Reference on EC 3.4.21.B4 - granzyme K
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Babe, L.M.; Yoast, S.; Dreyer, M.; Schmidt, B.F.
Heterologous expression of human granzyme K in Bacillus subtilis and characterization of its hydrolytic activity in vitro
Biotechnol. Appl. Biochem.
27
117-124
1998
Homo sapiens
Wilharm, E.; Tschopp, J.; Jenne, D.E.
Biological activities of granzyme K are conserved in the mouse and account for residual Z-Lys-SBzl activity in granzyme A-deficient mice
FEBS Lett.
459
139-142
1999
Homo sapiens, Mus musculus
Wilharm, E.; Parry, M.A.; Friebel, R.; Tschesche, H.; Matschiner, G.; Sommerhoff, C.P.; Jenne, D.E.
Generation of catalytically active granzyme K from Escherichia coli inclusion bodies and identification of efficient granzyme K inhibitors in human plasma
J. Biol. Chem.
274
27331-27337
1999
Homo sapiens
Hink-Schauer, C.; Estebanez-Perpina, E.; Wilharm, E.; Fuentes-Prior, P.; Klinkert, W.; Bode, W.; Jenne, D.E.
The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features
J. Biol. Chem.
277
50923-50933
2002
Homo sapiens
Shi, L.; Kam, C.M.; Powers, J.C.; Aebersold, R.; Greenberg, A.H.
Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions
J. Exp. Med.
176
1521-1529
1992
Rattus norvegicus
Hameed, A.; Lowrey, D.M.; Lichtenheld, M.; Podack, E.R.
Characterization of three serine esterases isolated from human IL-2 activated killer cells
J. Immunol.
141
3142-3147
1988
Homo sapiens
Sayers, T.J.; Wiltrout, T.A.; Smyth, M.J.; Ottaway, K.S.; Pilaro, A.M.; Sowder, R.; Henderson, L.E.; Sprenger, H.; Lloyd, A.R.
Purification and cloning of a novel serine protease, RNK-Tryp-2, from the granules of a rat NK cell leukemia
J. Immunol.
152
2289-2297
1994
Rattus norvegicus
Jackson, D.S.; Fraser, S.A.; Ni, L.M.; Kam, C.M.; Winkler, U.; Johnson, D.A.; Froelich, C.J.; Hudig, D.; Powers, J.C.
Synthesis and evaluation of diphenyl phosphonate esters as inhibitors of the trypsin-like granzymes A and K and mast cell tryptase
J. Med. Chem.
41
2289-2301
1998
Homo sapiens
Bratke, K.; Kuepper, M.; Bade, B.; Virchow, J.C.; Luttmann, W.
Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral blood
Eur. J. Immunol.
35
2608-2616
2005
Homo sapiens
Bade, B.; Lohrmann, J.; ten Brinke, A.; Wolbink, A.M.; Wolbink, G.J.; ten Berge, I.J.; Virchow, J.C.; Luttmann, W.; Hack, C.E.
Detection of soluble human granzyme K in vitro and in vivo
Eur. J. Immunol.
35
2940-2948
2005
Homo sapiens
Babe, L.M.; Schmidt, B.F.
Granzyme K
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner; j. F. , eds. )Academic Press
2
1552-1554
2004
Homo sapiens, Rattus norvegicus
-
Babe, L.M.; Schmidt, B.F.
Granzyme K
Handbook of Proteolytic Enzymes (Barrett,A. J. ;Rawlings,N. D. ,Woessner)
2
1552-1554
2004
Mus musculus
-
Hirata, Y.; Inagaki, H.; Shimizu, T.; Li, Q.; Nagahara, N.; Minami, M.; Kawada, T.
Expression of enzymatically active human granzyme 3 in Escherichia coli for analysis of its substrate specificity
Arch. Biochem. Biophys.
446
35-43
2006
Homo sapiens (P49863), Homo sapiens
Zhao, T.; Zhang, H.; Guo, Y.; Zhang, Q.; Hua, G.; Lu, H.; Hou, Q.; Liu, H.; Fan, Z.
Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells
Cell Death Differ.
14
489-499
2007
Homo sapiens
Zhao, T.; Zhang, H.; Guo, Y.; Fan, Z.
Granzyme K directly processes Bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death
J. Biol. Chem.
282
12104-12111
2007
Homo sapiens
Guo, Y.; Chen, J.; Zhao, T.; Fan, Z.
Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity
Mol. Immunol.
45
2225-2235
2008
Homo sapiens
Bovenschen, N.; Quadir, R.; van den Berg, A.L.; Brenkman, A.B.; Vandenberghe, I.; Devreese, B.; Joore, J.; Kummer, J.A.
Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A
J. Biol. Chem.
284
3504-3512
2009
Homo sapiens (P49863)
Bratke, K.; Klug, A.; Julius, P.; Kuepper, M.; Lommatzsch, M.; Sparmann, G.; Luttmann, W.; Virchow, J.C.
Granzyme K: a novel mediator in acute airway inflammation
Thorax
63
1006-1011
2008
Homo sapiens (P49863), Homo sapiens
Jenkins, M.R.; Trapani, J.A.; Doherty, P.C.; Turner, S.J.
Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice
Viral Immunol.
21
341-346
2008
Mus musculus (O35205)
Guo, Y.; Chen, J.; Shi, L.; Fan, Z.
Valosin-containing protein cleavage by granzyme K accelerates an endoplasmic reticulum stress leading to caspase-independent cytotoxicity of target tumor cells
J. Immunol.
185
5348-5359
2010
Homo sapiens
Cooper, D.M.; Pechkovsky, D.V.; Hackett, T.L.; Knight, D.A.; Granville, D.J.
Granzyme K activates protease-activated receptor-1
PLoS ONE
6
e21484
2011
Homo sapiens
Plasman, K.; Demol, H.; Bird, P.I.; Gevaert, K.; Van Damme, P.
Substrate specificities of the granzyme tryptases A and K
J. Proteome Res.
13
6067-6077
2014
Mus musculus, Homo sapiens (P49863), Homo sapiens
Wensink, A.C.; Kemp, V.; Fermie, J.; Garcia Laorden, M.I.; van der Poll, T.; Hack, C.E.; Bovenschen, N.
Granzyme K synergistically potentiates LPS-induced cytokine responses in human monocytes
Proc. Natl. Acad. Sci. USA
111
5974-5979
2014
Homo sapiens (P49863), Homo sapiens
Dutta, D.; Park, I.; Guililat, H.; Sang, S.; Talapatra, A.; Singhal, B.; Mills, N.C.
Testosterone regulates granzyme K expression in rat testes
Endocr. Regul.
51
193-204
2017
Rattus norvegicus (P49864)
Sharma, M.; Merkulova, Y.; Raithatha, S.; Parkinson, L.G.; Shen, Y.; Cooper, D.; Granville, D.J.
Extracellular granzyme K mediates endothelial activation through the cleavage of protease-activated receptor-1
FEBS J.
283
1734-1747
2016
Homo sapiens (P49863), Homo sapiens
Turner, C.T.; Zeglinski, M.R.; Richardson, K.C.; Zhao, H.; Shen, Y.; Papp, A.; Bird, P.I.; Granville, D.J.
Granzyme K expressed by classically activated macrophages contributes to inflammation and impaired remodeling
J. Invest. Dermatol.
139
930-939
2019
Mus musculus (O35205), Homo sapiens (P49863), Homo sapiens
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