Reference on EC 3.4.22.51 - cruzipain

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Alvarez, V.; Parussini, F.; Aslund, L.; Cazzulo, J.J.
Expression in insect cells of active mature cruzipain from Trypanosoma cruzi, containing its C-terminal domain
Protein Expr. Purif.
26
467-475
2002
Trypanosoma cruzi (Q598P5), Trypanosoma cruzi
Manually annotated by BRENDA team
Alves, L.C.; Melo, R.L.; Cezari, M.H.S.; Sanderson, S.J.; Mottram, J.C.; Coombs, G.H.; Juliano, L.; Juliano, M.A.
Analysis of the S2 subsite specificities of the recombinant cysteine proteinases CPB of Leishmania mexicana, and cruzain of Trypanosoma cruzi, using fluorescent substrates containing non-natural basic amino acids
Mol. Biochem. Parasitol.
117
137-143
2001
Trypanosoma cruzi (Q598P5), Trypanosoma cruzi
Manually annotated by BRENDA team
Cazzulo, J.J.; Bravo, M.; Raimond, A.; Engstroem, U.; Lindeberg, G.; Hellman, U.
Hydrolysis of synthetic peptides by cruzipain, the major cysteine proteinase from Trypanosoma cruzi, provides evidence for self-processing and the possibility of more specific substrates for the enzyme
Cell. Mol. Biol.
42
691-696
1996
Trypanosoma cruzi (Q598P5), Trypanosoma cruzi
Manually annotated by BRENDA team
Cazzulo, J.J.; Cazzulo Franke, M.C.; Martinez, J.; Franke de Cazzulo, B.M.
Some kinetic properties of a cysteine proteinase (cruzipain) from Trypanosoma cruzi
Biochim. Biophys. Acta
1037
186-191
1990
Trypanosoma cruzi (Q598P5)
Manually annotated by BRENDA team
Cazzulo, J.J.; Stoka, V.; Turk, V.
Cruzipain, the major cysteine proteinase from the protozoan parasite Trypanosoma cruzi
Biol. Chem.
378
1-10
1997
Trypanosoma cruzi (Q598P5), Trypanosoma cruzi
Manually annotated by BRENDA team
Del Nery, E.; Juliano, M.A.; Meldal, M.; Svendsen, I.; Scharfstein, J.; Walmsley, A.; Juliano, L.
Characterization of the substrate specificity of the major cysteine protease (cruzipain) from Trypanosoma cruzi using a portion-mixing combinatorial library and fluorogenic peptides
Biochem. J.
323
427-433
1997
Trypanosoma cruzi (Q598P5)
-
Manually annotated by BRENDA team
Eakin, A.E.; McGrath, M.E.; McKerrow, J.H.; Fletterick, R.J.; Craik, C.S.
Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi
J. Biol. Chem.
268
6115-6118
1993
Trypanosoma cruzi (Q598P5), Trypanosoma cruzi
Manually annotated by BRENDA team
Gillmor, S.A.; Craik, C.S.; Fletterick, R.J.
Structural determinants of specificity in the cysteine protease cruzain
Protein Sci.
6
1603-1611
1997
Trypanosoma cruzi (Q598P5), Trypanosoma cruzi
Manually annotated by BRENDA team
Judice, W.A.; Cezari, M.H.; Lima, A.P.; Scharfstein, J.; Chagas, J.R.; Tersariol, I.L.; Juliano, M.A.; Juliano, L.
Comparison of the specificity, stability and individual rate constants with respective activation parameters for the peptidase activity of cruzipain and its recombinant form, cruzain, from Trypanosoma cruzi
Eur. J. Biochem.
268
6578-6586
2001
Trypanosoma cruzi (Q598P5), Trypanosoma cruzi
Manually annotated by BRENDA team
Lalmanach, G.; Boulange, A.; Serveau, C.; Lecaille, F.; Scharfstein, J.; Gauthier, F.; Authie, E.
Congopain from Trypanosoma congolense: drug target and vaccine candidate
Biol. Chem.
383
739-749
2002
Trypanosoma congolense (Q26909), Trypanosoma congolense
Manually annotated by BRENDA team
Lima, A.P.C.A.; Almeida, P.C.; Tersariol, I.L.S.; Schmitz, V.; Schmaier, A.H.; Juliano, L.; Hirata, I.Y.; Muller-Esterl, W.; Chagas, J.R.; Scharfstein, J.
Heparan sulfate modulates kinin release by Trypanosoma cruzi through the activity of cruzipain
J. Biol. Chem.
277
5875-5881
2002
Trypanosoma cruzi (Q598P5), Trypanosoma cruzi
Manually annotated by BRENDA team
McGrath, M.E.; Eakin, A.E.; Engel, J.C.; McKerrow, J.H.; Craik, C.C.; Fletterick, R.J.
The crystal structure of cruzain: a therapeutic target for Chagas' disease
J. Mol. Biol.
247
251-259
1995
Trypanosoma cruzi (Q598P5), Trypanosoma cruzi
Manually annotated by BRENDA team
Ramos, A.M.; Duschak, V.G.; Gerez de Burgos, N.M.; Barboza, M.; Remedi, M.S.; Vides, M.A.; Chiabrando, G.A.
Trypanosoma cruzi: cruzipain and membrane-bound cysteine proteinase isoform(s) interacts with human alpha2-macroglobulin and pregnancy zone protein
Exp. Parasitol.
100
121-130
2002
Trypanosoma cruzi (Q598P5), Trypanosoma cruzi
Manually annotated by BRENDA team
Salvati, L.; Mattu, M.; Polticelli, F.; Tiberi, F.; Gradoni, L.; Venturini, G.; Bolognesi, M.; Ascenzi, P.
Modulation of the catalytic activity of cruzipain, the major cysteine proteinase from Trypanosoma cruzi, by temperature and pH
Eur. J. Biochem.
268
3253-3258
2001
Trypanosoma cruzi (Q598P5), Trypanosoma cruzi
Manually annotated by BRENDA team
Schnapp, A.R.; Eickhoff, C.S.; Sizemore, D.; Curtiss, R.3rd.; Hoft, D.F.
Cruzipain induces both mucosal and systemic protection against Trypanosoma cruzi in mice
Infect. Immun.
70
5065-5074
2002
Trypanosoma cruzi (Q598P5), Trypanosoma cruzi
Manually annotated by BRENDA team
Sterin-Borda, L.; Giordanengo, L.; Joensen, L.; Gea, S.
Cruzipain induces autoantibodies against cardiac muscarinic acetylcholine receptors. Functional and pathological implications
Eur. J. Immunol.
33
2459-2468
2003
Trypanosoma cruzi (Q598P5), Trypanosoma cruzi
Manually annotated by BRENDA team
Stoka, V.; Turk, B.; McKerrow, J.H.; Bjork, I.; Cazzulo, J.J.; Turk, V.
The high stability of cruzipain against pH-induced inactivation is not dependent on its C-terminal domain
FEBS Lett.
469
29-32
2000
Trypanosoma cruzi (Q598P5)
Manually annotated by BRENDA team
Cazzulo, J.J.; Martinez, J.; Parodi, A.J.; Wernstedt, C.; Hellman, U.
On the post-translational modifications at the C-terminal domain of the major cysteine proteinase (cruzipain) from Trypanosoma cruzi
FEMS Microbiol. Lett.
79
411-416
1992
Trypanosoma cruzi (Q598P5), Trypanosoma cruzi
Manually annotated by BRENDA team
Aoki, M.P.; Guinazu, N.L.; Pellegrini, A.V.; Gotoh, T.; Masih, D.T.; Gea, S.
Cruzipain, a major Trypanosoma cruzi antigen, promotes arginase-2 expression and survival of neonatal mouse cardiomyocytes
Am. J. Physiol.
286
C206-C212
2004
Trypanosoma cruzi
Manually annotated by BRENDA team
Polticelli, F.; Zaini, G.; Bolli, A.; Antonini, G.; Gradoni, L.; Ascenzi, P.
Probing the cruzain S2 recognition subsite: a kinetic and binding energy calculation study
Biochemistry
44
2781-2789
2005
Trypanosoma cruzi
Manually annotated by BRENDA team
Chiyanzu, I.; Hansell, E.; Gut, J.; Rosenthal, P.J.; McKerrow, J.H.; Chibale, K.
Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain
Bioorg. Med. Chem. Lett.
13
3527-3530
2003
Trypanosoma cruzi
Manually annotated by BRENDA team
Fujii, N.; Mallari, J.P.; Hansell, E.J.; Mackey, Z.; Doyle, P.; Zhou, Y.M.; Gut, J.; Rosenthal, P.J.; McKerrow, J.H.; Guy, R.K.
Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain
Bioorg. Med. Chem. Lett.
15
121-123
2005
Trypanosoma cruzi
Manually annotated by BRENDA team
Judice, W.A.; Puzer, L.; Cotrin, S.S.; Carmona, A.K.; Coombs, G.H.; Juliano, L.; Juliano, M.A.
Carboxydipeptidase activities of recombinant cysteine peptidases. Cruzain of Trypanosoma cruzi and CPB of Leishmania mexicana
Eur. J. Biochem.
271
1046-1053
2004
Trypanosoma cruzi
Manually annotated by BRENDA team
Duschak, V.G.; Barboza, M.; Couto, A.S.
Trypanosoma cruzi: partial characterization of minor cruzipain isoforms non-adsorbed to concanavalin A-Sepharose
Exp. Parasitol.
104
122-130
2003
Trypanosoma cruzi
Manually annotated by BRENDA team
Barboza, M.; Duschak, V.G.; Fukuyama, Y.; Nonami, H.; Erra-Balsells, R.; Cazzulo, J.J.; Couto, A.S.
Structural analysis of the N-glycans of the major cysteine proteinase of Trypanosoma cruzi. Identification of sulfated high-mannose type oligosaccharides
FEBS J.
272
3803-3815
2005
Trypanosoma cruzi
Manually annotated by BRENDA team
Barboza, M.; Duschak, V.G.; Cazzulo, J.J.; de Lederkremer, R.M.; Couto, A.S.
Presence of sialic acid in N-linked oligosaccharide chains and O-linked N-acetylglucosamine in cruzipain, the major cysteine proteinase of Trypanosoma cruzi
Mol. Biochem. Parasitol.
127
69-72
2003
Trypanosoma cruzi
Manually annotated by BRENDA team
Berasain, P.; Carmona, C.; Frangione, B.; Cazzulo, J.J.; Goni, F.
Specific cleavage sites on human IgG subclasses by cruzipain, the major cysteine proteinase from Trypanosoma cruzi
Mol. Biochem. Parasitol.
130
23-29
2003
Trypanosoma cruzi
Manually annotated by BRENDA team
Stempin, C.C.; Garrido, V.V.; Dulgerian, L.R.; Cerban, F.M.
Cruzipain and SP600125 induce p38 activation, alter NO/arginase balance and favor the survival of Trypanosoma cruzi in macrophages
Acta Trop.
106
119-127
2008
Trypanosoma cruzi
Manually annotated by BRENDA team
Reis, F.C.; Costa, T.F.; Sulea, T.; Mezzetti, A.; Scharfstein, J.; Broemme, D.; Menard, R.; Lima, A.P.
The propeptide of cruzipain--a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F
FEBS J.
274
1224-1234
2007
Trypanosoma cruzi
Manually annotated by BRENDA team
dos Reis, F.C.; Judice, W.A.; Juliano, M.A.; Juliano, L.; Scharfstein, J.; Lima, A.P.
The substrate specificity of cruzipain 2, a cysteine protease isoform from Trypanosoma cruzi
FEMS Microbiol. Lett.
259
215-220
2006
Trypanosoma cruzi
Manually annotated by BRENDA team
Scharfstein, J.; Monteiro, A.C.; Schmitz, V.; Svensjoe, E.
Angiotensin-converting enzyme limits inflammation elicited by Trypanosoma cruzi cysteine proteases: a peripheral mechanism regulating adaptive immunity via the innate kinin pathway
Biol. Chem.
389
1015-1024
2008
Trypanosoma cruzi
Manually annotated by BRENDA team
Chen, Y.T.; Lira, R.; Hansell, E.; McKerrow, J.H.; Roush, W.R.
Synthesis of macrocyclic trypanosomal cysteine protease inhibitors
Bioorg. Med. Chem. Lett.
18
5860-5863
2008
Trypanosoma brucei rhodesiense, Trypanosoma cruzi
Manually annotated by BRENDA team
Zanatta, N.; Amaral, S.S.; Dos Santos, J.M.; de Mello, D.L.; Fernandes, L.d.a..S.; Bonacorso, H.G.; Martins, M.A.; Andricopulo, A.D.; Borchhardt, D.M.
Convergent synthesis and cruzain inhibitory activity of novel 2-(N-benzylidenehydrazino)-4-trifluoromethyl-pyrimidines
Bioorg. Med. Chem.
16
10236-10243
2008
Trypanosoma cruzi
Manually annotated by BRENDA team
Porcal, W.; Hernandez, P.; Boiani, L.; Boiani, M.; Ferreira, A.; Chidichimo, A.; Cazzulo, J.J.; Olea-Azar, C.; Gonzalez, M.; Cerecetto, H.
New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle
Bioorg. Med. Chem.
16
6995-7004
2008
Trypanosoma cruzi, Trypanosoma cruzi Tulahuen 2
Manually annotated by BRENDA team
Romeiro, N.C.; Aguirre, G.; Hernandez, P.; Gonzalez, M.; Cerecetto, H.; Aldana, I.; Perez-Silanes, S.; Monge, A.; Barreiro, E.J.; Lima, L.M.
Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates
Bioorg. Med. Chem.
17
641-652
2009
Trypanosoma cruzi, Trypanosoma cruzi Tulahuen 2
Manually annotated by BRENDA team
Elias, C.G.; Pereira, F.M.; Dias, F.A.; Silva, T.L.; Lopes, A.H.; dAvila-Levy, C.M.; Branquinha, M.H.; Santos, A.L.
Cysteine peptidases in the tomato trypanosomatid Phytomonas serpens: influence of growth conditions, similarities with cruzipain and secretion to the extracellular environment
Exp. Parasitol.
120
343-352
2008
Trypanosoma cruzi, Trypanosoma cruzi Dm28c
Manually annotated by BRENDA team
dos Reis, F.C.; Smith, B.O.; Santos, C.C.; Costa, T.F.; Scharfstein, J.; Coombs, G.H.; Mottram, J.C.; Lima, A.P.
The role of conserved residues of chagasin in the inhibition of cysteine peptidases
FEBS Lett.
582
485-490
2008
Trypanosoma cruzi
Manually annotated by BRENDA team
SantAnna, C.; Parussini, F.; Lourenco, D.; de Souza, W.; Cazzulo, J.J.; Cunha-e-Silva, N.L.
All Trypanosoma cruzi developmental forms present lysosome-related organelles
Histochem. Cell Biol.
130
1187-1198
2008
Trypanosoma cruzi, Trypanosoma cruzi Y
Manually annotated by BRENDA team
Acosta, D.M.; Arnaiz, M.R.; Esteva, M.I.; Barboza, M.; Stivale, D.; Orlando, U.D.; Torres, S.; Laucella, S.A.; Couto, A.S.; Duschak, V.G.
Sulfates are main targets of immune responses to cruzipain and are involved in heart damage in BALB/c immunized mice
Int. Immunol.
20
461-470
2008
Trypanosoma cruzi, Trypanosoma cruzi Tulahuen 2
Manually annotated by BRENDA team
Brak, K.; Doyle, P.S.; McKerrow, J.H.; Ellman, J.A.
Identification of a new class of nonpeptidic inhibitors of cruzain
J. Am. Chem. Soc.
130
6404-6410
2008
Trypanosoma cruzi (P25779), Trypanosoma cruzi
Manually annotated by BRENDA team
Fricker, S.P.; Mosi, R.M.; Cameron, B.R.; Baird, I.; Zhu, Y.; Anastassov, V.; Cox, J.; Doyle, P.S.; Hansell, E.; Lau, G.; Langille, J.; Olsen, M.; Qin, L.; Skerlj, R.; Wong, R.S.; Santucci, Z.; McKerrow, J.H.
Metal compounds for the treatment of parasitic diseases
J. Inorg. Biochem.
102
1839-1845
2008
Trypanosoma cruzi
Manually annotated by BRENDA team
Fampa, P.; Lisboa, C.V.; Jansen, A.M.; Santos, A.L.; Ramirez, M.I.
Protease expression analysis in recently field-isolated strains of Trypanosoma cruzi: a heterogeneous profile of cysteine protease activities between TC I and TC II major phylogenetic groups
Parasitology
135
1093-1100
2008
Trypanosoma cruzi
Manually annotated by BRENDA team
Pereira, F.M.; Elias, C.G.; dAvila-Levy, C.M.; Branquinha, M.H.; Santos, A.L.
Cysteine peptidases in Herpetomonas samuelpessoai are modulated by temperature and dimethylsulfoxide-triggered differentiation
Parasitology
136
45-54
2009
Trypanosoma cruzi, Trypanosoma cruzi Dm28c
Manually annotated by BRENDA team
Abdulla, M.H.; OBrien, T.; Mackey, Z.B.; Sajid, M.; Grab, D.J.; McKerrow, J.H.
RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model
PLoS Negl. Trop. Dis.
2
e298
2008
Trypanosoma brucei
Manually annotated by BRENDA team
Cazorla, S.I.; Frank, F.M.; Becker, P.D.; Corral, R.S.; Guzman, C.A.; Malchiodi, E.L.
Prime-boost immunization with cruzipain co-administered with MALP-2 triggers a protective immune response able to decrease parasite burden and tissue injury in an experimental Trypanosoma cruzi infection model
Vaccine
26
1999-2009
2008
Trypanosoma cruzi, Trypanosoma cruzi RA
Manually annotated by BRENDA team
Huson, L.E.; Authie, E.; Boulange, A.F.; Goldring, J.P.; Coetzer, T.H.
Modulation of the immunogenicity of the Trypanosoma congolense cysteine protease, congopain, through complexation with alpha2-macroglobulin
Vet. Res.
40
52
2009
Trypanosoma congolense
Manually annotated by BRENDA team
Ortiz, P.A.; Maia da Silva, F.; Cortez, A.P.; Lima, L.; Campaner, M.; Pral, E.M.; Alfieri, S.C.; Teixeira, M.M.
Genes of cathepsin L-like proteases in Trypanosoma rangeli isolates: markers for diagnosis, genotyping and phylogenetic relationships
Acta Trop.
112
249-259
2009
Trypanosoma rangeli (D0QZL7), Trypanosoma rangeli (D0QZL8), Trypanosoma rangeli (D0QZM0), Trypanosoma rangeli (D0QZM2), Trypanosoma rangeli (D0QZM5), Trypanosoma rangeli (D0QZM6), Trypanosoma rangeli (D0QZM9)
Manually annotated by BRENDA team
Cortez, A.; Rodrigues, A.; Garcia, H.; Neves, L.; Batista, J.; Bengaly, Z.; Paiva, F.; Teixeira, M.
Cathepsin L-like genes of Trypanosoma vivax from Africa and South America - characterization, relationships and diagnostic implications
Mol. Cell. Probes
23
44-51
2009
Trypanosoma vivax (C0J3Y8), Trypanosoma vivax (C0J3Z1)
Manually annotated by BRENDA team
Pizzo, C.; Saiz, C.; Talevi, A.; Gavernet, L.; Palestro, P.; Bellera, C.; Blanch, L.B.; Benitez, D.; Cazzulo, J.J.; Chidichimo, A.; Wipf, P.; Mahler, S.G.
Synthesis of 2-hydrazolyl-4-thiazolidinones based on multicomponent reactions and biological evaluation against Trypanosoma cruzi
Chem. Biol. Drug Des.
77
166-172
2011
Trypanosoma cruzi
Manually annotated by BRENDA team
Borchhardt, D.; Mascarello, A.; Chiaradia, L.; Nunes, R.; Oliva, G.; Yunes, R.; Andricopulo, A.
Biochemical evaluation of a series of synthetic chalcone and hydrazide derivatives as novel inhibitors of cruzain from Trypanosoma cruzi
J. Braz. Chem. Soc.
21
142-150
2010
Trypanosoma cruzi
-
Manually annotated by BRENDA team
Trossini, G.; Malvezzi, A.; Amaral, A.; Rangel-Yagui, C.; Izidoro, M.; Cezari, M.; Juliano, L.; Chin, C.; Menezes, C.; Ferreira, E.
Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: Investigation of a new target in Trypanosoma cruzi
J. Enzyme Inhib. Med. Chem.
25
62-67
2010
Trypanosoma cruzi
Manually annotated by BRENDA team
Trossini, G.; Chin, C.; de Souza Menezes, C.; Ferreira, E.
Molecular modeling suggests cruzain specificity for peptide primaquine prodrugs
Lett. Drug Des. Discov.
7
528-533
2010
Trypanosoma cruzi
-
Manually annotated by BRENDA team
Acosta, D.M.; Soprano, L.L.; Ferrero, M.; Landoni, M.; Esteva, M.I.; Couto, A.S.; Duschak, V.G.
A striking common O-linked N-acetylglucosaminyl moiety between cruzipain and myosin
Parasite Immunol.
33
363-370
2011
Trypanosoma cruzi
Manually annotated by BRENDA team
Doyle, P.S.; Zhou, Y.M.; Hsieh, I.; Greenbaum, D.C.; McKerrow, J.H.; Engel, J.C.
The Trypanosoma cruzi protease cruzain mediates immune evasion
PLoS Pathog.
7
e1002139
2011
Trypanosoma cruzi
Manually annotated by BRENDA team
Merlino, A.; Benitez, D.; Campillo, N.; Páez, J.; Tinoco, L.; González, M.; Cerecetto, H.
Amidines bearing benzofuroxan or benzimidazole 1,3-dioxide core scaffolds as Trypanosoma cruzi-inhibitors: Structural basis for their interactions with cruzipain
MedChemComm
3
90-101
2012
Trypanosoma cruzi
-
Manually annotated by BRENDA team
Uehara, L.A.; Moreira, O.C.; Oliveira, A.C.; Azambuja, P.; Lima, A.P.; Britto, C.; dos Santos, A.L.; Branquinha, M.H.; dAvila-Levy, C.M.
Cruzipain promotes Trypanosoma cruzi adhesion to Rhodnius prolixus midgut
PLoS Negl. Trop. Dis.
6
e1958
2012
Trypanosoma cruzi, Trypanosoma cruzi Dm28c
Manually annotated by BRENDA team