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Disease on EC 3.4.21.B25 - PACE4 proprotein convertase

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DISEASE
TITLE OF PUBLICATION
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Adenocarcinoma
Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours.
PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression.
Anemia
Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.
Anthrax
A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen.
Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain.
Breast Neoplasms
Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: role of tissue inhibitors of metalloproteinase-1.
PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression.
PACE4 regulates proliferation, migration and invasion in human breast cancer MDA-MB-231 cells.
Pro-protein convertase gene expression in human breast cancer.
Carcinogenesis
Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases.
Expression of PACE4 in chemically induced carcinomas is associated with spindle cell tumor conversion and increased invasive ability.
PACE4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression.
Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis.
Carcinoma
Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours.
Expression of PACE4 in chemically induced carcinomas is associated with spindle cell tumor conversion and increased invasive ability.
Malignant conversion of non-tumorigenic murine skin keratinocytes overexpressing PACE4.
PACE4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression.
Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis.
Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells.
Transcriptional regulation of subtilisin-like proprotein convertase PACE4 by E2F: possible role of E2F-mediated upregulation of PACE4 in tumor progression.
Carcinoma, Non-Small-Cell Lung
Expression of paired basic amino acid-cleaving enzyme 4 (PACE4) correlated with prognosis in non-small cell lung cancer (NSCLC) patients.
Carcinoma, Squamous Cell
Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours.
Enhanced aggressiveness of benzopyrene-induced squamous carcinomas in transgenic mice overexpressing the proprotein convertase PACE4 (PCSK6).
Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis.
Choriocarcinoma
The expression of proprotein convertase PACE4 is highly regulated by Hash-2 in placenta: possible role of placenta-specific basic helix-loop-helix transcription factor, human achaete-scute homologue-2.
Diphtheria
Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain.
Endometrial Neoplasms
Proprotein convertases in post-menopausal endometrial cancer: Distinctive regulation and non-invasive diagnosis.
Hemochromatosis
Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.
Hyperthyroidism
PACE4: a subtilisin-like endoprotease prevalent in the anterior pituitary and regulated by thyroid status.
Lung Neoplasms
Expression of paired basic amino acid-cleaving enzyme 4 (PACE4) correlated with prognosis in non-small cell lung cancer (NSCLC) patients.
Lymphatic Metastasis
Expression of paired basic amino acid-cleaving enzyme 4 (PACE4) correlated with prognosis in non-small cell lung cancer (NSCLC) patients.
Melanoma
Paired Basic Amino Acid-cleaving Enzyme 4 (PCSK6): An Emerging New Target Molecule in Human Melanoma.
Nasopharyngeal Carcinoma
PACE4 Expression is a Novel Independent Prognostic Factor in Nasopharyngeal Carcinoma.
Neoplasm Metastasis
Enhanced aggressiveness of benzopyrene-induced squamous carcinomas in transgenic mice overexpressing the proprotein convertase PACE4 (PCSK6).
Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases.
Expression of paired basic amino acid-cleaving enzyme 4 (PACE4) correlated with prognosis in non-small cell lung cancer (NSCLC) patients.
Implications of Proprotein Convertases in Ovarian Cancer Cell Proliferation and Tumor Progression: Insights for PACE4 as a Therapeutic Target.
PACE4 Expression is a Novel Independent Prognostic Factor in Nasopharyngeal Carcinoma.
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
Paired Basic Amino Acid-cleaving Enzyme 4 (PCSK6): An Emerging New Target Molecule in Human Melanoma.
Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis.
Neoplasms
Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours.
Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor.
Engineering of alpha1-antitrypsin variants selective for subtilisin-like proprotein convertases PACE4 and PC6: importance of the P2' residue in stable complex formation of the serpin with proprotein convertase.
Enhanced aggressiveness of benzopyrene-induced squamous carcinomas in transgenic mice overexpressing the proprotein convertase PACE4 (PCSK6).
Enhanced anti-tumor activity of the Multi-Leu peptide PACE4 inhibitor transformed into an albumin-bound tumor-targeting prodrug.
Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases.
Evaluation of PACE4 isoforms as biomarkers in thyroid cancer.
Expression of PACE4 in chemically induced carcinomas is associated with spindle cell tumor conversion and increased invasive ability.
Expression of paired basic amino acid-cleaving enzyme 4 (PACE4) correlated with prognosis in non-small cell lung cancer (NSCLC) patients.
Implications of Proprotein Convertases in Ovarian Cancer Cell Proliferation and Tumor Progression: Insights for PACE4 as a Therapeutic Target.
Increased expression of the pro-protein convertase furin predicts decreased survival in ovarian cancer.
Increasing C-Terminal Hydrophobicity Improves the Cell Permeability and Antiproliferative Activity of PACE4 Inhibitors against Prostate Cancer Cell Lines.
Knockdown strategies for the study of proprotein convertases and proliferation in prostate cancer cells.
Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth.
Malignant conversion of non-tumorigenic murine skin keratinocytes overexpressing PACE4.
miR-124 exhibits antiproliferative and antiaggressive effects on prostate cancer cells through PACE4 pathway.
Molecular Validation of PACE4 as a Target in Prostate Cancer.
Multi-Leu PACE4 Inhibitor Retention within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity.
PACE4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression.
PACE4 Expression is a Novel Independent Prognostic Factor in Nasopharyngeal Carcinoma.
PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction increased apoptosis and impaired neovascularisation.
PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression.
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
PACE4 regulates proliferation, migration and invasion in human breast cancer MDA-MB-231 cells.
PACE4 Undergoes an Oncogenic Alternative Splicing Switch in Cancer.
PACE4-based molecular targeting of prostate cancer using an engineered ??Cu-radiolabeled peptide inhibitor.
Paired Basic Amino Acid-cleaving Enzyme 4 (PCSK6): An Emerging New Target Molecule in Human Melanoma.
Pro-protein convertase gene expression in human breast cancer.
Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis.
Proprotein convertases in post-menopausal endometrial cancer: Distinctive regulation and non-invasive diagnosis.
Proprotein convertases: "master switches" in the regulation of tumor growth and progression.
Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.
Role of proprotein convertases in prostate cancer progression.
The proprotein convertases furin and PACE4 play a significant role in tumor progression.
Transcriptional regulation of subtilisin-like proprotein convertase PACE4 by E2F: possible role of E2F-mediated upregulation of PACE4 in tumor progression.
Upregulation of PACE4 in Prostate Cancer is not dependent on E2F Transcription Factors.
Nervous System Neoplasms
Proprotein convertases: "master switches" in the regulation of tumor growth and progression.
Neuroblastoma
Proprotein convertase PACE4 is down-regulated by the basic helix-loop-helix transcription factor hASH-1 and MASH-1.
Osteoarthritis
A functional polymorphism in the paired basic amino acid-cleaving enzyme 4 gene confers osteoarthritis risk in a population of Eastern China.
A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype.
Osteoarthritis, Knee
A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype.
Ovarian Neoplasms
Epigenetic regulation of proprotein convertase PACE4 gene expression in human ovarian cancer cells.
Implications of Proprotein Convertases in Ovarian Cancer Cell Proliferation and Tumor Progression: Insights for PACE4 as a Therapeutic Target.
Pancreatic Neoplasms
PACE4 regulates apoptosis in human pancreatic cancer Panc?1 cells via the mitochondrial signaling pathway.
Prostatic Neoplasms
Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor.
Enhanced anti-tumor activity of the Multi-Leu peptide PACE4 inhibitor transformed into an albumin-bound tumor-targeting prodrug.
Evaluation of PACE4 isoforms as biomarkers in thyroid cancer.
Implications of Proprotein Convertases in Ovarian Cancer Cell Proliferation and Tumor Progression: Insights for PACE4 as a Therapeutic Target.
Improving the Selectivity of PACE4 Inhibitors through Modifications of the P1 Residue.
Increasing C-Terminal Hydrophobicity Improves the Cell Permeability and Antiproliferative Activity of PACE4 Inhibitors against Prostate Cancer Cell Lines.
Knockdown strategies for the study of proprotein convertases and proliferation in prostate cancer cells.
Macrocyclization of a potent PACE4 inhibitor: Benefits and limitations.
miR-124 exhibits antiproliferative and antiaggressive effects on prostate cancer cells through PACE4 pathway.
Molecular Validation of PACE4 as a Target in Prostate Cancer.
Multi-Leu PACE4 Inhibitor Retention within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity.
Novel Insights into Structure-Activity Relationships of N-Terminally Modified PACE4 Inhibitors.
PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction increased apoptosis and impaired neovascularisation.
PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression.
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
PACE4 Undergoes an Oncogenic Alternative Splicing Switch in Cancer.
PACE4-based molecular targeting of prostate cancer using an engineered ??Cu-radiolabeled peptide inhibitor.
Positional Scanning Identifies the Molecular Determinants of a High Affinity Multi-Leucine Inhibitor for Furin and PACE4.
Proprotein convertase inhibition: Paralyzing the cell's master switches.
Rational Design of a Highly Potent and Selective Peptide Inhibitor of PACE4 by Salt Bridge Interaction with D160 at Position P3.
Role of proprotein convertases in prostate cancer progression.
The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells.
Upregulation of PACE4 in Prostate Cancer is not dependent on E2F Transcription Factors.
Skin Neoplasms
Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases.
Spinal Cord Injuries
Gene expression alterations of neurotrophins, their receptors and prohormone convertases in a rat model of spinal cord contusion.
Thyroid Neoplasms
Evaluation of PACE4 isoforms as biomarkers in thyroid cancer.
Thyroid Nodule
Evaluation of PACE4 isoforms as biomarkers in thyroid cancer.
Vaccinia
Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals.
Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases.
Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways.
Comparison of substrate specificities against the fusion glycoprotein of virulent Newcastle disease virus between a chick embryo fibroblast processing protease and mammalian subtilisin-like proteases.
Processing of prothyrotropin-releasing hormone by the family of prohormone convertases.
Proprotein processing activity and cleavage site selectivity of the Kex2-like endoprotease PACE4.
Proprotein-processing endoproteases PC6 and furin both activate hemagglutinin of virulent avian influenza viruses.
Role of prohormone convertases in pro-neuropeptide Y processing: coexpression and in vitro kinetic investigations.