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Disease on EC 3.4.21.B6 - prostasin

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Axl and prostasin are biomarkers for prognosis of ovarian adenocarcinoma.
Blood-borne RT-PCR assay for prostasin- specific transcripts to identify circulating prostate cells in cancer patients.
Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas.
Targeted HAI-2 deletion causes excessive proteolysis with prolonged active prostasin and depletion of HAI-1 monomer in intestinal but not epidermal epithelial cells.
Tumor suppressor PRSS8 targets Sphk1/S1P/Stat3/Akt signaling in colorectal cancer.
Adenoma
Tumor suppressor PRSS8 targets Sphk1/S1P/Stat3/Akt signaling in colorectal cancer.
Albuminuria
Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin.
Breast Neoplasms
An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex.
Prostasin regulates epithelial monolayer function: cell-specific Gpld1-mediated secretion and functional role for GPI anchor.
Prostasin serine protease inhibits breast cancer invasiveness and is transcriptionally regulated by promoter DNA methylation.
Strong expression association between matriptase and its substrate prostasin in breast cancer.
The cell-surface anchored serine protease TMPRSS13 promotes breast cancer progression and resistance to chemotherapy.
Carcinogenesis
Axl and prostasin are biomarkers for prognosis of ovarian adenocarcinoma.
Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase.
Correction to: PRSS8 suppresses colorectal carcinogenesis and metastasis.
Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis.
Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth.
Prostasin may contribute to chemoresistance, repress cancer cells in ovarian cancer, and is involved in the signaling pathways of CASP/PAK2-p34/actin.
Prostasin regulates PD-L1 expression in human lung cancer cells.
PRSS8 suppresses colorectal carcinogenesis and metastasis.
Tumor suppressor PRSS8 targets Sphk1/S1P/Stat3/Akt signaling in colorectal cancer.
Carcinoma
Blood-borne RT-PCR assay for prostasin- specific transcripts to identify circulating prostate cells in cancer patients.
Correction: PRSS8 methylation and its significance in esophageal squamous cell carcinoma.
Decreased prostasin expression is associated with aggressiveness of oral squamous cell carcinoma.
Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis.
Ibuprofen regulates the expression and function of membrane-associated serine proteases prostasin and matriptase.
Loss of prostasin (PRSS8) in human bladder transitional cell carcinoma cell lines is associated with epithelial-mesenchymal transition (EMT).
Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA.
Phenotypic stability of a cytotoxic T-cell line directed against an immunodominant epitope of human carcinoembryonic antigen.
Prostasin induces protease-dependent and independent molecular changes in the human prostate carcinoma cell line PC-3.
Prostasin serine protease inhibits breast cancer invasiveness and is transcriptionally regulated by promoter DNA methylation.
PRSS8 methylation and its significance in esophageal squamous cell carcinoma.
The epidermal growth factor receptor (EGFR) is proteolytically modified by the Matriptase-Prostasin serine protease cascade in cultured epithelial cells.
Carcinoma, Hepatocellular
PRSS8 is Downregulated and Suppresses Tumour Growth and Metastases in Hepatocellular Carcinoma.
Carcinoma, Non-Small-Cell Lung
Protease Serine S1 Family Member 8 (PRSS8) Inhibits Tumor Growth In Vitro and In Vivo in Human Non-Small Cell Lung Cancer.
Carcinoma, Ovarian Epithelial
Evaluation of the sensitivity and specificity of serum level of prostasin, CA125, LDH, AFP, and hCG+? in epithelial ovarian cancer patients.
Prostasin, a potential serum marker for ovarian cancer: identification through microarray technology.
Prostasin, a potential tumor marker in ovarian cancer--a pilot study.
Carcinoma, Squamous Cell
PRSS8 methylation and its significance in esophageal squamous cell carcinoma.
Carcinoma, Transitional Cell
Ibuprofen regulates the expression and function of membrane-associated serine proteases prostasin and matriptase.
Loss of prostasin (PRSS8) in human bladder transitional cell carcinoma cell lines is associated with epithelial-mesenchymal transition (EMT).
Cardiovascular Diseases
Genetic polymorphism of the prostasin gene in hypertensive pregnant Pakistani females.
Cholera
A specific antimicrobial protein CAP-1 from Pseudomonas sp. isolated from the jellyfish Cyanea capillata.
Colitis
Altered Prostasin (CAP1/Prss8) Expression Favors Inflammation and Tissue Remodeling in DSS-induced Colitis.
Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis.
PRSS8 suppresses colorectal carcinogenesis and metastasis.
Colitis, Ulcerative
Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis.
Sodium absorption stimulator prostasin (PRSS8) has an anti-inflammatory effect via downregulation of TLR4 signaling in inflammatory bowel disease.
Colorectal Neoplasms
Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis.
Phase I/II combined chemoimmunotherapy with carcinoembryonic antigen-derived HLA-A2-restricted CAP-1 peptide and irinotecan, 5-fluorouracil, and leucovorin in patients with primary metastatic colorectal cancer.
PRSS8 suppresses colorectal carcinogenesis and metastasis.
Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes.
Tumor suppressor PRSS8 targets Sphk1/S1P/Stat3/Akt signaling in colorectal cancer.
Crohn Disease
Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis.
Sodium absorption stimulator prostasin (PRSS8) has an anti-inflammatory effect via downregulation of TLR4 signaling in inflammatory bowel disease.
Cystadenoma, Mucinous
Axl and prostasin are biomarkers for prognosis of ovarian adenocarcinoma.
Cystadenoma, Serous
Axl and prostasin are biomarkers for prognosis of ovarian adenocarcinoma.
Cystic Fibrosis
Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cells.
Divergent Inhibitor Susceptibility among Airway Lumen-Accessible Tryptic Proteases.
Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis.
Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line.
Prostasin: An Epithelial Sodium Channel Regulator.
Reduced Sodium Transport with Nasal Administration of the Prostasin Inhibitor Camostat in Cystic Fibrosis Subjects.
Regulation of the epithelial sodium channel by accessory proteins.
Dehydration
Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cells.
The Membrane-Anchored Serine Protease Prostasin (CAP1/PRSS8) Supports Epidermal Development and Postnatal Homeostasis Independent of its Enzymatic Activity.
Dengue
Prostasin impairs epithelial growth factor receptor activation to suppress dengue virus propagation.
Diabetes Mellitus
Liver-Specific Overexpression of Prostasin Attenuates High-Fat Diet-Induced Metabolic Dysregulation in Mice.
Diabetes Mellitus, Type 2
Liver-Specific Overexpression of Prostasin Attenuates High-Fat Diet-Induced Metabolic Dysregulation in Mice.
Diabetic Nephropathies
Diabetic nephropathy is associated with increased urine excretion of proteases plasmin, prostasin and urokinase and activation of amiloride-sensitive current in collecting duct cells.
Disseminated Intravascular Coagulation
Inhibition of prostasin secretion by serine protease inhibitors in the kidney.
Endotoxemia
The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling.
[Prostasin (PRSS8) as a new pathological factor].
Esophageal Squamous Cell Carcinoma
Correction: PRSS8 methylation and its significance in esophageal squamous cell carcinoma.
PRSS8 methylation and its significance in esophageal squamous cell carcinoma.
Essential Hypertension
Association of genetic variations of the prostasin gene with essential hypertension in the Xinjiang Kazakh population.
The phosphorylated sodium chloride cotransporter in urinary exosomes is superior to prostasin as a marker for aldosteronism.
[Association of genetic variations of prostasin gene with the essential hypertension in Xinjiang Kazakhs]
Glioma
Overexpression of Protease Serine 8 Inhibits Glioma Cell Proliferation, Migration, and Invasion via Suppressing the Akt/mTOR Signaling Pathway.
Hyperaldosteronism
Increased urinary excretion of the epithelial Na channel activator prostasin in patients with primary aldosteronism.
Regulation of prostasin by aldosterone in the kidney.
The phosphorylated sodium chloride cotransporter in urinary exosomes is superior to prostasin as a marker for aldosteronism.
Urinary prostasin: a candidate marker of epithelial sodium channel activation in humans.
Hyperkalemia
Inhibition of prostasin secretion by serine protease inhibitors in the kidney.
Hypertension
Adenovirus-mediated human prostasin gene delivery is linked to increased aldosterone production and hypertension in rats.
Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin.
Association of genetic variations of the prostasin gene with essential hypertension in the Xinjiang Kazakh population.
Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension.
Genetic polymorphism of the prostasin gene in hypertensive pregnant Pakistani females.
Prostasin: a possible candidate gene for human hypertension.
Prostasin: An Epithelial Sodium Channel Regulator.
Regulation of the epithelial Na+ channel by peptidases.
Structure of human prostasin, a target for the regulation of hypertension.
Hyponatremia
Inhibition of prostasin secretion by serine protease inhibitors in the kidney.
Ichthyosis
PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin.
Infections
Prostasin impairs epithelial growth factor receptor activation to suppress dengue virus propagation.
Infertility, Male
Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter.
Inflammatory Bowel Diseases
Altered Prostasin (CAP1/Prss8) Expression Favors Inflammation and Tissue Remodeling in DSS-induced Colitis.
Sodium absorption stimulator prostasin (PRSS8) has an anti-inflammatory effect via downregulation of TLR4 signaling in inflammatory bowel disease.
Influenza, Human
Activation of influenza virus-associated RNA polymerase by cap-1 structure (m7GpppNm).
Biochemical studies on capped RNA primers identify a class of oligonucleotide inhibitors of the influenza virus RNA polymerase.
Two mutations in the C-terminal domain of influenza virus RNA polymerase PB2 enhance transcription by enhancing cap-1 RNA binding activity.
Insulin Resistance
Liver-Specific Overexpression of Prostasin Attenuates High-Fat Diet-Induced Metabolic Dysregulation in Mice.
The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling.
Intestinal Failure
Loss of HAI-2 in mice with decreased prostasin activity leads to an early-onset intestinal failure resembling congenital tufting enteropathy.
Lung Neoplasms
Prostasin regulates PD-L1 expression in human lung cancer cells.
Protease Serine S1 Family Member 8 (PRSS8) Inhibits Tumor Growth In Vitro and In Vivo in Human Non-Small Cell Lung Cancer.
Lymphatic Metastasis
Clinical significance of low expression of Prostasin mRNA in human gastric cancer.
Neoplasm Metastasis
Axl and prostasin are biomarkers for prognosis of ovarian adenocarcinoma.
Clinical significance of low expression of Prostasin mRNA in human gastric cancer.
Correction to: PRSS8 suppresses colorectal carcinogenesis and metastasis.
Prostasin gene polymorphism at rs12597511 is associated with severe preeclampsia in Chinese Han women.
Prostasin regulates PD-L1 expression in human lung cancer cells.
Protease Serine S1 Family Member 8 (PRSS8) Inhibits Tumor Growth In Vitro and In Vivo in Human Non-Small Cell Lung Cancer.
PRSS8 is Downregulated and Suppresses Tumour Growth and Metastases in Hepatocellular Carcinoma.
PRSS8 suppresses colorectal carcinogenesis and metastasis.
Neoplasms
A Phase I study of active immunotherapy with carcinoembryonic antigen peptide (CAP-1)-pulsed, autologous human cultured dendritic cells in patients with metastatic malignancies expressing carcinoembryonic antigen.
A specific antimicrobial protein CAP-1 from Pseudomonas sp. isolated from the jellyfish Cyanea capillata.
An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex.
Axl and prostasin are biomarkers for prognosis of ovarian adenocarcinoma.
Clinical significance of low expression of Prostasin mRNA in human gastric cancer.
Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase.
Decreased prostasin expression is associated with aggressiveness of oral squamous cell carcinoma.
Down-regulated expression of prostasin in high-grade or hormone-refractory human prostate cancers.
Evaluation of the sensitivity and specificity of serum level of prostasin, CA125, LDH, AFP, and hCG+? in epithelial ovarian cancer patients.
Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis.
Function and clinical relevance of kallikrein-related peptidases and other serine proteases in gynecological cancers.
Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes.
Hsp70-like protein 1 fusion protein enhances induction of carcinoembryonic antigen-specific CD8+ CTL response by dendritic cell vaccine.
Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin.
Loss of prostasin (PRSS8) in human bladder transitional cell carcinoma cell lines is associated with epithelial-mesenchymal transition (EMT).
Mechanisms of sterol regulatory element-binding protein-2 (SREBP-2) regulation of human prostasin gene expression.
Overexpression of Protease Serine 8 Inhibits Glioma Cell Proliferation, Migration, and Invasion via Suppressing the Akt/mTOR Signaling Pathway.
Physical activity is associated with a large number of cardiovascular-specific proteins: Cross-sectional analyses in two independent cohorts.
Prostasin attenuates inducible nitric oxide synthase expression in lipopolysaccharide-induced urinary bladder inflammation.
Prostasin gene polymorphism at rs12597511 is associated with severe preeclampsia in Chinese Han women.
Prostasin may contribute to chemoresistance, repress cancer cells in ovarian cancer, and is involved in the signaling pathways of CASP/PAK2-p34/actin.
Prostasin regulates iNOS and cyclin D1 expression by modulating protease-activated receptor-2 signaling in prostate epithelial cells.
Prostasin regulates PD-L1 expression in human lung cancer cells.
Prostasin serine protease inhibits breast cancer invasiveness and is transcriptionally regulated by promoter DNA methylation.
Prostasin, a potential serum marker for ovarian cancer: identification through microarray technology.
Prostasin, a potential tumor marker in ovarian cancer--a pilot study.
Protease Serine S1 Family Member 8 (PRSS8) Inhibits Tumor Growth In Vitro and In Vivo in Human Non-Small Cell Lung Cancer.
Proteomic profiling for detection of early-stage heart failure in the community.
PRSS8 is Downregulated and Suppresses Tumour Growth and Metastases in Hepatocellular Carcinoma.
PRSS8 methylation and its significance in esophageal squamous cell carcinoma.
PRSS8 suppresses colorectal carcinogenesis and metastasis.
Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis.
The channel-activating protease CAP1/Prss8 is required for placental labyrinth maturation.
The epidermal growth factor receptor (EGFR) is proteolytically modified by the Matriptase-Prostasin serine protease cascade in cultured epithelial cells.
The serine protease prostasin (PRSS8) is a potential biomarker for early detection of ovarian cancer.
Tumor suppressor PRSS8 targets Sphk1/S1P/Stat3/Akt signaling in colorectal cancer.
Unraveling a difficult diagnosis: the tricks for early recognition of ovarian cancer.
[Anti-pancreatic cancer effects of human peripheral gammadeltaT cells in a mouse tumor model]
Nephrosis
Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin.
Nephrotic Syndrome
Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin.
Urinary serine proteases and activation of ENaC in kidney-implications for physiological renal salt handling and hypertensive disorders with albuminuria.
Neural Tube Defects
Reduced Prostasin (CAP1/PRSS8) Activity Eliminates HAI-1 and HAI-2 Deficiency-Associated Developmental Defects by Preventing Matriptase Activation.
Ovarian Neoplasms
Early detection biomarkers for ovarian cancer.
Prostasin may contribute to chemoresistance, repress cancer cells in ovarian cancer, and is involved in the signaling pathways of CASP/PAK2-p34/actin.
Prostasin, a potential serum marker for ovarian cancer: identification through microarray technology.
Prostasin, a potential tumor marker in ovarian cancer--a pilot study.
PSP94, an upstream signaling mediator of prostasin found highly elevated in ovarian cancer.
Recent advancements in fabrication of nanomaterial based biosensors for diagnosis of ovarian cancer: a comprehensive review.
The prognostic value of morphometrical features and cellular DNA content in cis-platin treated late ovarian cancer patients.
The serine protease prostasin (PRSS8) is a potential biomarker for early detection of ovarian cancer.
Unraveling a difficult diagnosis: the tricks for early recognition of ovarian cancer.
Pancreatitis
Inhibition of prostasin secretion by serine protease inhibitors in the kidney.
Placental Insufficiency
The channel-activating protease CAP1/Prss8 is required for placental labyrinth maturation.
Pre-Eclampsia
8C.02: THE SERINE PROTEASE PROSTASIN IS ABERRANTLY FILTRATED IN URINE IN PREECLAMPSIA WITH SIMILAR LEVELS IN PLASMA AND PLACENTA TISSUE COMPARED TO NORMAL PREGNANCY.
Association between preeclampsia and prostasin polymorphism in Pakistani females.
Increased expression of prostasin contributes to early-onset severe preeclampsia through inhibiting trophoblast invasion.
Prostasin and matriptase (ST14) in placenta from preeclamptic and healthy pregnant women.
Prostasin gene polymorphism at rs12597511 is associated with severe preeclampsia in Chinese Han women.
Prostasin, proteases, and preeclampsia.
Urinary serine proteases and activation of ENaC in kidney-implications for physiological renal salt handling and hypertensive disorders with albuminuria.
[Association of prostasin gene rs12597511 polymorphism with outcomes of pregnancy with severe preeclampsia].
Prostatic Hyperplasia
Prostasin regulates iNOS and cyclin D1 expression by modulating protease-activated receptor-2 signaling in prostate epithelial cells.
Prostatic Neoplasms
Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG.
Down-regulated expression of prostasin in high-grade or hormone-refractory human prostate cancers.
Down-regulation of prostasin serine protease: a potential invasion suppressor in prostate cancer.
Prostasin regulates iNOS and cyclin D1 expression by modulating protease-activated receptor-2 signaling in prostate epithelial cells.
Prostasin serine protease inhibits breast cancer invasiveness and is transcriptionally regulated by promoter DNA methylation.
Regulation of prostasin expression and function in the prostate.
Proteinuria
Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin.
Urinary serine proteases and activation of ENaC in kidney-implications for physiological renal salt handling and hypertensive disorders with albuminuria.
Pruritus
PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin.
Pseudohypoaldosteronism
Pseudohypoaldosteronism type 1 and the genes encoding prostasin, alpha-spectrin, and Nedd4.
Seminoma
Gene expression microarray analysis of adult testicular germ cell tumor: a comparison between pure-type seminomas and seminoma components in mixed tumors.
Skin Diseases
PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin.
Squamous Cell Carcinoma of Head and Neck
Decreased prostasin expression is associated with aggressiveness of oral squamous cell carcinoma.
Stomach Neoplasms
Clinical significance of low expression of Prostasin mRNA in human gastric cancer.
Loss of prostasin (PRSS8) in human bladder transitional cell carcinoma cell lines is associated with epithelial-mesenchymal transition (EMT).
Tetanus
Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes.
Urinary Bladder Neoplasms
Ibuprofen regulates the expression and function of membrane-associated serine proteases prostasin and matriptase.
Loss of prostasin (PRSS8) in human bladder transitional cell carcinoma cell lines is associated with epithelial-mesenchymal transition (EMT).
The serine protease prostasin (PRSS8) is a potential biomarker for early detection of ovarian cancer.
Uterine Cervical Neoplasms
LINP1 promotes the progression of cervical cancer by scaffolding EZH2, LSD1, and DNMT1 to inhibit the expression of KLF2 and PRSS8.