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Disease on EC 3.4.22.10 - streptopain

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Anti-Glomerular Basement Membrane Disease
The IgG-degrading enzyme of Streptococcus pyogenes causes rapid clearance of anti-glomerular basement membrane antibodies in patients with refractory anti-glomerular basement membrane disease.
Arthritis
Blocking of experimental arthritis by cleavage of IgG antibodies in vivo.
Arthritis, Infectious
Expression and characterization of group A Streptococcus extracellular cysteine protease recombinant mutant proteins and documentation of seroconversion during human invasive disease episodes.
Bacteremia
Expression and characterization of group A Streptococcus extracellular cysteine protease recombinant mutant proteins and documentation of seroconversion during human invasive disease episodes.
Histopathologic changes in kidney and liver correlate with streptococcal pyrogenic exotoxin B production in the mouse model of group A streptococcal infection.
Cellulitis
Expression and characterization of group A Streptococcus extracellular cysteine protease recombinant mutant proteins and documentation of seroconversion during human invasive disease episodes.
Exanthema
The production of pyrogenic exotoxins by group A streptococci.
Fasciitis, Necrotizing
Crystal structure of the zymogen form of the group A Streptococcus virulence factor SpeB: an integrin-binding cysteine protease.
Diagnosis of group A streptococcal necrotizing fasciitis by using PCR to amplify the streptococcal pyrogenic exotoxin B gene.
Foodborne Diseases
Time course of virulence factors produced by group A streptococcus during a food-borne epidemic.
Glomerulonephritis
Acute poststreptococcal glomerulonephritis with acute interstitial nephritis related to streptococcal pyrogenic exotoxin B.
Bacterial infection-related glomerulonephritis in adults.
Immunohistochemical and serological evidence for the role of streptococcal proteinase in acute post-streptococcal glomerulonephritis.
Is the nephritogenic antigen in post-streptococcal glomerulonephritis pyrogenic exotoxin B (SPE B) or GAPDH?
Role of streptococcal proteinase in acute post-streptococcal glomerulonephritis.
Streptococcal pyrogenic exotoxin B antibodies in a mouse model of glomerulonephritis.
Infections
An amino-terminal signal peptide of Vfr protein negatively influences RopB-dependent SpeB expression and attenuates virulence in Streptococcus pyogenes.
Antibody to streptococcal cysteine proteinase as a seromarker of group A Streptococcal (Streptococcus pyogenes) infections.
Application of the c3-binding motif of streptococcal pyrogenic exotoxin B to protect mice from invasive group a streptococcal infection.
Clinical and microbiological characteristics of severe group A streptococcus infections and streptococcal toxic shock syndrome.
Degradation of complement 3 by streptococcal pyrogenic exotoxin B inhibits complement activation and neutrophil opsonophagocytosis.
Determining antibody-binding site of streptococcal pyrogenic exotoxin B to protect mice from group a streptococcus infection.
Histopathologic changes in kidney and liver correlate with streptococcal pyrogenic exotoxin B production in the mouse model of group A streptococcal infection.
Leaderless secreted peptide signaling molecule alters global gene expression and increases virulence of a human bacterial pathogen.
Metal-mediated modulation of streptococcal cysteine protease activity and its biological implications.
Molecular analysis of the role of the group A streptococcal cysteine protease, hyaluronic acid capsule, and M protein in a murine model of human invasive soft-tissue infection.
Streptococcal mitogenic exotoxin, SmeZ, is the most susceptible M1T1 streptococcal superantigen to degradation by the streptococcal cysteine protease, SpeB.
Streptococcal pyrogenic exotoxin B cleaves properdin and inhibits complement-mediated opsonophagocytosis.
Streptococcal pyrogenic exotoxin B inhibits apoptotic cell clearance by macrophages through protein S cleavage.
Structure of the mature streptococcal cysteine protease exotoxin mSpeB in its active dimeric form.
Substrate specificity of the streptococcal cysteine protease.
Synergistic effects of streptolysin S and streptococcal pyrogenic exotoxin B on the mouse model of group A streptococcal infection.
Lung Injury
Streptococcal cysteine protease augments lung injury induced by products of group A streptococci.
Melanoma
Cleavage of interleukin 1 beta (IL-1 beta) precursor to produce active IL-1 beta by a conserved extracellular cysteine protease from Streptococcus pyogenes.
Nephritis, Interstitial
A possible rare cause of renal failure in streptococcal infection.
Acute poststreptococcal glomerulonephritis with acute interstitial nephritis related to streptococcal pyrogenic exotoxin B.
Pharyngitis
Detection of invasive protein profile of Streptococcus pyogenes M1 isolates from pharyngitis patients.
The production of pyrogenic exotoxins by group A streptococci.
Pneumonia
Expression and characterization of group A Streptococcus extracellular cysteine protease recombinant mutant proteins and documentation of seroconversion during human invasive disease episodes.
Shock, Septic
Cysteine protease activity and histamine release from the human mast cell line HMC-1 stimulated by recombinant streptococcal pyrogenic exotoxin B/streptococcal cysteine protease.
Expression and characterization of group A Streptococcus extracellular cysteine protease recombinant mutant proteins and documentation of seroconversion during human invasive disease episodes.
Molecular structure of staphylococcus and streptococcus superantigens.
Nucleotide sequence of the streptococcal pyrogenic exotoxin type B gene and relationship between the toxin and the streptococcal proteinase precursor.
The potential role of bacterial superantigens in the pathogenesis of Kawasaki syndrome.
Starvation
Life in protein-rich environments: the relA-independent response of Streptococcus pyogenes to amino acid starvation.
Temporal production of streptococcal erythrogenic toxin B (streptococcal cysteine proteinase) in response to nutrient depletion.
Streptococcal Infections
Abrogation of streptococcal pyrogenic exotoxin B-mediated suppression of phagocytosis in U937 cells by Cordyceps sinensis mycelium via production of cytokines.
Application of the c3-binding motif of streptococcal pyrogenic exotoxin B to protect mice from invasive group a streptococcal infection.
Cysteine protease activity and histamine release from the human mast cell line HMC-1 stimulated by recombinant streptococcal pyrogenic exotoxin B/streptococcal cysteine protease.
Histopathologic changes in kidney and liver correlate with streptococcal pyrogenic exotoxin B production in the mouse model of group A streptococcal infection.
Identification and characterization of bicistronic speB and prsA gene expression in the group A Streptococcus.
Inverse relation between disease severity and expression of the streptococcal cysteine protease, SpeB, among clonal M1T1 isolates recovered from invasive group A streptococcal infection cases.
Role of streptococcal pyrogenic exotoxin B in the mouse model of group A streptococcal infection.
Studies of recombinant streptococcal pyrogenic exotoxin B/cysteine protease (rSPE B/SCP) in the skin of guinea pigs & the release of histamine from cultured mast cells & basophilic leukocytes.
Synergistic effects of streptolysin S and streptococcal pyrogenic exotoxin B on the mouse model of group A streptococcal infection.