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Information on EC 3.4.22.1 - cathepsin B and Organism(s) Caenorhabditis elegans and UniProt Accession P43508

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.1 cathepsin B
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This record set is specific for:
Caenorhabditis elegans
UNIPROT: P43508 not found.
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Word Map
The taxonomic range for the selected organisms is: Caenorhabditis elegans
The expected taxonomic range for this enzyme is: Eukaryota, Archaea
Reaction Schemes
Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-/- bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides
Synonyms
cathepsin b, cathepsin-b, cysteine cathepsin, devdase, cat b, cathepsin b1, cathb, cath b, smcb1, cath-b, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
APP secretase
-
-
-
-
cathepsin B1
-
-
-
-
cathepsin II
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
esterification
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
9047-22-7
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
cathepsin B mediates radiation induced bystander effects. The enzyme seems to exert radiation induced bystander effects by acting through the insulin-like growth factor receptor DAF-2
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CPR4_CAEEL
335
0
36493
Swiss-Prot
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Peng, Y.; Zhang, M.; Zheng, L.; Liang, Q.; Li, H.; Chen, J.T.; Guo, H.; Yoshina, S.; Chen, Y.Z.; Zhao, X.; Wu, X.; Liu, B.; Mitani, S.; Yu, J.S.; Xue, D.
Cysteine protease cathepsin B mediates radiation-induced bystander effects
Nature
547
458-462
2017
Caenorhabditis elegans (P43508), Caenorhabditis elegans
Manually annotated by BRENDA team