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10-hydroxyusambarensine
binding energy -10.4 kcal/mol, additionally binds to ACE2 and SARS-CoV-2 spike protein
-
6-carbamimidoylnaphthalen-2-yl 2-chloro-4-[(diaminomethylidene)amino]benzoate
variant of inhibitors nafamostat, predicted binding energy -174.16 kcal/mol. EC50 value for inhibition of cytopathic effect caused by SARS-CoV-2 infection is 8 nM
-
6-carbamimidoylnaphthalen-2-yl 4-[(diaminomethylidene)amino]-2-methylbenzoate
variant of inhibitors nafamostat, predicted binding energy -172.38 kcal/mol. EC50 value for inhibition of cytopathic effect caused by SARS-CoV-2 infection is 15 nM
-
6-carbamimidoylnaphthalen-2-yl 4-[(diaminomethylidene)amino]-3-methylbenzoate
variant of inhibitors nafamostat, predicted binding energy -178.94 kcal/mol. EC50 value for inhibition of cytopathic effect caused by SARS-CoV-2 infection is 9.6 nM
-
alpha-1-antitrypsin
the reactive center loop of alpha-1-antitrypsin adopts an inhibitory-competent conformation compared with the crystal structure of TMPRSS2 bound to nafamostat or HAI-2 TMPRSS2 inhibitor. Negatively-charged heparin bridges adjacent electropositive patches at the TMPRSS2-alpha-1-antitrypsin interface, neutralizing otherwise repulsive forces. Heparinoid enoxaparin enhances alpha-1-antitrypsin inhibition of both TMPRSS2 activity and infection of human airway epithelial cells with coronavirus HCoV-229E
-
caffeic acid phenethyl ester
binds and stably interacts at the catalytic site of TMPRSS2, binding energy -6.2 kcal/mol, Gly464 and Ser436 are involved in hydrogen bond interactions
calmostat
topical TMPRSS2 inhibition when delivered in a clinically relevant and achievable dose to differentiated airways cells markedly restricts SARC-CoV-2 cellular infection
-
camostat
residues Asp435 and Glu299 significantly contribute to the binding. EC50 value for inhibition of cytopathic effect caused by SARS-CoV-2 infection is 66 nM
cryptoquindoline
binding energy -9.7 kcal/mol, additionally binds to ACE2 and SARS-CoV-2 spike protein
-
cryptospirolepine
binding energy -9.9 kcal/mol, additionally binds to ACE2 and SARS-CoV-2 spike protein
-
enoxaparin
heparinoid enoxaparin enhances alpha-1-antitrypsin inhibition of both TMPRSS2 activity and infection of human airway epithelial cells with coronavirus HCoV-229E
N-(6-carbamimidoylnaphthalen-2-yl)-4-[(diaminomethylidene)amino]benzamide
variant of inhibitors nafamostat, predicted binding energy -179.65 kcal/mol. EC50 value for inhibition of cytopathic effect caused by SARS-CoV-2 infection is 17 nM
-
N-(6-cyanonaphthalen-2-yl)-4-[(diaminomethylidene)amino]benzamide
variant of inhibitors nafamostat, predicted binding energy -127.92 kcal/mol
-
strychnopentamine
binding energy -8.8 kcal/mol, additionally binds to ACE2 and SARS-CoV-2 spike protein
-
withaferin A
binds and stably interacts at the catalytic site of TMPRSS2, binding energy -5.6 kcal/mol, residues Glu299 and Lys342 are mainly involved in polar interactions
withanone
binds and stably interacts at the catalytic site of TMPRSS2 and is able to induce changes in its allosteric site. Docking score is -4.3 kcal/nmol, Gly462 of TMPRSS2 is involved in the polar interactions. Withanone downregulates the expression of TMPRSS2 in MCF7 cells
-
(3R)-1-[(3-[(1R)-1-amino-2-[(3S,4R)-1-[[4-(aminomethyl)phenyl]methyl]-4-methylpyrrolidin-3-yl]ethyl]phenyl)methyl]piperidin-3-ol
-
inhibitor developed by fragment-based drug design
-
(3R,4R)-1-[[4-(aminomethyl)phenyl]methyl]-4-(2-[(1R,2Z)-2-[(5-hydroxy-2-methoxyphenyl)methylidene]cyclobutyl]ethyl)pyrrolidin-3-ol
-
inhibitor developed by fragment-based drug design
-
(3S)-1-[(3-[(1S)-1-amino-3-[(3S,4R)-1-[[4-(aminomethyl)phenyl]methyl]-4-methylpyrrolidin-3-yl]propyl]phenyl)methyl]piperidin-3-ol
-
inhibitor developed by fragment-based drug design
-
(3S)-3-(aminomethyl)-5-[(3R,4S)-1-[[4-(aminomethyl)phenyl]methyl]-4-methylpyrrolidin-3-yl]-1-(3,4-dihydroisoquinolin-2(1H)-yl)pentan-1-one
-
inhibitor developed by fragment-based drug design
-
(3S)-4-[(3R)-3-amino-3-(4-[[(3S)-3-hydroxypyrrolidin-1-yl]methyl]phenyl)propyl]-1-[[4-(aminomethyl)phenyl]methyl]pyrrolidin-3-ol
-
inhibitor developed by fragment-based drug design
-
(4S)-4-amino-5-[(3R,4S)-1-[[4-(aminomethyl)phenyl]methyl]-4-hydroxypyrrolidin-3-yl]-1-(1,4-dihydro-3H-2,3-benzoxazin-3-yl)pentan-1-one
-
inhibitor developed by fragment-based drug design
-
(4S)-4-amino-7-[(3R,4R)-1-[[4-(aminomethyl)phenyl]methyl]-4-hydroxypyrrolidin-3-yl]-1-(1,4-dihydro-3H-2,3-benzoxazin-3-yl)heptan-1-one
-
inhibitor developed by fragment-based drug design
-
2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-amine
-
compound exhibits a nearly effective TMPRSS2 inhibitory activity relative to tafenoquine , while it is deficient in SARS-CoV-2 main protease inhibition
-
3-[(Z)-[(2R,3R)-3-amino-2-[3-[(3S)-1-[[4-(aminomethyl)phenyl]methyl]pyrrolidin-3-yl]propyl]cyclobutylidene]methyl]-4-methoxyphenol
-
inhibitor developed by fragment-based drug design
-
5-[(1R,3R)-3-[[(3S)-3-acetamidopiperidin-1-yl]methyl]-1-aminocyclobutyl]-N-(2,3-dihydro-1H-isoindol-4-yl)-N2-methyl-D-norvalinamide
-
inhibitor developed by fragment-based drug design
-
5-[(1r,3S)-1-amino-3-[(2-methylpyridin-4-yl)amino]cyclobutyl]-N-[(1R)-4,6-difluoro-2,3-dihydro-1H-inden-1-yl]-D-norvalinamide
-
inhibitor developed by fragment-based drug design
-
tafenoquine
-
inhibits TMPRSS2 protease activity, tafenoquine may block SARS-CoV-2 by inhibiting enzymatic activities of both SARS-CoV-2 main protease and host TMPRSS2
-
camostat mesylate
-
camostat mesylate
docking score -5.9 kcal/mol, residue Gly464 forms a hydrogen bond
Nafamostat
-
Nafamostat
formation of a covalent bond between its acyl substructure and Ser441 in TMPRSS2. Residue Asp435 significantly contributes to the binding. EC50 value for inhibition of cytopathic effect caused by SARS-CoV-2 infection is 11 nM
additional information
synthesis of variants of inhibitors nafamostat and camostat. Their predicted binding affinity does not correlate with their anti-SARS-CoV-2 activity. The substitution of the ester bond with an amide bond in nafamostat results in significantly weakened anti-SARS-CoV-2 activity
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additional information
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homology modeling of TMPRSS2 protein and application of the fragment-based drug design technique to develop effective TMPRSS2 inhibitors reveals 10 molecules with docking score below -14.982 kcal/mol compared to ambroxol with a docking score of - 6.464 kcal/mol
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Acute Kidney Injury
Can transmembrane protease serine 2 be attributed to coronavirus disease-2019 related acute kidney injury predominance in males?
Acute Kidney Injury
Novel Evidence of Acute Kidney Injury in COVID-19.
Acute Lung Injury
COVID-19-The Potential Beneficial Therapeutic Effects of Spironolactone during SARS-CoV-2 Infection.
Adenocarcinoma of Lung
Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection.
Adenocarcinoma of Lung
Comparative Investigation of Composition, Antifungal, and Anti-Inflammatory Effects of the Essential Oil from Three Industrial Hemp Varieties from Italian Cultivation.
Adenocarcinoma of Lung
Structural variations and expression profiles of the SARS-CoV-2 host invasion genes in lung cancer.
Alopecia
Early Antiandrogen Therapy With Dutasteride Reduces Viral Shedding, Inflammatory Responses, and Time-to-Remission in Males With COVID-19: A Randomized, Double-Blind, Placebo-Controlled Interventional Trial (EAT-DUTA AndroCoV Trial - Biochemical).
Breast Neoplasms
Cross talk between COVID-19 and breast cancer.
Carcinogenesis
Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.
Carcinogenesis
Prevalence and clinical application of TMPRSS2-ERG fusion in Asian prostate cancer patients: a large-sample study in Chinese people and a systematic review.
Carcinoma
Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection.
Carcinoma
Cloning and characterization of the cDNA and gene for human epitheliasin.
Carcinoma, Squamous Cell
Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection.
Carcinoma, Squamous Cell
Structural variations and expression profiles of the SARS-CoV-2 host invasion genes in lung cancer.
Common Cold
Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry.
Coronavirus Infections
A Review on Expression, Pathological Roles, and Inhibition of TMPRSS2, the Serine Protease Responsible for SARS-CoV-2 Spike Protein Activation.
Coronavirus Infections
COVID-19 and human reproduction: A pandemic that packs a serious punch.
Coronavirus Infections
Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection?
Coronavirus Infections
The Anticoagulant Nafamostat Potently Inhibits SARS-CoV-2 S Protein-Mediated Fusion in a Cell Fusion Assay System and Viral Infection In Vitro in a Cell-Type-Dependent Manner.
COVID-19
Acute Pancreatitis in a Patient With COVID-19 After the Resolution of Respiratory Symptoms.
COVID-19
Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD.
COVID-19
Alpha-1-antitrypsin: A possible host protective factor against Covid-19.
COVID-19
Association between SARS-CoV-2 infection and disease severity among prostate cancer patients on androgen deprivation therapy: a systematic review and meta-analysis.
COVID-19
Cellular Tropism of SARS-CoV-2 across Human Tissues and Age-related Expression of ACE2 and TMPRSS2 in Immune-inflammatory Stromal Cells.
COVID-19
Characteristics of Angiotensin I-converting enzyme 2, type II transmembrane serine protease 2 and 4 in tree shrew indicate it as a potential animal model for SARS-CoV-2 infection.
COVID-19
Classical and alternative receptors for SARS-CoV-2 therapeutic strategy.
COVID-19
Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study.
COVID-19
Comprehensive analysis of two potential novel SARS-CoV-2 entries, TMPRSS2 and IFITM3, in healthy individuals and cancer patients.
COVID-19
COVID-19 and human reproduction: A pandemic that packs a serious punch.
COVID-19
COVID-19-The Potential Beneficial Therapeutic Effects of Spironolactone during SARS-CoV-2 Infection.
COVID-19
COVID-19: Understanding Inter-Individual Variability and Implications for Precision Medicine.
COVID-19
Cross talk between COVID-19 and breast cancer.
COVID-19
Dealing with lung cancer in the COVID-19 scenario (A review).
COVID-19
Differential Expression of Rab5 and Rab7 Small GTPase Proteins in Placental Tissues From Pregnancies Affected by Maternal Coronavirus Disease 2019.
COVID-19
Do Anti-androgens Have Potential as Therapeutics for COVID-19?
COVID-19
Does severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) cause orchitis in patients with coronavirus disease 2019 (COVID-19)?
COVID-19
Early Antiandrogen Therapy With Dutasteride Reduces Viral Shedding, Inflammatory Responses, and Time-to-Remission in Males With COVID-19: A Randomized, Double-Blind, Placebo-Controlled Interventional Trial (EAT-DUTA AndroCoV Trial - Biochemical).
COVID-19
Effect of bromhexine in hospitalized patients with COVID-19.
COVID-19
Estrogen receptors are linked to angiotensin-converting enzyme 2 (ACE2), ADAM metallopeptidase domain 17 (ADAM-17), and transmembrane protease serine 2 (TMPRSS2) expression in the human atrium: insights into COVID-19.
COVID-19
Existence of SARS-CoV-2 Entry Molecules in the Oral Cavity.
COVID-19
Expression of Endogenous Angiotensin-Converting Enzyme 2 in Human Induced Pluripotent Stem Cell-Derived Retinal Organoids.
COVID-19
From bedside to bench: regulation of host factors in SARS-CoV-2 infection.
COVID-19
Gastrointestinal cancers, ACE-2/TMPRSS2 expression and susceptibility to COVID-19.
COVID-19
GB-2 inhibits ACE2 and TMPRSS2 expression: In vivo and in vitro studies.
COVID-19
Gene expression network analysis provides potential targets against SARS-CoV-2.
COVID-19
Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection?
COVID-19
Human genetic basis of coronavirus disease 2019.
COVID-19
Impact of COVID-19 on the Endocrine System - a mini-review.
COVID-19
Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2.
COVID-19
Is There a Link between Bisphenol A (BPA), a Key Endocrine Disruptor, and the Risk for SARS-CoV-2 Infection and Severe COVID-19?
COVID-19
Low risk of the TMPRSS2 inhibitor camostat mesylate and its metabolite GBPA to act as perpetrators of drug-drug interactions.
COVID-19
Male balding as a major risk factor for severe COVID-19: a possible role for targeting androgens and transmembrane protease serine 2 to protect vulnerable individuals.
COVID-19
Mechanics Insights of Alpha-Lipoic Acid against Cardiovascular Diseases during COVID-19 Infection.
COVID-19
No evidence of severe acute respiratory syndrome-coronavirus 2 in semen of males recovering from coronavirus disease 2019.
COVID-19
Paediatric COVID-19 and the GUT.
COVID-19
Pan?cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS?CoV?2 infection leading to COVID-19.
COVID-19
Pandemic COVID-19 caused by SARS-CoV-2: genetic structure, vaccination, and therapeutic approaches.
COVID-19
Pernio (Chilblains), SARS-CoV-2, and COVID Toes Unified Through Cutaneous and Systemic Mechanisms.
COVID-19
Phyto-pharmacological perspective of Silymarin: A potential prophylactic or therapeutic agent for COVID-19, based on its promising immunomodulatory, anti-coagulant and anti-viral property.
COVID-19
Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion.
COVID-19
Possible use of the mucolytic drug, bromhexine hydrochloride, as a prophylactic agent against SARS-CoV-2 infection based on its action on the Transmembrane Serine Protease 2.
COVID-19
Questionnaire Survey on the Current Situation and Experience in Prevention and Control Measures at Urology Clinics During the COVID-19 Epidemic in China.
COVID-19
Roles of existing drug and drug targets for COVID-19 management.
COVID-19
SARS-CoV-2 entry inhibitors by dual targeting TMPRSS2 and ACE2: An in silico drug repurposing study.
COVID-19
SARS-CoV-2 infection and smoking: What is the association? A brief review.
COVID-19
Stress Decreases Host Viral Resistance and Increases Covid Susceptibility in Embryonic Stem Cells.
COVID-19
Strong Correlation between the Case Fatality Rate of COVID-19 and the rs6598045 Single Nucleotide Polymorphism (SNP) of the Interferon-Induced Transmembrane Protein 3 (IFITM3) Gene at the Population-Level.
COVID-19
Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2.
COVID-19
Testosterone target therapy: focus on immune response, controversies and clinical implications in patients with COVID-19 infection.
COVID-19
The contrasting role of nasopharyngeal angiotensin converting enzyme 2 (ACE2) transcription in SARS-CoV-2 infection: A cross-sectional study of people tested for COVID-19 in British Columbia, Canada.
COVID-19
The role of androgens in COVID-19.
COVID-19
Type 2 inflammation modulates ACE2 and TMPRSS2 in airway epithelial cells.
COVID-19
Understanding structural malleability of the SARS-CoV-2 proteins and relation to the comorbidities.
COVID-19
Unravelling high-affinity binding compounds towards transmembrane protease serine 2 enzyme in treating SARS-CoV-2 infection using molecular modelling and docking studies.
COVID-19
White Button Mushroom (Agaricus bisporus) Interrupts Tissue AR-TMPRSS2 Expression and Attenuates Pro-inflammatory Cytokines in C57BL/6 Mice: Implication for COVID-19 Dietary Intervention.
COVID-19
Why does SARS-CoV-2 hit in different ways? Host genetic factors can influence the acquisition or the course of COVID-19.
COVID-19
Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections.
Cystic Fibrosis
SARS-CoV-2 Entry Genes Expression in Relation with Interferon Response in Cystic Fibrosis Patients.
Cytomegalovirus Infections
Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections.
Disseminated Intravascular Coagulation
The Anticoagulant Nafamostat Potently Inhibits SARS-CoV-2 S Protein-Mediated Fusion in a Cell Fusion Assay System and Viral Infection In Vitro in a Cell-Type-Dependent Manner.
Hepatitis
Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection?
Infections
A Cytopathic Effect-Based Tissue Culture Method for HCoV-OC43 Titration Using TMPRSS2-Expressing VeroE6 Cells.
Infections
Alpha-1 Antitrypsin for COVID-19 Treatment: Dual Role in Antiviral Infection and Anti-Inflammation.
Infections
Can SARS-CoV-2 infect the eye? An overview of the receptor status in ocular tissue.
Infections
Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study.
Infections
COVID-19 and bronchial asthma: current perspectives.
Infections
COVID-19-The Potential Beneficial Therapeutic Effects of Spironolactone during SARS-CoV-2 Infection.
Infections
Do Anti-androgens Have Potential as Therapeutics for COVID-19?
Infections
Effect of bromhexine in hospitalized patients with COVID-19.
Infections
Efficient activation of SARS coronavirus spike protein by the transmembrane protease, TMPRSS2.
Infections
Expression of severe acute respiratory syndrome coronavirus 2 cell entry genes, angiotensin-converting enzyme 2 and transmembrane protease serine 2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia.
Infections
Human eggs, zygotes, and embryos express the receptor angiotensin 1-converting enzyme 2 and transmembrane serine protease 2 protein necessary for severe acute respiratory syndrome coronavirus 2 infection.
Infections
Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2.
Infections
Pan?cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS?CoV?2 infection leading to COVID-19.
Infections
Pernio (Chilblains), SARS-CoV-2, and COVID Toes Unified Through Cutaneous and Systemic Mechanisms.
Infections
Potential repurposing of the HDAC inhibitor valproic acid for patients with COVID-19.
Infections
Role of Structural and Non-Structural Proteins and Therapeutic Targets of SARS-CoV-2 for COVID-19.
Infections
Roles of existing drug and drug targets for COVID-19 management.
Infections
SARS-CoV-2 pseudovirus infectivity and expression of viral entry-related factors ACE2, TMPRSS2, Kim-1, and NRP-1 in human cells from the respiratory, urinary, digestive, reproductive, and immune systems.
Infections
The Anticoagulant Nafamostat Potently Inhibits SARS-CoV-2 S Protein-Mediated Fusion in a Cell Fusion Assay System and Viral Infection In Vitro in a Cell-Type-Dependent Manner.
Infections
Transmembrane serine protease 2 Polymorphisms and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection: A German Case-Control Study.
Infections
[Can SARS-CoV-2 infect the eye?-An overview of the receptor status in ocular tissue].
Influenza in Birds
Establishment of MDCK Stable Cell Lines Expressing TMPRSS2 and MSPL and Their Applications in Propagating Influenza Vaccine Viruses in Absence of Exogenous Trypsin.
Influenza, Human
Airway proteases: an emerging drug target for influenza and other respiratory virus infections.
Influenza, Human
Effect of bromhexine in hospitalized patients with COVID-19.
Influenza, Human
Influenza virus activating host proteases: Identification, localization and inhibitors as potential therapeutics.
Influenza, Human
The human Transmembrane Protease Serine 2 is necessary for the production of Group 2 influenza A virus pseudotypes.
Influenza, Human
White button mushroom interrupts tissue AR-mediated TMPRSS2 expression and attenuates pro-inflammatory cytokines in C57BL/6 mice.
Liver Diseases
Single-Cell RNA-seq Reveals Angiotensin-Converting Enzyme 2 and Transmembrane Serine Protease 2 Expression in TROP2+ Liver Progenitor Cells: Implications in Coronavirus Disease 2019-Associated Liver Dysfunction.
Neoplasm Metastasis
Targeting the intestinal TMPRSS2 protease to prevent SARS-CoV-2 entry into enterocytes-prospects and challenges.
Neoplasms
A pressor dose of angiotensin II has no influence on the angiotensin-converting enzyme 2 and other molecules associated with SARS-CoV-2 infection in mice.
Neoplasms
Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.
Neoplasms
ACE2 and TMPRSS2 Potential Involvement in Genetic Susceptibility to SARS-COV-2 in Cancer Patients.
Neoplasms
Distinct prostate cancer-related mRNA cargo in extracellular vesicle subsets from prostate cell lines.
Neoplasms
Downregulation of ACE2 expression by SARS-CoV-2 worsens the prognosis of KIRC and KIRP patients via metabolism and immunoregulation.
Neoplasms
Genetic Susceptibility of ACE2 and TMPRSS2 in Six Common Cancers and Possible Impacts on COVID-19.
Neoplasms
Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection?
Neoplasms
Micro-RNA-204 Participates in TMPRSS2/ERG Regulation and Androgen Receptor Reprogramming in Prostate Cancer.
Neoplasms
Potential detrimental role of soluble ACE2 in severe COVID-19 comorbid patients.
Neoplasms
Saccharomyces cerevisiae-like 1 overexpression is frequent in prostate cancer and has markedly different effects in Ets-related gene fusion-positive and fusion-negative cancers.
Neoplasms
Targeted Next-generation Sequencing of Advanced Prostate Cancer Identifies Potential Therapeutic Targets and Disease Heterogeneity.
Neoplasms
Targeting the intestinal TMPRSS2 protease to prevent SARS-CoV-2 entry into enterocytes-prospects and challenges.
Neoplasms
The role of T2E mediated CBF-1/RBP-J? signaling in metastatic thyroid cancer.
Neoplasms
TMPRSS2-ERG Fusion Promotes Recruitment of Regulatory T cells and Tumor Growth in Prostate Cancer.
Neoplasms
TMPRSS2-ERG Status in Circulating Tumor Cells as a Predictive Biomarker of Sensitivity in Castration-Resistant Prostate Cancer Patients Treated With Abiraterone Acetate.
Neoplastic Cells, Circulating
TMPRSS2-ERG Status in Circulating Tumor Cells as a Predictive Biomarker of Sensitivity in Castration-Resistant Prostate Cancer Patients Treated With Abiraterone Acetate.
Paramyxoviridae Infections
Effect of bromhexine in hospitalized patients with COVID-19.
Periodontal Pocket
Role of NLRP3 inflammasome in COVID-19 and periodontitis: Possible protective effect of melatonin.
Pneumonia
COVID-19-The Potential Beneficial Therapeutic Effects of Spironolactone during SARS-CoV-2 Infection.
Pre-Eclampsia
Expression of severe acute respiratory syndrome coronavirus 2 cell entry genes, angiotensin-converting enzyme 2 and transmembrane protease serine 2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia.
Premature Birth
Expression of severe acute respiratory syndrome coronavirus 2 cell entry genes, angiotensin-converting enzyme 2 and transmembrane protease serine 2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia.
Prostatic Neoplasms
Androgen receptor and gene network: Micromechanics reassemble the signaling machinery of TMPRSS2-ERG positive prostate cancer cells.
Prostatic Neoplasms
Antibody-independent targeted quantification of TMPRSS2-ERG fusion protein products in prostate cancer.
Prostatic Neoplasms
Assessment of long-term outcomes associated with urinary prostate cancer antigen 3 and TMPRSS2:ERG gene fusion at repeat biopsy.
Prostatic Neoplasms
Clinical significance of ERG rearrangement subtype and its association with increased p53 expression in Japanese and German prostate cancer.
Prostatic Neoplasms
Comparative assessment of urinary prostate cancer antigen 3 and TMPRSS2:ERG gene fusion with the serum [-2]proprostate-specific antigen-based prostate health index for detection of prostate cancer.
Prostatic Neoplasms
Correlation of urine TMPRSS2:ERG and PCA3 to ERG+ and total prostate cancer burden.
Prostatic Neoplasms
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide.
Prostatic Neoplasms
ERG expression in prostate cancer: biological relevance and clinical implication.
Prostatic Neoplasms
ERG immunohistochemistry is not predictive for PSA recurrence, local recurrence or overall survival after radical prostatectomy for prostate cancer.
Prostatic Neoplasms
ERG oncoprotein expression in prostate carcinoma patients of different ethnicities.
Prostatic Neoplasms
ERG-TMPRSS2 rearrangement is shared by concurrent prostatic adenocarcinoma and prostatic small cell carcinoma and absent in small cell carcinoma of the urinary bladder: evidence supporting monoclonal origin.
Prostatic Neoplasms
Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer.
Prostatic Neoplasms
ETS Gene Fusions in Prostate Cancer: From Discovery to Daily Clinical Practice.
Prostatic Neoplasms
Expression of the Androgen-Regulated Fusion Gene TMPRSS2-ERG Does Not Predict Response to Endocrine Treatment in Hormone-Naïve, Node-Positive Prostate Cancer.
Prostatic Neoplasms
High concordance of TMPRSS-ERG fusion between primary prostate cancer and its lymph node metastases.
Prostatic Neoplasms
Management of men with previous negative prostate biopsy.
Prostatic Neoplasms
Obesity and Prostate Cancer Risk According to Tumor TMPRSS2:ERG Gene Fusion Status.
Prostatic Neoplasms
Phosphorylation of the oncogenic transcription factor ERG in prostate cells dissociates polycomb repressive complex 2 allowing target gene activation.
Prostatic Neoplasms
Prevalence and clinical application of TMPRSS2-ERG fusion in Asian prostate cancer patients: a large-sample study in Chinese people and a systematic review.
Prostatic Neoplasms
Prostate cancer proteomics: Current trends and future perspectives for biomarker discovery.
Prostatic Neoplasms
T2E (TMPRSS2-ERG) fusion transcripts are associated with higher levels of AMACR mRNA and a subsequent prostate cancer diagnosis in patients with atypical small acinar proliferation.
Prostatic Neoplasms
The discovery and application of gene fusions in prostate cancer.
Prostatic Neoplasms
The discovery of common recurrent transmembrane protease serine 2 (TMPRSS2)-erythroblastosis virus E26 transforming sequence (ETS) gene fusions in prostate cancer: significance and clinical implications.
Prostatic Neoplasms
The Significance of ERG and Androgen Receptor Expression in Adenocarcinoma Prostate.
Prostatic Neoplasms
The TMPRSS2:ERG Rearrangement, ERG Expression, and Prostate Cancer Outcomes: A Cohort Study and Meta-analysis.
Prostatic Neoplasms
TMPRSS2-ERG Fusion Gene Expression in Prostate Tumor Cells and Its Clinical and Biological Significance in Prostate Cancer Progression.
Prostatic Neoplasms
TMPRSS2-ERG Fusion Promotes Recruitment of Regulatory T cells and Tumor Growth in Prostate Cancer.
Prostatic Neoplasms
TMPRSS2-ERG Fusions Are Strongly Linked to Young Patient Age in Low-grade Prostate Cancer.
Prostatic Neoplasms
TMPRSS2-ERG gene fusion in Turkish patients with localized prostate cancer: results of radical prostatectomy specimens.
Prostatic Neoplasms
TMPRSS2-ERG gene fusions induce prostate tumorigenesis by modulating microRNA miR-200c.
Prostatic Neoplasms
TRANSMEMBRANE PROTEASE SERINE 2 IN PROSTATE CANCER.
Prostatic Neoplasms
Urine TMPRSS2:ERG Fusion Transcript Stratifies Prostate Cancer Risk in Men with Elevated Serum PSA.
Prostatic Neoplasms
White Button Mushroom (Agaricus bisporus) Interrupts Tissue AR-TMPRSS2 Expression and Attenuates Pro-inflammatory Cytokines in C57BL/6 Mice: Implication for COVID-19 Dietary Intervention.
Prostatic Neoplasms
White button mushroom interrupts tissue AR-mediated TMPRSS2 expression and attenuates pro-inflammatory cytokines in C57BL/6 mice.
Prostatic Neoplasms
[Frequency and transcript variant analysis of gene fusions between TMPRSS2 and ETS transcription factor genes in prostate cancer]
Prostatic Neoplasms
[The progress of TMPRSS2-ETS gene fusions and their mechanism in prostate cancer].
Renal Insufficiency, Chronic
Kidney ACE2 expression: Implications for chronic kidney disease.
Retinoblastoma
Targeted Next-generation Sequencing of Advanced Prostate Cancer Identifies Potential Therapeutic Targets and Disease Heterogeneity.
Severe Acute Respiratory Syndrome
A Review on Expression, Pathological Roles, and Inhibition of TMPRSS2, the Serine Protease Responsible for SARS-CoV-2 Spike Protein Activation.
Severe Acute Respiratory Syndrome
Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD.
Severe Acute Respiratory Syndrome
Alpha-1 Antitrypsin for COVID-19 Treatment: Dual Role in Antiviral Infection and Anti-Inflammation.
Severe Acute Respiratory Syndrome
Camostat Mesylate May Reduce Severity of Coronavirus Disease 2019 Sepsis: A First Observation.
Severe Acute Respiratory Syndrome
Circulating Soluble ACE2 and Upstream microRNA Expressions in Serum of Type 2 Diabetes Mellitus Patients.
Severe Acute Respiratory Syndrome
Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study.
Severe Acute Respiratory Syndrome
COVID-19 and bronchial asthma: current perspectives.
Severe Acute Respiratory Syndrome
COVID-19 and human reproduction: A pandemic that packs a serious punch.
Severe Acute Respiratory Syndrome
COVID-19: Understanding Inter-Individual Variability and Implications for Precision Medicine.
Severe Acute Respiratory Syndrome
Diesel Particulate Matter 2.5 Induces Epithelial-to-Mesenchymal Transition and Upregulation of SARS-CoV-2 Receptor during Human Pluripotent Stem Cell-Derived Alveolar Organoid Development.
Severe Acute Respiratory Syndrome
Do Anti-androgens Have Potential as Therapeutics for COVID-19?
Severe Acute Respiratory Syndrome
Does severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) cause orchitis in patients with coronavirus disease 2019 (COVID-19)?
Severe Acute Respiratory Syndrome
Downregulation of ACE2 expression by SARS-CoV-2 worsens the prognosis of KIRC and KIRP patients via metabolism and immunoregulation.
Severe Acute Respiratory Syndrome
Early Antiandrogen Therapy With Dutasteride Reduces Viral Shedding, Inflammatory Responses, and Time-to-Remission in Males With COVID-19: A Randomized, Double-Blind, Placebo-Controlled Interventional Trial (EAT-DUTA AndroCoV Trial - Biochemical).
Severe Acute Respiratory Syndrome
Estrogen and Androgen Receptor Inhibitors: Unexpected Allies in the Fight Against COVID-19.
Severe Acute Respiratory Syndrome
Existence of SARS-CoV-2 Entry Molecules in the Oral Cavity.
Severe Acute Respiratory Syndrome
Expression of ACE2, TMPRSS2, and Furin in Mouse Ear Tissue, and the Implications for SARS-CoV-2 Infection.
Severe Acute Respiratory Syndrome
Expression of severe acute respiratory syndrome coronavirus 2 cell entry genes, angiotensin-converting enzyme 2 and transmembrane protease serine 2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia.
Severe Acute Respiratory Syndrome
Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection.
Severe Acute Respiratory Syndrome
Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection?
Severe Acute Respiratory Syndrome
Human eggs, zygotes, and embryos express the receptor angiotensin 1-converting enzyme 2 and transmembrane serine protease 2 protein necessary for severe acute respiratory syndrome coronavirus 2 infection.
Severe Acute Respiratory Syndrome
Kidney ACE2 expression: Implications for chronic kidney disease.
Severe Acute Respiratory Syndrome
Micronutrients and bioactive substances: Their potential roles in combating COVID-19.
Severe Acute Respiratory Syndrome
miR-98 Regulates TMPRSS2 Expression in Human Endothelial Cells: Key Implications for COVID-19.
Severe Acute Respiratory Syndrome
No evidence of severe acute respiratory syndrome-coronavirus 2 in semen of males recovering from coronavirus disease 2019.
Severe Acute Respiratory Syndrome
Paediatric COVID-19 and the GUT.
Severe Acute Respiratory Syndrome
Pernio (Chilblains), SARS-CoV-2, and COVID Toes Unified Through Cutaneous and Systemic Mechanisms.
Severe Acute Respiratory Syndrome
SARS-CoV-2 pseudovirus infectivity and expression of viral entry-related factors ACE2, TMPRSS2, Kim-1, and NRP-1 in human cells from the respiratory, urinary, digestive, reproductive, and immune systems.
Severe Acute Respiratory Syndrome
Sex Hormones and Hormone Therapy during COVID-19 Pandemic: Implications for Patients with Cancer.
Severe Acute Respiratory Syndrome
Spironolactone may provide protection from SARS-CoV-2: Targeting androgens, angiotensin converting enzyme 2 (ACE2), and renin-angiotensin-aldosterone system (RAAS).
Severe Acute Respiratory Syndrome
Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2.
Severe Acute Respiratory Syndrome
TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein.
Severe Acute Respiratory Syndrome
Transmembrane serine protease 2 Polymorphisms and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection: A German Case-Control Study.
Viremia
An Update on Coronavirus Disease 2019 (COVID-19) and Pregnancy.
Viremia
Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic.
Virus Diseases
Dodging COVID-19 infection: low expression and localization of ACE2 and TMPRSS2 in multiple donor-derived lines of human umbilical cord-derived mesenchymal stem cells.
Virus Diseases
Targeting the intestinal TMPRSS2 protease to prevent SARS-CoV-2 entry into enterocytes-prospects and challenges.
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David, A.; Parkinson, N.; Peacock, T.; Pairo-Castineira, E.; Khanna, T.; Cobat, A.; Tenesa, A.; Sancho-Shimizu, V.; Casanova, J.; Abel, L.; Barclay, W.; Baillie, J.; Sternberg, M.
A common TMPRSS2 variant has a protective effect against severe COVID-19
Curr. Res. Transl. Med.
70
103333
2022
Homo sapiens (O15393)
brenda
Baristaite, G.; Gurwitz, D.
Estradiol reduces ACE2 and TMPRSS2 mRNA levels in A549 human lung epithelial cells
Drug Dev. Res.
2022
1-6
2022
Homo sapiens (O15393)
brenda
Alzain, A.A.; Elbadwi, F.A.; Alsamani, F.O.
Discovery of novel TMPRSS2 inhibitors for COVID-19 using in silico fragment-based drug design, molecular docking, molecular dynamics, and quantum mechanics studies
Inform. Med. Unlocked
29
100870
2022
Homo sapiens
brenda
Schneider, M.A.; Richtmann, S.; Gruending, A.R.; Wrenger, S.; Welte, T.; Meister, M.; Kriegsmann, M.; Winter, H.; Muley, T.; Janciauskiene, S.
Transmembrane serine protease 2 is a prognostic factor for lung adenocarcinoma
Int. J. Oncol.
60
39
2022
Homo sapiens (O15393)
brenda
Chen, Y.; Yang, W.; Chen, H.; Huang, L.; Gao, J.; Lin, C.; Wang, Y.; Yang, C.; Liu, Y.; Hou, M.; Tsai, C.; Chou, Y.; Huang, B.; Hung, C.; Hung, Y.; Wang, W.; Su, W.; Kumar, V.; Wu, Y.; Chao, S.; Chang, C.; Chen, J.; Chiang, Y.; Cho, D.; Jeng, L.; Tsai, C.
Tafenoquine and its derivatives as inhibitors for the severe acute respiratory syndrome coronavirus 2
J. Biol. Chem.
298
101658
2022
Homo sapiens
brenda
Kumar, V.; Dhanjal, J.; Bhargava, P.; Kaul, A.; Wang, J.; Zhang, H.; Kaul, S.; Wadhwa, R.; Sundar, D.
Withanone and Withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells
J. Biomol. Struct. Dyn.
40
1-13
2022
Homo sapiens (O15393)
brenda
Gyebi, G.A.; Adegunloye, A.P.; Ibrahim, I.M.; Ogunyemi, O.M.; Afolabi, S.O.; Ogunro, O.B.
Prevention of SARS-CoV-2 cell entry insight from in silico interaction of drug-like alkaloids with spike glycoprotein, human ACE2, and TMPRSS2
J. Biomol. Struct. Dyn.
40
2121-2145
2022
Homo sapiens (O15393)
brenda
Lee, J.H.; Lee, C.E.; Yoo, Y.; Shin, E.; An, J.; Park, S.Y.; Song, W.J.; Kwon, H.S.; Cho, Y.S.; Moon, H.B.; Kim, T.B.
Soluble ACE2 and TMPRSS2 levels in the serum of asthmatic patients
J. Korean Med. Sci.
37
e65
2022
Homo sapiens (O15393)
brenda
Salleh, M.Z.; Deris, Z.Z.
In silico molecular characterization of human TMPRSS2 protease polymorphic variants and associated SARS-CoV-2 susceptibility
Life
12
231
2022
Homo sapiens (O15393)
brenda
Guo, W.; Porter, L.M.; Crozier, T.W.; Coates, M.; Jha, A.; McKie, M.; Nathan, J.A.; Lehner, P.J.; Greenwood, E.J.; McCaughan, F.
Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway cultures
Life Sci. Alliance
5
e202101116
2022
Homo sapiens (O15393)
brenda
Park, G.C.; Bang, S.Y.; Lee, H.W.; Choi, K.U.; Kim, J.M.; Shin, S.C.; Cheon, Y.I.; Sung, E.S.; Lee, M.; Lee, J.C.; Kim, H.S.; Lee, B.J.
ACE2 and TMPRSS2 immunolocalization and oral manifestations of COVID-19
Oral Dis.
2022
1-9
2022
Homo sapiens (O15393)
brenda
Bai, X.; Buckle, A.M.; Vladar, E.K.; Janoff, E.N.; Khare, R.; Ordway, D.; Beckham, D.; Fornis, L.B.; Majluf-Cruz, A.; Fugit, R.V.; Freed, B.M.; Kim, S.; Sandhaus, R.A.; Chan, E.D.
Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19
Sci. Rep.
12
5207
2022
Homo sapiens (O15393)
brenda
Kapczynski, D.R.; Sweeney, R.; Spackman, E.; Pantin-Jackwood, M.; Suarez, D.L.
Development of an in vitro model for animal species susceptibility to SARS-CoV-2 replication based on expression of ACE2 and TMPRSS2 in avian cells
Virology
569
1-12
2022
Capra hircus (A0A452FYA6), Felis catus (Q56H28), Homo sapiens (O15393), Mesocricetus auratus
brenda
Fujimoto, K.J.; Hobbs, D.C.F.; Umeda, M.; Nagata, A.; Yamaguchi, R.; Sato, Y.; Sato, A.; Ohmatsu, K.; Ooi, T.; Yanai, T.; Kimura, H.; Murata, T.
In silico analysis and synthesis of nafamostat derivatives and evaluation of their anti-SARS-CoV-2 activity
Viruses
14
389
2022
Homo sapiens (O15393)
brenda