show all | hide all No of entries

Information on EC 3.4.21.B40 - kallikrein 9 and Organism(s) Homo sapiens and UniProt Accession Q9UKQ9

for references in articles please use BRENDA:EC3.4.21.B40
preliminary BRENDA-supplied EC number
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.B40 kallikrein 9
Specify your search results
Select one or more organisms in this record:
This record set is specific for:
Homo sapiens
UNIPROT: Q9UKQ9
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
proteolytic cleavage of polypeptides, preferential cleavage site at paired basic amino acid residues
Synonyms
egf-bp, epidermal growth factor-binding protein, egf-binding protein, hmw-egf, epidermal growth factor urogastrone, human tissue kallikrein 9, high molecular weight epidermal growth factor, s3 kallikrein, kallikrein-related peptidase 9, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hk9
247
-
human tissue kallikrein 9
247
-
K9
273743
-
kallikrein 9
247
-
S01.307
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
CAS REGISTRY NUMBER
COMMENTARY hide
9001-01-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
polypeptide + H2O
peptides
show the reaction diagram
-
-
?
additional information
?
-
enzyme is regulated by steroid hormones in breast cancer cell line BT-474
-
-
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
polypeptide + H2O
peptides
show the reaction diagram
Q9UKQ9
-
-
?
additional information
?
-
Q9UKQ9
enzyme is regulated by steroid hormones in breast cancer cell line BT-474
-
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
low content
Manually annotated by BRENDA team
high content in adult, low content in fetal brain
Manually annotated by BRENDA team
low content
Manually annotated by BRENDA team
low content
Manually annotated by BRENDA team
low content
Manually annotated by BRENDA team
low content
Manually annotated by BRENDA team
additional information
no enzyme expression in uterus, heart, adrenal gland, colon, spleen, skeletal muscle, pancreas, kidney, and fetal liver
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
Sequence
KLK9_HUMAN
250
0
27513
Swiss-Prot
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
45000
-
SDS-PAGE
PURIFICATION/commentary
ORGANISM
UNIPROT
LITERATURE
Ni-affinity chromatography to homogeneity
-
CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
DNA sequence determination and analysis, gene is part of the human kallikrein multigene family, that mapps on chromosome 19q13.3-q13.4
His-tag fuision protein, expression in Escherichia coli BL21(DE3)
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (Q9UKQ9), Mus musculus (P15949), Rattus norvegicus (P07647)
Manually annotated by BRENDA team
Yousef, G.M.; Diamandis, E.P.
The expanded human kallikrein gene family: locus characterization and molecular cloning of a new member, KLK-L3 (KLK9)
Genomics
65
184-194
2000
Homo sapiens (Q9UKQ9)
Manually annotated by BRENDA team
Tan, O.L.; Whitbread, A.K.; Clements, J.A.; Dong, Y.
Kallikrein-related peptidase (KLK) family mRNA variants and protein isoforms in hormone-related cancers: do they have a function?
Biol. Chem.
387
697-705
2006
Homo sapiens
Manually annotated by BRENDA team
Memari, N.; Grass, L.; Nakamura, T.; Karakucuk, I.; Diamandis, E.P.
Human tissue kallikrein 9: production of recombinant proteins and specific antibodies
Biol. Chem.
387
733-740
2006
Homo sapiens
Manually annotated by BRENDA team
Select items on the left to see more content.