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Ala-Lys-Nle-Arg-7-amido-4-methylcoumarin + H2O
Ala-Lys-Nle-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzoyl-Ile-Glu(gamma-OR)-Gly-Arg-4-nitroanilide + H2O
benzoyl-Ile-Glu(gamma-OR)-Gly-Arg + 4-nitroaniline
i.e. A-2222, weak chromogenic substrate
-
?
CH2SO2-D-cyclohexylalanine-butanoyl-Arg-4-nitroanilide + H2O
CH2SO2-D-cyclohexylalanine-butanoyl-Arg + 4-nitroaniline
i.e. Pefa-5979, chromogenic substrate
-
?
CH2SO2-D-cyclohexylglycine-Gly-Arg-4-nitroanilide
CH2SO2-D-cyclohexylglycine-Gly-Arg + 4-nitroaniline
i.e. Pefa-3107, chromogenic substrate
-
?
CH3-OCO-D-cyclohexylalanine-Gly-Arg-4-nitroanilide + H2O
CH3-OCO-D-cyclohexylalanine-Gly-Arg + 4-nitroaniline
i.e. Pefa-5523, chromogenic substrate
-
?
D-Ala-cyclohexyltyrosine-Lys-4-nitroanilide + H2O
D-Ala-cyclohexyltyrosine-Lys + 4-nitroaniline
i.e. Pefa-5329, weak chromogenic substrate
-
?
D-cyclohexylglycine-Ala-Arg-4-nitroanilide + H2O
D-cyclohexylglycine-Ala-Arg + 4-nitroaniline
i.e. Pefa-5114, good chromogenic substrate
-
?
D-Lys(benzyloxycarbonyl)-Pro-Arg-4-nitroanilide + H2O
D-Lys(benzyloxycarbonyl)-Pro-Arg + 4-nitroaniline
i.e. Pefa-5773, chromogenic substrate
-
?
D-Phe-Pip-Arg-4-nitroanilide + H2O
D-Phe-Pip-Arg + 4-nitroaniline
i.e. S-2238, chromogenic substrate
-
?
DL-pyroglutamic acid-cyclohexylglycine-Arg-4-nitroanilide + H2O
DL-pyroglutamic acid-cyclohexylglycine-Arg + 4-nitroaniline
i.e. Pefa-3297, good chromogenic substrate
-
?
Fibrinogen + H2O
?
-
-
-
?
L-pyroglutamic acid-Pro-Arg-4-nitroanilide + H2O
L-pyroglutamic acid-Pro-Arg + 4-nitroaniline
i.e. S-2366, chromogenic substrate
-
?
L-pyroglutamylglycyl-L-arginine-p-nitroanilide + H2O
L-pyroglutamylglycyl-L-arginine + p-nitroaniline
-
-
-
?
Z-D-Arg-Gly-Arg-4-nitroanilide + H2O
Z-D-Arg-Gly-Arg + 4-nitroaniline
i.e. S-2765, good chromogenic substrate
-
?
basic fibroblast growth factor + H2O
?
coagulation factor FVII + H2O
?
-
-
-
?
CTCF + H2O
?
-
essential factor for optimal transcription from the amyloid beta-protein precursor promoter, enzyme cleaves CTCF at three major sites
-
?
D-isoleucyl-L-prolyl-L-arginine-p-nitroanilide + H2O
?
-
-
-
-
?
factor VII + H2O
activated factor VII + ?
-
-
-
-
?
fibrinogen + ?
?
-
cleaves the alpha-chain at multiple sites and the beta-chain between lysine53 and lysine54 but not the gamma-chain
-
?
fibroblast growth factor receptor 1 + H2O
?
-
HABP activates the p44/42-dependent MAPK (ERK1/2) signalling cascade independent of the B2-receptor, involving the fibroblast growth factor receptor-1 and basic fibroblast growth factor. This signalling pathway leads to phosphorylation of the kinases Raf, MEK1/2 and ERK1/2
-
-
?
fibronectin + ?
?
-
-
-
?
high molecular weight kininogen + H2O
activated cofactor kininogen + bradykinin
-
activates kininogen
-
?
high molecular weight kininogen + H2O
low molecular weight kininogen + bradykinin
high molecular weight kininogen profactor + H2O
activated kininogen + bradykinin
kininogen + H2O
bradykinin + ?
-
-
-
?
L-pyroglutamic acid-cyclo-hexylglycine-Arg-para-nitroanilide + H2O
?
-
P-3342, fluorogenic substrate
-
?
low molecular weight kininogen + H2O
bradykinin + ?
-
-
-
?
N-tert-butoxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O
N-tert-butoxycarbonyl-Phe-Ser-Arg + 7-amino-4-methylcoumarin
-
synthetic substrate
-
?
plasminogen activator precursor + H2O
?
-
-
-
?
platelet derived growth factor-AA + H2O
?
-
-
-
-
?
platelet derived growth factor-BB + H2O
?
-
-
-
-
?
platelet-derived growth factor-BB + H2O
?
pro-uPA + H2O
?
-
-
-
-
?
pro-uPa + H2O
uPa
-
-
-
-
?
prourokinase + H2O
?
-
-
-
?
prourokinase + H2O
urokinase + ?
-
-
-
-
?
single chain urokinase type plasminogen activator + H2O
two chain urokinase type plasminogen activator
-
-
-
-
?
Spectrozyme TH + H2O
? + 4-nitroaniline
-
-
-
-
?
tissue factor pathway inhibitor + H2O
?
-
the enzyme inhibits tissue factor pathway inhibitor, cleavage occurs between kringle domains K1 and K2 (Lys86-Thr87), as well as in the active site of K2 (Arg107-Gly108) and K3 (Arg199-Ala200) domains
-
-
?
tissue type plasminogen activator + H2O
?
-
-
-
-
?
transcription factor of amyloid beta protein precursor + H2O
?
-
-
-
?
urinary plasminogen activator + ?
?
-
converts the inactive single chain urinary plasminogen activator to the active two chain form
-
?
vacular endothelial cell growth factor + H2O
?
-
-
-
-
?
Vitronectin + H2O
?
-
-
-
?
additional information
?
-
basic fibroblast growth factor + H2O
?
-
-
-
-
?
basic fibroblast growth factor + H2O
?
-
HABP activates the p44/42-dependent MAPK (ERK1/2) signalling cascade independent of the B2-receptor, involving the fibroblast growth factor receptor-1 and basic fibroblast growth factor. This signalling pathway leads to phosphorylation of the kinases Raf, MEK1/2 and ERK1/2
-
-
?
factor V + H2O
?
-
-
-
?
factor VII + H2O
?
-
-
-
?
factor VII + H2O
?
-
-
-
-
?
factor VIII + H2O
?
-
-
-
?
factor VIII + H2O
?
-
-
-
?
Fibrinogen + H2O
?
-
-
-
?
Fibrinogen + H2O
?
-
-
-
-
?
Fibrinogen + H2O
?
-
cleaves the alpha-chain at multiple sites and the beta-chain between lysine53 and lysine54 but not the gamma-chain
-
-
?
Fibronectin + H2O
?
-
-
-
?
Fibronectin + H2O
?
-
-
-
-
?
high molecular weight kininogen + H2O
low molecular weight kininogen + bradykinin
-
-
-
-
?
high molecular weight kininogen + H2O
low molecular weight kininogen + bradykinin
-
HABP triggers Ca2+ release in HUVEC cells via the bradykinin B2 receptor
-
-
?
high molecular weight kininogen profactor + H2O
activated kininogen + bradykinin
-
-
-
-
?
high molecular weight kininogen profactor + H2O
activated kininogen + bradykinin
-
activates kininogen, cleaves between Arg419 and Lys 420
-
?
platelet-derived growth factor-BB + H2O
?
-
-
-
-
?
platelet-derived growth factor-BB + H2O
?
-
the enzyme inhibits platelet-derived growth factor-BB
-
-
?
Protein + H2O
?
-
-
-
?
Protein + H2O
?
-
cleaves C-terminal side of Arg effectively and that of Lys weakly
-
?
additional information
?
-
regulation of FSAP activity is dependent on its EGF-3 domain and over-expression of active variants induces cell death
-
-
?
additional information
?
-
substrate Ala-Lys-Nle-Arg-7-amido-4-methylcoumarin is based on a representive FSAP-cleaved sequence obtained from positional scanning substrate combinatorial library method. The results show a predilection for cleavage at a cluster of basic amino acids on the nonprime side. Molecular modelling studies show a preference for Arg over Lys at the P1 site
-
-
?
additional information
?
-
-
enzyme displays pro-urokinase-activating properties as well as factor VII-activating protease activity
-
?
additional information
?
-
-
no substrates: prothrombin, plasminogen
-
?
additional information
?
-
-
role in hemostasis is likely
-
?
additional information
?
-
-
extracellular activity of HABP affects gene expression level through phosphorylation of two transcription factors, the cAMP responsive element binding protein CREB and the protooncogene c-Myc
-
-
?
additional information
?
-
-
FSAP circulates as single-chain zymogen in plasma, which is autoactivated to an enzymatically active two-chain form
-
-
?
additional information
?
-
-
single-chain inactive zymogen is autoactivated to the two-chain active enzyme
-
-
?
additional information
?
-
-
zymogen undergoes autocatalytic activation
-
-
?
additional information
?
-
-
pro-plasma hyaluronan-binding protein autoproteolytically converts to an active two-chain form with the aid of an effector such as spermidine and heparin. Tannic acid, delphinidin, hamamelitannin, (-)-epicatechin gallate, and 3,5-di-O-caffeoylquinic inhibit spermidine-induced pro-plasma hyaluronan-binding protein autoactivation
-
-
?
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Abortion, Habitual
Hyaluronan-binding protein 2 (HABP2) gene variation in women with recurrent miscarriage.
Abortion, Spontaneous
Hyaluronan-binding protein 2 (HABP2) gene variation in women with recurrent miscarriage.
Acute Coronary Syndrome
Circulating Factor VII Activating Protease (FSAP) Is Associated With Clinical Outcome in Acute Coronary Syndrome.
Acute Kidney Injury
The delayed administration of pHBSP, a novel non-erythropoietic analogue of erythropoietin, attenuates acute kidney injury.
Acute Lung Injury
Hyaluronic Acid binding protein 2 is a novel regulator of vascular integrity.
Adenocarcinoma
Novel candidate tumor marker genes for lung adenocarcinoma.
Adenocarcinoma of Lung
HABP2 is a Novel Regulator of Hyaluronan-Mediated Human Lung Cancer Progression.
Atherosclerosis
Factor VII-activating protease (FSAP): vascular functions and role in atherosclerosis.
Atherosclerosis
Protease activated receptors (PAR)-1 and -2 mediate cellular effects of factor VII activating protease (FSAP).
Atherosclerosis
Qualitative detection of the Marburg I alloenzyme of factor VII-activating protease by an immunoassay and its comparison to PCR testing.
Atherosclerosis
The Factor VII-activating Protease (FSAP) Enhances the Activity of Bone Morphogenetic Protein-2 (BMP-2).
Atrial Fibrillation
Association of circulating factor seven activating protease (FSAP) and of oral Omega-3 fatty acids supplements with clinical outcome in patients with atrial fibrillation: the OMEGA-AF study.
Brain Injuries
Neuroprotection with an Erythropoietin Mimetic Peptide (pHBSP) in a Model of Mild Traumatic Brain Injury Complicated by Hemorrhagic Shock.
Breast Neoplasms
Common genetic variation and novel loci associated with volumetric mammographic density.
Breast Neoplasms
HABP2 p.G534E variant in patients with family history of thyroid and breast cancer.
Carcinoma
Expression of the factor VII activating protease, hepsin, in situ in renal cell carcinoma.
Carcinoma
HABP2 is a Novel Regulator of Hyaluronan-Mediated Human Lung Cancer Progression.
Carcinoma
Novel candidate tumor marker genes for lung adenocarcinoma.
Carcinoma, Non-Small-Cell Lung
HABP2 is a Novel Regulator of Hyaluronan-Mediated Human Lung Cancer Progression.
Carcinoma, Renal Cell
Expression of the factor VII activating protease, hepsin, in situ in renal cell carcinoma.
Carcinoma, Squamous Cell
Novel candidate tumor marker genes for lung adenocarcinoma.
Cardiovascular Diseases
Factor VII-activating protease: sex-related association with coronary artery calcification.
Cardiovascular Diseases
Structure-function analysis of factor VII activating protease (FSAP): sequence determinants for heparin binding and cellular functions.
Cardiovascular Diseases
The G534E polymorphism of the gene encoding the factor VII-activating protease is associated with cardiovascular risk due to increased neointima formation.
Carotid Stenosis
Marburg I polymorphism of factor VII-activating protease is associated with idiopathic venous thromboembolism.
Carotid Stenosis
Qualitative detection of the Marburg I alloenzyme of factor VII-activating protease by an immunoassay and its comparison to PCR testing.
Carotid Stenosis
Tests for the measurement of factor VII-activating protease (FSAP) activity and antigen levels in citrated plasma, their correlation to PCR testing, and utility for the detection of the Marburg I-polymorphism of FSAP.
Carotid Stenosis
The G534E polymorphism of the gene encoding the factor VII-activating protease is associated with cardiovascular risk due to increased neointima formation.
Cerebral Infarction
[Marburg I polymorphism of Factor VII-activating protease and cerebral infarction]
Coronary Artery Disease
Expression of the Marburg I Single Nucleotide Polymorphism (MI-SNP) and the Marburg II Single Nucleotide Polymorphism (MII-SNP) of the Factor VII-Activating Protease (FSAP) Gene and Risk of Coronary Artery Disease (CAD): A Pilot Study in a Single Population.
Endometrial Neoplasms
Diagnostic and prognostic value of HABP2 as a novel biomarker for endometrial cancer.
endopeptidase la deficiency
Factor VII-activating protease deficiency promotes neointima formation by enhancing leukocyte accumulation.
Hamartoma Syndrome, Multiple
Familial non-medullary thyroid cancer: unraveling the genetic maze.
Hepatitis C
The Marburg I variant (G534E) of the factor VII-activating protease determines liver fibrosis in hepatitis C infection by reduced proteolysis of platelet-derived growth factor BB.
hyaluronan-binding serine protease deficiency
Factor VII-activating protease deficiency promotes neointima formation by enhancing leukocyte accumulation.
Hypotension
Neuroprotection with an Erythropoietin Mimetic Peptide (pHBSP) in a Model of Mild Traumatic Brain Injury Complicated by Hemorrhagic Shock.
Infections
The Marburg I variant (G534E) of the factor VII-activating protease determines liver fibrosis in hepatitis C infection by reduced proteolysis of platelet-derived growth factor BB.
Infertility
Variation in Hyaluronan-Binding Protein 2 (HABP2) Promoter Region is Associated With Unexplained Female Infertility.
Insulin Resistance
Nonerythropoietic Erythropoietin-Derived Peptide Suppresses Adipogenesis, Inflammation, Obesity and Insulin Resistance.
Ischemic Stroke
Association of GWAS-Reported Variant rs11196288 near HABP2 with Ischemic Stroke in Chinese Han Population.
Ischemic Stroke
Deficiency of Factor VII activating protease alters the outcome of ischemic stroke in mice.
Ischemic Stroke
Factor seven activating protease (FSAP) predicts response to intravenous thrombolysis in acute ischemic stroke.
Liver Cirrhosis
Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men.
Liver Cirrhosis
Factor VII activating protease (FSAP): A novel protective factor in liver fibrosis.
Liver Cirrhosis
Structure-function analysis of factor VII activating protease (FSAP): sequence determinants for heparin binding and cellular functions.
Liver Cirrhosis
The Marburg I variant (G534E) of the factor VII-activating protease determines liver fibrosis in hepatitis C infection by reduced proteolysis of platelet-derived growth factor BB.
Liver Cirrhosis
Transforming growth factor-beta (TGF-?) inhibits the expression of factor VII activating protease (FSAP) in hepatocytes.
Lung Injury
Changes in factor VII-activating protease in a bleomycin-induced lung injury rat model and its influence on human pulmonary fibroblasts in vitro.
Lung Injury
Current view on alveolar coagulation and fibrinolysis in acute inflammatory and chronic interstitial lung diseases.
Lung Injury
Erythropoietin-Derived Peptide Protects Against Acute Lung Injury After Rat Traumatic Brain Injury.
Lung Neoplasms
HABP2 is a Novel Regulator of Hyaluronan-Mediated Human Lung Cancer Progression.
Neoplasm Metastasis
HABP2 is a Novel Regulator of Hyaluronan-Mediated Human Lung Cancer Progression.
Neoplasm, Residual
Diagnostic and prognostic value of HABP2 as a novel biomarker for endometrial cancer.
Neoplasms
Common genetic variation and novel loci associated with volumetric mammographic density.
Neoplasms
Diagnostic and prognostic value of HABP2 as a novel biomarker for endometrial cancer.
Neoplasms
Germline HABP2 Mutation Causing Familial Nonmedullary Thyroid Cancer.
Neoplasms
HABP2 G534E Variant in Papillary Thyroid Carcinoma.
Neoplasms
HABP2 germline variants are uncommon in familial nonmedullary thyroid cancer.
Neoplasms
HABP2 is a Novel Regulator of Hyaluronan-Mediated Human Lung Cancer Progression.
Neoplasms
HABP2 p.G534E variant in patients with family history of thyroid and breast cancer.
Neoplasms
Multiple HABP2 variants in familial papillary thyroid carcinoma: Contribution of a group of "thyroid-checked" controls.
Neoplasms
Pitfalls of exome sequencing: a case study of the attribution of HABP2 rs7080536 in familial non-medullary thyroid cancer.
Neoplasms
Protease activated receptors (PAR)-1 and -2 mediate cellular effects of factor VII activating protease (FSAP).
Neoplasms
Segregation and expression analyses of hyaluronan-binding protein 2 (HABP2): insights from a large series of familial non-medullary thyroid cancers and literature review.
Obesity
Nonerythropoietic Erythropoietin-Derived Peptide Suppresses Adipogenesis, Inflammation, Obesity and Insulin Resistance.
Respiratory Distress Syndrome
Current view on alveolar coagulation and fibrinolysis in acute inflammatory and chronic interstitial lung diseases.
Respiratory Distress Syndrome
Plasminogen activator inhibitor-1 is an inhibitor of factor VII-activating protease in patients with acute respiratory distress syndrome.
Respiratory Distress Syndrome
Raised protein levels and altered cellular expression of factor VII activating protease (FSAP) in the lungs of patients with acute respiratory distress syndrome (ARDS).
Sepsis
Complexes of factor VII-activating protease with plasminogen activator inhibitor-1 in human sepsis.
Stroke
Factor seven activating protease (FSAP) predicts response to intravenous thrombolysis in acute ischemic stroke.
Stroke
Factor VII activating protease (FSAP) influences vascular remodeling in the mouse hind limb ischemia model.
Stroke
Factor VII activating protease (FSAP) regulates the expression of inflammatory genes in vascular smooth muscle and endothelial cells.
Stroke
Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality.
Stroke
Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2.
Stroke
Protease activated receptors (PAR)-1 and -2 mediate cellular effects of factor VII activating protease (FSAP).
Thromboembolism
Qualitative detection of the Marburg I alloenzyme of factor VII-activating protease by an immunoassay and its comparison to PCR testing.
Thrombophilia
Direct chromogenic substrate immuno-capture activity assay for testing of factor VII-activating protease.
Thrombophilia
Qualitative detection of the Marburg I alloenzyme of factor VII-activating protease by an immunoassay and its comparison to PCR testing.
Thrombosis
Defective thrombus formation in mice lacking endogenous factor VII activating protease (FSAP).
Thrombosis
Factor VII activating protease (FSAP) influences vascular remodeling in the mouse hind limb ischemia model.
Thrombosis
Factor VII-activating protease deficiency promotes neointima formation by enhancing leukocyte accumulation.
Thrombosis
Protease activated receptors (PAR)-1 and -2 mediate cellular effects of factor VII activating protease (FSAP).
Thyroid Cancer, Papillary
Frequent and Rare HABP2 Variants Are Not Associated with Increased Susceptibility to Familial Nonmedullary Thyroid Carcinoma in the Spanish Population.
Thyroid Cancer, Papillary
Germline HABP2 Mutation Causing Familial Nonmedullary Thyroid Cancer.
Thyroid Cancer, Papillary
HABP2 G534E Mutation in Familial Nonmedullary Thyroid Cancer.
Thyroid Cancer, Papillary
HABP2 G534E Variant in Papillary Thyroid Carcinoma.
Thyroid Cancer, Papillary
HABP2 germline variants are uncommon in familial nonmedullary thyroid cancer.
Thyroid Cancer, Papillary
HABP2 p.G534E variant in patients with family history of thyroid and breast cancer.
Thyroid Cancer, Papillary
Letter regarding the article: "Multiple HABP2 variants in familial papillary thyroid carcinoma: Contribution of a group of "thyroid-checked" controls" by Kern et al.
Thyroid Cancer, Papillary
Multiple HABP2 variants in familial papillary thyroid carcinoma: Contribution of a group of "thyroid-checked" controls.
Thyroid Cancer, Papillary
RE: HABP2 G534E Mutation in Familial Nonmedullary Thyroid Cancer.
Thyroid Cancer, Papillary
Segregation and expression analyses of hyaluronan-binding protein 2 (HABP2): insights from a large series of familial non-medullary thyroid cancers and literature review.
Thyroid Cancer, Papillary
The G534E variant in HABP2 is not associated with increased risk of familial nonmedullary thyroid cancer in Brazilian Kindreds.
Thyroid Cancer, Papillary
The p.G534E variant of HABP2 is not associated with sporadic papillary thyroid carcinoma in a Polish population.
Thyroid Neoplasms
G534E Variant in HABP2 and Nonmedullary Thyroid Cancer.
Thyroid Neoplasms
Germline HABP2 Mutation Causing Familial Nonmedullary Thyroid Cancer.
Thyroid Neoplasms
HABP2 G534E Mutation in Familial Nonmedullary Thyroid Cancer.
Thyroid Neoplasms
HABP2 G534E variation in familial non-medullary thyroid cancer: an Italian series.
Thyroid Neoplasms
HABP2 germline variants are uncommon in familial nonmedullary thyroid cancer.
Thyroid Neoplasms
HABP2 in Familial Non-medullary Thyroid Cancer: Will the Real Mutation Please Stand Up?
Thyroid Neoplasms
HABP2 Mutation and Nonmedullary Thyroid Cancer.
Thyroid Neoplasms
Lac color inhibits development of rat thyroid carcinomas through targeting activation of plasma hyaluronan-binding protein.
Thyroid Neoplasms
Letter regarding the article: "Multiple HABP2 variants in familial papillary thyroid carcinoma: Contribution of a group of "thyroid-checked" controls" by Kern et al.
Thyroid Neoplasms
Pitfalls of exome sequencing: a case study of the attribution of HABP2 rs7080536 in familial non-medullary thyroid cancer.
Thyroid Neoplasms
RE: HABP2 G534E Mutation in Familial Nonmedullary Thyroid Cancer.
Thyroid Neoplasms
Segregation and expression analyses of hyaluronan-binding protein 2 (HABP2): insights from a large series of familial non-medullary thyroid cancers and literature review.
Thyroid Neoplasms
The G534E variant in HABP2 is not associated with increased risk of familial nonmedullary thyroid cancer in Brazilian Kindreds.
Thyroid Neoplasms
The HABP2 G534E polymorphism does not increase nonmedullary thyroid cancer risk in Hispanics.
Thyroid Neoplasms
The HABP2 G534E variant is an unlikely cause of familial non-medullary thyroid cancer.
Thyroid Neoplasms
The p.G534E variant of HABP2 is not associated with sporadic papillary thyroid carcinoma in a Polish population.
Vascular Diseases
Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality.
Vascular System Injuries
Factor VII activating protease (FSAP) regulates the expression of inflammatory genes in vascular smooth muscle and endothelial cells.
Venous Thromboembolism
Marburg I polymorphism of factor VII-activating protease and risk of recurrent venous thromboembolism.
Venous Thromboembolism
Marburg I polymorphism of factor VII-activating protease and risk of venous thromboembolism.
Venous Thromboembolism
Marburg I polymorphism of factor VII-activating protease is associated with idiopathic venous thromboembolism.
Venous Thromboembolism
Tests for the measurement of factor VII-activating protease (FSAP) activity and antigen levels in citrated plasma, their correlation to PCR testing, and utility for the detection of the Marburg I-polymorphism of FSAP.
Venous Thromboembolism
The Marburg I polymorphism of factor VII-activating protease and the risk of venous thromboembolism.
Venous Thrombosis
Factor VII-activating protease in patients with acute deep venous thrombosis.
Venous Thrombosis
The G534E-polymorphism of the gene encoding the Factor VII-activating protease is a risk factor for venous thrombosis and recurrent events.
Venous Thrombosis
The Marburg I polymorphism of factor VII-activating protease is not associated with venous thrombosis.
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Etscheid, M.; Hunfeld, A.; Konig, H.; Seitz, R.; Dodt, J.
Activation of proPHBSP, the zymogen of a plasma hyaluronan binding serine protease, by an intermolecular autocatalytic mechanism
Biol. Chem.
381
1223-1231
2000
Homo sapiens
brenda
Romisch, J.
Factor VII activating protease (FSAP): a novel protease in hemostasis
Biol. Chem.
383
1119-1124
2002
Homo sapiens
brenda
Etscheid, M.; Beer, N.; Fink, E.; Seitz, R.; Johannes, D.
The hyaluronan-binding serine protease from human plasma cleaves HMW and LMW kininogen and releases bradykinin
Biol. Chem.
383
1633-1643
2002
Homo sapiens
brenda
Choi-Miura, N.H.; Yoda, M.; Saito, K.; Takahashi, K.; Tomita, M.
Identification of the substrates for plasma hyaluronan binding protein
Biol. Pharm. Bull.
24
140-143
2001
Homo sapiens
brenda
Choi-Miura, N.H.; Saito, K.; Takahashi, K.; Yoda, M.; Tomita, M.
Regulation mechanism of the serine protease activity of plasma hyaluronan binding protein
Biol. Pharm. Bull.
24
221-225
2001
Homo sapiens
brenda
Choi-Miura, N.H.; Takahashi, K.; Yoda, M.; Saito, K.; Mazda, T.; Tomita, M.
Proteolytic activation and inactivation of the serine protease activity of plasma hyaluronan binding protein
Biol. Pharm. Bull.
24
448-452
2001
Homo sapiens
brenda
Kannemeier, C.; Feussner, A.; Stohr, H.A.; Weisse, J.; Preissner, K.T.; Romisch, J.
Factor VII and single-chain plasminogen activator-activating protease: activation and autoactivation of the proenzyme
Eur. J. Biochem.
268
3789-3796
2001
Homo sapiens
brenda
Hunfeld, A.; Etscheid, M.; Konig, H.; Seitz, R.; Dodt, J.
Detection of a novel plasma serine protease during purification of vitamin K-dependent coagulation factors
FEBS Lett.
456
290-294
1999
Homo sapiens (Q14520), Homo sapiens
brenda
Vostrov, A.A.; Quitschke, W.W.
Plasma hyaluronan-binding protein is a serine protease
J. Biol. Chem.
275
22978-22985
2000
Bos taurus, Equus sp., Homo sapiens, Oryctolagus cuniculus
brenda
Etscheid, M.; Beer, N.; Dodt, J.
The hyaluronan-binding protease upregulates ERK1/2 and PI3K/Akt signalling pathways in fibroblasts and stimulates cell proliferation and migration
Cell. Signal.
17
1486-1494
2005
Homo sapiens
brenda
Choi-Miura, N.H.
Novel human plasma proteins, IHRP (acute phase protein) and PHBP (serine protease), which bind to glycosaminoglycans
Curr. Med. Chem. Cardiovasc. Hematol. Agents
2
239-248
2004
Homo sapiens
brenda
Parahuleva, M.S.; Kanse, S.M.; Parviz, B.; Barth, A.; Tillmanns, H.; Bohle, R.M.; Sedding, D.G.; Hoelschermann, H.
Factor Seven Activating Protease (FSAP) expression in human monocytes and accumulation in unstable coronary atherosclerotic plaques
Atherosclerosis
196
164-171
2008
Homo sapiens
brenda
Muhl, L.; Nykjaer, A.; Wygrecka, M.; Monard, D.; Preissner, K.T.; Kanse, S.M.
Inhibition of PDGF-BB by Factor VII-activating protease (FSAP) is neutralized by protease nexin-1, and the FSAP-inhibitor complexes are internalized via LRP
Biochem. J.
404
191-196
2007
Homo sapiens
brenda
Shibamiya, A.; Muhl, L.; Tannert-Otto, S.; Preissner, K.T.; Kanse, S.M.
Nucleic acids potentiate Factor VII-activating protease (FSAP)-mediated cleavage of platelet-derived growth factor-BB and inhibition of vascular smooth muscle cell proliferation
Biochem. J.
404
45-50
2007
Homo sapiens
brenda
Kress, J.A.; Seitz, R.; Dodt, J.; Etscheid, M.
Induction of intracellular signalling in human endothelial cells by the hyaluronan-binding protease involves two distinct pathways
Biol. Chem.
387
1275-1283
2006
Homo sapiens
brenda
Etscheid, M.; Kress, J.; Seitz, R.; Dodt, J.
The hyaluronic acid-binding protease: a novel vascular and inflammatory mediator?
Int. Immunopharmacol.
8
166-170
2008
Homo sapiens
brenda
Wygrecka, M.; Morty, R.E.; Markart, P.; Kanse, S.M.; Andreasen, P.A.; Wind, T.; Guenther, A.; Preissner, K.T.
Plasminogen activator inhibitor-1 is an inhibitor of factor VII-activating protease in patients with acute respiratory distress syndrome
J. Biol. Chem.
282
21671-21682
2007
Homo sapiens
brenda
Kanse, S.M.; Parahuleva, M.; Muhl, L.; Kemkes-Matthes, B.; Sedding, D.; Preissner, K.T.
Factor VII-activating protease (FSAP): vascular functions and role in atherosclerosis
Thromb. Haemost.
99
286-289
2008
Homo sapiens
brenda
Stephan, S.; Schwarz, H.; Borchert, A.; Bussfeld, D.; Quak, E.; Simshaeuser-Knaub, B.; Teigelkamp, S.; Behrens, F.; Vitzthum, F.
Tests for the measurement of factor VII-activating protease (FSAP) activity and antigen levels in citrated plasma, their correlation to PCR testing, and utility for the detection of the Marburg I-polymorphism of FSAP
Clin. Chem. Lab. Med.
46
1109-1116
2008
Homo sapiens (Q14520)
brenda
Muhl, L.; Hersemeyer, K.; Preissner, K.T.; Weimer, T.; Kanse, S.M.
Structure-function analysis of factor VII activating protease (FSAP): sequence determinants for heparin binding and cellular functions
FEBS Lett.
583
1994-1998
2009
Homo sapiens (Q14520)
brenda
Wasmuth, H.E.; Tag, C.G.; Van de Leur, E.; Hellerbrand, C.; Mueller, T.; Berg, T.; Puhl, G.; Neuhaus, P.; Samuel, D.; Trautwein, C.; Kanse, S.M.; Weiskirchen, R.
The Marburg I variant (G534E) of the factor VII-activating protease determines liver fibrosis in hepatitis C infection by reduced proteolysis of platelet-derived growth factor BB
Hepatology
49
775-780
2009
Homo sapiens (Q14520), Homo sapiens
brenda
Parahuleva, M.S.; Hoelschermann, H.; Erdogan, A.; Langanke, E.; Prickartz, I.; Parviz, B.; Weiskirchen, R.; Tillmanns, H.; Kanse, S.M.
Factor Seven Activating Protease (FSAP) levels during normal pregnancy and in women using oral contraceptives
Thromb. Res.
126
e36-e40
2010
Homo sapiens
brenda
Kanse, S.M.; Declerck, P.J.; Ruf, W.; Broze, G.; Etscheid, M.
Factor VII-activating protease promotes the proteolysis and inhibition of tissue factor pathway inhibitor
Arterioscler. Thromb. Vasc. Biol.
32
427-433
2012
Homo sapiens
brenda
Yamamoto, E.; Nishimura, N.; Okada, K.; Sekido, C.; Yamamichi, S.; Hasumi, K.
Inhibitors of autoactivation of plasma hyaluronan-binding protein (factor VII activating protease)
Biol. Pharm. Bull.
34
462-470
2011
Homo sapiens
brenda
Sidelmann, J.J.; Skouby, S.O.; Kluft, C.; Winkler, U.; Vitzthum, F.; Schwarz, H.; Gram, J.; Jespersen, J.
Plasma factor VII-activating protease is increased by oral contraceptives and induces factor VII activation in-vivo
Thromb. Res.
128
e67-e72
2011
Homo sapiens
brenda
Sperling, C.; Maitz, M.F.; Grasso, S.; Werner, C.; Kanse, S.M.
A positively charged surface triggers coagulation activation through factor VII activating protease (FSAP)
ACS Appl. Mater. Interfaces
9
40107-40116
2017
Homo sapiens (Q14520)
brenda
Byskov, K.; Boettger, T.; Ruehle, P.F.; Nielsen, N.V.; Etscheid, M.; Kanse, S.M.
Factor VII activating protease (FSAP) regulates the expression of inflammatory genes in vascular smooth muscle and endothelial cells
Atherosclerosis
265
133-139
2017
Homo sapiens (Q14520), Homo sapiens
brenda
Etscheid, M.; Subramaniam, S.; Lochnit, G.; Zabczyk, M.; Undas, A.; Lang, I.M.; Hanschmann, K.M.; Kanse, S.M.
Altered structure and function of fibrinogen after cleavage by Factor VII Activating Protease (FSAP)
Biochim. Biophys. Acta Mol. Basis Dis.
1864
3397-3406
2018
Homo sapiens (Q14520), Homo sapiens
brenda
Ramanathan, R.; Gram, J.B.; Sand, N.P.R.; Norgaard, B.L.; Diederichsen, A.C.P.; Vitzthum, F.; Schwarz, H.; Sidelmann, J.J.
Factor VII-activating protease sex-related association with coronary artery calcification
Blood Coagul. Fibrinolysis
28
558-563
2017
Homo sapiens (Q14520), Homo sapiens
brenda
Mirzapoiazova, T.; Mambetsariev, N.; Lennon, F.E.; Mambetsariev, B.; Berlind, J.E.; Salgia, R.; Singleton, P.A.
HABP2 is a novel regulator of hyaluronan-mediated human lung cancer progression
Front. Oncol.
5
164
2015
Homo sapiens (Q14520), Homo sapiens
brenda
de Jong, H.K.; Koh, G.C.; Bulder, I.; Stephan, F.; Wiersinga, W.J.; Zeerleder, S.S.
Diabetes-independent increase of factor VII-activating protease activation in patients with Gram-negative sepsis (melioidosis)
J. Thromb. Haemost.
13
41-6
2015
Homo sapiens (Q14520)
brenda
Kara, E.; Manna, D.; Loeset, G..; Schneider, E.L.; Craik, C.S; Kanse, S.
Analysis of the substrate specificity of Factor VII activating protease (FSAP) and design of specific and sensitive peptide substrates
Thromb. Haemost.
117
1750-1760
2017
Homo sapiens (Q14520)
brenda
Grasso, S.; Neumann, A.; Lang, I.M.; Etscheid, M.; von Kckritz-Blickwede, M.; Kanse, S.M.
Interaction of factor VII activating protease (FSAP) with neutrophil extracellular traps (NETs)
Thromb. Res.
161
36-42
2018
Homo sapiens (Q14520), Homo sapiens
brenda