Reference on EC 3.4.21.B6 - prostasin
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Liu, L.; Hering-Smith, K.S.; Schiro, F.R.; Hamm, L.L.
Serine protease activity in M-1 cortical collecting duct cells
Hypertension
39
860-864
2002
Mus musculus
Yu, J.X.; Chao, L.; Chao, J.
Prostasin is a novel human serine proteinase from seminal fluid. Purification, tissue distribution, and localization in prostate gland
J. Biol. Chem.
269
18843-18848
1994
Homo sapiens
Chen, L.M.; Skinner, M.L.; Kauffman, S.W.; Chao, J.; Chao, L.; Thaler, C.D.; Chai, K.X.
Prostasin is a glycosylphosphatidylinositol-anchored active serine protease
J. Biol. Chem.
276
21434-21442
2001
Homo sapiens
Tong, Z.; Illek, B.; Bhagwandin, V.J.; Verghese, G.M.; Caughey, G.H.
Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line
Am. J. Physiol. Lung Cell Mol. Physiol.
287
L928-L935
2004
Homo sapiens
Chen, L.M.; Wang, C.; Chen, M.; Marcello, M.R.; Chao, J.; Chao, L.; Chai, K.X.
Prostasin attenuates inducible nitric oxide synthase expression in lipopolysaccharide-induced urinary bladder inflammation
Am. J. Physiol. Renal Physiol.
291
F567-F577
2006
Mus musculus, Homo sapiens (Q16651), Homo sapiens
Shipway, A.; Danahay, H.; Williams, J.A.; Tully, D.C.; Backes, B.J.; Harris, J.L.
Biochemical characterization of prostasin, a channel activating protease
Biochem. Biophys. Res. Commun.
324
953-963
2004
Homo sapiens
Chao, J.
Prostasin
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , Eds. ) Academic Press
2
1708-1709
2004
Homo sapiens, Mus musculus, Rattus norvegicus, Xenopus laevis
-
Olivieri, O.; Castagna, A.; Guarini, P.; Chiecchi, L.; Sabaini, G.; Pizzolo, F.; Corrocher, R.; Righetti, P.G.
Urinary prostasin: a candidate marker of epithelial sodium channel activation in humans
Hypertension
46
683-688
2005
Homo sapiens
Tuyen, d.o.G.; Kitamura, K.; Adachi, M.; Miyoshi, T.; Wakida, N.; Nagano, J.; Nonoguchi, H.; Tomita, K.
Inhibition of prostasin expression by TGF-beta1 in renal epithelial cells
Kidney Int.
67
193-200
2005
Rattus norvegicus
Chen, L.M.; Zhang, X.; Chai, K.X.
Regulation of prostasin expression and function in the prostate
Prostate
59
1-12
2004
Homo sapiens (Q16651)
Verghese, G.M.; Gutknecht, M.F.; Caughey, G.H.
Prostasin regulates epithelial monolayer function: cell-specific Gpld1-mediated secretion and functional role for GPI anchor
Am. J. Physiol.
291
C1258-C1270
2006
Mus musculus (Q99L44), Mus musculus
Myerburg, M.M.; McKenna, E.E.; Luke, C.J.; Frizzell, R.A.; Kleyman, T.R.; Pilewski, J.M.
Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis
Am. J. Physiol. Lung Cell Mol. Physiol.
294
L932-L941
2008
Homo sapiens
Chen, M.; Chen, L.M.; Chai, K.X.
Mechanisms of sterol regulatory element-binding protein-2 (SREBP-2) regulation of human prostasin gene expression
Biochem. Biophys. Res. Commun.
346
1245-1253
2006
Homo sapiens
Chen, M.; Fu, Y.; Lin, C.; Chen, L.; Chai, K.X.
Prostasin induces protease-dependent and independent molecular changes in the human prostate carcinoma cell line PC-3
Biochim. Biophys. Acta
1773
1133-1140
2007
Homo sapiens
Netzel-Arnett, S.; Currie, B.M.; Szabo, R.; Lin, C.Y.; Chen, L.M.; Chai, K.X.; Antalis, T.M.; Bugge, T.H.; List, K.
Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation
J. Biol. Chem.
281
32941-32945
2006
Mus musculus
Bruns, J.B.; Carattino, M.D.; Sheng, S.; Maarouf, A.B.; Weisz, O.A.; Pilewski, J.M.; Hughey, R.P.; Kleyman, T.R.
Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit
J. Biol. Chem.
282
6153-6160
2007
Mus musculus
List, K.; Hobson, J.P.; Molinolo, A.; Bugge, T.H.
Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase
J. Cell. Physiol.
213
237-245
2007
Mus musculus
Lin, H.Y.; Zhang, H.; Yang, Q.; Wang, H.X.; Wang, H.M.; Chai, K.X.; Chen, L.M.; Zhu, C.
Expression of prostasin and protease nexin-1 in rhesus monkey (Macaca mulatta) endometrium and placenta during early pregnancy
J. Histochem. Cytochem.
54
1139-1147
2006
Macaca mulatta
Zhang, H.; Lin, H.Y.; Yang, Q.; Wang, H.X.; Chai, K.X.; Chen, L.M.; Zhu, C.
Expression of prostasin serine protease and protease nexin-1 (PN-1) in rhesus monkey ovary during menstrual cycle and early pregnancy
J. Histochem. Cytochem.
55
1237-1244
2007
Macaca mulatta
Chen, M.; Chen, L.; Chai, K.X.
Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG
Prostate
66
911-920
2006
Homo sapiens (Q16651), Homo sapiens
Zhu, H.; Guo, D.; Li, K.; Yan, W.; Tan, Y.; Wang, X.; Treiber, F.A.; Chao, J.; Snieder, H.; Dong, Y.
Prostasin: a possible candidate gene for human hypertension
Am. J. Hypertens.
21
1028-1033
2008
Homo sapiens (Q16651), Homo sapiens
Tully, D.C.; Vidal, A.; Chatterjee, A.K.; Williams, J.A.; Roberts, M.J.; Petrassi, H.M.; Spraggon, G.; Bursulaya, B.; Pacoma, R.; Shipway, A.; Schumacher, A.M.; Danahay, H.; Harris, J.L.
Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design
Bioorg. Med. Chem. Lett.
18
5895-5899
2008
Homo sapiens (Q16651)
Rickert, K.W.; Kelley, P.; Byrne, N.J.; Diehl, R.E.; Hall, D.L.; Montalvo, A.M.; Reid, J.C.; Shipman, J.M.; Thomas, B.W.; Munshi, S.K.; Darke, P.L.; Su, H.P.
Structure of human prostasin, a target for the regulation of hypertension
J. Biol. Chem.
283
34864-34872
2008
Homo sapiens (Q16651), Homo sapiens
Spraggon, G.; Hornsby, M.; Shipway, A.; Tully, D.C.; Bursulaya, B.; Danahay, H.; Harris, J.L.; Lesley, S.A.
Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations
Protein Sci.
18
1081-1094
2009
Homo sapiens (Q16651), Homo sapiens
Selzer-Plon, J.; Bornholdt, J.; Friis, S.; Bisgaard, H.C.; Lothe, I.M.; Tveit, K.M.; Kure, E.H.; Vogel, U.; Vogel, L.K.
Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis
BMC Cancer
9
201
2009
Homo sapiens
Chen, L.; Verity, N.; Chai, K.
Loss of prostasin (PRSS8) in human bladder transitional cell carcinoma cell lines is associated with epithelial-mesenchymal transition (EMT)
BMC Cancer
9
377
2009
Homo sapiens
Costa, F.P.; Batista, E.L.; Zelmanowicz, A.; Svedman, C.; Devenz, G.; Alves, S.; Silva, A.S.; Garicochea, B.
Prostasin, a potential tumor marker in ovarian cancer--a pilot study
Clinics (Sao Paulo)
64
641-644
2009
Homo sapiens
Ma, X.J.; Fu, Y.Y.; Li, Y.X.; Chen, L.M.; Chai, K.; Wang, Y.L.
Prostasin inhibits cell invasion in human choriocarcinomal JEG-3 cells
Histochem. Cell Biol.
132
639-646
2009
Homo sapiens
Fu, Y.Y.; Gao, W.L.; Chen, M.; Chai, K.X.; Wang, Y.L.; Chen, L.M.
Prostasin regulates human placental trophoblast cell proliferation via the epidermal growth factor receptor signaling pathway
Hum. Reprod.
25
623-632
2010
Homo sapiens
Chen, Y.W.; Wang, J.K.; Chou, F.P.; Chen, C.Y.; Rorke, E.A.; Chen, L.M.; Chai, K.X.; Eckert, R.L.; Johnson, M.D.; Lin, C.Y.
Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 (HAI-1) during epidermal differentiation
J. Biol. Chem.
285
31755-31762
2010
Homo sapiens
Ko, T.; Kakizoe, Y.; Wakida, N.; Hayata, M.; Uchimura, K.; Shiraishi, N.; Miyoshi, T.; Adachi, M.; Aritomi, S.; Konda, T.; Tomita, K.; Kitamura, K.
Regulation of adrenal aldosterone production by serine protease prostasin
J. Biomed. Biotechnol.
2010
793843
2010
Homo sapiens
Chen, M.; Chen, L.M.; Lin, C.Y.; Chai, K.X.
Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor
Mol. Cell. Biochem.
337
259-266
2010
Homo sapiens
Chen, L.M.; Hatfield, M.L.; Fu, Y.Y.; Chai, K.X.
Prostasin regulates iNOS and cyclin D1 expression by modulating protease-activated receptor-2 signaling in prostate epithelial cells
Prostate
69
1790-1801
2009
Homo sapiens
Bergum, C.; Zoratti, G.; Boerner, J.; List, K.
Strong expression association between matriptase and its substrate prostasin in breast cancer
J. Cell. Physiol.
227
1604-1609
2012
Homo sapiens (Q16651)
Carattino, M.D.; Mueller, G.M.; Palmer, L.G.; Frindt, G.; Rued, A.C.; Hughey, R.P.; Kleyman, T.R.
Prostasin interacts with the epithelial Na+ channel and facilitates cleavage of the gamma-subunit by a second protease
Am. J. Physiol. Renal Physiol.
307
F1080-F1087
2014
Xenopus laevis (Q9ES87)
Miller, G.S.; List, K.
The matriptase-prostasin proteolytic cascade in epithelial development and pathology
Cell Tissue Res.
351
245-253
2013
Mus musculus (Q9ESD1)
Buzza, M.S.; Martin, E.W.; Driesbaugh, K.H.; Desilets, A.; Leduc, R.; Antalis, T.M.
Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway
J. Biol. Chem.
288
10328-10337
2013
Homo sapiens (Q16651)
Peters, D.E.; Szabo, R.; Friis, S.; Shylo, N.A.; Uzzun Sales, K.; Holmbeck, K.; Bugge, T.H.
The membrane-anchored serine protease prostasin (CAP1/PRSS8) supports epidermal development and postnatal homeostasis independent of its enzymatic activity
J. Biol. Chem.
289
14740-14749
2014
Mus musculus (Q99L44), Mus musculus C57BL/6N (Q99L44)
Uchimura, K.; Hayata, M.; Mizumoto, T.; Miyasato, Y.; Kakizoe, Y.; Morinaga, J.; Onoue, T.; Yamazoe, R.; Ueda, M.; Adachi, M.; Miyoshi, T.; Shiraishi, N.; Ogawa, W.; Fukuda, K.; Kondo, T.; Matsumura, T.; Araki, E.; Tomita, K.; Kitamura, K.
The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling
Nat. Commun.
5
3428
2014
Homo sapiens (Q16651), Mus musculus (Q9ESD1)
Chai, A.C.; Robinson, A.L.; Chai, K.X.; Chen, L.M.
Ibuprofen regulates the expression and function of membrane-associated serine proteases prostasin and matriptase
BMC Cancer
15
1025
2015
Homo sapiens (Q16651), Homo sapiens
Szabo, R.; Lantsman, T.; Peters, D.E.; Bugge, T.H.
Delineation of proteolytic and non-proteolytic functions of the membrane-anchored serine protease prostasin
Development
143
2818-2828
2016
Mus musculus (Q9ESD1), Mus musculus
Friis, S.; Madsen, D.H.; Bugge, T.H.
Distinct developmental functions of prostasin (CAP1/PRSS8) zymogen and activated prostasin
J. Biol. Chem.
291
2577-2582
2016
Mus musculus (Q9ESD1)
Buzza, M.S.; Johnson, T.A.; Conway, G.D.; Martin, E.W.; Mukhopadhyay, S.; Shea-Donohue, T.; Antalis, T.M.
Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis
J. Biol. Chem.
292
10801-10812
2017
Homo sapiens (Q16651), Homo sapiens, Mus musculus (Q9ESD1)
Frederiksen-Moeller, B.; Joergensen, J.S.; Hansen, M.R.; Krigslund, O.; Vogel, L.K.; Andersen, L.B.; Jensen, B.L.
Prostasin and matriptase (ST14) in placenta from preeclamptic and healthy pregnant women
J. Hypertens.
34
298-306
2016
Homo sapiens (Q16651), Homo sapiens
Lin, C.K.; Tseng, C.K.; Wu, Y.H.; Lin, C.Y.; Huang, C.H.; Wang, W.H.; Liaw, C.C.; Chen, Y.H.; Lee, J.C.
Prostasin impairs epithelial growth factor receptor activation to suppress Dengue virus propagation
J. Infect. Dis.
219
1377-1388
2019
Homo sapiens (Q16651), Homo sapiens, Mus musculus (Q9ESD1)
Tamir, A.; Gangadharan, A.; Balwani, S.; Tanaka, T.; Patel, U.; Hassan, A.; Benke, S.; Agas, A.; DAgostino, J.; Shin, D.; Yoon, S.; Goy, A.; Pecora, A.; Suh, K.
The serine protease prostasin (PRSS8) is a potential biomarker for early detection of ovarian cancer
J. Ovarian Res.
9
20
2016
Homo sapiens (Q16651), Homo sapiens
Drees, L.; Koenigsmann, T.; Jaspers, M.H.J.; Pflanz, R.; Riedel, D.; Schuh, R.
Conserved function of the matriptase-prostasin proteolytic cascade during epithelial morphogenesis
PLoS Genet.
15
e1007882
2019
Drosophila melanogaster (Q9W2C8)
Lee, S.P.; Kao, C.Y.; Chang, S.C.; Chiu, Y.L.; Chen, Y.J.; Chen, M.G.; Chang, C.C.; Lin, Y.W.; Chiang, C.P.; Wang, J.K.; Lin, C.Y.; Johnson, M.D.
Tissue distribution and subcellular localizations determine in vivo functional relationship among prostasin, matriptase, HAI-1, and HAI-2 in human skin
PLoS ONE
13
e0192632
2018
Homo sapiens (Q16651), Homo sapiens
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