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Acid-denatured hemoglobin + H2O
?
-
-
-
-
?
Cbz-Phe-Arg-7-amido-4-methylcoumarin + H2O
Cbz-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Hemoglobin + H2O
?
-
denaturation
-
-
?
Performic acid-oxidized ribonuclease A + H2O
Hydrolyzed performic acid-oxidized ribonuclease A
Tyrosine aminotransferase + H2O
?
-
involved in generation of isozymic forms of tyrosine transferase
-
-
?
tyrosine aminotransferase + H2O
truncated tyrosine aminotransferase + peptide
Tyrosine aminotransferase form I + H2O
Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide
additional information
?
-
azocasein + H2O
?
-
-
-
-
?
azocasein + H2O
?
-
degradation
-
-
?
Performic acid-oxidized ribonuclease A + H2O
Hydrolyzed performic acid-oxidized ribonuclease A
-
-
-
-
?
Performic acid-oxidized ribonuclease A + H2O
Hydrolyzed performic acid-oxidized ribonuclease A
-
even at 0øC
several fragments
?
tyrosine aminotransferase + H2O
truncated tyrosine aminotransferase + peptide
-
53 kDa substrate monomer, cleavage at the N-terminus of the protein, interconversion of the 3 different forms of the substrate enzyme without alteration of its enzymatic activity related to the substrate's short half-life in the cell
49 kDa product monomer and 4.5 kDa N-terminal peptide
-
?
tyrosine aminotransferase + H2O
truncated tyrosine aminotransferase + peptide
-
53 kDa substrate monomer, cleavage at the N-terminus of the protein, interconversion of the 3 different forms of the substrate enzyme without alteration of its enzymatic activity
49 kDa product monomer and 4.5 kDa N-terminal peptide
-
?
Tyrosine aminotransferase form I + H2O
Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide
-
-
-
-
?
Tyrosine aminotransferase form I + H2O
Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide
-
dimer of MW 52000 subunits
enzyme form II: dimer of MW 53000 + MW 49000, enzyme form III: dimer of MW 48000
?
Tyrosine aminotransferase form I + H2O
Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide
-
enzyme converses native larger subunit to smaller subunit
-
-
?
Tyrosine aminotransferase form I + H2O
Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide
-
from rat liver cytosol
enzyme form II: dimer of MW 53000 + MW 49000, enzyme form III: dimer of MW 48000
?
Tyrosine aminotransferase form I + H2O
Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide
-
from rat liver cytosol
no release of amino acids, amino acid composition of acidic peptide
?
Tyrosine aminotransferase form I + H2O
Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide
-
thereby generating multiple forms of tyrosine aminotransferase
-
-
?
Tyrosine aminotransferase form I + H2O
Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide
-
thereby generating multiple forms of tyrosine aminotransferase
enzyme form II: dimer of MW 53000 + MW 49000, enzyme form III: dimer of MW 48000
?
Tyrosine aminotransferase form I + H2O
Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide
-
thereby generating multiple forms of tyrosine aminotransferase
no release of amino acids, amino acid composition of acidic peptide
?
Tyrosine aminotransferase form I + H2O
Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide
-
thereby generating multiple forms of tyrosine aminotransferase
enzyme form III: dimer of MW 49000
?
Tyrosine aminotransferase form I + H2O
Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide
-
i.e. L-tyrosine:2-oxoglutarate aminotransferase or EC 2.6.1.5
enzyme form II: dimer of MW 53000 + MW 49000, enzyme form III: dimer of MW 48000
?
additional information
?
-
-
no hydrolysis of synthetic low MW substrates for exopeptidases, e.g. Gly-(L)-Phe-beta-naphthylamide, L-Ser-(L)-Tyr-beta-naphthylamide, L-Leu-beta-naphthylamide, L-Arg-beta-naphthylamide, L-leucinamide, hippuryl-L-arginine, hippuryl-L-phenylalanine, N-benzoyl-L-tyrosine ethyl ester
-
-
?
additional information
?
-
-
cytosolic or mitochondrial forms of aspartate aminotransferase
-
-
?
additional information
?
-
-
cytosolic or mitochondrial forms of aspartate aminotransferase
-
-
?
additional information
?
-
-
Nalpha-benzoyl-(DL)-Arg-beta-naphthylamide
-
-
?
additional information
?
-
-
little or no activity at 0øC with glucose 6-phosphate dehydrogenase, native ribonuclease A, native bovine serum albumin, cytochrome c or oxidized insulin B-chain
-
-
?
additional information
?
-
-
little or no activity at 0øC with glucose 6-phosphate dehydrogenase, native ribonuclease A, native bovine serum albumin, cytochrome c or oxidized insulin B-chain
-
-
?
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Gohda, E.; Pitot, H.C.
Purification and characterization of a new thiol proteinase from rat kidney
Biochim. Biophys. Acta
659
114-122
1981
Rattus norvegicus
brenda
Gohda, E.; Pitot, H.C.
A new thiol proteinase from rat liver
J. Biol. Chem.
256
2567-2572
1981
Rattus norvegicus
brenda
Hargrove, J.L.; Gohda, E.; Pitot, H.C.; Granner, D.K.
Cathepsin T (convertase) generates the multiple forms of tyrosine aminotransferase by limited proteolysis
Biochemistry
21
283-289
1982
Rattus norvegicus
brenda
Lenney, J.F.; Liao, J.R.; Sugg, S.L.; Gopalakrishnan, V.; Wong, H.C.H.; Ouye, K.H.; Chan, P.W.H.
Low molecular weight inhibitors of cathepsins B, H and T in human serum, synovial fluid and CSF
Biochem. Biophys. Res. Commun.
108
1581-1587
1982
Rattus norvegicus
brenda
Gohda, E.; Nagahama, J.; Nakamura, O.; Tsubouchi, H.; Daikuhara, Y.; Pitot, H.C.
Increased activities of liver cathepsins T and D in carbon tetrachloride-treated rats
Biochim. Biophys. Acta
802
362-371
1984
Rattus norvegicus
brenda
Pitot, H.C.; Gohda, E.
Cathepsin T
Methods Enzymol.
142
279-289
1987
Rattus norvegicus
brenda
Gohda, E.; Pitot, H.C.
Purification and characterization of a factor catalyzing the conversion of the multiple forms of tyrosine aminotransferase from rat liver
J. Biol. Chem.
255
7371-7379
1980
Rattus norvegicus
brenda
Ruemenapf, T.; Thiel, H.J.
434. Cathepsin T
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
2nd Ed.
1404
2004
Rattus norvegicus
-
brenda