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Information on EC 3.4.22.38 - cathepsin K and Organism(s) Mus musculus and UniProt Accession P55097
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3.4.22.38 cathepsin KSpecify your search results
Word Map
- 3.4.22.38
- resorption
- osteoporosis
-
osteoclastogenesis
- rankl
-
tartrate-resistant
- osteoblast
- collagen
- nfatc1
-
rankl-induced
-
multinucleated
- mmp-9
- c-fos
-
fracture
-
trabecular
- pi
- calcitonin
- osteocalcin
- osteoprotegerin
-
osteolytic
-
resorb
- m-csf
-
collagenolytic
- bisphosphonates
-
osteoclast-mediated
-
trap-positive
-
osteoclast-specific
- odanacatib
- oscar
-
antiresorptive
- tracp
- lacuna
-
ovariectomy-induced
-
rankl-mediated
-
dc-stamp
-
bone-resorbing
-
sclerostin
-
osteoclast-related
-
telopeptide
-
osteoclast-like
-
osteoclastogenic
-
denosumab
-
preosteoclasts
-
teriparatide
- pharmacology
-
anti-osteoclastogenic
- osteosclerosis
-
anti-osteoporotic
- atp6v0d2
- medicine
-
ranelate
- drug development
-
deoxypyridinoline
-
rankl-stimulated
- diagnostics
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
cathepsin k, cathepsin-k, cat k, cath k, cat-k, cathepsin o2, oc-2 protein, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Cathepsin O2
-
-
-
-
OC-2 protein
-
-
-
-
rhCK
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
94716-09-3
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Benzyloxycarbonyl-Leu-Arg 4-methoxy-2-naphthylamide + H2O
Benzyloxycarbonyl-Leu-Arg + 4-methoxy-2-naphthylamine
-
-
-
-
?
Benzyloxycarbonyl-Leu-Arg 4-methylcoumarin 7-amide + H2O
Benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
carbobenzyloxy-Leu-Arg-4-methoxy-2-naphthylamide + H2O
carbobenzyloxy-Leu-Arg + 4-methoxy-2-naphthylamine
-
-
-
-
?
collagen I + H2O
?
-
cathepsin K inhibition by cathepsin K inhibitor significantly increases the bone mineral density and the bone volume of the primary and secondary spongiosa, with a reduction of the urinary C-telopeptide of type I collagen that is increased by ovariectomized surgery compared to sham surgery, respectively, overview
-
-
?
collagen I + H2O
?
-
cathepsin K is responsible for the degradation of type I collagen in osteoclast-mediated bone resorption. Cathepsin K interaction with type I collagen is required for 1. the release of cryptic Arg-Gly-Asp motifs during the initial attachment of osteoclasts and 2. termination of resorption via the creation of autocrine signals originating from type I collagen degradation, overview
-
-
?
collagen I + H2O
?
-
cathepsin K regulates adipocyte differentiation, possible involvement of type I collagen degradation and regulation of collagen type I expression, molecular mechanism, overview
-
-
?
collagen I + H2O
?
-
CatK is a cysteine protease expressed predominantly in osteoclastsosteoclasts, that plays a prominent role in degrading type I collagen. Growing CatK null mice have osteopetrosis associated with a reduced ability to degrade bone matrix
-
-
?
collagen I + H2O
?
-
inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice, overview
-
-
?
collagen I + H2O
?
-
osteoclasts degrade bone matrix by demineralization followed by degradation of type I collagen through secretion of the cysteine protease, cathepsin K
-
-
?
kinin + H2O
?
-
the potency of cathepsin K to modulate bradikinin-dependent contraction of smooth muscles, cathepsin K may act as a kininase
-
-
?
additional information
?
-
-
cathepsin K plays a role in collagen degradation
-
-
?
additional information
?
-
-
2-aminobenzoyl-RP-PGFSPFR-(3-nitrotyrosine) is not cleaved by the mutant enzyme Y67L/L205A
-
-
?
additional information
?
-
-
absence of leucocyte CatK results in dramatically decreased collagen and increased macrophage content of the atherosclerotic lesions while lesion size is not affected
-
-
?
additional information
?
-
-
Cat K plays a key role in matrix degradation during bone resorption
-
-
?
additional information
?
-
-
cathepsin K plays a role in bone tissue development as well as skeletal remodeling, overview
-
-
?
additional information
?
-
-
deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism, reducing serum glucose and insulin levels, in mice, selective inhibition of the enzyme in adipose tissue blocks the lipid accumulation in preadipocytes, overview
-
-
?
additional information
?
-
-
media from cells on plastic show higher CatK activation than cells on dentin, consistent with cellular expression of cathepsin K mRNA, 2fold upregulation of cathepsin K mRNA from cells cultured on plastic correlates with increased cathepsin K activation, overview
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
kinin + H2O
?
-
the potency of cathepsin K to modulate bradikinin-dependent contraction of smooth muscles, cathepsin K may act as a kininase
-
-
?
collagen I + H2O
?
-
cathepsin K inhibition by cathepsin K inhibitor significantly increases the bone mineral density and the bone volume of the primary and secondary spongiosa, with a reduction of the urinary C-telopeptide of type I collagen that is increased by ovariectomized surgery compared to sham surgery, respectively, overview
-
-
?
collagen I + H2O
?
-
cathepsin K is responsible for the degradation of type I collagen in osteoclast-mediated bone resorption. Cathepsin K interaction with type I collagen is required for 1. the release of cryptic Arg-Gly-Asp motifs during the initial attachment of osteoclasts and 2. termination of resorption via the creation of autocrine signals originating from type I collagen degradation, overview
-
-
?
collagen I + H2O
?
-
cathepsin K regulates adipocyte differentiation, possible involvement of type I collagen degradation and regulation of collagen type I expression, molecular mechanism, overview
-
-
?
collagen I + H2O
?
-
CatK is a cysteine protease expressed predominantly in osteoclastsosteoclasts, that plays a prominent role in degrading type I collagen. Growing CatK null mice have osteopetrosis associated with a reduced ability to degrade bone matrix
-
-
?
collagen I + H2O
?
-
inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice, overview
-
-
?
collagen I + H2O
?
-
osteoclasts degrade bone matrix by demineralization followed by degradation of type I collagen through secretion of the cysteine protease, cathepsin K
-
-
?
additional information
?
-
-
cathepsin K plays a role in collagen degradation
-
-
?
additional information
?
-
-
absence of leucocyte CatK results in dramatically decreased collagen and increased macrophage content of the atherosclerotic lesions while lesion size is not affected
-
-
?
additional information
?
-
-
Cat K plays a key role in matrix degradation during bone resorption
-
-
?
additional information
?
-
-
cathepsin K plays a role in bone tissue development as well as skeletal remodeling, overview
-
-
?
additional information
?
-
-
deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism, reducing serum glucose and insulin levels, in mice, selective inhibition of the enzyme in adipose tissue blocks the lipid accumulation in preadipocytes, overview
-
-
?
additional information
?
-
-
media from cells on plastic show higher CatK activation than cells on dentin, consistent with cellular expression of cathepsin K mRNA, 2fold upregulation of cathepsin K mRNA from cells cultured on plastic correlates with increased cathepsin K activation, overview
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
N'-cyano-N,N',4-trimethyl-2-(4'-(methylsulfonyl)-[1,1'-biphenyl]-3-yl)pentanehydrazide
racemic
N'-cyano-N,N',4-trimethyl-2-(4'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)pentanehydrazide
racemic
benzyl [(2S)-1-{2-[(2-{(2S)-2-[(2-amino-3-phenylpropanoyl)amino]-4-methylpentanoyl}hydrazinyl)carbonyl]hydrazinyl}-4-methyl-1-oxopentan-2-yl]carbamate
-
-
dibenzyl [(2-oxopropane-1,3-diyl)bis{imino[(2S)-4-methyl-1-oxopentane-1,2-diyl]}]biscarbamate
-
-
N-(1-([(cyanomethyl)amino]carbonyl)cyclohexyl)-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide
-
i.e. L-006235 or CRA-013788/L
E-64
-
i.e. epoxysuccinyl-L-leucylamido-{4-guanidino} butane, nonspecific inhibitor
additional information
-
stem bark extracts of Ulmus davidiana, a deciduous tree from Korea and an antiinflammatory in traditional Korean medicine, prevents the osteoclast-mediated intracellular processing of Cat K, suggesting that it may disrupt the intracellular transport of pro Cat K. Ulmus davidiana dose-dependently inhibits in vitro bone resorption with a potency similar to that observed for inhibition of Cat K processing
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.000044
benzyl [(2S)-1-{2-[(2-{(2S)-2-[(2-amino-3-phenylpropanoyl)amino]-4-methylpentanoyl}hydrazinyl)carbonyl]hydrazinyl}-4-methyl-1-oxopentan-2-yl]carbamate
Mus musculus
-
pH and temperature not specified in the publication
0.000296
Boc-Phe-Leu-NHNH-CO-NHNH-Leu-Z
Mus musculus
-
pH and temperature not specified in the publication
0.00426
dibenzyl [(2-oxopropane-1,3-diyl)bis{imino[(2S)-4-methyl-1-oxopentane-1,2-diyl]}]biscarbamate
Mus musculus
-
pH and temperature not specified in the publication
0.000018
Mu-Leu-Hph-fluoromethylketone
Mus musculus
-
pH and temperature not specified in the publication
0.0000024
N-(1-([(cyanomethyl)amino]carbonyl)cyclohexyl)-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide
Mus musculus
-
recombinant cathepsin K
additional information
additional information
Mus musculus
-
Ulmus diviana stem bral extracts show an IC50 of 0.0875 mg/ml
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5.5
6 - 7.4
-
kcat/Km with 2-aminobenzoyl-RPPGFSPFR-(3-nitrotyrosine) is 1.4fold higher at pH 6.0 than at pH 7.4
additional information
-
CatK is a lysosomal cysteine protease that degrades type I collagen at neutral and acidic pH
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
additional information
-
cathepsin K transcripts are highly increased in the lungs after silica treatment compared to cathepsin S, L and B. The upregulation is specific for the fibrotic process
-
qunatitative determination of enzyme content by immunohistochemistry, real time RT-PCR and western blotting
-
cathepsin K is downregulated by the profibrotic growth factor TGF-beta1
-
primary lung fibroblasts derived from CTSK-/- mice show a decreased collagenolytic activity
-
from either wild-type for cathepsin K, CK+/+, heterozygous for cathepsin K, CK+/-, or deficient in cathepsin K, CK-/-, mice, phenotypes, overview
additional information
-
media from cells on plastic show higher CatK activation than cells on dentin, consistent with cellular expression of cathepsin K mRNA, 2fold upregulation of cathepsin K mRNA from cells cultured on plastic correlates with increased cathepsin K activation, overview
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
malfunction
-
catK deficiency has major impact on various vasculopathies, catK deficiency does not protect against aneurysm formation nor does it affect medial elastin breaks, cathepsin K deficiency with angiotensin II infusion increases granulocyte population and activates T cell numbers
malfunction
-
ablation of cathepsin K mitigates injury-induced neointimal hyperplasia. Smooth muscle cell movement is impaired in enzyme-deficient mice. Enzyme inhibition alleviates vascular remodeling. Enzyme deficiency also impairs the smooth muscle cell proliferation ability induced by platelet-derived growth factor-BB. Enzyme deficiency impairs inflammatory action in response to injury
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). CATK_MOUSE
329
0
36889
Swiss-Prot
Secretory Pathway (Reliability: 1)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
proteolytic modification
proteolytic modification
-
processing of the proenzyme for activation involving reentry and delivery of proenzyme into lysosome which is enhanced by mannose-6-phosphate and mediated by the mannose-6-phosphate receptor, overview
proteolytic modification
-
trypsin cleaves at the cathepsin K recognition site activating cathepsin K
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Y67L/L205A
-
2-aminobenzoyl-RP-PGFSPFR-(3-nitrotyrosine) is not cleaved by the the mutant enzyme
additional information
additional information
-
targeted disruption of cathepsin K results in defective Toll-like receptor 9 signaling in dendritic cells in response to unmethylated CpG DNA, which in turn leads to an attenuated induction of T helper 17 cells, without affecting the antigen-presenting ability of dendritic cells
additional information
-
the effects of cathepsin K deficiency (ctsK-/-) on atherosclerotic plaque formation in brachiocephalic arteries in an aggressive atherosclerosis model using apoE-deficient mice on cholate-containing high fat diet is examined. Cathepsin K deficiency appears to increase lesion stability in brachiocephalic arteries by maintaining the integrity of the tunica media and by decreasing plaque vulnerability to rupture
additional information
-
10-week-old male cathepsin K-deficient knockout mice show bones that are mechanically more brittle, while both osteoclasts and osteoblasts show impaired activity relative to the wild type, phenotype with significant hypercalcification of the calcified cartilage and cortices, overview
additional information
-
bone marrow transplantation for selective disruption of CatK in the haematopoietic system, usage of total bone marrow progenitor cells from CatK-/-, CatK-/+, and CatK+/+, and low-density lipoprotein receptor knockout mice. Silencing of leucocyte CatK results in phenotypic changes in bone formation with an increased total bone mineral density in the CatK2/2 chimeras, effect of leucocyte cathepsin K deficiency on bone remodelling, overview
additional information
-
catK-deficient cells show a similar suppression of actin rings as wild-type osteoclasts treated with inhibitor LHVS
additional information
-
construction of male and female wild-type, heterozygous, and homozygous CatK null mice, phenotypes in young mice, bone mass, strength, resorption, and formation, overview. CatK-/- mice show higher bone mineral density at the central and distal femur. Central femur ultimate load is positively influenced by genotype, and is positively correlated with both cortical area and bone mineral content. Lumbar vertebral body ultimate load is also positively correlated to bone mineral content. Genotype does not influence the relationship of ultimate load to bone mineral content in either the central femur or vertebral body
additional information
-
construction of transgenic UTU17 mice, overexpression of cathepsin K accelerates the resorption cycle and osteoblast differentiation in vitro, cathepsin K overexpression enhances osteogenesis and induces the formation of exceptionally small, actively resorbing osteoclasts from their bone marrow precursors in vitro, intracellular mechanisms, overview. The number of cathepsin K-containing vesicles in UTU17+/+ osteoclasts is highly increased
additional information
-
enzyme deficiency leads to blocked adipogenesis in 3T3-L1 preadipocytes, while CatK overexpression leads to enhanced adipogenesis, phenotypes, overview
additional information
-
overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis, overview. Cathepsin K protein levels are strongly increased in alveolar macrophages and lung parenchymal tissue of mock-treated cathepsin K transgenic mice relative to wild-type mice
additional information
-
phenotype comparisons of C57BL/6 mice either wild-type for cathepsin K, CK+/+, heterozygous for cathepsin K, CK+/-, or deficient in cathepsin K, CK-/-, no influence of cathepsin K deficiency on the severity of inflammation in arthritic knee joints, overview, Maintenance of the osteopetrosis phenotype of cathepsin K-deficient mice in arthritic mice
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
genotyping of C57BL/6 mice either wild-type for cathepsin K, CK+/+, heterozygous for cathepsin K, CK+/-, or deficient in cathepsin K, CK-/-, overview
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
receptor activator of nuclear factor-kappaB or small GTPase Rab do not mediate cathepsin K induction
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
drug development
-
lysosomal cysteine protease is an interesting target molecule with therapeutic potential to attenuate bleomycin-induced pulmonary fibrosis in mice
medicine
pharmacology
medicine
-
cathepsin K is linked to the pathogenesis of osteoporosis, arthritis, cardiovascular and respiratory diseases
medicine
-
the results suggest that cathepsin K plays an important role in the immune system and serves as a valid therapeutic target in autoimmune diseases
medicine
-
cathepsin K is a target for the pharmacological treatment of osteoporosis
pharmacology
-
CTSK is a possible therapeutic target in the treatment of obesity
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kamiya, T.; Kobayashi, Y.; Kanaoka, K.; Nakashima, T.; Kato, Y.; Mizuno, A.; Sakai, H.
Fluorescence microscopic demonstration of cathepsin K activity a the major lysosomal cystein proteinase in osteoclasts
J. Biochem.
123
752-759
1998
Oryctolagus cuniculus, Mus musculus
Rantakokko, J.; Aro, H.T.; Savontaus, M.; Vuorio, E.
Mouse cathepsin K: cDNA cloning and predominant expression of the gene in osteoclasts, and in some hypertrophing chondrocytes during mouse development
FEBS Lett.
393
307-313
1996
Mus musculus
Buehling, F.; Roecken, C.; Brasch, F.; Hartig, R.; Yasuda, Y.; Saftig, P.; Broemme, D.; Welte, T.
Pivotal role of cathepsin K in lung fibrosis
Am. J. Pathol.
164
2203-2216
2004
Homo sapiens, Mus musculus
Godat, E.; Lecaille, F.; Desmazes, C.; Duchene, S.; Weidauer, E.; Saftig, P.; Broemme, D.; Vandier, C.; Lalmanach, G.
Cathepsin K: a cysteine protease with unique kinin-degrading properties
Biochem. J.
383
501-506
2004
Mus musculus
van den Brule, S.; Misson, P.; Buehling, F.; Lison, D.; Huaux, F.
Overexpression of cathepsin K during silica-induced lung fibrosis and control by TGF-beta
Respir. Res.
6
84
2005
Homo sapiens, Mus musculus
Samokhin, A.O.; Wong, A.; Saftig, P.; Broemme, D.
Role of cathepsin K in structural changes in brachiocephalic artery during progression of atherosclerosis in apoE-deficient mice
Atherosclerosis
200
58-68
2008
Mus musculus
Asagiri, M.; Hirai, T.; Kunigami, T.; Kamano, S.; Gober, H.J.; Okamoto, K.; Nishikawa, K.; Latz, E.; Golenbock, D.T.; Aoki, K.; Ohya, K.; Imai, Y.; Morishita, Y.; Miyazono, K.; Kato, S.; Saftig, P.; Takayanagi, H.
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis
Science
319
624-627
2008
Mus musculus, Rattus norvegicus
Yang, M.; Sun, J.; Zhang, T.; Liu, J.; Zhang, J.; Shi, M.A.; Darakhshan, F.; Guerre-Millo, M.; Clement, K.; Gelb, B.D.; Dolgnov, G.; Shi, G.P.
Deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism in mice
Arterioscler. Thromb. Vasc. Biol.
28
2202-2208
2008
Homo sapiens, Mus musculus
Schurigt, U.; Hummel, K.M.; Petrow, P.K.; Gajda, M.; Stoeckigt, R.; Middel, P.; Zwerina, J.; Janik, T.; Bernhardt, R.; Schueler, S.; Scharnweber, D.; Beckmann, F.; Saftig, P.; Kollias, G.; Schett, G.; Wiederanders, B.; Braeuer, R.
Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor-transgenic mice
Arthritis Rheum.
58
422-434
2008
Mus musculus
Yamane, H.; Sakai, A.; Mori, T.; Tanaka, S.; Moridera, K.; Nakamura, T.
The anabolic action of intermittent PTH in combination with cathepsin K Inhibitor or alendronate differs depending on the remodeling status in bone in ovariectomized mice
Bone
44
1055-1062
2008
Mus musculus
Kozloff, K.M.; Quinti, L.; Patntirapong, S.; Hauschka, P.V.; Tung, C.H.; Weissleder, R.; Mahmood, U.
Non-invasive optical detection of cathepsin K-mediated fluorescence reveals osteoclast activity in vitro and in vivo
Bone
44
190-198
2009
Homo sapiens, Mus musculus
Pennypacker, B.; Shea, M.; Liu, Q.; Masarachia, P.; Saftig, P.; Rodan, S.; Rodan, G.; Kimmel, D.
Bone density, strength, and formation in adult cathepsin K (-/-) mice
Bone
44
199-207
2009
Mus musculus
Morko, J.; Kiviranta, R.; Mulari, M.T.; Ivaska, K.K.; Vaeaenaenen, H.K.; Vuorio, E.; Laitala-Leinonen, T.
Overexpression of cathepsin K accelerates the resorption cycle and osteoblast differentiation in vitro
Bone
44
717-728
2009
Mus musculus
Boskey, A.L.; Gelb, B.D.; Pourmand, E.; Kudrashov, V.; Doty, S.B.; Spevak, L.; Schaffler, M.B.
Ablation of cathepsin K activity in the young mouse causes hypermineralization of long bone and growth plates
Calcif. Tissue Int.
84
229-239
2009
Mus musculus, Mus musculus C57Bl6/J
Guo, J.; Bot, I.; de Nooijer, R.; Hoffman, S.J.; Stroup, G.B.; Biessen, E.A.; Benson, G.M.; Groot, P.H.; Van Eck, M.; Van Berkel, T.J.
Leucocyte cathepsin K affects atherosclerotic lesion composition and bone mineral density in low-density lipoprotein receptor deficient mice
Cardiovasc. Res.
81
278-285
2009
Mus musculus
Han, J.; Luo, T.; Gu, Y.; Li, G.; Jia, W.; Luo, M.
Cathepsin K regulates adipocyte differentiation: possible involvement of type I collagen degradation
Endocr. J.
56
55-63
2009
Mus musculus
Svelander, L.; Erlandsson-Harris, H.; Astner, L.; Grabowska, U.; Klareskog, L.; Lindstrom, E.; Hewitt, E.
Inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice
Eur. J. Pharmacol.
613
155-162
2009
Homo sapiens, Mus musculus, Mus musculus DBA/1J
Wilson, S.R.; Peters, C.; Saftig, P.; Broemme, D.
Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption
J. Biol. Chem.
284
2584-2592
2009
Homo sapiens, Mus musculus, Mus musculus C57BL/6
Kim, K.W.; Park, J.S.; Kim, K.S.; Jin, U.H.; Kim, J.K.; Suh, S.J.; Kim, C.H.
Inhibition of Ulmus davidiana Planch (Ulmaceae) on bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts
Phytother. Res.
22
511-517
2008
Mus musculus
Srivastava, M.; Steinwede, K.; Kiviranta, R.; Morko, J.; Hoymann, H.G.; Laenger, F.; Buhling, F.; Welte, T.; Maus, U.A.
Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis
Respir. Res.
9
54
2008
Mus musculus, Mus musculus FVB/N
Bai, L.; Beckers, L.; Wijnands, E.; Lutgens, S.P.; Herias, M.V.; Saftig, P.; Daemen, M.J.; Cleutjens, K.; Lutgens, E.; Biessen, E.A.; Heeneman, S.
Cathepsin K gene disruption does not affect murine aneurysm formation
Atherosclerosis
209
96-103
2010
Mus musculus
Desmarais, S.; Masse, F.; Percival, M.D.
Pharmacological inhibitors to identify roles of cathepsin K in cell-based studies: a comparison of available tools
Biol. Chem.
390
941-948
2009
Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus
Sun, Y.; Ishibashi, M.; Seimon, T.; Lee, M.; Sharma, S.M.; Fitzgerald, K.A.; Samokhin, A.O.; Wang, Y.; Sayers, S.; Aikawa, M.; Jerome, W.G.; Ostrowski, M.C.; Bromme, D.; Libby, P.; Tabas, I.A.; Welch, C.L.; Tall, A.R.
Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K
Circ. Res.
104
455-465
2009
Mus musculus
Hu, L.; Cheng, X.W.; Song, H.; Inoue, A.; Jiang, H.; Li, X.; Shi, G.P.; Kozawa, E.; Okumura, K.; Kuzuya, M.
Cathepsin K activity controls injury-related vascular repair in mice
Hypertension
63
607-615
2014
Mus musculus
Yuan, X.Y.; Ren, Z.; Wu, Y.; Bougault, C.; Brizuela, L.; Magne, D.; Buchet, R.; Mebarek, S.
Design, synthesis and biological evaluation of inhibitors of cathepsin K on dedifferentiated chondrocytes
Bioorg. Med. Chem.
27
1034-1042
2019
Homo sapiens (P43235), Homo sapiens, Mus musculus (P55097), Mus musculus
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