Information on EC 3.4.22.43 - cathepsin V and Organism(s) Homo sapiens and UniProt Accession P07711

specific inhibition of elastolytic activity, formation of specific complexes with the enzyme, no inhibition of the activity with Z-Phe-Arg-4-methyl-7-coumaryl amide

669257

chymostatin

Homo sapiens

-

citibrasine

-

citrusinine-I

-

citrusinine-II

-

clitocypin

-

-

cystatin

2 entries

-

cystatin C

Homo sapiens

O60911

endogenous inhibitor of cathepsin V analyzed, expression of cystatin C increased in stenotic valves, cystatin C protein particularly found in areas with infiltrates of inflammatory cells

683107

-

cystatin M/E

4 entries

-

cystatins

Homo sapiens

-

668763

-

E-64

3 entries

fragment p41 of major histocompatibility complex class II-associated invariant chain

Homo sapiens

-

inhibitory to human cathepsin V, cathepsin L, cathepsin K, cathepsin F with Ki values in the low nanomolar range. Ki values are sufficiently low to ensure complex formation at physiological concentrations. Regulation of the proteolytic activity of most of the cysteine cathepsins by the p41 fragment is an important and widespread control mechanism of antigen presentation

698753

-

glycocitrine-I

-

glycocitrine-IV

-

iodoacetic acid

-

leupeptin

macrocypin-1

-

-

morpholineurea-leucyl-homophenylalanine-vinylsulfone phenyl

Homo sapiens

-

669257

morpholineurea-naphthyl-homophenylalanine-vinylsulfone naphthyl

Homo sapiens

-

669257

-

N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide

2 entries

peptidl vinyl sulfones

Homo sapiens

-

668763

-

pyranofoline

-

saquinavir

SQV, the HIV protease inhibitor Inhibits the interaction between cathepsin V and the TLR4-MyD88 receptor complex, also blocks disulfide HMGB1-induced TLR4 activation

754753

serpin

Homo sapiens

O60911

cofactors fine tuning serpin activity in the extracellular milieu analyzed, DNA accelerate the rate at which the model serpin MENT inhibit cathepsin V up to 50-fold, primarily effected via the protease and secondarily by the recruitment of the DNA as a template onto which cathepsin V and MENT are bound, altered substrate turnover and conformational change within the protease observed, enzyme concentration constant at 0.1 nM, serpin concentration varying between 0.5 and 60 nM with a maximum of 5 nM serpin in the presence of DNA

683662

-

STO33438

Homo sapiens

O60911

334, a mammalian protease inhibitor, inhibits cathepsin V, also blocks disulfide HMGB1-induced TLR4 activation

754753

trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane

2 entries

VBY-825

Homo sapiens

-

reversible cathepsin inhibitor with high potency against cathepsins V

707590

additional information

2 entries

-

additional information

Homo sapiens

O60911

the recombinant proenzyme is autocatalytically activated in vitro by incubation at pH 4.0 and 30°C

732867

-

0.0016

2-aminobenzoyl-ALRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

recombinant enzyme, pH 5.5, 37°C

667305

0.0017

2-aminobenzoyl-EE-epsilon-amino-caproic acid-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

recombinant enzyme, pH 5.5, 37°C

667305

0.002

2-aminobenzoyl-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

recombinant enzyme, pH 5.5, 37°C

667305

0.0008

2-aminobenzoyl-KK-epsilon-amino-caproic acid-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

recombinant enzyme, pH 5.5, 37°C

667305

0.0006

2-aminobenzoyl-KLRSIKQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

recombinant enzyme, pH 5.5, 37°C

667305

0.0012

2-aminobenzoyl-KLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

recombinant enzyme, pH 5.5, 37°C

667305

0.0006

2-aminobenzoyl-KLRVSKQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

recombinant enzyme, pH 5.5, 37°C

667305

0.0044

benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin

Homo sapiens

O60911

in 0.1 M sodium acetate buffer pH 5.5 containing 2.5 mM dithiothreitol and 1 mM EDTA, at 25°C

732867

0.0024

benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin

Homo sapiens

O60911

in 0.1 M sodium acetate buffer pH 5.5 containing 2.5 mM dithiothreitol and 1 mM EDTA, at 25°C

732867

0.0041 - 0.0048

Z-Phe-Arg-4-methyl-7-coumaryl amide

2 entries

additional information

3 entries

-

4

2-aminobenzoyl-ALRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

recombinant enzyme, pH 5.5, 37°C

667305

1.3

2-aminobenzoyl-EE-epsilon-amino-caproic acid-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

recombinant enzyme, pH 5.5, 37°C

667305

0.6

2-aminobenzoyl-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

recombinant enzyme, pH 5.5, 37°C

667305

1.7

2-aminobenzoyl-KK-epsilon-amino-caproic acid-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

recombinant enzyme, pH 5.5, 37°C

667305

1.5

2-aminobenzoyl-KLRSIKQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

recombinant enzyme, pH 5.5, 37°C

667305

1.3

2-aminobenzoyl-KLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

recombinant enzyme, pH 5.5, 37°C

667305

0.9

2-aminobenzoyl-KLRVSKQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

recombinant enzyme, pH 5.5, 37°C

667305

156

benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin

Homo sapiens

O60911

in 0.1 M sodium acetate buffer pH 5.5 containing 2.5 mM dithiothreitol and 1 mM EDTA, at 25°C

732867

19

benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin

Homo sapiens

O60911

in 0.1 M sodium acetate buffer pH 5.5 containing 2.5 mM dithiothreitol and 1 mM EDTA, at 25°C

732867

3.4 - 3.7

Z-Phe-Arg-4-methyl-7-coumaryl amide

2 entries

additional information

3 entries

-

496

2-aminobenzoyl-KPPVVLLPDQ-N-[2,4-dinitrophenyl]ethylenediamine

Homo sapiens

-

at 37°C, in 0.1 M sodium acetate buffer, pH 5.5

707626

903

2-aminobenzoyl-KPVSTEQLAQ-N-[2,4-dinitrophenyl]ethylenediamine

Homo sapiens

-

at 37°C, in 0.1 M sodium acetate buffer, pH 5.5

707626

4528

2-aminobenzoyl-LFEKQ-N-[2,4-dinitrophenyl]ethylenediamine

Homo sapiens

-

at 37°C, in 0.1 M sodium acetate buffer, pH 5.5

707626

3055

2-aminobenzoyl-VLFEKKQ-N-[2,4-dinitrophenyl]ethylenediamine

Homo sapiens

-

at 37°C, in 0.1 M sodium acetate buffer, pH 5.5

707626

6833

2-aminobenzoyl-VLFEKKVYLQ-N-[2,4-dinitrophenyl]ethylenediamine

Homo sapiens

-

at 37°C, pH 5.5

707626

4277

2-aminobenzoyl-VLFEKQ-N-[2,4-dinitrophenyl]ethylenediamine

Homo sapiens

-

at 37°C, in 0.1 M sodium acetate buffer, pH 5.5

707626

35000

benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin

Homo sapiens

O60911

in 0.1 M sodium acetate buffer pH 5.5 containing 2.5 mM dithiothreitol and 1 mM EDTA, at 25°C

732867

7900

benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin

Homo sapiens

O60911

in 0.1 M sodium acetate buffer pH 5.5 containing 2.5 mM dithiothreitol and 1 mM EDTA, at 25°C

732867

0.0012

1,3,5-trihydroxy-2,8-bis(3-methylbut-2-enyl)-10-methyl-9-acridone

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.0005

1,3,5-trihydroxy-4-methoxy-10-methyl-2,8-bis(3-methylbut-2-enyl)acridin-9(10H)-one

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.0044

2,3-dihydro-4,9-dihydroxy-2-(2-hydroxy-propan-2-yl)-11-methoxy-10-methylfuro[3,2-b]acridin-5(10H)-one

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.0017

3,4-dihydro-3,5,8-trihydroxy-6-methoxy-2,2,7-trimethyl-2H-pyrano[2,3-a]acridin-12(7H)-one

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.0102

cathepsin V propeptide

Homo sapiens

O60911

varying concentrations tested

683207

-

0.0002

citibrasine

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.001

citrusinine-I

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.0042

citrusinine-II

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.00000008

clitocypin

Homo sapiens

O60911

pH and temperature not specified in the publication

709133

-

0.00000047

cystatin M/E

Homo sapiens

-

pH and temperature not specified in the publication

709405

-

0.0000000072

fragment p41 of major histocompatibility complex class II-associated invariant chain

Homo sapiens

-

pH 6.0, 25°C

698753

-

0.01

glycocitrine-I

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.0011

glycocitrine-IV

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.00000069

macrocypin-1

Homo sapiens

O60911

pH and temperature not specified in the publication

709133

-

0.00000034

mutant N64A cystatin M/E

Homo sapiens

-

pH 5.5, 22°C

669460

-

0.00000025

VBY-825

Homo sapiens

-

apparent value, in 50 mM MES pH 6.5, 2.5 mM DTT, 2.5 mM EDTA, 100 mM NaCl, 0.01% (w/v) bovine serum albumin, and 10% (v/v) DMSO, at 25°C

707590

0.00000047

wild-type cystatin M/E

Homo sapiens

-

pH 5.5, 22°C

669460

-

0.024

4-fluoro-N-prop-2-yn-1-yl-N2-[(1S)-2,2,2-trifluoro-1-[4'-(methanesulfonyl)[1,1'-biphenyl]-4-yl]ethyl]-L-leucinamide

Homo sapiens

P07711

50 mM MES pH 5.5, 25 mM EDTA and 2.5 mM DTT. 0.05% Tween 20 (v/v), 37°C

753977

0.000016

N-(3-bromoprop-2-yn-1-yl)-4-fluoro-N2-[(1S)-2,2,2-trifluoro-1-[4'-(methanesulfonyl)[1,1'-biphenyl]-4-yl]ethyl]-L-leucinamide

Homo sapiens

P07711

50 mM MES pH 5.5, 25 mM EDTA and 2.5 mM DTT. 0.05% Tween 20 (v/v), 37°C

753977

0.00091

N-(cyanomethyl)-4-fluoro-N2-[(1S)-2,2,2-trifluoro-1-[4'-(methanesulfonyl)[1,1'-biphenyl]-4-yl]ethyl]-L-leucinamide

Homo sapiens

P07711

50 mM MES pH 5.5, 25 mM EDTA and 2.5 mM DTT. 0.05% Tween 20 (v/v), 37°C

753977

0.046

N-but-3-yn-2-yl-4-fluoro-N2-[(1S)-2,2,2-trifluoro-1-[4'-(methanesulfonyl)[1,1'-biphenyl]-4-yl]ethyl]-L-leucinamide

Homo sapiens

P07711

50 mM MES pH 5.5, 25 mM EDTA and 2.5 mM DTT. 0.05% Tween 20 (v/v), 37°C

753977

0.0006

odanacatib

Homo sapiens

P07711

50 mM MES pH 5.5, 25 mM EDTA and 2.5 mM DTT. 0.05% Tween 20 (v/v), 37°C

753977

0.0039

1,3,5-trihydroxy-2,8-bis(3-methylbut-2-enyl)-10-methyl-9-acridone

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.0025

1,3,5-trihydroxy-4-methoxy-10-methyl-2,8-bis(3-methylbut-2-enyl)acridin-9(10H)-one

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.0052

2,3-dihydro-4,9-dihydroxy-2-(2-hydroxy-propan-2-yl)-11-methoxy-10-methylfuro[3,2-b]acridin-5(10H)-one

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.0028

3,4-dihydro-3,5,8-trihydroxy-6-methoxy-2,2,7-trimethyl-2H-pyrano[2,3-a]acridin-12(7H)-one

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.048

5-hydroxynoracronycine

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.0012

citibrasine

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.0022

citrusinine-I

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.01

citrusinine-II

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.025

glycocitrine-I

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.0022

glycocitrine-IV

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

0.044

pyranofoline

Homo sapiens

-

in 100 mM sodium acetate buffer (pH 5.5) containing 5 mM EDTA and 5 mM dithioerythritol, at 27°C

717374

additional information

5.5

5.5 - 6

-

5.5 - 6.5

-

assay at

5.7

-

6.5

plasminogen digestion assay at

683210

4 - 6

Homo sapiens

-

cathepsin V is active at pH 4.0 and 6.0

717159

4 - 7.2

Homo sapiens

O60911

less than 50% of maximal activity above and below

137269

additional information

Homo sapiens

-

bell-shaped pH profile

668763

22

Homo sapiens

-

assay at room temperature

669460

25

Homo sapiens

-

assay at

37

-

UniProt

expression in aorta valve, control valves and stenotic valves analyzed

cathepsin V localized to endothelial cells in areas rich of neovascularization

683107

aortic endothelial cell

-

-

-

-

breast adenocarcinoma cell

Homo sapiens

-

ZR-75-1, Hs-578T, MDA-MB435

137271

bronchoalveolar lavage fluid

Homo sapiens

O60911

from healthy subjects and Besnier-Boeck-Schaumann (BBS) disease patients, the latter show decreased cathepsin V concentrations, while contents of endostatin, an inhibitor of lung epithelial cells, are increased

-

-

-

-

colorectal cancer cell

Homo sapiens

O60911

-

732591

commercial preparation

Homo sapiens

O60911

recombinant human cathepsin V for inhibition studies, N-terminal propeptide domains as inhibitors of cathepsin V

683207

cornea

3 entries

endometrial cancer cell

-

-

-

-

-

thymic and corneal

-

-

-

-

-

-

-

-

-

-

-

-

-

-

pancreatic islet cancer cell

-

-

-

-

-

-

-

-

-

in the human thymic cortex, CTSV is the predominately expressed protease

-

-

-

additional information

3 entries

extracellular

Homo sapiens

-

the enzyme is secreted

-

-

cathepsin V is located on the outside of the nucleus

-

malfunction

metabolism

physiological function

7 entries

P07711 pBLAST

CATL1_HUMAN

Homo sapiens

333

0

37564

Swiss-Prot

Show Sequence

-

23000

Homo sapiens

-

x * 23000, nonglycosylated form, SDS-PAGE

717159

23999

Homo sapiens

-

2 * 23999, amino acid sequence calculation of the mature enzyme, 2 * 31000, recombinant mature enzyme from insect cells and Pichia pastoris, 2 * 38000-45000, recombinant proenzyme from Pichi pastoris

668763

24000

2 entries

31000

Homo sapiens

-

2 * 23999, amino acid sequence calculation of the mature enzyme, 2 * 31000, recombinant mature enzyme from insect cells and Pichia pastoris, 2 * 38000-45000, recombinant proenzyme from Pichi pastoris

668763

35000

2 entries

35500

Homo sapiens

-

proprotein, SDS-PAGE

37000

37330

preproprotein, containing a 17 amino acid signal peptide, a 96 amino acid propeptide and a 221 amino acid mature region, calculation from sequence of cDNA

137269

39000

Homo sapiens

-

glycosylated enzyme form, SDS-PAGE

137270

41000

Homo sapiens

-

glycosylated enzyme form, SDS-PAGE

137270

52000

Homo sapiens

-

recombinant GST-tagged enzyme

668763

?

5 entries

dimer

Homo sapiens

-

2 * 23999, amino acid sequence calculation of the mature enzyme, 2 * 31000, recombinant mature enzyme from insect cells and Pichia pastoris, 2 * 38000-45000, recombinant proenzyme from Pichi pastoris

668763

additional information

Homo sapiens

-

three-dimensional two-domain structure analysis at 1.6 A resolution, overview

668763

glycoprotein

4 entries

proteolytic modification

2 entries

cathepsin V in complex with clitocypin, vapor diffusion method, using 0.4 M Li2SO4, 12% (w/v) polyethylene glycol 800, 20% (v/v) glycerol

Homo sapiens

O60911

709133

molecular modeling of complex with fragment p41 of major histocompatibility complex class II-associated invariant chain

Homo sapiens

-

698753

space group P6422, crystal structure at 1.6 A resolution

Homo sapiens

-

137272

additional information

6 entries

4.5 - 5.5

Homo sapiens

-

very stable

668763

5.5

2 entries

6.5

Homo sapiens

O60911

2 h, residual acitviy

137269

7

Homo sapiens

O60911

1 h, residual acitviy

137269

additional information

Homo sapiens

-

rapid loss of activity at neutral pH

668763

37

Homo sapiens

-

pH 5.5, loss of 60% activity within 20 min

669257

-

Homo sapiens

-

137272

gel filtration, pre-activated before use

Homo sapiens

O60911

683662

gel filtration, recombinant human cathepsin V

Homo sapiens

O60911

683210

Ni-NTA column chromatography

Homo sapiens

O60911

732867

recombinant enzyme from Pichia pastoris to homogeneity, activated mature native enzyme by hyrophobic interaction chromatography, recombinant GST-tagged enzyme from Escherichia coli by glutathione affinity chromatography

Homo sapiens

-

668763

recombinant enzyme from Pichia pastoris, further purified by gel filtration after activation by pepsin treatment

-

-

-

cathepsin V with mutated glycosylation site is expressed in Pichia pastoris

Homo sapiens

-

717159

expressed in Escherichia coli

Homo sapiens

O60911

683207

expressed in Pichia pastoris

2 entries

expressed in thymus of transgenic Mus musculus

Homo sapiens

-

707591

expression in Escherichia coli

Homo sapiens

-

137271

expression in Pichia pastoris

2 entries

from cDNA libraries, the gene maps to chromosome 9q21, DNA and amino acid sequence determination and analysis, genomic organization, expression in insect cells using the baculovirus system, in Pichia pastoris, and as GST-tagged enzyme with low activity in Escherichia coli

Homo sapiens

-

668763

gene CTSV, real-time PCR enzyme expression analysis

Homo sapiens

O60911

753117

human cathepsins V expressed in Pichia pastoris

Homo sapiens

O60911

683662

recombinant human cathepsin V produced using the Pichia pastoris expression system

Homo sapiens

O60911

683210

recombinant procathepsin V is expressed in soluble form in the cytoplasm of Escherichia coli Rosetta-gami B (DE3) pLysS cells

Homo sapiens

O60911

732867

transgenic expression in cathepsin L-deficient mice, phylogenetic tree

Homo sapiens

-

668472

CTSL2 transcript levels are strongly elevated in endometrial cancer, particularly in G3 tumors

Homo sapiens

O60911

731573

E2F1 activates cathepsin like 2 gene promoter activity

Homo sapiens

O60911

732591

L-homocysteine induces cathepsin V expression, L-homocysteine promoted cathepsin V expression in HUVECs. Methylation of the promoter region of cathepsin V is decreased following L-Hcy stimulation

Homo sapiens

O60911

753117

siRNA-cathepsin V inhibits the up-regulation of cathepsin V-induced by L-homocysteine

Homo sapiens

O60911

753117

there is decreased expression of cathepsin V in lesional atopic dermatitis and psoriasis epidermis at the mRNA level as well as the protein level

Homo sapiens

-

707906

tissue necrosis factor alpha increases cathepsin V expression and activity by 2fold. Tissue necrosis factor alpha and co-culturing with THP-1 monocytes stimulates a 460% increase in cathepsin V active enzyme

diagnostics

-

the enzyme is a potential marker for certain colon tumors and breast cancer

668763

medicine

2 entries

137269

Br�mme, D.; Li, Z.; Barnes, M.; Mehler, E.

Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization

Biochemistry

38

2377-2385

1999

Homo sapiens (O60911), Homo sapiens

10029531

137270

Adachi, W.; Kawamoto, S.; Ohno, I.; Nishida, K.; Kinoshita, S.; Matsubara, K.; Okubo, K.

Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium

Invest. Ophthalmol. Vis. Sci.

39

1789-1796

1998

Homo sapiens

9727401

137271

Santamaria, I.; Velasco, G.; Cazorla, M.; Fueyo, A.; Campo, E.; Lopez-Otin, C.

Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas

Cancer Res.

58

1624-1630

1998

Homo sapiens

9563472

137272

Somoza, J.R.; Zhan, H.; Bowman, K.K.; Yu, L.; Mortara, K.D.; Palmer, J.T.; Clark, J.M.; McGrath, M.E.

Crystal structure of human cathepsin V

Biochemistry

39

12543-12551

2000

Homo sapiens

11027133

667305

Puzer, L.; Cotrin, S.S.; Alves, M.F.; Egborge, T.; Araujo, M.S.; Juliano, M.A.; Juliano, L.; Broemme, D.; Carmona, A.K.

Comparative substrate specificity analysis of recombinant human cathepsin V and cathepsin L

Arch. Biochem. Biophys.

430

274-283

2004

Homo sapiens

15369827

668472

Hagemann, S.; Guenther, T.; Dennemaerker, J.; Lohmueller, T.; Broemme, D.; Schuele, R.; Peters, C.; Reinheckel, T.

The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles

Eur. J. Cell Biol.

83

775-780

2004

Homo sapiens

15679121

668763

Broemme, D.

Cathepsin V

Handbook of Proteolytic Enzymes (Barrett, A.J., Rawlings, N.D., Woessner, J.F., eds)

2nd Ed.

1107-1109

2004

Homo sapiens

-

669009

Kenney, M.C.; Chwa, M.; Atilano, S.R.; Tran, A.; Carballo, M.; Saghizadeh, M.; Vasiliou, V.; Adachi, W.; Brown, D.J.

Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder

Invest. Ophthalmol. Vis. Sci.

46

823-832

2005

Homo sapiens

15728537

669257

Yasuda, Y.; Li, Z.; Greenbaum, D.; Bogyo, M.; Weber, E.; Broemme, D.

Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages

J. Biol. Chem.

279

36761-36770

2004

Homo sapiens

15192101

669460

Cheng, T.; Hitomi, K.; van Vlijmen-Willems, I.M.; de Jongh, G.J.; Yamamoto, K.; Nishi, K.; Watts, C.; Reinheckel, T.; Schalkwijk, J.; Zeeuwen, P.L.

Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification

J. Biol. Chem.

281

15893-15899

2006

Homo sapiens

16565075

669754

Zeeuwen, P.L.; Ishida-Yamamoto, A.; van Vlijmen-Willems, I.M.; Cheng, T.; Bergers, M.; Iizuka, H.; Schalkwijk, J.

Colocalization of cystatin M/E and cathepsin V in lamellar granules and corneodesmosomes suggests a functional role in epidermal differentiation

J. Invest. Dermatol.

127

120-128

2006

Homo sapiens

16874311

683107

Helske, S.; Syvaeranta, S.; Lindstedt, K.A.; Lappalainen, J.; Oeoerni, K.; Maeyraenpaeae, M.I.; Lommi, J.; Turto, H.; Werkkala, K.; Kupari, M.; Kovanen, P.T.

Increased Expression of Elastolytic Cathepsins S, K, and V and Their Inhibitor Cystatin C in Stenotic Aortic Valves

Arterioscler. Thromb. Vasc. Biol.

26

1791-1798

2006

Homo sapiens (O60911)

16728655

683207

Burden, R.E.; Snoddy, P.; Jefferies, C.A.; Walker, B.; Scott, C.J.

Inhibition of cathepsin L-like proteases by cathepsin V propeptide

Biol. Chem.

388

541-545

2007

Homo sapiens (O60911)

17516850

683210

Puzer, L.; Barros, N.M.; Paschoalin, T.; Hirata, I.Y.; Tanaka, A.S.; Oliveira, M.C.; Broemme, D.; Carmona, A.K.

Cathepsin V, but not cathepsins L, B and K, may release angiostatin-like fragments from plasminogen

Biol. Chem.

389

195-200

2008

Homo sapiens (O60911), Homo sapiens

18163891

683662

Ong, P.C.; McGowan, S.; Pearce, M.C.; Irving, J.A.; Kan, W.T.; Grigoryev, S.A.; Turk, B.; Silverman, G.A.; Brix, K.; Bottomley, S.P.; Whisstock, J.C.; Pike, R.N.

DNA accelerates the inhibition of human cathepsin V by serpins

J. Biol. Chem.

282

36980-36986

2007

Homo sapiens (O60911), Homo sapiens

17923478

698753

Mihelic, M.; Dobersek, A.; Guncar, G.; Turk, D.

Inhibitory fragment from the p41 form of invariant chain can regulate activity of cysteine cathepsins in antigen presentation

J. Biol. Chem.

283

14453-14460

2008

Homo sapiens

18362148

707590

Elie, B.T.; Gocheva, V.; Shree, T.; Dalrymple, S.A.; Holsinger, L.J.; Joyce, J.A.

Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model

Biochimie

92

1618-1624

2010

Homo sapiens

20447439

707591

Sevenich, L.; Hagemann, S.; Stoeckle, C.; Tolosa, E.; Peters, C.; Reinheckel, T.

Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice

Biochimie

92

1674-1680

2010

Homo sapiens

20347002

707626

Coppini, L.P.; Barros, N.M.; Oliveira, M.; Hirata, I.Y.; Alves, M.F.; Paschoalin, T.; Assis, D.M.; Juliano, M.A.; Puzer, L.; Broemme, D.; Carmona, A.K.

Plasminogen hydrolysis by cathepsin S and identification of derived peptides as selective substrate for cathepsin V and cathepsin L inhibitor

Biol. Chem.

391

561-570

2010

Homo sapiens

20302511

707906

Cheng, T.; Tjabringa, G.S.; van Vlijmen-Willems, I.M.; Hitomi, K.; van Erp, P.E.; Schalkwijk, J.; Zeeuwen, P.L.

The cystatin M/E-controlled pathway of skin barrier formation: expression of its key components in psoriasis and atopic dermatitis

Br. J. Dermatol.

161

253-264

2009

Homo sapiens

19438477

709133

Renko, M.; Sabotic, J.; Mihelic, M.; Brzin, J.; Kos, J.; Turk, D.

Versatile loops in mycocypins inhibit three protease families

J. Biol. Chem.

285

308-316

2010

Homo sapiens (O60911)

19846555

709405

Zeeuwen, P.L.; Cheng, T.; Schalkwijk, J.

The biology of cystatin M/E and its cognate target proteases

J. Invest. Dermatol.

129

1327-1338

2009

Homo sapiens

19262604

717159

Wilder, C.L.; Park, K.Y.; Keegan, P.M.; Platt, M.O.

Manipulating substrate and pH in zymography protocols selectively distinguishes cathepsins K, L, S, and V activity in cells and tissues

Arch. Biochem. Biophys.

516

52-57

2011

Homo sapiens

21982919

717374

Severino, R.P.; Guido, R.V.; Marques, E.F.; Broemme, D.; da Silva, M.F.; Fernandes, J.B.; Andricopulo, A.D.; Vieira, P.C.

Acridone alkaloids as potent inhibitors of cathepsin V

Bioorg. Med. Chem.

19

1477-1481

2011

Homo sapiens

21277783

717375

Piovan, L.; Alves, M.F.; Juliano, L.; Broemme, D.; Cunha, R.L.; Andrade, L.H.

Structure-activity relationships of hypervalent organochalcogenanes as inhibitors of cysteine cathepsins V and S

Bioorg. Med. Chem.

19

2009-2014

2011

Homo sapiens

21345684

731573

Skrzypczak, M.; Springwald, A.; Lattrich, C.; Haering, J.; Schueler, S.; Ortmann, O.; Treeck, O.

Expression of cysteine protease cathepsin L is increased in endometrial cancer and correlates with expression of growth regulatory genes

Cancer Invest.

30

398-403

2012

Homo sapiens (O60911), Homo sapiens

22452389

732049

Funkelstein, L.; Lu, W.D.; Koch, B.; Mosier, C.; Toneff, T.; Taupenot, L.; O'Connor, D.T.; Reinheckel, T.; Peters, C.; Hook, V.

Human cathepsin V protease participates in production of enkephalin and NPY neuropeptide neurotransmitters

J. Biol. Chem.

287

15232-15241

2012

Homo sapiens (O60911), Homo sapiens

22393040

732502

Keegan, P.M.; Wilder, C.L.; Platt, M.O.

Tumor necrosis factor alpha stimulates cathepsin K and V activity via juxtacrine monocyte-endothelial cell signaling and JNK activation

Mol. Cell. Biochem.

367

65-72

2012

Homo sapiens (O60911), Homo sapiens

22562303

732591

Wong, C.H.; Wu, Z.; Yu, Q.

CTSL2 is a pro-apoptotic target of E2F1 and a modulator of histone deacetylase inhibitor and DNA damage-induced apoptosis

Oncogene

33

1249-1257

2014

Homo sapiens (O60911), Homo sapiens

23542171

732867

Novinec, M.; Pavsic, M.; Lenarcic, B.

A simple and efficient protocol for the production of recombinant cathepsin V and other cysteine cathepsins in soluble form in Escherichia coli

Protein Expr. Purif.

82

1-5

2012

Homo sapiens (O60911)

22100277

752418

Naumnik, W.; Ossolinska, M.; Plonska, I.; Chyczewska, E.; Niklinski, J.

Endostatin and cathepsin-V in bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis

Adv. Exp. Med. Biol.

833

55-61

2015

Homo sapiens (O60911), Homo sapiens

25252891

752678

Homma, T.; Kageyama, S.; Nishikawa, A.; Nagata, K.

Melanosome degradation in epidermal keratinocytes related to lysosomal protease cathepsin V

Biochem. Biophys. Res. Commun.

500

339-343

2018

Homo sapiens (O60911)

29654760

753117

Leng, Y.P.; Ma, Y.S.; Li, X.G.; Chen, R.F.; Zeng, P.Y.; Li, X.H.; Qiu, C.F.; Li, Y.P.; Zhang, Z.; Chen, A.F.

L-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia

Br. J. Pharmacol.

175

1157-1172

2018

Homo sapiens (O60911), Homo sapiens

28631302

753828

Huang, K.; Gao, L.; Yang, M.; Wang, J.; Wang, Z.; Wang, L.; Wang, G.; Li, H.

Exogenous cathepsin V protein protects human cardiomyocytes HCM from angiotensin II-induced hypertrophy

Int. J. Biochem. Cell Biol.

89

6-15

2017

Homo sapiens (O60911), Homo sapiens

28522343

753977

Mons, E.; Jansen, I.D.C.; Loboda, J.; van Doodewaerd, B.R.; Hermans, J.; Verdoes, M.; van Boeckel, C.A.A.; van Veelen, P.A.; Turk, B.; Turk, D.; Ovaa, H.

The Alkyne moiety as a latent electrophile in irreversible covalent small molecule inhibitors of cathepsin K

J. Am. Chem. Soc.

141

3507-3514

2019

Homo sapiens (P07711)

30689386

754753

Pribis, J.P.; Al-Abed, Y.; Yang, H.; Gero, D.; Xu, H.; Montenegro, M.F.; Bauer, E.M.; Kim, S.; Chavan, S.S.; Cai, C.; Li, T.; Szoleczky, P.; Szabo, C.; Tracey, K.J.; Billiar, T.R.

The HIV protease inhibitor saquinavir inhibits HMGB1-driven inflammation by targeting the interaction of cathepsin V with TLR4/MyD88

Mol. Med.

21

749-757

2015

Homo sapiens (O60911), Homo sapiens

26349060

ExplorEnz (official portal for IUBMB Enzyme Nomenclature)

Expasy Enzyme Nomenclature Database

KEGG

MetaCyc

SABIO-RK

NCBI: PubMed, Protein, Nucleotide, Structure, Gene, OMIM

Enzyme Nomenclature (alternative site)

UniProt

PDB

PROSITE Database of protein families and domains

InterPro (database of protein families, domains and functional sites)