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Reference on EC 3.4.22.29 - picornain 2A

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Krusslich, H.G.; Wimmer, E.
Viral proteinases
Annu. Rev. Biochem.
57
701-754
1988
coxsackievirus, enterovirus, Hepatovirus A, Human rhinovirus sp., picornaviridae, Enterovirus C
Manually annotated by BRENDA team
Glaser, W.; Skern, T.
Extremely efficient cleavage of eIF4G by picornaviral proteinases L and 2A in vitro
FEBS Lett.
480
151-155
2000
Human rhinovirus sp.
Manually annotated by BRENDA team
Bazan, J.F.; Fletterick, R.J.
Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications
Proc. Natl. Acad. Sci. USA
85
7872-7876
1988
coxsackievirus, enterovirus, Human rhinovirus sp., picornaviridae, Enterovirus C
Manually annotated by BRENDA team
Skern, T.; Liebig, H.D.
Picornains 2A and 3C
Methods Enzymol.
244
583-595
1994
coxsackievirus, enterovirus, Human rhinovirus sp., picornaviridae, Enterovirus C
Manually annotated by BRENDA team
Toyoda, H.; Nicklin, M.J.H.; Murray, M.G.; Anderson, C.W.; Dunn, J.J.; Studier, F.W.; Wimmer, E.
A second virus-encoded proteinase involved in proteolytic processing of poliovirus polyprotein
Cell
45
761-770
1986
Enterovirus C
Manually annotated by BRENDA team
Knig, H.; Rosenwirth, B.
Purification and partial characterization of poliovirus protease 2A by means of a functional assay
J. Virol.
62
1243-1250
1988
Enterovirus C
Manually annotated by BRENDA team
Alvey, J.C.; Wyckoff, E.E.; Yu, S.F.; Lloyd, R.; Ehrenfeld, E.
cis- and trans-cleavage activities of poliovirus 2A protease expressed in Escherichia coli
J. Virol.
65
6077-6083
1991
Enterovirus C
Manually annotated by BRENDA team
Yu, S.F.; Lloyd, R.
Characterization of the roles of conserved cysteine and histidine residues in poliovirus 2A protease
Virology
186
725-735
1992
coxsackievirus, enterovirus, Human rhinovirus sp., Enterovirus C
Manually annotated by BRENDA team
Sommergruber, W.; Ahorn, H.; Zphel, A.; Maurer-Fogy, I.; Fessl, F.; Schnorrenberg, G.; Liebig, H.D.; Blaas, D.; Kuechler, E.; Skern, T.
Cleavage specificity on synthetic peptide substrates of human rhinovirus 2 proteinase 2A
J. Biol. Chem.
267
22639-22644
1992
Human rhinovirus sp.
Manually annotated by BRENDA team
Liebig, H.D.; Ziegler, E.; Yan, R.; Hartmut, K.; Klump, H.; Kowalski, H.; Blaas, D.; Sommergruber, W.; Frasel, L.; Lamphear, B.; Rhoads, R.; Kuechler, E.; Skern, T.
Purification of two picornaviral 2A proteinases: interaction with eIF-4 gamma and influence on in vitro translation
Biochemistry
32
7581-7588
1993
coxsackievirus, Human rhinovirus sp.
Manually annotated by BRENDA team
Lamphear, B.J.; Yan, R.; Yang, F.; Waters, D.; Liebig, H.D.; Klump, H.; Kuechler, E.; Skern, T.; Rhoads, R.E.
Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus
J. Biol. Chem.
268
19200-19203
1993
coxsackievirus, Human rhinovirus sp.
Manually annotated by BRENDA team
Sommergruber, W.; Casari, G.; Fessl, F.; Seipelt, J.; Skern, T.
The 2A proteinase of human rhinovirus is a zinc containing enzyme
Virology
204
815-818
1994
Human rhinovirus sp.
Manually annotated by BRENDA team
Sommergruber, W.; Ahorn, H.; Klump, H.; Seipelt, J.; Zphel, A.; Fessl, F.; Krystek, E.; Blaas, D.; Kuechler, E.; Liebig, H.D.; Skern, T.
2A Proteinases of coxsackie- and rhinovirus cleave peptides derived from eIF-4 gamma via a common recognition motif
Virology
198
741-745
1994
coxsackievirus, Human rhinovirus sp.
Manually annotated by BRENDA team
Voss, T.; Meyer, R.; Sommergruber, W.
Spectroscopic characterization of rhinoviral protease 2A: Zn is essential for the structural integrity
Protein Sci.
4
2526-2531
1995
Human rhinovirus sp.
Manually annotated by BRENDA team
Badorff, C.; Lee, G.H.; Lamphear, B.J.; Martone, M.E.; Campbell, K.P.; Rhoads, R.E.; Knowlton, K.U.
Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy
Nat. Med.
5
320-326
1999
coxsackievirus
Manually annotated by BRENDA team
Badorff, C.; Berkely, N.; Mehrotra, S.; Talhouk, J.W.; Rhoads, R.E.; Knowlton, K.U.
Enteroviral protease 2A directly cleaves dystrophin and is inhibited by a dystrophin-based substrate analogue
J. Biol. Chem.
275
11191-11197
2000
coxsackievirus
Manually annotated by BRENDA team
Bovee, M.L.; Lamphear, B.J.; Rhoads, R.E.; Lloyd, R.E.
Direct cleavage of eIF4G by poliovirus 2A protease is inefficient in vitro
Virology
245
241-249
1998
coxsackievirus, Human rhinovirus sp., Enterovirus C
Manually annotated by BRENDA team
Glaser, W.; Triendl, A.; Skern, T.
The processing of eIF4GI by human rhinovirus type 2 2Apro: Relationship to self-cleavage and role of zinc
J. Virol.
77
5021-5025
2003
Human rhinovirus sp.
Manually annotated by BRENDA team
Gradi, A.; Svitkin, Y.V.; Sommergruber, W.; Imataka, H.; Morino, S.; Skern, T.; Sonenberg, N.
Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different
J. Virol.
77
5026-5029
2003
Human rhinovirus sp.
Manually annotated by BRENDA team
Petersen, J.F.W.; Cherney, M.M.; Liebig, H.D.; Skern, T.; Kuechler, E.; James, M.N.G.
The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host-cell protein synthesis
EMBO J.
18
5463-5475
1999
Human rhinovirus sp.
Manually annotated by BRENDA team
Sarkany, Z.; Skern, T.; Polgar, L.
Characterization of the active site thiol group of rhinovirus 2A proteinase
FEBS Lett.
481
289-292
2000
Human rhinovirus sp.
Manually annotated by BRENDA team
Seipelt, J.; Liebig, H.D.; Sommergruber, W.; Gerner, C.; Kuechler, E.
2A proteinase of human rhinovirus cleaves cytokeratin 8 in infected HeLa cells
J. Biol. Chem.
275
20084-20089
2000
coxsackievirus, Human rhinovirus sp.
Manually annotated by BRENDA team
Sommergruber, W.; Seipelt, J.; Fessl, F.; Skern, T.; Liebig, H.D.; Casari, G.
Mutational analyses support a model for the HRV2 2A proteinase
Virology
234
203-214
1997
Human rhinovirus sp.
Manually annotated by BRENDA team
Wang, Q.M.; Sommergruber, W.; Johnson, R.B.
Cleavage specificity of human rhinovirus-2 2A protease for peptide substrates
Biochem. Biophys. Res. Commun.
235
562-566
1997
Human rhinovirus sp.
Manually annotated by BRENDA team
Wang, Q.M.; Johnson, R.B.; Sommergruber, W.; Shepherd, T.A.
Development of in vitro peptide substrates for human rhinovirus-14 2A protease
Arch. Biochem. Biophys.
356
12-18
1998
Human rhinovirus sp.
Manually annotated by BRENDA team
Deszcz, L.; Seipelt, J.; Vassilieva, E.; Roetzer, A.; Kuechler, E.
Antiviral activity of caspase inhibitors: effect on picornaviral 2A proteinase
FEBS Lett.
560
51-55
2004
picornaviridae
Manually annotated by BRENDA team
Inoue, T.; Alexandersen, S.; Clark, A.T.; Murphy, C.; Quan, M.; Reid, S.M.; Sakoda, Y.; Johns, H.L.; Belsham, G.J.
Importance of arginine 20 of the swine vesicular disease virus 2A protease for activity and virulence
J. Virol.
79
428-440
2005
swine vesicular disease virus
Manually annotated by BRENDA team
Baxter, N.J.; Roetzer, A.; Liebig, H.D.; Sedelnikova, S.E.; Hounslow, A.M.; Skern, T.; Waltho, J.P.
Structure and dynamics of coxsackievirus B4 2A proteinase, an enzyme involved in the etiology of heart disease
J. Virol.
80
1451-1462
2006
Coxsackievirus B4
Manually annotated by BRENDA team
Di Napoli, A.; Maltese, E.; Bucci, M.; Pagnotti, P.; Seipelt, J.; Duquerroy, S.; Perez Bercoff, R.
Molecular cloning, expression and purification of protein 2A of hepatitis A virus
New Microbiol.
27
105-112
2004
Hepatovirus A
Manually annotated by BRENDA team
Jurgens, C.K.; Barton, D.J.; Sharma, N.; Morasco, B.J.; Ogram, S.A.; Flanegan, J.B.
2Apro is a multifunctional protein that regulates the stability, translation and replication of poliovirus RNA
Virology
345
346-357
2006
Enterovirus C
Manually annotated by BRENDA team
Calandria, C.; Irurzun, A.; Barco, A.; Carrasco, L.
Individual expression of poliovirus 2Apro and 3Cpro induces activation of caspase-3 and PARP cleavage in HeLa cells
Virus Res.
104
39-49
2004
Enterovirus C
Manually annotated by BRENDA team
Chau, D.H.; Yuan, J.; Zhang, H.; Cheung, P.; Lim, T.; Liu, Z.; Sall, A.; Yang, D.
Coxsackievirus B3 proteases 2A and 3C induce apoptotic cell death through mitochondrial injury and cleavage of eIF4GI but not DAP5/p97/NAT1
Apoptosis
12
513-524
2007
Coxsackievirus B3
Manually annotated by BRENDA team
Muto, S.; Miyoshi, H.; Nishikawa, H.; Nakashima, H.
Novel recognition sequence of coxsackievirus 2A proteinase
Biochem. Biophys. Res. Commun.
348
1436-1442
2006
coxsackievirus
Manually annotated by BRENDA team
Xiong, D.; Yajima, T.; Lim, B.K.; Stenbit, A.; Dublin, A.; Dalton, N.D.; Summers-Torres, D.; Molkentin, J.D.; Duplain, H.; Wessely, R.; Chen, J.; Knowlton, K.U.
Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy
Circulation
115
94-102
2007
enterovirus
Manually annotated by BRENDA team
Sousa, C.; Schmid, E.M.; Skern, T.
Defining residues involved in human rhinovirus 2A proteinase substrate recognition
FEBS Lett.
580
5713-5717
2006
Human rhinovirus sp.
Manually annotated by BRENDA team
Inoue, T.; Zhang, Z.; Wang, L.; West, L.; Bashiruddin, J.B.; Belsham, G.J.
Significance of arginine 20 in the 2A protease for swine vesicular disease virus pathogenicity
J. Gen. Virol.
88
2275-2279
2007
swine vesicular disease virus, swine vesicular disease virus J1
Manually annotated by BRENDA team
Funston, G.M.; Kallioinen, S.E.; de Felipe, P.; Ryan, M.D.; Iggo, R.D.
Expression of heterologous genes in oncolytic adenoviruses using picornaviral 2A sequences that trigger ribosome skipping
J. Gen. Virol.
89
389-396
2008
picornaviridae
Manually annotated by BRENDA team
Bonderoff, J.M.; Larey, J.L.; Lloyd, R.E.
Cleavage of poly(A)-binding protein by poliovirus 3C proteinase inhibits viral internal ribosome entry site-mediated translation
J. Virol.
82
9389-9399
2008
coxsackievirus
Manually annotated by BRENDA team
Morrison, J.M.; Racaniello, V.R.
Proteinase 2Apro is essential for enterovirus replication in type I interferon-treated cells
J. Virol.
83
4412-4422
2009
picornaviridae
Manually annotated by BRENDA team
Krenn, B.M.; Gaudernak, E.; Holzer, B.; Lanke, K.; Van Kuppeveld, F.J.; Seipelt, J.
Antiviral activity of the zinc ionophores pyrithione and hinokitiol against picornavirus infections
J. Virol.
83
58-64
2009
enterovirus
Manually annotated by BRENDA team
Belsham, G.J.; Nielsen, I.; Normann, P.; Royall, E.; Roberts, L.O.
Monocistronic mRNAs containing defective hepatitis C virus-like picornavirus internal ribosome entry site elements in their 5 untranslated regions are efficiently translated in cells by a cap-dependent mechanism
RNA
14
1671-1680
2008
picornaviridae
Manually annotated by BRENDA team
Rivera, C.I.; Lloyd, R.E.
Modulation of enteroviral proteinase cleavage of poly(A)-binding protein (PABP) by conformation and PABP-associated factors
Virology
375
59-72
2008
coxsackievirus
Manually annotated by BRENDA team
Castello, A.; Izquierdo, J.M.; Welnowska, E.; Carrasco, L.
RNA nuclear export is blocked by poliovirus 2A protease and is concomitant with nucleoporin cleavage
J. Cell Sci.
122
3799-3809
2009
Enterovirus C
Manually annotated by BRENDA team
Igarashi, H.; Yoshino, Y.; Miyazawa, M.; Horie, H.; Ohka, S.; Nomoto, A.
2A protease is not a prerequisite for poliovirus replication
J. Virol.
84
5947-5957
2010
Enterovirus C
Manually annotated by BRENDA team
Maghsoudi, N.; Tafreshi, N.K.h.; Khodagholi, F.; Zakeri, Z.; Esfandiarei, M.; Hadi-Alijanvand, H.; Sabbaghian, M.; Maghsoudi, A.H.; Sajadi, M.; Zohri, M.; Moosavi, M.; Zeinoddini, M.
Targeting enteroviral 2A protease by a 16-mer synthetic peptide: inhibition of 2Apro-induced apoptosis in a stable Tet-on HeLa cell line
Virology
399
39-45
2010
Coxsackievirus B3
Manually annotated by BRENDA team
Sanz, M.A.; Welnowska, E.; Redondo, N.; Carrasco, L.
Translation driven by picornavirus IRES is hampered from Sindbis virus replicons: rescue by poliovirus 2A protease
J. Mol. Biol.
402
101-117
2010
Enterovirus C
Manually annotated by BRENDA team
Redondo, N.; Sanz, M.; Welnowska, E.; Carrasco, L.
Translation without eiF2 promoted by poliovirus 2A protease
PLoS ONE
6
e25699
2011
Enterovirus C
Manually annotated by BRENDA team
Wang, C.L.; Wang, J.Y.; Liu, Z.Y.; Ma, X.M.; Wang, X.W.; Jin, H.; Zhang, X.P.; Fu, D.; Hou, L.J.; Lu, Y.C.
Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma
Carcinogenesis
35
1500-1509
2014
Homo sapiens
Manually annotated by BRENDA team
Wong, J.; Zhang, J.; Yanagawa, B.; Luo, Z.; Yang, X.; Chang, J.; McManus, B.; Luo, H.
Cleavage of serum response factor mediated by enteroviral protease 2A contributes to impaired cardiac function
Cell Res.
22
360-371
2012
Coxsackievirus B3
Manually annotated by BRENDA team
Neubauer, D.; Aumayr, M.; Goesler, I.; Skern, T.
Specificity of human rhinovirus 2Apro is determined by combined spatial properties of four cleavage site residues
J. Gen. Virol.
94
1535-1546
2013
rhinovirus A2, human rhinovirus 1A
Manually annotated by BRENDA team
Mu, Z.; Wang, B.; Zhang, X.; Gao, X.; Qin, B.; Zhao, Z.; Cui, S.
Crystal structure of 2A proteinase from hand, foot and mouth disease virus
J. Mol. Biol.
425
4530-4543
2013
Enterovirus A71 (Q66479), Enterovirus A71
Manually annotated by BRENDA team
Alvarez, E.; Castello, A.; Carrasco, L.; Izquierdo, J.
Poliovirus 2A protease triggers a selective nucleo-cytoplasmic redistribution of splicing factors to regulate alternative pre-mRNA splicing
PLoS ONE
8
e73723
2013
Enterovirus C
Manually annotated by BRENDA team
Lee, W.; Watters, K.E.; Troupis, A.T.; Reinen, N.M.; Suchy, F.P.; Moyer, K.L.; Frederick, R.O.; Tonelli, M.; Aceti, D.J.; Palmenberg, A.C.; Markley, J.L.
Solution structure of the 2A protease from a common cold agent, human rhinovirus C2, strain W12
PLoS ONE
9
e97198
2014
rhinovirus C2 (I2CMJ2), rhinovirus C2, rhinovirus C2 W12 (I2CMJ2)
Manually annotated by BRENDA team
Sun, Y.; Wang, X.; Yuan, S.; Dang, M.; Li, X.; Zhang, X.C.; Rao, Z.
An open conformation determined by a structural switch for 2A protease from coxsackievirus A16
Protein Cell
4
782-792
2013
Coxsackievirus A16 (Q9QF31), Coxsackievirus A16
Manually annotated by BRENDA team
Wu, S.; Wang, Y.; Lin, L.; Si, X.; Wang, T.; Zhong, X.; Tong, L.; Luan, Y.; Chen, Y.; Li, X.; Zhang, F.; Zhao, W.; Zhong, Z.
Protease 2A induces stress granule formation during coxsackievirus B3 and enterovirus 71 infections
Virol. J.
11
192
2015
Coxsackievirus B3 (Q66282), Coxsackievirus B3, Enterovirus A71 (Q66478), Enterovirus A71, Coxsackievirus B3 Woodruff (Q66282)
Manually annotated by BRENDA team
Ling, H.; Yang, P.; Hou, H.; Sun, Y.
Structural view of the 2A protease from human rhinovirus C15
Acta Crystallogr. Sect. F
74
255-261
2018
rhinovirus C15 (A0A2P1DXU1), rhinovirus C15
Manually annotated by BRENDA team
Duan, H.; Zhu, M.; Xiong, Q.; Wang, Y.; Xu, C.; Sun, J.; Wang, C.; Zhang, H.; Xu, P.; Peng, Y.
Regulation of enterovirus 2A protease-associated viral IRES activities by the cell's ERK signaling cascade implicating ERK as an efficiently antiviral target
Antiviral Res.
143
13-21
2017
Enterovirus A71
Manually annotated by BRENDA team
Hanson, P.J.; Ye, X.; Qiu, Y.; Zhang, H.M.; Hemida, M.G.; Wang, F.; Lim, T.; Gu, A.; Cho, B.; Kim, H.; Fung, G.; Granville, D.J.; Yang, D.
Cleavage of DAP5 by coxsackievirus B3 2A protease facilitates viral replication and enhances apoptosis by altering translation of IRES-containing genes
Cell Death Differ.
23
828-840
2016
Coxsackievirus B3
Manually annotated by BRENDA team
Deng, H.; Fung, G.; Qiu, Y.; Wang, C.; Zhang, J.; Jin, Z.G.; Luo, H.
Cleavage of Grb2-associated binding protein 2 by viral proteinase 2A during coxsackievirus infection
Front. Cell. Infect. Microbiol.
7
85
2017
Coxsackievirus B3
Manually annotated by BRENDA team
Walker, E.; Jensen, L.; Croft, S.; Wei, K.; Fulcher, A.J.; Jans, D.A.; Ghildyal, R.
Rhinovirus 16 2A protease affects nuclear localization of 3CD during infection
J. Virol.
90
11032-11042
2016
rhinovirus A16
Manually annotated by BRENDA team
Visser, L.J.; Langereis, M.A.; Rabouw, H.H.; Wahedi, M.; Muntjewerff, E.M.; de Groot, R.J.; van Kuppeveld, F.J.M.
Essential role of enterovirus 2A protease in counteracting stress granule formation and the induction of type I Interferon
J. Virol.
93
e00222-19
2019
Coxsackievirus A21, Coxsackievirus B3, Enterovirus A71, Enterovirus D68, no activity in Encephalomyocarditis virus
Manually annotated by BRENDA team
Qiu, Y.; Ye, X.; Zhang, H.M.; Hanson, P.; Zhao, G.; Tong, L.; Xie, R.; Yang, D.
Cleavage of osmosensitive transcriptional factor NFAT5 by Coxsackieviral protease 2A promotes viral replication
PLoS Pathog.
13
e1006744
2017
Coxsackievirus B3
Manually annotated by BRENDA team
Yang, X.; Hu, Z.; Fan, S.; Zhang, Q.; Zhong, Y.; Guo, D.; Qin, Y.; Chen, M.
Picornavirus 2A protease regulates stress granule formation to facilitate viral translation
PLoS Pathog.
14
e1006901
2018
Enterovirus A71 (Q66478), Enterovirus A71, Enterovirus A71 BrCR (Q66478)
Manually annotated by BRENDA team
Younus, A.; Bhatti, M.
A comprehensive computational mutation structure-function approach for determining potential drug target sites in poliovirus 2A protease
Trop. J. Pharm. Res.
16
2831-2841
2017
Human poliovirus 1 (T1WTS3), Human poliovirus 1 (T1WU96)
-
Manually annotated by BRENDA team
Dial, C.N.; Tate, P.M.; Kicmal, T.M.; Mounce, B.C.
Coxsackievirus B3 responds to polyamine depletion via enhancement of 2A and 3C protease activity
Viruses
11
403
2019
Coxsackievirus B3, Coxsackievirus B3 Nancy
Manually annotated by BRENDA team