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Information on EC 3.4.22.29 - picornain 2A and Organism(s) Coxsackievirus A16 and UniProt Accession Q9QF31

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.29 picornain 2A
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This record set is specific for:
Coxsackievirus A16
UNIPROT: Q9QF31 not found.
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The taxonomic range for the selected organisms is: Coxsackievirus A16
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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selective cleavage of Tyr-/-Gly bond in picornavirus polyprotein
Synonyms
2apro, 2a protease, usp2a, protease 2a, 2a proteinase, proteinase 2a, poliovirus 2apro, poliovirus 2a protease, ubiquitin-specific protease 2a, poliovirus protease 2a, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2A protease
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2A proteinase
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P2A
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picornaviral 2A proteinase
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picornavirus 2A proteinase
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picornavirus endopeptidase 2A
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poliovirus protease 2A
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protease 2A
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proteinase 2Apro
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proteinase, poliovirus, 2A
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rhinovirus protease 2A
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Y-G proteinase 2A
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
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-
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-
CAS REGISTRY NUMBER
COMMENTARY hide
103406-62-8
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
eukaryotic translation initiation factor 4G I + H2O
?
show the reaction diagram
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-
-
?
eukaryotic translation initiation factor 4G II + H2O
?
show the reaction diagram
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?
thrombin + H2O
?
show the reaction diagram
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-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
eukaryotic translation initiation factor 4G I + H2O
?
show the reaction diagram
-
-
-
?
eukaryotic translation initiation factor 4G II + H2O
?
show the reaction diagram
-
-
-
?
thrombin + H2O
?
show the reaction diagram
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Zn2+
contains zinc
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
EDTA
the enzyme is slightly inhibited by 10 mM EDTA
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexamer
x-ray crystallography
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
HiTrap Q column chromatography
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sun, Y.; Wang, X.; Yuan, S.; Dang, M.; Li, X.; Zhang, X.C.; Rao, Z.
An open conformation determined by a structural switch for 2A protease from coxsackievirus A16
Protein Cell
4
782-792
2013
Coxsackievirus A16 (Q9QF31), Coxsackievirus A16
Manually annotated by BRENDA team