Disease on EC 3.4.21.92 - Endopeptidase Clp

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DISEASE
TITLE OF PUBLICATION
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Anemia, Hypochromic
Chlorosis during nitrogen starvation is altered by carbon dioxide and temperature status and is mediated by the ClpP1 protease in Synechococcus elongatus.
ClpC1, an ATP-dependent Clp protease in plastids, is involved in iron homeostasis in Arabidopsis leaves.
Inactivation of the clpC1 gene encoding a chloroplast Hsp100 molecular chaperone causes growth retardation, leaf chlorosis, lower photosynthetic activity, and a specific reduction in photosystem content.
Dehydration
A nuclear gene, erd1, encoding a chloroplast-targeted Clp protease regulatory subunit homolog is not only induced by water stress but also developmentally up-regulated during senescence in Arabidopsis thaliana.
Hypersensitivity
Communication of ClpXP protease hypersensitivity to bacteriophage Mu repressor isoforms.
Infections
Caseinolytic protease: a protein vaccine which could elicit serotype-independent protection against invasive pneumococcal infection.
CspA regulation of Staphylococcus aureus carotenoid levels and ?B activity is controlled by YjbH and Spx.
Development of high throughput screening methods for inhibitors of ClpC1P1P2 from Mycobacteria tuberculosis.
Disruption of the genes for ClpXP protease in Salmonella enterica serovar Typhimurium results in persistent infection in mice, and development of persistence requires endogenous gamma interferon and tumor necrosis factor alpha.
Dual RNA-seq in Streptococcus pneumoniae Infection Reveals Compartmentalized Neutrophil Responses in Lung and Pleural Space.
Escherichia coli rnlA and rnlB Compose a Novel Toxin-Antitoxin System.
Helicobacter pylori mutants defective in the clpP ATP-dependant protease and the chaperone clpA display reduced macrophage and murine survival.
In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1.
Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection.
Oral immunization with ATP-dependent protease-deficient mutants protects mice against subsequent oral challenge with virulent Salmonella enterica serovar typhimurium.
Proteomic comparison of Mycobacterium avium subspecies paratuberculosis grown in vitro and isolated from clinical cases of ovine paratuberculosis.
Regulation of host hemoglobin binding by the Staphylococcus aureus Clp proteolytic system.
Rufomycin Targets ClpC1 Proteolysis in Mycobacterium tuberculosis and M. abscessus.
The ClpC ATPase of Listeria monocytogenes is a general stress protein required for virulence and promoting early bacterial escape from the phagosome of macrophages.
The ClpP peptidase of Wolbachia endobacteria is a novel target for drug development against filarial infections.
The cytokine balance in the maintenance of a persistent infection with Salmonella enterica serovar Typhimurium in mice.
The development of small-molecule modulators for ClpP protease activity.
Two isoforms of Clp peptidase in Pseudomonas aeruginosa control distinct aspects of cellular physiology.
Infertility
Association of tubal factor infertility with elevated antibodies to Chlamydia trachomatis caseinolytic protease P.
Leprosy
Autoimmunity to Tropomyosin-Specific Peptides Induced by Mycobacterium leprae in Leprosy Patients: Identification of Mimicking Proteins.
Liver Cirrhosis, Biliary
Antibodies against homologous microbial caseinolytic proteases P characterise primary biliary cirrhosis.
Antibodies against the COOH-terminal region of E. coli ClpP protease in patients with primary biliary cirrhosis.
Antibodies to Clp protease in primary biliary cirrhosis: possible role of a mimicking T-cell epitope.
Liver Diseases
Antibodies against the COOH-terminal region of E. coli ClpP protease in patients with primary biliary cirrhosis.
Malaria
A cyanobacterial serine protease of Plasmodium falciparum is targeted to the apicoplast and plays an important role in its growth and development.
A novel class of Plasmodial ClpP protease inhibitors as potential antimalarial agents.
Bayesian analysis of new and old malaria parasite DNA sequence data demonstrates the need for more phylogenetic signal to clarify the descent of Plasmodium falciparum.
Malaria parasite sequences from chimpanzee support the co-speciation hypothesis for the origin of virulent human malaria (Plasmodium falciparum).
Plasmodium (Haemamoeba) cathemerium gene sequences for phylogenetic analysis of malaria parasites.
Malaria, Avian
Plasmodium (Haemamoeba) cathemerium gene sequences for phylogenetic analysis of malaria parasites.
Neoplasm Metastasis
The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis.
Neoplasms
Disruption of the genes for ClpXP protease in Salmonella enterica serovar Typhimurium results in persistent infection in mice, and development of persistence requires endogenous gamma interferon and tumor necrosis factor alpha.
Identification of potential mitochondrial CLPXP protease interactors and substrates suggests its central role in energy metabolism.
The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis.
The up-regulation of proteasome subunits and lysosomal proteases in hepatocellular carcinomas of the HBx gene knockin transgenic mice.
Neuroblastoma
Streptococcus pneumoniae ClpP protease induces apoptosis via caspase-independent pathway in human neuroblastoma cells: cytoplasmic relocalization of p53.
Neurodegenerative Diseases
Identification of potential mitochondrial CLPXP protease interactors and substrates suggests its central role in energy metabolism.
Pneumococcal Infections
Caseinolytic protease: a protein vaccine which could elicit serotype-independent protection against invasive pneumococcal infection.
Enhanced protection against pneumococcal infection elicited by immunization with the combination of PspA, PspC, and ClpP.
Immunization with a combination of three pneumococcal proteins confers additive and broad protection against Streptococcus pneumoniae Infections in Mice.
Mucosal immunization with caseinolytic protease X elicited cross-protective immunity against pneumococcal infection in mice.
Mucosal immunization with purified ClpP could elicit protective efficacy against pneumococcal pneumonia and sepsis in mice.
Protoporphyria, Erythropoietic
The role of ClpX in erythropoietic protoporphyria.
Salmonella Infections
Oral immunization with ATP-dependent protease-deficient mutants protects mice against subsequent oral challenge with virulent Salmonella enterica serovar typhimurium.
Sepsis
Streptococcus pneumoniae: proteomics of surface proteins for vaccine development.
Starvation
Chlorosis during nitrogen starvation is altered by carbon dioxide and temperature status and is mediated by the ClpP1 protease in Synechococcus elongatus.
Global role for ClpP-containing proteases in stationary-phase adaptation of Escherichia coli.
Regulation of Escherichia coli starvation sigma factor (sigma s) by ClpXP protease.
Role of Clp protease subunits in degradation of carbon starvation proteins in Escherichia coli.
Role of the response regulator RssB in sigma recognition and initiation of sigma proteolysis in Escherichia coli.
Structural basis of degradation signal recognition by SspB, a specificity-enhancing factor for the ClpXP proteolytic machine.
Validation of the essential ClpP protease in Mycobacterium tuberculosis as a novel drug target.
Tuberculosis
A ClpP protein model as tuberculosis target for screening marine compounds.
Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease.
Anti-tuberculosis lead molecules from natural products targeting Mycobacterium tuberculosis ClpC1.
Antibacterial Activity of and Resistance to Small Molecule Inhibitors of the ClpP Peptidase.
Assembly and proteolytic processing of mycobacterial ClpP1 and ClpP2.
Characterization of a Clp protease gene regulator and the reaeration response in Mycobacterium tuberculosis.
Cloning and characterization of Clp protease proteolytic subunit 2 and its implication in clinical diagnosis of tuberculosis.
Correction: The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1.
Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery.
Gift from Nature: Cyclomarin?A Kills Mycobacteria and Malaria Parasites by Distinct Modes of Action.
High-Resolution Structure of ClpC1-Rufomycin and Ligand Binding Studies Provide a Framework to Design and Optimize Anti-Tuberculosis Leads.
In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1.
Insights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1.
Missense Mutations in the Unfoldase ClpC1 of the Caseinolytic Protease Complex Are Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis.
Mutation analysis of the interactions between Mycobacterium tuberculosis caseinolytic protease C1 (ClpC1) and ecumicin.
Mutation in clpC1 encoding an ATP-dependent ATPase involved in protein degradation is associated with pyrazinamide resistance in Mycobacterium tuberculosis.
Mycobacterial Caseinolytic Protease Gene Regulator ClgR Is a Substrate of Caseinolytic Protease.
Mycobacterium tuberculosis ClpC1 N-Terminal Domain Is Dispensable for Adaptor Protein-Dependent Allosteric Regulation.
Mycobacterium tuberculosis ClpC1: characterization and role of the N-terminal domain in its function.
Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection.
Mycobacterium tuberculosis ClpX interacts with FtsZ and interferes with FtsZ assembly.
Post-Translational Regulation via Clp Protease Is Critical for Survival of Mycobacterium tuberculosis.
Rufomycin Targets ClpC1 Proteolysis in Mycobacterium tuberculosis and M. abscessus.
Species variation in ATP-dependent protein degradation: protease profiles differ between mycobacteria and protease functions differ between Mycobacterium smegmatis and Escherichia coli.
Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase.
The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring.
The antibiotic cyclomarin blocks arginine-phosphate-induced millisecond dynamics in the N-terminal domain of ClpC1 from Mycobacterium tuberculosis.
The C-terminus of ClpC1 of Mycobacterium tuberculosis is crucial for its oligomerization and function.
The Clp Chaperones and Proteases of the Human Malaria Parasite Plasmodium falciparum.
The Cyclic Peptide Ecumicin Targeting ClpC1 Is Active against Mycobacterium tuberculosis In Vivo.
The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1.
The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease.
Total synthesis of cyclomarins A, C and D, marine cyclic peptides with interesting anti-tuberculosis and anti-malaria activities.
Validation of the essential ClpP protease in Mycobacterium tuberculosis as a novel drug target.
[Prediction and Analysis of Epitopes in clpP2 of Mycobacterium tuberculosis].