Disease on EC 3.4.21.B6 - prostasin and Organism(s) Homo sapiens and UniProt Accession Q16651
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Adenocarcinoma
Blood-borne RT-PCR assay for prostasin- specific transcripts to identify circulating prostate cells in cancer patients.
Adenocarcinoma
Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas.
Adenocarcinoma
Targeted HAI-2 deletion causes excessive proteolysis with prolonged active prostasin and depletion of HAI-1 monomer in intestinal but not epidermal epithelial cells.
Adenocarcinoma
Tumor suppressor PRSS8 targets Sphk1/S1P/Stat3/Akt signaling in colorectal cancer.
Albuminuria
Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin.
Breast Neoplasms
An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex.
Breast Neoplasms
Prostasin regulates epithelial monolayer function: cell-specific Gpld1-mediated secretion and functional role for GPI anchor.
Breast Neoplasms
Prostasin serine protease inhibits breast cancer invasiveness and is transcriptionally regulated by promoter DNA methylation.
Breast Neoplasms
Strong expression association between matriptase and its substrate prostasin in breast cancer.
Breast Neoplasms
The cell-surface anchored serine protease TMPRSS13 promotes breast cancer progression and resistance to chemotherapy.
Carcinogenesis
Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase.
Carcinogenesis
Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis.
Carcinogenesis
Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth.
Carcinogenesis
Prostasin may contribute to chemoresistance, repress cancer cells in ovarian cancer, and is involved in the signaling pathways of CASP/PAK2-p34/actin.
Carcinogenesis
Tumor suppressor PRSS8 targets Sphk1/S1P/Stat3/Akt signaling in colorectal cancer.
Carcinoma
Blood-borne RT-PCR assay for prostasin- specific transcripts to identify circulating prostate cells in cancer patients.
Carcinoma
Correction: PRSS8 methylation and its significance in esophageal squamous cell carcinoma.
Carcinoma
Decreased prostasin expression is associated with aggressiveness of oral squamous cell carcinoma.
Carcinoma
Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis.
Carcinoma
Ibuprofen regulates the expression and function of membrane-associated serine proteases prostasin and matriptase.
Carcinoma
Loss of prostasin (PRSS8) in human bladder transitional cell carcinoma cell lines is associated with epithelial-mesenchymal transition (EMT).
Carcinoma
Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA.
Carcinoma
Phenotypic stability of a cytotoxic T-cell line directed against an immunodominant epitope of human carcinoembryonic antigen.
Carcinoma
Prostasin induces protease-dependent and independent molecular changes in the human prostate carcinoma cell line PC-3.
Carcinoma
Prostasin serine protease inhibits breast cancer invasiveness and is transcriptionally regulated by promoter DNA methylation.
Carcinoma
The epidermal growth factor receptor (EGFR) is proteolytically modified by the Matriptase-Prostasin serine protease cascade in cultured epithelial cells.
Carcinoma, Hepatocellular
PRSS8 is Downregulated and Suppresses Tumour Growth and Metastases in Hepatocellular Carcinoma.
Carcinoma, Non-Small-Cell Lung
Protease Serine S1 Family Member 8 (PRSS8) Inhibits Tumor Growth In Vitro and In Vivo in Human Non-Small Cell Lung Cancer.
Carcinoma, Ovarian Epithelial
Evaluation of the sensitivity and specificity of serum level of prostasin, CA125, LDH, AFP, and hCG+? in epithelial ovarian cancer patients.
Carcinoma, Ovarian Epithelial
Prostasin, a potential serum marker for ovarian cancer: identification through microarray technology.
Carcinoma, Ovarian Epithelial
Prostasin, a potential tumor marker in ovarian cancer--a pilot study.
Carcinoma, Squamous Cell
PRSS8 methylation and its significance in esophageal squamous cell carcinoma.
Carcinoma, Transitional Cell
Ibuprofen regulates the expression and function of membrane-associated serine proteases prostasin and matriptase.
Carcinoma, Transitional Cell
Loss of prostasin (PRSS8) in human bladder transitional cell carcinoma cell lines is associated with epithelial-mesenchymal transition (EMT).
Cardiovascular Diseases
Genetic polymorphism of the prostasin gene in hypertensive pregnant Pakistani females.
Cholera
A specific antimicrobial protein CAP-1 from Pseudomonas sp. isolated from the jellyfish Cyanea capillata.
Colitis
Altered Prostasin (CAP1/Prss8) Expression Favors Inflammation and Tissue Remodeling in DSS-induced Colitis.
Colitis
Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis.
Colitis, Ulcerative
Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis.
Colitis, Ulcerative
Sodium absorption stimulator prostasin (PRSS8) has an anti-inflammatory effect via downregulation of TLR4 signaling in inflammatory bowel disease.
Colorectal Neoplasms
Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis.
Colorectal Neoplasms
Phase I/II combined chemoimmunotherapy with carcinoembryonic antigen-derived HLA-A2-restricted CAP-1 peptide and irinotecan, 5-fluorouracil, and leucovorin in patients with primary metastatic colorectal cancer.
Colorectal Neoplasms
Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes.
Colorectal Neoplasms
Tumor suppressor PRSS8 targets Sphk1/S1P/Stat3/Akt signaling in colorectal cancer.
Crohn Disease
Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis.
Crohn Disease
Sodium absorption stimulator prostasin (PRSS8) has an anti-inflammatory effect via downregulation of TLR4 signaling in inflammatory bowel disease.
Cystadenoma, Mucinous
Axl and prostasin are biomarkers for prognosis of ovarian adenocarcinoma.
Cystadenoma, Serous
Axl and prostasin are biomarkers for prognosis of ovarian adenocarcinoma.
Cystic Fibrosis
Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cells.
Cystic Fibrosis
Divergent Inhibitor Susceptibility among Airway Lumen-Accessible Tryptic Proteases.
Cystic Fibrosis
Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis.
Cystic Fibrosis
Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line.
Cystic Fibrosis
Reduced Sodium Transport with Nasal Administration of the Prostasin Inhibitor Camostat in Cystic Fibrosis Subjects.
Dehydration
Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cells.
Dehydration
The Membrane-Anchored Serine Protease Prostasin (CAP1/PRSS8) Supports Epidermal Development and Postnatal Homeostasis Independent of its Enzymatic Activity.
Dengue
Prostasin impairs epithelial growth factor receptor activation to suppress dengue virus propagation.
Diabetes Mellitus
Liver-Specific Overexpression of Prostasin Attenuates High-Fat Diet-Induced Metabolic Dysregulation in Mice.
Diabetes Mellitus, Type 2
Liver-Specific Overexpression of Prostasin Attenuates High-Fat Diet-Induced Metabolic Dysregulation in Mice.
Diabetic Nephropathies
Diabetic nephropathy is associated with increased urine excretion of proteases plasmin, prostasin and urokinase and activation of amiloride-sensitive current in collecting duct cells.
Disseminated Intravascular Coagulation
Inhibition of prostasin secretion by serine protease inhibitors in the kidney.
Endotoxemia
The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling.
Esophageal Squamous Cell Carcinoma
Correction: PRSS8 methylation and its significance in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
PRSS8 methylation and its significance in esophageal squamous cell carcinoma.
Essential Hypertension
Association of genetic variations of the prostasin gene with essential hypertension in the Xinjiang Kazakh population.
Essential Hypertension
The phosphorylated sodium chloride cotransporter in urinary exosomes is superior to prostasin as a marker for aldosteronism.
Essential Hypertension
[Association of genetic variations of prostasin gene with the essential hypertension in Xinjiang Kazakhs]
Glioma
Overexpression of Protease Serine 8 Inhibits Glioma Cell Proliferation, Migration, and Invasion via Suppressing the Akt/mTOR Signaling Pathway.
Hyperaldosteronism
Increased urinary excretion of the epithelial Na channel activator prostasin in patients with primary aldosteronism.
Hyperaldosteronism
The phosphorylated sodium chloride cotransporter in urinary exosomes is superior to prostasin as a marker for aldosteronism.
Hyperaldosteronism
Urinary prostasin: a candidate marker of epithelial sodium channel activation in humans.
Hyperkalemia
Inhibition of prostasin secretion by serine protease inhibitors in the kidney.
Hypertension
Adenovirus-mediated human prostasin gene delivery is linked to increased aldosterone production and hypertension in rats.
Hypertension
Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin.
Hypertension
Association of genetic variations of the prostasin gene with essential hypertension in the Xinjiang Kazakh population.
Hypertension
Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension.
Hypertension
Genetic polymorphism of the prostasin gene in hypertensive pregnant Pakistani females.
Hyponatremia
Inhibition of prostasin secretion by serine protease inhibitors in the kidney.
Ichthyosis
PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin.
Infections
Prostasin impairs epithelial growth factor receptor activation to suppress dengue virus propagation.
Infertility, Male
Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter.
Inflammatory Bowel Diseases
Altered Prostasin (CAP1/Prss8) Expression Favors Inflammation and Tissue Remodeling in DSS-induced Colitis.
Inflammatory Bowel Diseases
Sodium absorption stimulator prostasin (PRSS8) has an anti-inflammatory effect via downregulation of TLR4 signaling in inflammatory bowel disease.
Influenza, Human
Activation of influenza virus-associated RNA polymerase by cap-1 structure (m7GpppNm).
Influenza, Human
Biochemical studies on capped RNA primers identify a class of oligonucleotide inhibitors of the influenza virus RNA polymerase.
Influenza, Human
Two mutations in the C-terminal domain of influenza virus RNA polymerase PB2 enhance transcription by enhancing cap-1 RNA binding activity.
Insulin Resistance
Liver-Specific Overexpression of Prostasin Attenuates High-Fat Diet-Induced Metabolic Dysregulation in Mice.
Insulin Resistance
The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling.
Intestinal Failure
Loss of HAI-2 in mice with decreased prostasin activity leads to an early-onset intestinal failure resembling congenital tufting enteropathy.
Lung Neoplasms
Protease Serine S1 Family Member 8 (PRSS8) Inhibits Tumor Growth In Vitro and In Vivo in Human Non-Small Cell Lung Cancer.
Lymphatic Metastasis
Clinical significance of low expression of Prostasin mRNA in human gastric cancer.
Neoplasm Metastasis
Axl and prostasin are biomarkers for prognosis of ovarian adenocarcinoma.
Neoplasm Metastasis
Clinical significance of low expression of Prostasin mRNA in human gastric cancer.
Neoplasm Metastasis
Correction to: PRSS8 suppresses colorectal carcinogenesis and metastasis.
Neoplasm Metastasis
Prostasin gene polymorphism at rs12597511 is associated with severe preeclampsia in Chinese Han women.
Neoplasm Metastasis
Prostasin regulates PD-L1 expression in human lung cancer cells.
Neoplasm Metastasis
Protease Serine S1 Family Member 8 (PRSS8) Inhibits Tumor Growth In Vitro and In Vivo in Human Non-Small Cell Lung Cancer.
Neoplasm Metastasis
PRSS8 is Downregulated and Suppresses Tumour Growth and Metastases in Hepatocellular Carcinoma.
Neoplasms
A Phase I study of active immunotherapy with carcinoembryonic antigen peptide (CAP-1)-pulsed, autologous human cultured dendritic cells in patients with metastatic malignancies expressing carcinoembryonic antigen.
Neoplasms
A specific antimicrobial protein CAP-1 from Pseudomonas sp. isolated from the jellyfish Cyanea capillata.
Neoplasms
An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex.
Neoplasms
Clinical significance of low expression of Prostasin mRNA in human gastric cancer.
Neoplasms
Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase.
Neoplasms
Decreased prostasin expression is associated with aggressiveness of oral squamous cell carcinoma.
Neoplasms
Down-regulated expression of prostasin in high-grade or hormone-refractory human prostate cancers.
Neoplasms
Evaluation of the sensitivity and specificity of serum level of prostasin, CA125, LDH, AFP, and hCG+? in epithelial ovarian cancer patients.
Neoplasms
Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis.
Neoplasms
Function and clinical relevance of kallikrein-related peptidases and other serine proteases in gynecological cancers.
Neoplasms
Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes.
Neoplasms
Hsp70-like protein 1 fusion protein enhances induction of carcinoembryonic antigen-specific CD8+ CTL response by dendritic cell vaccine.
Neoplasms
Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin.
Neoplasms
Loss of prostasin (PRSS8) in human bladder transitional cell carcinoma cell lines is associated with epithelial-mesenchymal transition (EMT).
Neoplasms
Mechanisms of sterol regulatory element-binding protein-2 (SREBP-2) regulation of human prostasin gene expression.
Neoplasms
Overexpression of Protease Serine 8 Inhibits Glioma Cell Proliferation, Migration, and Invasion via Suppressing the Akt/mTOR Signaling Pathway.
Neoplasms
Physical activity is associated with a large number of cardiovascular-specific proteins: Cross-sectional analyses in two independent cohorts.
Neoplasms
Prostasin attenuates inducible nitric oxide synthase expression in lipopolysaccharide-induced urinary bladder inflammation.
Neoplasms
Prostasin gene polymorphism at rs12597511 is associated with severe preeclampsia in Chinese Han women.
Neoplasms
Prostasin may contribute to chemoresistance, repress cancer cells in ovarian cancer, and is involved in the signaling pathways of CASP/PAK2-p34/actin.
Neoplasms
Prostasin regulates iNOS and cyclin D1 expression by modulating protease-activated receptor-2 signaling in prostate epithelial cells.
Neoplasms
Prostasin serine protease inhibits breast cancer invasiveness and is transcriptionally regulated by promoter DNA methylation.
Neoplasms
Prostasin, a potential serum marker for ovarian cancer: identification through microarray technology.
Neoplasms
Protease Serine S1 Family Member 8 (PRSS8) Inhibits Tumor Growth In Vitro and In Vivo in Human Non-Small Cell Lung Cancer.
Neoplasms
PRSS8 is Downregulated and Suppresses Tumour Growth and Metastases in Hepatocellular Carcinoma.
Neoplasms
Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis.
Neoplasms
The channel-activating protease CAP1/Prss8 is required for placental labyrinth maturation.
Neoplasms
The epidermal growth factor receptor (EGFR) is proteolytically modified by the Matriptase-Prostasin serine protease cascade in cultured epithelial cells.
Neoplasms
The serine protease prostasin (PRSS8) is a potential biomarker for early detection of ovarian cancer.
Neoplasms
Tumor suppressor PRSS8 targets Sphk1/S1P/Stat3/Akt signaling in colorectal cancer.
Neoplasms
Unraveling a difficult diagnosis: the tricks for early recognition of ovarian cancer.
Neoplasms
[Anti-pancreatic cancer effects of human peripheral gammadeltaT cells in a mouse tumor model]
Nephrosis
Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin.
Nephrotic Syndrome
Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin.
Nephrotic Syndrome
Urinary serine proteases and activation of ENaC in kidney-implications for physiological renal salt handling and hypertensive disorders with albuminuria.
Neural Tube Defects
Reduced Prostasin (CAP1/PRSS8) Activity Eliminates HAI-1 and HAI-2 Deficiency-Associated Developmental Defects by Preventing Matriptase Activation.
Ovarian Neoplasms
Prostasin may contribute to chemoresistance, repress cancer cells in ovarian cancer, and is involved in the signaling pathways of CASP/PAK2-p34/actin.
Ovarian Neoplasms
Prostasin, a potential serum marker for ovarian cancer: identification through microarray technology.
Ovarian Neoplasms
PSP94, an upstream signaling mediator of prostasin found highly elevated in ovarian cancer.
Ovarian Neoplasms
Recent advancements in fabrication of nanomaterial based biosensors for diagnosis of ovarian cancer: a comprehensive review.
Ovarian Neoplasms
The prognostic value of morphometrical features and cellular DNA content in cis-platin treated late ovarian cancer patients.
Ovarian Neoplasms
The serine protease prostasin (PRSS8) is a potential biomarker for early detection of ovarian cancer.
Ovarian Neoplasms
Unraveling a difficult diagnosis: the tricks for early recognition of ovarian cancer.
Pancreatitis
Inhibition of prostasin secretion by serine protease inhibitors in the kidney.
Placental Insufficiency
The channel-activating protease CAP1/Prss8 is required for placental labyrinth maturation.
Pre-Eclampsia
8C.02: THE SERINE PROTEASE PROSTASIN IS ABERRANTLY FILTRATED IN URINE IN PREECLAMPSIA WITH SIMILAR LEVELS IN PLASMA AND PLACENTA TISSUE COMPARED TO NORMAL PREGNANCY.
Pre-Eclampsia
Association between preeclampsia and prostasin polymorphism in Pakistani females.
Pre-Eclampsia
Increased expression of prostasin contributes to early-onset severe preeclampsia through inhibiting trophoblast invasion.
Pre-Eclampsia
Prostasin and matriptase (ST14) in placenta from preeclamptic and healthy pregnant women.
Pre-Eclampsia
Prostasin gene polymorphism at rs12597511 is associated with severe preeclampsia in Chinese Han women.
Pre-Eclampsia
Urinary serine proteases and activation of ENaC in kidney-implications for physiological renal salt handling and hypertensive disorders with albuminuria.
Pre-Eclampsia
[Association of prostasin gene rs12597511 polymorphism with outcomes of pregnancy with severe preeclampsia].
Prostatic Hyperplasia
Prostasin regulates iNOS and cyclin D1 expression by modulating protease-activated receptor-2 signaling in prostate epithelial cells.
Prostatic Neoplasms
Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG.
Prostatic Neoplasms
Down-regulated expression of prostasin in high-grade or hormone-refractory human prostate cancers.
Prostatic Neoplasms
Down-regulation of prostasin serine protease: a potential invasion suppressor in prostate cancer.
Prostatic Neoplasms
Prostasin regulates iNOS and cyclin D1 expression by modulating protease-activated receptor-2 signaling in prostate epithelial cells.
Prostatic Neoplasms
Prostasin serine protease inhibits breast cancer invasiveness and is transcriptionally regulated by promoter DNA methylation.
Proteinuria
Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin.
Proteinuria
Urinary serine proteases and activation of ENaC in kidney-implications for physiological renal salt handling and hypertensive disorders with albuminuria.
Pruritus
PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin.
Pseudohypoaldosteronism
Pseudohypoaldosteronism type 1 and the genes encoding prostasin, alpha-spectrin, and Nedd4.
Seminoma
Gene expression microarray analysis of adult testicular germ cell tumor: a comparison between pure-type seminomas and seminoma components in mixed tumors.
Skin Diseases
PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin.
Squamous Cell Carcinoma of Head and Neck
Decreased prostasin expression is associated with aggressiveness of oral squamous cell carcinoma.
Stomach Neoplasms
Clinical significance of low expression of Prostasin mRNA in human gastric cancer.
Stomach Neoplasms
Loss of prostasin (PRSS8) in human bladder transitional cell carcinoma cell lines is associated with epithelial-mesenchymal transition (EMT).
Tetanus
Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes.
Urinary Bladder Neoplasms
Ibuprofen regulates the expression and function of membrane-associated serine proteases prostasin and matriptase.
Urinary Bladder Neoplasms
Loss of prostasin (PRSS8) in human bladder transitional cell carcinoma cell lines is associated with epithelial-mesenchymal transition (EMT).
Urinary Bladder Neoplasms
The serine protease prostasin (PRSS8) is a potential biomarker for early detection of ovarian cancer.
Uterine Cervical Neoplasms
LINP1 promotes the progression of cervical cancer by scaffolding EZH2, LSD1, and DNMT1 to inhibit the expression of KLF2 and PRSS8.