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Information on EC 3.4.21.B12 - prostase and Organism(s) Mus musculus and UniProt Accession Q9Z0M1

for references in articles please use BRENDA:EC3.4.21.B12
preliminary BRENDA-supplied EC number
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.B12 prostase
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This record set is specific for:
Mus musculus
UNIPROT: Q9Z0M1
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
proteolysis of polypeptides
Synonyms
kallikrein 4, serine protease 1, kallikrein-related peptidase 4, emsp1, kallikrein-4, prss17, prostase, kallikrein-related peptidase-4, klk-l1, klk-4 proteinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
EMSP1
Q9JIS2
-
PRSS17
Q9JIS2
-
serine protease 17
Q9JIS2
-
kallikrein 4
-
-
-
-
S01.251
-
-
-
-
additional information
Q9JIS2
PRSS17 is not a member of the kallikrein gene family of serine proteases but has originated prior to the divergence of the kallikrein and trypsin families of proteases
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
proteolysis of polypeptides
show the reaction diagram
enzyme is a serine protease
Q9JIS2
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
226408-87-3
-
9001-01-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
polypeptide + H2O
peptides
show the reaction diagram
Q9JIS2
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
polypeptide + H2O
peptides
show the reaction diagram
Q9JIS2
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
Q9JIS2
-
Manually annotated by BRENDA team
the expression of KLK4 is initiated from postnatal day 1 expressed in molar ameloblasts. From postnatal day 5 on, KLK4 is distributed not only in ameloblasts, but also in the degenerating satellite reticulum of molar enamel organ
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
coincidence of KLK4 and dipeptidyl-peptidase I distribution in ameloblasts strongly suggests that dipeptidyl-peptidase I activates KLK4
physiological function
KLK4 most likely plays a proteolytic role in degeneration of enamel organ
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
KLK4_MOUSE
255
0
27488
Swiss-Prot
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA sequence determination and analysis, chromosome mapping and genomic organization, promotor analysis
Q9JIS2
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hu, J.C.C.; Zhang, C.; Sun, X.; Yang, Y.; Cao, X.; Ryu, O.; Simmer, J.P.
Characterization of the mouse and human PRSS17 genes, their relationship to other serine proteases, and the expression of PRSS17 in developing mouse incisors
Gene
251
1-8
2000
Homo sapiens (Q9Y5K2), Homo sapiens, Mus musculus (Q9JIS2), Mus musculus
Manually annotated by BRENDA team
Wang, L.; Xie, X.; Sun, Y.; Wang, J.; Wang, Y.; Wang, X.
KLK4 is synchronically expressed to CTSC in ameloblasts during amelogenesis molars
Int. J. Clin. Exp. Pathol.
10
5751-5757
2017
Mus musculus (Q9Z0M1)
-
Manually annotated by BRENDA team