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Information on EC 3.4.22.46 - L-peptidase and Organism(s) Mycobacterium tuberculosis and UniProt Accession P9WKA1

for references in articles please use BRENDA:EC3.4.22.46
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.46 L-peptidase
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This record set is specific for:
Mycobacterium tuberculosis
UNIPROT: P9WKA1 not found.
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Word Map
The taxonomic range for the selected organisms is: Mycobacterium tuberculosis
The enzyme appears in selected viruses and cellular organisms
Synonyms
3c protease, 3cpro, leader protease, l proteinase, nsp1alpha, lab protein, p1a protein, fmdv 3cpro, leader peptidase nisp, leader peptidase b, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Eukaryotic signal peptidase
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-
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Eukaryotic signal proteinase
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L proteinase
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-
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Leader peptidase
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-
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Leader peptide hydrolase
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-
-
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Leader proteinase
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-
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Lpro
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-
-
-
Peptidase, signal
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-
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Prokaryotic leader peptidase
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-
-
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Prokaryotic signal peptidase
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-
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Prokaryotic signal proteinase
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-
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Propeptidase
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-
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Proteinase, eukaryotic signal
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-
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Proteinase, signal
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Signal peptidase
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Signalase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
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-
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CAS REGISTRY NUMBER
COMMENTARY hide
934238-57-0
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2S,3R,4R)-2-{[2-(2,3-dihydroxyphenyl)-5,8-dihydroxy-4-oxo-4H-chromen-7-yl]oxy}-4-hydroxy-4-(hydroxymethyl)tetrahydrofuran-3-yl alpha-D-galactopyranoside
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2-(3,4-dihydroxyphenyl)ethyl 4-O-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]-6-O-alpha-L-lyxopyranosyl-beta-D-glucopyranoside
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
the inhibition of LepB results in repressing the cleavage of the signal peptide from the preproteins which would lead to arresting the folding of proteins which are essential for the growth and pathogenesis of Mycobacterium tuberculosis into their active mature conformation
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dhiman, H.; Dhanjal, J.K.; Sharma, S.; Chacko, S.; Grover, S.; Grover, A.
Resisting resistant Mycobacterium tuberculosis naturally: mechanistic insights into the inhibition of the parasites sole signal peptidase Leader peptidase B
Biochem. Biophys. Res. Commun.
433
552-557
2013
Mycobacterium tuberculosis (P9WKA1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WKA1)
Manually annotated by BRENDA team