential target for limiting development of rhabdomyosarcoma tumor as well as their metastatic behavior
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shastri, R.; Jagadeesh, G.; Anandaraj, M.P.J.S.
Human placental calcium activated neutral proteinase: Separation and functional characterization of subunits
J. Biosci.
15
427-434
1990
Homo sapiens
-
Rojas, F.J.; Brush, M.; Moretti-Rojas, I.
Calpain-calpastatin: a novel, complete calcium-dependent protease system in human spermatozoa
Mol. Hum. Reprod.
5
520-526
1999
Homo sapiens
Strobl S.; Fernandez-Catalan C.; Braun M.; Huber R.; Masumoto H.; Nakagawa K.; Irie A.; Sorimachi H.; Bourenkow G.; Bartunik H.; Suzuki K.; Bode W.
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium
Proc. Natl. Acad. Sci. USA
97
588-592
2000
Homo sapiens (P17655), Homo sapiens
Imajoh S.; Aoki K.; Ohno S.; Emori Y.; Kawasaki H.; Sugihara H.; Suzuki K.
Molecular cloning of the cDNA for the large subunit of the high-Ca2+-requiring form of human Ca2+-activated neutral protease
Biochemistry
27
8122-8128
1988
Homo sapiens (P17655)
Hata A.; Ohno S.; Akita Y.; Suzuki K.
Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit of calcium-dependent protease
J. Biol. Chem.
264
6404-6411
1989
Homo sapiens (P17655)
Ye Z.; Connor J.R.
cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs
Biochem. Biophys. Res. Commun.
275
223-227
2000
Homo sapiens (P17655)
Strausberg R.L.; Feingold E.A.; Grouse L.H.; Derge J.G.; et al.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
Proc. Natl. Acad. Sci. USA
99
16899-16903
2002
Homo sapiens (P17655)
Masumoto, H.; Yoshizawa, T.; Sorimachi, H.; Nishino, T.; Ishiura, S.; Suzuki, K.
Overexpression, purification, and characterization of human m-calpain and its active site mutant, m-C105S-calpain, using a baculovirus expression system
J. Biochem.
124
957-961
1998
Homo sapiens
Dedieu, S.; Mazeres, G.; Dourdin, N.; Cottin, P.; Brustis, J.J.
Transactivation of capn2 by Myogenic Regulatory Factors During Myogenesis
J. Mol. Biol.
326
453-465
2003
Homo sapiens
Veerann, V.; Kaji, T.; Boland, B.; Odrljin, T.; Mohan, P.; Basavarajappa, B.S.; Peterhoff, C.; Cataldo, A.; Rudnicki, A.; Amin, N.; Li, B.S.; Pant, H.C.; Hungund, B.L.; Arancio, O.; Nixon, R.A.
Calpain mediates calcium-induced activation of the Erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: Relevance to Alzheimers disease
Am. J. Pathol.
165
795-805
2004
Homo sapiens
Li, H.; Thompson, V.F.; Goll, D.E.
Effects of autolysis on properties of mu- and m-calpain
Biochim. Biophys. Acta
1691
91-103
2004
Homo sapiens
Carragher, N.O.
Calpain inhibition: a therapeutic strategy targeting multiple disease states
Curr. Pharm. Des.
12
615-638
2006
Homo sapiens (P07384), Homo sapiens
Upla, P.; Marjomaeki, V.; Nissinen, L.; Nylund, C.; Waris, M.; Hyypiae, T.; Heino, J.
Calpain 1 and 2 are required for RNA replication of echovirus 1
J. Virol.
82
1581-1590
2008
Homo sapiens
Miyazaki, T.; Honda, K.; Ohata, H.
Requirement of Ca2+ influx- and phosphatidylinositol 3-kinase-mediated m-calpain activity for shear stress-induced endothelial cell polarity
Am. J. Physiol.
293
C1216-C1225
2007
Homo sapiens
Shanmuga Sundaram, J.; Mohana Rao, V.; Meena, A.K.; Anandaraj, M.P.
Altered expression, intracellular distribution and activity of lymphocyte calpain II in Duchenne muscular dystrophy
Clin. Chim. Acta
373
82-87
2006
Homo sapiens
Su, Y.; Cui, Z.; Li, Z.; Bloc, E.R.
Calpain-2 regulation of VEGF-mediated angiogenesis
FASEB J.
20
1443-1451
2006
Homo sapiens
Maehara, H.; Suzuki, K.; Sasaki, T.; Oshita, H.; Wada, E.; Inoue, T.; Shimizu, K.
G1-G2 aggrecan product that can be generated by M-calpain on truncation at Ala709-Ala710 is present abundantly in human articular cartilage
J. Biochem.
141
469-477
2007
Homo sapiens
Sanchez-Sanchez, F.; Martinez-Redondo, F.; Aroca-Aguilar, J.D.; Coca-Prados, M.; Escribano, J.
Characterization of the intracellular proteolytic cleavage of myocilin and identification of calpain II as a myocilin-processing protease
J. Biol. Chem.
282
27810-27824
2007
Homo sapiens
Cortesio, C.L.; Chan, K.T.; Perrin, B.J.; Burton, N.O.; Zhang, S.; Zhang, Z.Y.; Huttenlocher, A.
Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion
J. Cell Biol.
180
957-971
2008
Homo sapiens
Nuzzi, P.A.; Senetar, M.A.; Huttenlocher, A.
Asymmetric localization of calpain 2 during neutrophil chemotaxis
Mol. Biol. Cell
18
795-805
2007
Homo sapiens
Qiu, K.; Su, Y.; Block, E.R.
Use of recombinant calpain-2 siRNA adenovirus to assess calpain-2 modulation of lung endothelial cell migration and proliferation
Mol. Cell. Biochem.
292
69-78
2006
Homo sapiens
Garnham, C.; Hanna, R.; Chou, J.; Low, K.; Gourlay, K.; Campbell, R.; Beckmann, J.; Davies, P.
Limb-girdle muscular dystrophy type 2A can result from accelerated autoproteolytic inactivation of calpain 3
Biochemistry
48
3457-3467
2009
Homo sapiens (P04632), Rattus norvegicus (Q07009)
Vissing, K.; Overgaard, K.; Nedergaard, A.; Fredsted, A.; Schjerling, P.
Effects of concentric and repeated eccentric exercise on muscle damage and calpain-calpastatin gene expression in human skeletal muscle
Eur. J. Appl. Physiol.
103
323-332
2008
Homo sapiens (P17655), Homo sapiens
Babbin, B.A.; Koch, S.; Bachar, M.; Conti, M.A.; Parkos, C.A.; Adelstein, R.S.; Nusrat, A.; Ivanov, A.I.
Non-muscle myosin IIA differentially regulates intestinal epithelial cell restitution and matrix invasion
Am. J. Pathol.
174
436-448
2009
Homo sapiens
Wang, H.C.; Huang, Y.S.; Ho, C.C.; Jeng, J.C.; Shih, H.M.
SUMO modification modulates the activity of calpain-2
Biochem. Biophys. Res. Commun.
384
444-449
2009
Homo sapiens
Meng, X.N.; Jin, Y.; Yu, Y.; Bai, J.; Liu, G.Y.; Zhu, J.; Zhao, Y.Z.; Wang, Z.; Chen, F.; Lee, K.Y.; Fu, S.B.
Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion
Br. J. Cancer
101
327-334
2009
Homo sapiens
Barbero, S.; Mielgo, A.; Torres, V.; Teitz, T.; Shields, D.J.; Mikolon, D.; Bogyo, M.; Barila, D.; Lahti, J.M.; Schlaepfer, D.; Stupack, D.G.
Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis
Cancer Res.
69
3755-3763
2009
Homo sapiens
Pilop, C.; Aregger, F.; Gorman, R.C.; Brunisholz, R.; Gerrits, B.; Schaffner, T.; Gorman, J.H.; Matyas, G.; Carrel, T.; Frey, B.M.
Proteomic analysis in aortic media of patients with Marfan syndrome reveals increased activity of calpain 2 in aortic aneurysms
Circulation
120
983-991
2009
Homo sapiens
Roumes, H.; Leloup, L.; Dargelos, E.; Brustis, J.J.; Daury, L.; Cottin, P.
Calpains: markers of tumor aggressiveness?
Exp. Cell Res.
316
1587-1599
2010
Homo sapiens
Chen, H.; Libertini, S.J.; Wang, Y.; Kung, H.J.; Ghosh, P.; Mudryj, M.
ERK regulates calpain 2-induced androgen receptor proteolysis in CWR22 relapsed prostate tumor cell lines
J. Biol. Chem.
285
2368-2374
2010
Homo sapiens
Liu, Z.; Wang, S.; Zhou, H.; Yang, Y.; Zhang, M.
Na+/H+ exchanger mediates TNF-alpha-induced hepatocyte apoptosis via the calpain-dependent degradation of Bcl-xL
J. Gastroenterol. Hepatol.
24
879-885
2009
Homo sapiens
Su, L.T.; Chen, H.C.; Gonzalez-Pagan, O.; Overton, J.D.; Xie, J.; Yue, L.; Runnels, L.W.
TRPM7 activates m-calpain by stress-dependent stimulation of p38 MAPK and c-Jun N-terminal kinase
J. Mol. Biol.
396
858-869
2010
Homo sapiens
Zadran, S.; Jourdi, H.; Rostamiani, K.; Qin, Q.; Bi, X.; Baudry, M.
Brain-derived neurotrophic factor and epidermal growth factor activate neuronal m-calpain via mitogen-activated protein kinase-dependent phosphorylation
J. Neurosci.
30
1086-1095
2010
Homo sapiens
Ma, H.; Tochigi, A.; Shearer, T.R.; Azuma, M.
Calpain inhibitor SNJ-1945 attenuates events prior to angiogenesis in cultured human retinal endothelial cells
J. Ocul. Pharmacol. Ther.
25
409-414
2009
Homo sapiens
Jang, H.S.; Lal, S.; Greenwood, J.A.
Calpain 2 is required for glioblastoma cell invasion: regulation of matrix metalloproteinase 2
Neurochem. Res.
35
1796-1804
2010
Homo sapiens
Svensson, L.; McDowall, A.; Giles, K.M.; Stanley, P.; Feske, S.; Hogg, N.
Calpain 2 controls turnover of LFA-1 adhesions on migrating T lymphocytes
PLoS ONE
5
e15090
2010
Homo sapiens
Prangsaengtong, O.; Senda, K.; Doki, Y.; Park, J.Y.; Jo, M.; Sakurai, H.; Shibahara, N.; Saiki, I.; Koizumi, K.
Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation
Hum. Cell
25
36-44
2012
Homo sapiens
Telechea-Fernandez, M.; Rodriguez-Fernandez, L.; Garcia, C.; Zaragoza, R.; Vina, J.; Cervantes, A.; Garcia-Trevijano, E.R.
New localization and function of calpain-2 in nucleoli of colorectal cancer cells in ribosomal biogenesis effect of KRAS status
Oncotarget
9
9100-9113
2018
Homo sapiens (P17655)
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