Reference on EC 3.4.21.B12 - prostase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (Q9Y5K2)
Yousef, G.M.; Diamandis, E.P.
The new human tissue kallikrein gene family: structure, function, and association to disease
Endocr. Rev.
22
184-204
2001
Homo sapiens (Q9Y5K2)
Simmer, J.P.; Fukae, M.; Tanabe, T.; Yamakoshi, Y.; Uchida, T.; Xue, J.; Margolis, H.C.; Shimizu, M.; DeHart, B.C.; Hu, J.C.C.; Bartlett, J.D.
Purification, characterization, and cloning of enamel matrix serine proteinase 1
J. Dent. Res.
77
377-386
1998
Sus scrofa (Q9XSN6), Sus scrofa, Sus scrofa EMSP1 (Q9XSN6)
Yousef, G.M.; Obiezu, C.V.; Luo, L.Y.; Black, M.H.; Diamandis, E.P.
Prostase/KLK-L1 is a new member of the human kallikrein gene family, is expressed in prostate and breast tissues, and is hormonally regulated
Cancer Res.
59
4252-4256
1999
Homo sapiens (Q9Y5K2), Homo sapiens
Stephenson, S.A.; Verity, K.; Ashworth, L.K.; Clements, J.A.
Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4
J. Biol. Chem.
274
23210-23214
1999
Homo sapiens (Q9Y5K2)
Nelson, P.S.; Gan, L.; Ferguson, C.; Moss, P.; Gelinas, R.; Hood, L.; Wang, K.
Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression
Proc. Natl. Acad. Sci. USA
96
3114-3119
1999
Homo sapiens (Q9Y5K2), Homo sapiens
Hu, J.C.C.; Zhang, C.; Sun, X.; Yang, Y.; Cao, X.; Ryu, O.; Simmer, J.P.
Characterization of the mouse and human PRSS17 genes, their relationship to other serine proteases, and the expression of PRSS17 in developing mouse incisors
Gene
251
1-8
2000
Mus musculus (Q9JIS2), Mus musculus, Homo sapiens (Q9Y5K2), Homo sapiens
Takayama, T.K.; McMullen, B.A.; Nelson, P.S.; Matsumura, M.; Fujikawa, K.
Characterization of hK4 (prostase), a prostate-specific serine protease: activation of the precursor of prostate specific antigen (pro-PSA) and single-chain urokinase-type plasminogen activator and degradation of prostatic acid phosphatase
Biochemistry
40
15341-15348
2001
Homo sapiens
Ryu, O.; Hu, J.C.; Yamakoshi, Y.; Villemain, J.L.; Cao, X.; Zhang, C.; Bartlett, J.D.; Simmer, J.P.
Porcine kallikrein-4 activation, glycosylation, activity, and expression in prokaryotic and eukaryotic hosts
Eur. J. Oral Sci.
110
358-365
2002
Sus scrofa (Q9XSN6), Sus scrofa
Beaufort, N.; Debela, M.; Creutzburg, S.; Kellermann, J.; Bode, W.; Schmitt, M.; Pidard, D.; Magdolen, V.
Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR)
Biol. Chem.
387
217-222
2006
Homo sapiens
Prezas, P.; Arlt, M.J.; Viktorov, P.; Soosaipillai, A.; Holzscheiter, L.; Schmitt, M.; Talieri, M.; Diamandis, E.P.; Krueger, A.; Magdolen, V.
Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells
Biol. Chem.
387
807-811
2006
Homo sapiens
Davidson, B.; Xi, Z.; Klokk, T.I.; Trope, C.G.; D?rum, A.; Scheistr?en, M.; Saatcioglu, F.
Kallikrein 4 expression is up-regulated in epithelial ovarian carcinoma cells in effusions
Am. J. Clin. Pathol.
123
360-368
2005
Homo sapiens
Obiezu, C.V.; Michael, I.P.; Levesque, M.A.; Diamandis, E.P.
Human kallikrein 4: enzymatic activity, inhibition, and degradation of extracellular matrix proteins
Biol. Chem.
387
749-759
2006
Homo sapiens
Xi, Z.; Klokk, T.I.; Korkmaz, K.; Kurys, P.; Elbi, C.; Risberg, B.; Danielsen, H.; Loda, M.; Saatcioglu, F.
Kallikrein 4 is a predominantly nuclear protein and is overexpressed in prostate cancer
Cancer Res.
64
2365-2370
2004
Homo sapiens
Obiezu, C.V.; Shan, S.J.; Soosaipillai, A.; Luo, L.Y.; Grass, L.; Sotiropoulou, G.; Petraki, C.D.; Papanastasiou, P.A.; Levesque, M.A.; Diamandis, E.P.
Human kallikrein 4: quantitative study in tissues and evidence for its secretion into biological fluids
Clin. Chem.
51
1432-1442
2005
Homo sapiens
Hart, P.S.; Hart, T.C.; Michalec, M.D.; Ryu, O.H.; Simmons, D.; Hong, S.; Wright, J.T.
Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta
J. Med. Genet.
41
545-549
2004
Homo sapiens
Westermann, D.; Schultheiss, H.P.; Tschoepe, C.
New perspective on the tissue kallikrein-kinin system in myocardial infarction: role of angiogenesis and cardiac regeneration
Int. Immunopharmacol.
8
148-154
2008
Homo sapiens
Debela, M.; Magdolen, V.; Schechter, N.; Valachova, M.; Lottspeich, F.; Craik, C.S.; Choe, Y.; Bode, W.; Goettig, P.
Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences
J. Biol. Chem.
281
25678-25688
2006
Homo sapiens (Q9Y5K2)
Debela, M.; Magdolen, V.; Grimminger, V.; Sommerhoff, C.; Messerschmidt, A.; Huber, R.; Friedrich, R.; Bode, W.; Goettig, P.
Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site
J. Mol. Biol.
362
1094-1107
2006
Homo sapiens
Fernando, S.C.; Buck, J.S.; Ashworth, M.D.; Ross, J.W.; Geisert, R.D.; DeSilva, U.
Porcine endometrial and conceptus tissue kallikrein 1, 4, 11, and 14 gene expression
Reproduction
132
939-947
2006
Sus scrofa
Klokk, T.I.; Kilander, A.; Xi, Z.; Waehre, H.; Risberg, B.; Danielsen, H.E.; Saatcioglu, F.
Kallikrein 4 is a proliferative factor that is overexpressed in prostate cancer
Cancer Res.
67
5221-5230
2007
Homo sapiens
Davidson, B.; Xi, Z.; Saatcioglu, F.
Kallikrein 4 is expressed in malignant mesothelioma--further evidence for the histogenetic link between mesothelial and epithelial cells
Diagn. Cytopathol.
35
80-84
2007
Homo sapiens
Wright, J.T.; Daly, B.; Simmons, D.; Hong, S.; Hart, S.P.; Hart, T.C.; Atsawasuwan, P.; Yamauchi, M.
Human enamel phenotype associated with amelogenesis imperfecta and a kallikrein-4 (g.2142G>A) proteinase mutation
Eur. J. Oral Sci.
114 Suppl 1; 13-7
discussion 39-41, 379
2006
Homo sapiens
Yamakoshi, Y.; Hu, J.C.; Fukae, M.; Yamakoshi, F.; Simmer, J.P.
How do enamelysin and kallikrein 4 process the 32-kDa enamelin?
Eur. J. Oral Sci.
114 Suppl 1; 45-51; discussion 93-5
379-80
2006
Sus scrofa
Ramsay, A.J.; Dong, Y.; Hunt, M.L.; Linn, M.; Samaratunga, H.; Clements, J.A.; Hooper, J.D.
Kallikrein-related peptidase (KLK) 4 initiates intracellular signalling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progression
J. Biol. Chem.
283
12293-12304
2008
Homo sapiens
Gao, J.; Collard, R.L.; Bui, L.; Herington, A.C.; Nicol, D.L.; Clements, J.A.
Kallikrein 4 is a potential mediator of cellular interactions between cancer cells and osteoblasts in metastatic prostate cancer
Prostate
67
348-360
2007
Homo sapiens
Debela, M.; Beaufort, N.; Magdolen, V.; Schechter, N.M.; Craik, C.S.; Schmitt, M.; Bode, W.; Goettig, P.
Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7
Biol. Chem.
389
623-632
2008
Homo sapiens (Q9Y5K2)
Lu, Y.; Papagerakis, P.; Yamakoshi, Y.; Hu, J.C.; Bartlett, J.D.; Simmer, J.P.
Functions of KLK4 and MMP-20 in dental enamel formation
Biol. Chem.
389
695-700
2008
Homo sapiens (Q9Y5K2)
Tye, C.E.; Pham, C.T.; Simmer, J.P.; Bartlett, J.D.
DPPI may activate KLK4 during enamel formation
J. Dent. Res.
88
323-327
2009
Homo sapiens (Q9Y5K2)
Wang, W.; Mize, G.J.; Zhang, X.; Takayama, T.K.
Kallikrein-related peptidase-4 initiates tumor-stroma interactions in prostate cancer through protease-activated receptor-1
Int. J. Cancer
126
599-610
2010
Homo sapiens
Avgeris, M.; Stravodimos, K.; Scorilas, A.
Kallikrein-related peptidase 4 gene (KLK4) in prostate tumors: quantitative expression analysis and evaluation of its clinical significance
Prostate
71
1780-1789
2011
Homo sapiens
Lisle, J.E.; Mertens-Walker, I.; Stephens, C.R.; Stansfield, S.H.; Clements, J.A.; Herington, A.C.; Stephenson, S.A.
Murine, but not human, ephrin-B2 can be efficiently cleaved by the serine protease kallikrein-4: implications for xenograft models of human prostate cancer
Exp. Cell Res.
333
136-146
2015
Homo sapiens (Q9YSK2), Homo sapiens
Mukai, S.; Yorita, K.; Yamasaki, K.; Nagai, T.; Kamibeppu, T.; Sugie, S.; Kida, K.; Onizuka, C.; Tsukino, H.; Kamimura, T.; Kamoto, T.; Kataoka, H.
Expression of human kallikrein 1-related peptidase 4 (KLK4) and MET phosphorylation in prostate cancer tissue: immunohistochemical analysis
Hum. Cell
28
133-142
2015
Homo sapiens (Q9YSK2), Homo sapiens
Swedberg, J.E.; Ghani, H.A.; Harris, J.M.; de Veer, S.J.; Craik, D.J.
Potent, selective, and cell-penetrating inhibitors of kallikrein-related peptidase 4 based on the cyclic peptide MCoTI-II
ACS Med. Chem. Lett.
9
1258-1262
2018
Homo sapiens (Q9Y5K2), Homo sapiens
Papagerakis, P.; Pannone, G.; Zheng, L.I.; Athanassiou-Papaefthymiou, M.; Yamakoshi, Y.; McGuff, H.S.; Shkeir, O.; Ghirtis, K.; Papagerakis, S.
Clinical significance of kallikrein-related peptidase-4 in oral cancer
Anticancer Res.
35
1861-1866
2015
Homo sapiens (Q9Y5K2), Homo sapiens
Perez, V.; Mangum, J.; Hubbard, M.
Direct evidence that KLK4 is a hydroxyapatite-binding protein
Biochem. Biophys. Res. Commun.
495
1896-1900
2017
Homo sapiens (Q9Y5K2)
Yang, F.; Aubele, M.; Walch, A.; Gross, E.; Napieralski, R.; Zhao, S.; Ahmed, N.; Kiechle, M.; Reuning, U.; Dorn, J.; Sweep, F.; Magdolen, V.; Schmitt, M.
Tissue kallikrein-related peptidase 4 (KLK4), a novel biomarker in triple-negative breast cancer
Biol. Chem.
398
1151-1164
2017
Homo sapiens (Q9Y5K2), Homo sapiens
Wang, L.; Xie, X.; Sun, Y.; Wang, J.; Wang, Y.; Wang, X.
KLK4 is synchronically expressed to CTSC in ameloblasts during amelogenesis molars
Int. J. Clin. Exp. Pathol.
10
5751-5757
2017
Mus musculus (Q9Z0M1)
-
Fuhrman-Luck, R.A.; Stansfield, S.H.; Stephens, C.R.; Loessner, D.; Clements, J.A.
Prostate cancer-associated kallikrein-related peptidase 4 activates matrix metalloproteinase-1 and thrombospondin-1
J. Proteome Res.
15
2466-2478
2016
Homo sapiens (Q9Y5K2)
Vickers, A.; Vertosick, E.A.; Sjoberg, D.D.; Roobol, M.J.; Hamdy, F.; Neal, D.; Bjartell, A.; Hugosson, J.; Donovan, J.L.; Villers, A.; Zappala, S.; Lilja, H.
Properties of the 4-kallikrein panel outside the diagnostic gray zone meta-analysis of patients with positive digital rectal examination or prostate specific antigen 10 ng/ml and above
J. Urol.
197
607-613
2017
Homo sapiens (Q9Y5K2)
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