Disease on EC 3.4.21.B39 - stratum corneum tryptic enzyme and Organism(s) Homo sapiens and UniProt Accession Q9Y337
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Adenocarcinoma
Clinical significance of kallikrein 5 as a novel prognostic biomarker in gastric adenocarcinoma.
Adenocarcinoma of Lung
PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma.
Breast Neoplasms
Down-regulation of kallikrein-related peptidase 5 (KLK5) expression in breast cancer patients: a biomarker for the differential diagnosis of breast lesions.
Breast Neoplasms
Evaluation of Kallikrein-related Peptidase 5 Expression and its Significance for Breast Cancer Patients: Association with Kallikrein-related Peptidase 7 Expression.
Breast Neoplasms
Kallikrein-related peptidase 5 induces miRNA-mediated anti-oncogenic pathways in breast cancer.
Breast Neoplasms
Molecular signatures associated with transformation and progression to breast cancer in the isogenic MCF10 model.
Breast Neoplasms
The new kallikrein-like gene, KLK-L2. Molecular characterization, mapping, tissue expression, and hormonal regulation.
Carcinogenesis
Kallikrein 5 Inhibition by the Lympho-Epithelial Kazal-Type Related Inhibitor Hinders Matriptase-Dependent Carcinogenesis.
Carcinoma
Human kallikrein 5: an interesting novel biomarker in ovarian cancer patients that elicits humoral response.
Carcinoma
Kallikrein 5 Inhibition by the Lympho-Epithelial Kazal-Type Related Inhibitor Hinders Matriptase-Dependent Carcinogenesis.
Carcinoma
Kallikrein-5 promotes cleavage of desmoglein-1 and loss of cell-cell cohesion in oral squamous cell carcinoma.
Carcinoma
Kallikrein-related Peptidase 5 (KLK5) Expression and Distribution in Canine Cutaneous Squamous Cell Carcinoma.
Carcinoma
The Co-Expression of Kallikrein 5 and Kallikrein 7 Associates with Poor Survival in Non-HPV Oral Squamous-Cell Carcinoma.
Carcinoma, Squamous Cell
Kallikrein-related Peptidase 5 (KLK5) Expression and Distribution in Canine Cutaneous Squamous Cell Carcinoma.
Chronic Urticaria
Decreased plasma kallikrein 5 concentrations in patients with chronic spontaneous urticaria.
Colitis
Glutathione peroxidase 2 and aquaporin 8 as new markers for colonic inflammation in experimental colitis and inflammatory bowel diseases: an important role for H2O2?
Dermatitis
Increase in pruritogenic kallikrein 5 in the skin of NC mice with chronic dermatitis.
Dermatitis
Skin pH Is the Master Switch of Kallikrein 5-Mediated Skin Barrier Destruction in a Murine Atopic Dermatitis Model.
Eczema
Transcriptional gene silencing of kallikrein 5 and kallikrein 7 using siRNA prevents epithelial cell detachment induced by alkaline shock in an in vitro model of eczema.
Eosinophilic Esophagitis
Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis.
Influenza, Human
Cleavage activation of human-adapted influenza virus subtypes by kallikrein-related peptidases 5 and 12.
Influenza, Human
Kallikrein-related peptidase 5 and seasonal influenza viruses, limitations of the experimental models for activating proteases.
Influenza, Human
Kallikrein-Related Peptidase 5 Contributes to H3N2 Influenza Virus Infection in Human Lungs.
Mycosis Fungoides
Mechanisms of itching in mycosis fungoides: grade of itching correlates with eosinophil infiltration and kallikrein 5 expression.
Neoplasms
Assessment of kallikrein-related peptidase 5 (KLK5) protein expression in tumor tissue of advanced ovarian cancer patients by immunohistochemistry and ELISA: correlation with clinical outcome.
Neoplasms
Biochemical and enzymatic characterization of human kallikrein 5 (hK5), a novel serine protease potentially involved in cancer progression.
Neoplasms
Biological evaluation and docking studies of natural isocoumarins as inhibitors for human kallikrein 5 and 7.
Neoplasms
Exploration of potential prognostic biomarkers in aflibercept plus FOLFIRI in Japanese patients with metastatic colorectal cancer.
Neoplasms
Exploring the active site binding specificity of kallikrein-related peptidase 5 (KLK5) guides the design of new peptide substrates and inhibitors.
Neoplasms
Human kallikrein 3 (prostate specific antigen) and human kallikrein 5 expression in salivary gland tumors.
Neoplasms
Isomannide-based peptidomimetics as inhibitors for human tissue kallikreins 5 and 7.
Neoplasms
Kallikrein 5 overexpression is associated with poor prognosis in uterine cervical cancer.
Neoplasms
Kallikrein-related peptidase 5 induces miRNA-mediated anti-oncogenic pathways in breast cancer.
Neoplasms
Parallel underexpression of kallikrein 5 and kallikrein 7 mRNA in breast malignancies.
Neoplasms
PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma.
Neoplasms
Quantitative analysis of human kallikrein 5 (KLK5) expression in prostate needle biopsies: an independent cancer biomarker.
Neoplasms
Synthesis, biological evaluation and molecular modeling of pseudo-peptides based statine as inhibitors for human tissue kallikrein 5.
Netherton Syndrome
A Potent and Selective Kallikrein-5 Inhibitor Delivers High Pharmacological Activity in Skin from Patients with Netherton Syndrome.
Netherton Syndrome
Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors.
Netherton Syndrome
Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome.
Netherton Syndrome
Exploring the active site binding specificity of kallikrein-related peptidase 5 (KLK5) guides the design of new peptide substrates and inhibitors.
Netherton Syndrome
Identification by in silico and in vitro screenings of small organic molecules acting as reversible inhibitors of kallikreins.
Netherton Syndrome
Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome.
Netherton Syndrome
Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome.
Netherton Syndrome
SPINK5 knockdown in organotypic human skin culture as a model system for Netherton syndrome: effect of genetic inhibition of serine proteases kallikrein 5 and kallikrein 7.
Netherton Syndrome
Structure guided drug design to develop kallikrein 5 inhibitors to treat Netherton syndrome.
Netherton Syndrome
Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome.
Ovarian Neoplasms
Assessment of kallikrein-related peptidase 5 (KLK5) protein expression in tumor tissue of advanced ovarian cancer patients by immunohistochemistry and ELISA: correlation with clinical outcome.
Ovarian Neoplasms
Human kallikrein 5: a potential novel serum biomarker for breast and ovarian cancer.
Ovarian Neoplasms
Human kallikrein 5: an interesting novel biomarker in ovarian cancer patients that elicits humoral response.
Ovarian Neoplasms
Immunofluorometric quantification of human kallikrein 5 expression in ovarian cancer cytosols and its association with unfavorable patient prognosis.
Ovarian Neoplasms
Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer.
Ovarian Neoplasms
The human kallikrein protein 5 (hK5) is enzymatically active, glycosylated and forms complexes with two protease inhibitors in ovarian cancer fluids.
Prostatic Neoplasms
Differential expression of a human kallikrein 5 (KLK5) splice variant in ovarian and prostate cancer.
Prostatic Neoplasms
Human tissue kallikrein 5 is a member of a proteolytic cascade pathway involved in seminal clot liquefaction and potentially in prostate cancer progression.
Pruritus
Decreased plasma kallikrein 5 concentrations in patients with chronic spontaneous urticaria.
Pruritus
Mechanisms of itching in mycosis fungoides: grade of itching correlates with eosinophil infiltration and kallikrein 5 expression.
Rosacea
A Novel Mechanism of Carvedilol Efficacy for Rosacea Treatment: Toll-Like Receptor 2 Inhibition in Macrophages.
Rosacea
Cathelicidin, kallikrein 5, and serine protease activity is inhibited during treatment of rosacea with azelaic acid 15% gel.
Rosacea
Citron Essential Oils Alleviate the Mediators Related to Rosacea Pathophysiology in Epidermal Keratinocytes.
Rosacea
Coptis chinensis Franch Directly Inhibits Proteolytic Activation of Kallikrein 5 and Cathelicidin Associated with Rosacea in Epidermal Keratinocytes.
Rosacea
Doxycycline Indirectly Inhibits Proteolytic Activation of Tryptic Kallikrein-Related Peptidases and Activation of Cathelicidin.
Rosacea
Hyaluronan Oligosaccharides Improve Rosacea-Like Phenotype through Anti-Inflammatory and Epidermal Barrier-Improving Effects.
Rosacea
Kallikrein 5-Mediated Inflammation in Rosacea: Clinically Relevant Correlations with Acute and Chronic Manifestations in Rosacea and How Individual Treatments May Provide Therapeutic Benefit.
Rosacea
Multifunctional Serine Protease Inhibitor-Coated Water-Soluble Gold Nanoparticles as a Novel Targeted Approach for the Treatment of Inflammatory Skin Diseases.
Rosacea
TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes.
Skin Diseases
Exploring the active site binding specificity of kallikrein-related peptidase 5 (KLK5) guides the design of new peptide substrates and inhibitors.
Skin Diseases
Hyaluronan Oligosaccharides Improve Rosacea-Like Phenotype through Anti-Inflammatory and Epidermal Barrier-Improving Effects.
Skin Diseases
Multifunctional Serine Protease Inhibitor-Coated Water-Soluble Gold Nanoparticles as a Novel Targeted Approach for the Treatment of Inflammatory Skin Diseases.
Skin Diseases
Screening of chemical libraries in pursuit of kallikrein-5 specific inhibitors for the treatment of inflammatory dermatoses.
Squamous Cell Carcinoma of Head and Neck
Kallikrein 5 Inhibition by the Lympho-Epithelial Kazal-Type Related Inhibitor Hinders Matriptase-Dependent Carcinogenesis.
Squamous Cell Carcinoma of Head and Neck
Kallikrein-5 promotes cleavage of desmoglein-1 and loss of cell-cell cohesion in oral squamous cell carcinoma.
Triple Negative Breast Neoplasms
Human kallikrein 5 as a novel prognostic biomarker for triple-negative breast cancer: tissue expression analysis and relationship with disease course.
Ureteral Obstruction
MiR-382 targeting of kallikrein 5 contributes to renal inner medullary interstitial fibrosis.
Urticaria
Decreased plasma kallikrein 5 concentrations in patients with chronic spontaneous urticaria.
Uterine Cervical Neoplasms
Kallikrein 5 overexpression is associated with poor prognosis in uterine cervical cancer.
Virus Diseases
Kallikrein-Related Peptidase 5 Contributes to H3N2 Influenza Virus Infection in Human Lungs.
Vulvodynia
Decreased concentration of protease inhibitors: possible contributors to allodynia and hyperalgesia in women with vestibulodynia.