Disease on EC 3.4.21.B12 - prostase and Organism(s) Homo sapiens and UniProt Accession Q9Y5K2
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Adenocarcinoma
Kallikrein 4 is expressed in malignant mesothelioma--further evidence for the histogenetic link between mesothelial and epithelial cells.
Adenocarcinoma
Kallikrein-related peptidase 4 (KLK4) mRNA predicts short-term relapse in colorectal adenocarcinoma patients.
Amelogenesis Imperfecta
Human enamel phenotype associated with amelogenesis imperfecta and a kallikrein-4 (g.2142G>A) proteinase mutation.
Amelogenesis Imperfecta
Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta.
Breast Neoplasms
Specific increase of human kallikrein 4 mRNA and protein levels in breast cancer stromal cells.
Carcinogenesis
Kallikrein-related peptidase signaling in colon carcinoma cells: Targeting proteinase-activated receptors (PARs).
Carcinogenesis
MiR-378a-5p inhibits angiogenesis of oral squamous cell carcinoma by targeting KLK4.
Carcinoma
Kallikrein 4 expression is up-regulated in epithelial ovarian carcinoma cells in effusions.
Carcinoma
Kallikrein-related peptidase 4 contributes to the tumor metastasis of oral squamous cell carcinoma.
Carcinoma
Low mRNA expression levels of kallikrein-related peptidase 4 (KLK4) predict short-term relapse in patients with laryngeal squamous cell carcinoma.
Carcinoma, Ovarian Epithelial
Kallikrein 4 expression is up-regulated in epithelial ovarian carcinoma cells in effusions.
Carcinoma, Squamous Cell
Elevated levels of both microRNA 378 (miR-378) and kallikrein-related peptidase 4 (KLK4) mRNA are associated with an unfavorable prognosis in triple-negative breast cancer.
Colonic Neoplasms
Kallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cells.
Endometrial Neoplasms
Kallikrein 4 (KLK4), a new member of the human kallikrein gene family is up-regulated by estrogen and progesterone in the human endometrial cancer cell line, KLE.
Endometrial Neoplasms
Kallikrein 4 overexpression in endometrial carcinoma and upregulation by estrogen via mitogen-activated protein kinase signal pathway.
Endometriosis
Kallikrein-related peptidase 4 promotes migration and invasion of endometrial stromal cells in endometriosis by inducing epithelial-mesenchymal transition.
Hepatitis C
Mannan binding lectin-associated serine protease 1 is induced by hepatitis C virus infection and activates human hepatic stellate cells.
Hepatitis C
Severe fibrosis in hepatitis C virus-infected patients is associated with increased activity of the mannan-binding lectin (MBL)/MBL-associated serine protease 1 (MASP-1) complex.
Infections
Identification of a Highly Antigenic Region of Subtilisin-Like Serine Protease 1 for Serodiagnosis of Neospora caninum Infection.
Leukoencephalopathies
A Case of Cerebral Small Vessel Disease Related to a Heterozygous Nonsense Mutation in HTRA1.
Leukoencephalopathies
Genetically Confirmed CARASIL: Case Report with Novel HTRA1 Mutation and Literature Review.
Lupus Nephritis
Micro-RNA analysis of renal biopsies in human lupus nephritis demonstrates up-regulated miR-422a driving reduction of kallikrein-related peptidase 4.
Lupus Nephritis
Role of miR-422a and kallikrein-related peptidase 4 implicated in the development of lupus nephritis. Do we work in this direction?
Mesothelioma, Malignant
Kallikrein 4 is expressed in malignant mesothelioma--further evidence for the histogenetic link between mesothelial and epithelial cells.
Neoplasm Metastasis
Kallikrein-related peptidase 4 contributes to the tumor metastasis of oral squamous cell carcinoma.
Neoplasm Metastasis
MiR-378a-5p inhibits angiogenesis of oral squamous cell carcinoma by targeting KLK4.
Neoplasm Metastasis
Prostate Cancer-Associated Kallikrein-Related Peptidase 4 Activates Matrix Metalloproteinase-1 and Thrombospondin-1.
Neoplasms
Characterization of kallikrein-related peptidase 4 (KLK4) mRNA expression in tumor tissue of advanced high-grade serous ovarian cancer patients.
Neoplasms
Comparative Temporospatial Expression Profiling of Murine Amelotin Protein during Amelogenesis.
Neoplasms
Direct progesterone receptor and indirect androgen receptor interactions with the kallikrein-related peptidase 4 gene promoter in breast and prostate cancer.
Neoplasms
Elevated levels of both microRNA 378 (miR-378) and kallikrein-related peptidase 4 (KLK4) mRNA are associated with an unfavorable prognosis in triple-negative breast cancer.
Neoplasms
Kallikrein 4 is a potential mediator of cellular interactions between cancer cells and osteoblasts in metastatic prostate cancer.
Neoplasms
Kallikrein 4 is expressed in malignant mesothelioma--further evidence for the histogenetic link between mesothelial and epithelial cells.
Neoplasms
Kallikrein-related peptidase 4 (KLK4) initiates intracellular signaling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progression.
Neoplasms
Kallikrein-related peptidase 4 contributes to the tumor metastasis of oral squamous cell carcinoma.
Neoplasms
Kallikrein-related peptidase 4 gene (KLK4) in prostate tumors: Quantitative expression analysis and evaluation of its clinical significance.
Neoplasms
Kallikrein-related peptidase 4 promotes migration and invasion of endometrial stromal cells in endometriosis by inducing epithelial-mesenchymal transition.
Neoplasms
Kallikrein-related peptidase signaling in colon carcinoma cells: Targeting proteinase-activated receptors (PARs).
Neoplasms
KLK4 Induces Anti-Tumor Effects in Human Xenograft Mouse Models of Orthotopic and Metastatic Prostate Cancer.
Neoplasms
MiR-378a-5p inhibits angiogenesis of oral squamous cell carcinoma by targeting KLK4.
Odontogenic Tumors
Kallikrein 4 and matrix metalloproteinase-20 immunoexpression in malignant, benign and infiltrative odontogenic tumors.
Ovarian Neoplasms
Characterization of kallikrein-related peptidase 4 (KLK4) mRNA expression in tumor tissue of advanced high-grade serous ovarian cancer patients.
Ovarian Neoplasms
Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment.
Pancreatic Neoplasms
PRSS1 mutations and the proteinase/antiproteinase imbalance in the pathogenesis of pancreatic cancer.
Pancreatitis
High Incidence of PRSS1 and SPINK1 Mutations in Korean Children With Acute Recurrent and Chronic Pancreatitis.
Pancreatitis, Chronic
High Incidence of PRSS1 and SPINK1 Mutations in Korean Children With Acute Recurrent and Chronic Pancreatitis.
Pancreatitis, Chronic
Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis.
Pancreatitis, Chronic
Mutation That Promotes Activation of Trypsinogen Increases Severity of Secretagogue-Induced Pancreatitis in Mice.
Prostatic Neoplasms
Compartmentalized expression of kallikrein 4 (KLK4/hK4) isoforms in prostate cancer: nuclear, cytoplasmic and secreted forms.
Prostatic Neoplasms
Crystal structure of the inhibitor-free form of the serine protease kallikrein-4.
Prostatic Neoplasms
Detection of human kallikrein 4 in healthy and cancerous prostatic tissues by immunofluorometry and immunohistochemistry.
Prostatic Neoplasms
Direct progesterone receptor and indirect androgen receptor interactions with the kallikrein-related peptidase 4 gene promoter in breast and prostate cancer.
Prostatic Neoplasms
Epithelial-mesenchymal transition in prostate cancer and the potential role of kallikrein serine proteases.
Prostatic Neoplasms
Expression of human kallikrein 1-related peptidase 4 (KLK4) and MET phosphorylation in prostate cancer tissue: immunohistochemical analysis.
Prostatic Neoplasms
Human kallikrein 4 signal peptide induces cytotoxic T cell responses in healthy donors and prostate cancer patients.
Prostatic Neoplasms
Kallikrein 4 (hK4) and prostate-specific antigen (PSA) are associated with the loss of E-cadherin and an epithelial-mesenchymal transition (EMT)-like effect in prostate cancer cells.
Prostatic Neoplasms
Kallikrein 4 is a potential mediator of cellular interactions between cancer cells and osteoblasts in metastatic prostate cancer.
Prostatic Neoplasms
Kallikrein 4 is a predominantly nuclear protein and is overexpressed in prostate cancer.
Prostatic Neoplasms
Kallikrein 4 is a proliferative factor that is overexpressed in prostate cancer.
Prostatic Neoplasms
Kallikrein-related peptidase 4 (KLK4) initiates intracellular signaling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progression.
Prostatic Neoplasms
Kallikrein-related peptidase-4 initiates tumor-stroma interactions in prostate cancer through protease-activated receptor-1.
Prostatic Neoplasms
KLK4 Induces Anti-Tumor Effects in Human Xenograft Mouse Models of Orthotopic and Metastatic Prostate Cancer.
Prostatic Neoplasms
Mastering the canonical loop of serine protease inhibitors: enhancing potency by optimising the internal hydrogen bond network.
Prostatic Neoplasms
Murine, but not human, ephrin-B2 can be efficiently cleaved by the serine protease kallikrein-4: Implications for xenograft models of human prostate cancer.
Prostatic Neoplasms
Polyclonal antibodies against kallikrein-related peptidase 4 (KLK4): immunohistochemical assessment of KLK4 expression in healthy tissues and prostate cancer.
Prostatic Neoplasms
Potent, Selective, and Cell-Penetrating Inhibitors of Kallikrein-Related Peptidase 4 Based on the Cyclic Peptide MCoTI-II.
Prostatic Neoplasms
Prostate Cancer-Associated Kallikrein-Related Peptidase 4 Activates Matrix Metalloproteinase-1 and Thrombospondin-1.
Prostatic Neoplasms
Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4.
Sepsis
Identification of Potential Biomarkers by Serum Proteomics Analysis in Rats With Sepsis.
Squamous Cell Carcinoma of Head and Neck
Kallikrein-related peptidase 4 contributes to the tumor metastasis of oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Low mRNA expression levels of kallikrein-related peptidase 4 (KLK4) predict short-term relapse in patients with laryngeal squamous cell carcinoma.
Triple Negative Breast Neoplasms
Elevated levels of both microRNA 378 (miR-378) and kallikrein-related peptidase 4 (KLK4) mRNA are associated with an unfavorable prognosis in triple-negative breast cancer.
Triple Negative Breast Neoplasms
Tissue kallikrein-related peptidase 4 (KLK4), a novel biomarker in triple-negative breast cancer.
Virus Diseases
Mannan binding lectin-associated serine protease 1 is induced by hepatitis C virus infection and activates human hepatic stellate cells.