Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 3.4.21.B12 - prostase and Organism(s) Homo sapiens and UniProt Accession Q9Y5K2

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Kallikrein 4 is expressed in malignant mesothelioma--further evidence for the histogenetic link between mesothelial and epithelial cells.
Kallikrein-related peptidase 4 (KLK4) mRNA predicts short-term relapse in colorectal adenocarcinoma patients.
Amelogenesis Imperfecta
Human enamel phenotype associated with amelogenesis imperfecta and a kallikrein-4 (g.2142G>A) proteinase mutation.
Hypomaturation enamel defects in Klk4 knockout/LacZ knockin mice.
MMP20 hemopexin domain mutation in amelogenesis imperfecta.
Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta.
Premature stop codon in MMP20 causing amelogenesis imperfecta.
Breast Neoplasms
Specific increase of human kallikrein 4 mRNA and protein levels in breast cancer stromal cells.
Carcinogenesis
Kallikrein-related peptidase signaling in colon carcinoma cells: Targeting proteinase-activated receptors (PARs).
MiR-378a-5p inhibits angiogenesis of oral squamous cell carcinoma by targeting KLK4.
Carcinoma
Human kallikrein 4 (KLK4) is highly expressed in serous ovarian carcinomas.
Kallikrein 4 expression is up-regulated in epithelial ovarian carcinoma cells in effusions.
Kallikrein-related peptidase 4 contributes to the tumor metastasis of oral squamous cell carcinoma.
Low mRNA expression levels of kallikrein-related peptidase 4 (KLK4) predict short-term relapse in patients with laryngeal squamous cell carcinoma.
Carcinoma, Ovarian Epithelial
Kallikrein 4 expression is up-regulated in epithelial ovarian carcinoma cells in effusions.
Carcinoma, Squamous Cell
Elevated levels of both microRNA 378 (miR-378) and kallikrein-related peptidase 4 (KLK4) mRNA are associated with an unfavorable prognosis in triple-negative breast cancer.
Colonic Neoplasms
Kallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cells.
Endometrial Neoplasms
Kallikrein 4 (KLK4), a new member of the human kallikrein gene family is up-regulated by estrogen and progesterone in the human endometrial cancer cell line, KLE.
Kallikrein 4 overexpression in endometrial carcinoma and upregulation by estrogen via mitogen-activated protein kinase signal pathway.
Endometriosis
Kallikrein-related peptidase 4 promotes migration and invasion of endometrial stromal cells in endometriosis by inducing epithelial-mesenchymal transition.
Hepatitis C
Mannan binding lectin-associated serine protease 1 is induced by hepatitis C virus infection and activates human hepatic stellate cells.
Severe fibrosis in hepatitis C virus-infected patients is associated with increased activity of the mannan-binding lectin (MBL)/MBL-associated serine protease 1 (MASP-1) complex.
Infections
Identification of a Highly Antigenic Region of Subtilisin-Like Serine Protease 1 for Serodiagnosis of Neospora caninum Infection.
Leukoencephalopathies
A Case of Cerebral Small Vessel Disease Related to a Heterozygous Nonsense Mutation in HTRA1.
Genetically Confirmed CARASIL: Case Report with Novel HTRA1 Mutation and Literature Review.
Lupus Nephritis
Micro-RNA analysis of renal biopsies in human lupus nephritis demonstrates up-regulated miR-422a driving reduction of kallikrein-related peptidase 4.
Role of miR-422a and kallikrein-related peptidase 4 implicated in the development of lupus nephritis. Do we work in this direction?
Mesothelioma, Malignant
Kallikrein 4 is expressed in malignant mesothelioma--further evidence for the histogenetic link between mesothelial and epithelial cells.
Mouth Neoplasms
Clinical significance of kallikrein-related peptidase-4 in oral cancer.
Neoplasm Metastasis
A KLK4 proteinase substrate capture approach to antagonize PAR1.
Kallikrein-related peptidase 4 contributes to the tumor metastasis of oral squamous cell carcinoma.
MiR-378a-5p inhibits angiogenesis of oral squamous cell carcinoma by targeting KLK4.
Prostate Cancer-Associated Kallikrein-Related Peptidase 4 Activates Matrix Metalloproteinase-1 and Thrombospondin-1.
Neoplasms
A KLK4 proteinase substrate capture approach to antagonize PAR1.
Aberrant KLK4 gene promoter hypomethylation in pediatric hepatoblastomas.
Characterization of kallikrein-related peptidase 4 (KLK4) mRNA expression in tumor tissue of advanced high-grade serous ovarian cancer patients.
Comparative Temporospatial Expression Profiling of Murine Amelotin Protein during Amelogenesis.
Direct progesterone receptor and indirect androgen receptor interactions with the kallikrein-related peptidase 4 gene promoter in breast and prostate cancer.
Elevated levels of both microRNA 378 (miR-378) and kallikrein-related peptidase 4 (KLK4) mRNA are associated with an unfavorable prognosis in triple-negative breast cancer.
Kallikrein 4 is a potential mediator of cellular interactions between cancer cells and osteoblasts in metastatic prostate cancer.
Kallikrein 4 is expressed in malignant mesothelioma--further evidence for the histogenetic link between mesothelial and epithelial cells.
Kallikrein-related peptidase 4 (KLK4) initiates intracellular signaling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progression.
Kallikrein-related peptidase 4 contributes to the tumor metastasis of oral squamous cell carcinoma.
Kallikrein-related peptidase 4 gene (KLK4) in prostate tumors: Quantitative expression analysis and evaluation of its clinical significance.
Kallikrein-related peptidase 4 promotes migration and invasion of endometrial stromal cells in endometriosis by inducing epithelial-mesenchymal transition.
Kallikrein-related peptidase signaling in colon carcinoma cells: Targeting proteinase-activated receptors (PARs).
KLK4 Induces Anti-Tumor Effects in Human Xenograft Mouse Models of Orthotopic and Metastatic Prostate Cancer.
MiR-378a-5p inhibits angiogenesis of oral squamous cell carcinoma by targeting KLK4.
Ovarian cancer specific kallikrein profile in effusions.
Odontogenic Tumors
Kallikrein 4 and matrix metalloproteinase-20 immunoexpression in malignant, benign and infiltrative odontogenic tumors.
Ovarian Neoplasms
Characterization of kallikrein-related peptidase 4 (KLK4) mRNA expression in tumor tissue of advanced high-grade serous ovarian cancer patients.
Kallikrein 4 is associated with paclitaxel resistance in ovarian cancer.
Ovarian cancer specific kallikrein profile in effusions.
Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment.
Pancreatic Neoplasms
PRSS1 mutations and the proteinase/antiproteinase imbalance in the pathogenesis of pancreatic cancer.
Pancreatitis
Hereditary pancreatitis for the endoscopist.
High Incidence of PRSS1 and SPINK1 Mutations in Korean Children With Acute Recurrent and Chronic Pancreatitis.
Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis.
Pancreatitis, Chronic
High Incidence of PRSS1 and SPINK1 Mutations in Korean Children With Acute Recurrent and Chronic Pancreatitis.
Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis.
Mutation That Promotes Activation of Trypsinogen Increases Severity of Secretagogue-Induced Pancreatitis in Mice.
Prostatic Neoplasms
Compartmentalized expression of kallikrein 4 (KLK4/hK4) isoforms in prostate cancer: nuclear, cytoplasmic and secreted forms.
Crystal structure of the inhibitor-free form of the serine protease kallikrein-4.
Detection of human kallikrein 4 in healthy and cancerous prostatic tissues by immunofluorometry and immunohistochemistry.
Direct progesterone receptor and indirect androgen receptor interactions with the kallikrein-related peptidase 4 gene promoter in breast and prostate cancer.
Epithelial-mesenchymal transition in prostate cancer and the potential role of kallikrein serine proteases.
Expression of human kallikrein 1-related peptidase 4 (KLK4) and MET phosphorylation in prostate cancer tissue: immunohistochemical analysis.
Human kallikrein 4 signal peptide induces cytotoxic T cell responses in healthy donors and prostate cancer patients.
Kallikrein 4 (hK4) and prostate-specific antigen (PSA) are associated with the loss of E-cadherin and an epithelial-mesenchymal transition (EMT)-like effect in prostate cancer cells.
Kallikrein 4 is a potential mediator of cellular interactions between cancer cells and osteoblasts in metastatic prostate cancer.
Kallikrein 4 is a predominantly nuclear protein and is overexpressed in prostate cancer.
Kallikrein 4 is a proliferative factor that is overexpressed in prostate cancer.
Kallikrein-related peptidase 4 (KLK4) initiates intracellular signaling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progression.
Kallikrein-related peptidase-4 initiates tumor-stroma interactions in prostate cancer through protease-activated receptor-1.
KLK4 Induces Anti-Tumor Effects in Human Xenograft Mouse Models of Orthotopic and Metastatic Prostate Cancer.
Mastering the canonical loop of serine protease inhibitors: enhancing potency by optimising the internal hydrogen bond network.
Murine, but not human, ephrin-B2 can be efficiently cleaved by the serine protease kallikrein-4: Implications for xenograft models of human prostate cancer.
Polyclonal antibodies against kallikrein-related peptidase 4 (KLK4): immunohistochemical assessment of KLK4 expression in healthy tissues and prostate cancer.
Potent, Selective, and Cell-Penetrating Inhibitors of Kallikrein-Related Peptidase 4 Based on the Cyclic Peptide MCoTI-II.
Prostate Cancer-Associated Kallikrein-Related Peptidase 4 Activates Matrix Metalloproteinase-1 and Thrombospondin-1.
Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4.
Sepsis
Identification of Potential Biomarkers by Serum Proteomics Analysis in Rats With Sepsis.
Squamous Cell Carcinoma of Head and Neck
Kallikrein-related peptidase 4 contributes to the tumor metastasis of oral squamous cell carcinoma.
Low mRNA expression levels of kallikrein-related peptidase 4 (KLK4) predict short-term relapse in patients with laryngeal squamous cell carcinoma.
Triple Negative Breast Neoplasms
Elevated levels of both microRNA 378 (miR-378) and kallikrein-related peptidase 4 (KLK4) mRNA are associated with an unfavorable prognosis in triple-negative breast cancer.
Tissue kallikrein-related peptidase 4 (KLK4), a novel biomarker in triple-negative breast cancer.
Virus Diseases
Mannan binding lectin-associated serine protease 1 is induced by hepatitis C virus infection and activates human hepatic stellate cells.